LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDH3_LEIIN
TriTrypDb:
LINF_360027000
Length:
367

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDH3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 175 179 PF00656 0.405
CLV_C14_Caspase3-7 64 68 PF00656 0.565
CLV_NRD_NRD_1 116 118 PF00675 0.503
CLV_NRD_NRD_1 134 136 PF00675 0.461
CLV_NRD_NRD_1 254 256 PF00675 0.495
CLV_PCSK_KEX2_1 116 118 PF00082 0.460
CLV_PCSK_KEX2_1 134 136 PF00082 0.508
CLV_PCSK_KEX2_1 194 196 PF00082 0.479
CLV_PCSK_KEX2_1 254 256 PF00082 0.488
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.387
CLV_PCSK_SKI1_1 223 227 PF00082 0.564
CLV_PCSK_SKI1_1 352 356 PF00082 0.529
DEG_APCC_DBOX_1 246 254 PF00400 0.570
DEG_Nend_UBRbox_1 1 4 PF02207 0.592
DOC_MAPK_MEF2A_6 73 80 PF00069 0.581
DOC_USP7_MATH_1 200 204 PF00917 0.409
DOC_USP7_MATH_1 232 236 PF00917 0.617
DOC_USP7_MATH_1 277 281 PF00917 0.623
DOC_USP7_MATH_1 35 39 PF00917 0.732
DOC_WW_Pin1_4 6 11 PF00397 0.567
DOC_WW_Pin1_4 71 76 PF00397 0.602
LIG_14-3-3_CanoR_1 40 44 PF00244 0.776
LIG_14-3-3_CanoR_1 58 63 PF00244 0.562
LIG_14-3-3_CanoR_1 73 79 PF00244 0.715
LIG_14-3-3_CanoR_1 97 105 PF00244 0.689
LIG_Actin_WH2_2 112 129 PF00022 0.432
LIG_Actin_WH2_2 25 42 PF00022 0.509
LIG_BRCT_BRCA1_1 41 45 PF00533 0.589
LIG_deltaCOP1_diTrp_1 146 150 PF00928 0.446
LIG_FHA_1 100 106 PF00498 0.734
LIG_FHA_1 121 127 PF00498 0.515
LIG_FHA_1 328 334 PF00498 0.497
LIG_FHA_2 236 242 PF00498 0.577
LIG_FHA_2 346 352 PF00498 0.342
LIG_FHA_2 62 68 PF00498 0.719
LIG_FHA_2 83 89 PF00498 0.510
LIG_LIR_Gen_1 146 153 PF02991 0.544
LIG_LIR_Gen_1 27 37 PF02991 0.530
LIG_LIR_Gen_1 330 340 PF02991 0.427
LIG_LIR_Nem_3 146 150 PF02991 0.556
LIG_LIR_Nem_3 27 32 PF02991 0.758
LIG_LIR_Nem_3 330 335 PF02991 0.483
LIG_MYND_1 317 321 PF01753 0.580
LIG_PCNA_PIPBox_1 279 288 PF02747 0.461
LIG_PCNA_yPIPBox_3 278 286 PF02747 0.421
LIG_Rb_LxCxE_1 167 186 PF01857 0.421
LIG_SH2_CRK 344 348 PF00017 0.366
LIG_SH2_STAT5 285 288 PF00017 0.544
LIG_SH2_STAT5 294 297 PF00017 0.436
LIG_SH3_3 303 309 PF00018 0.399
LIG_SH3_3 311 317 PF00018 0.422
LIG_SH3_3 330 336 PF00018 0.342
LIG_SH3_3 41 47 PF00018 0.668
LIG_SH3_3 63 69 PF00018 0.725
LIG_SH3_3 8 14 PF00018 0.587
LIG_SH3_3 88 94 PF00018 0.578
LIG_SUMO_SIM_par_1 74 79 PF11976 0.553
LIG_SUMO_SIM_par_1 87 95 PF11976 0.459
LIG_TRAF2_1 263 266 PF00917 0.479
