Inosine-guanosine transporter

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inosine-guanosine transporter

Species:

Leishmania infantum

UniProt:

A4IDG6_LEIIN

TriTrypDb:

LINF_360026000

Length:

499

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Annotations by Jardim et al.

Transporters, Inosine-guanosine transporter NT2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 53
NetGPI	no	yes: 0, no: 53

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	5
GO:0016020	membrane	2	54
GO:0110165	cellular anatomical entity	1	54

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDG6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0015851	nucleobase transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	54
GO:0005337	nucleoside transmembrane transporter activity	4	54
GO:0015205	nucleobase transmembrane transporter activity	3	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	54
GO:0022857	transmembrane transporter activity	2	54
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	54

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.474
CLV_NRD_NRD_1	251	253	PF00675	0.243
CLV_PCSK_KEX2_1	250	252	PF00082	0.276
CLV_PCSK_KEX2_1	343	345	PF00082	0.283
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.239
CLV_PCSK_SKI1_1	111	115	PF00082	0.248
CLV_PCSK_SKI1_1	280	284	PF00082	0.143
CLV_PCSK_SKI1_1	325	329	PF00082	0.351
CLV_PCSK_SKI1_1	393	397	PF00082	0.284
DOC_CKS1_1	459	464	PF01111	0.463

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P486	Leptomonas seymouri	31%	100%
A0A0N0P6Z5	Leptomonas seymouri	68%	100%
A0A0N1I1J0	Leptomonas seymouri	30%	100%
A0A0N1I8E8	Leptomonas seymouri	25%	100%
A0A0N1PBQ1	Leptomonas seymouri	34%	99%
A0A0S4JBS4	Bodo saltans	31%	100%
A0A1X0NN91	Trypanosomatidae	32%	100%
A0A1X0NPL0	Trypanosomatidae	34%	100%
A0A1X0NV38	Trypanosomatidae	33%	100%
A0A1X0NWJ5	Trypanosomatidae	32%	100%

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