LIG_TRAF2_1 85 88 PF00917 0.541
LIG_TRFH_1 332 336 PF08558 0.409
LIG_UBA3_1 183 188 PF00899 0.353
MOD_CDK_SPxxK_3 6 13 PF00069 0.569
MOD_CK1_1 100 106 PF00069 0.591
MOD_CK1_1 151 157 PF00069 0.409
MOD_CK1_1 174 180 PF00069 0.362
MOD_CK1_1 235 241 PF00069 0.598
MOD_CK1_1 38 44 PF00069 0.695
MOD_CK1_1 74 80 PF00069 0.645
MOD_CK2_1 214 220 PF00069 0.403
MOD_CK2_1 235 241 PF00069 0.586
MOD_CK2_1 260 266 PF00069 0.481
MOD_CK2_1 82 88 PF00069 0.513
MOD_GlcNHglycan 234 237 PF01048 0.577
MOD_GlcNHglycan 255 258 PF01048 0.495
MOD_GlcNHglycan 41 44 PF01048 0.684
MOD_GSK3_1 160 167 PF00069 0.566
MOD_GSK3_1 228 235 PF00069 0.585
MOD_GSK3_1 35 42 PF00069 0.700
MOD_GSK3_1 97 104 PF00069 0.648
MOD_N-GLC_1 151 156 PF02516 0.401
MOD_N-GLC_1 6 11 PF02516 0.581
MOD_NEK2_1 253 258 PF00069 0.446
MOD_NEK2_1 268 273 PF00069 0.464
MOD_NEK2_1 39 44 PF00069 0.614
MOD_NEK2_2 35 40 PF00069 0.512
MOD_PIKK_1 225 231 PF00454 0.534
MOD_PIKK_1 268 274 PF00454 0.440
MOD_PIKK_1 321 327 PF00454 0.499
MOD_PKA_2 253 259 PF00069 0.467
MOD_PKA_2 39 45 PF00069 0.766
MOD_PKA_2 98 104 PF00069 0.622
MOD_PKB_1 97 105 PF00069 0.665
MOD_Plk_4 24 30 PF00069 0.622
MOD_Plk_4 61 67 PF00069 0.605
MOD_ProDKin_1 6 12 PF00069 0.569
MOD_ProDKin_1 71 77 PF00069 0.601
MOD_SUMO_rev_2 203 213 PF00179 0.422
MOD_SUMO_rev_2 259 269 PF00179 0.482
MOD_SUMO_rev_2 357 363 PF00179 0.420
TRG_DiLeu_BaEn_2 327 333 PF01217 0.483
TRG_DiLeu_BaEn_4 241 247 PF01217 0.464
TRG_DiLeu_BaLyEn_6 154 159 PF01217 0.390
TRG_ENDOCYTIC_2 344 347 PF00928 0.409
TRG_ER_diArg_1 115 117 PF00400 0.558
TRG_ER_diArg_1 253 255 PF00400 0.440
TRG_ER_diArg_1 57 60 PF00400 0.600
TRG_ER_diArg_1 96 99 PF00400 0.624
TRG_ER_diLys_1 362 367 PF00400 0.464
TRG_NLS_MonoExtC_3 192 198 PF00514 0.385
TRG_Pf-PMV_PEXEL_1 117 121 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 157 162 PF00026 0.601
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.629
TRG_Pf-PMV_PEXEL_1 284 288 PF00026 0.557

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6L0 Leptomonas seymouri 47% 100%
A0A1X0P8R8 Trypanosomatidae 33% 100%
A0A3Q8INP8 Leishmania donovani 100% 100%
A4HP68 Leishmania braziliensis 74% 100%
D0A360 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9ASX6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q1M2 Leishmania major 91% 100%
V5BGD4 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS