LeishMANIAdb
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Inosine-guanosine transporter

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Inosine-guanosine transporter
Gene product:
inosine-guanosine transporter
Species:
Leishmania infantum
UniProt:
A4IDG6_LEIIN
TriTrypDb:
LINF_360026000
Length:
499

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Annotations by Jardim et al.

Transporters, Inosine-guanosine transporter NT2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0005886 plasma membrane 3 5

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDG6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 259 263 PF00656 0.474
CLV_NRD_NRD_1 251 253 PF00675 0.243
CLV_PCSK_KEX2_1 250 252 PF00082 0.276
CLV_PCSK_KEX2_1 343 345 PF00082 0.283
CLV_PCSK_PC1ET2_1 343 345 PF00082 0.239
CLV_PCSK_SKI1_1 111 115 PF00082 0.248
CLV_PCSK_SKI1_1 280 284 PF00082 0.143
CLV_PCSK_SKI1_1 325 329 PF00082 0.351
CLV_PCSK_SKI1_1 393 397 PF00082 0.284
DOC_CKS1_1 459 464 PF01111 0.463
DOC_MAPK_DCC_7 415 424 PF00069 0.293
DOC_MAPK_DCC_7 427 435 PF00069 0.243
DOC_MAPK_gen_1 343 350 PF00069 0.460
DOC_MAPK_gen_1 399 409 PF00069 0.502
DOC_MAPK_HePTP_8 108 120 PF00069 0.473
DOC_MAPK_MEF2A_6 104 112 PF00069 0.493
DOC_MAPK_MEF2A_6 211 220 PF00069 0.356
DOC_MAPK_MEF2A_6 373 382 PF00069 0.348
DOC_MAPK_MEF2A_6 393 400 PF00069 0.404
DOC_MAPK_MEF2A_6 402 409 PF00069 0.462
DOC_MAPK_MEF2A_6 415 424 PF00069 0.319
DOC_MAPK_MEF2A_6 427 435 PF00069 0.257
DOC_MAPK_NFAT4_5 111 119 PF00069 0.397
DOC_PP1_RVXF_1 209 215 PF00149 0.230
DOC_PP2B_LxvP_1 116 119 PF13499 0.275
DOC_PP4_FxxP_1 368 371 PF00568 0.294
DOC_USP7_MATH_1 257 261 PF00917 0.503
DOC_USP7_MATH_1 295 299 PF00917 0.364
DOC_USP7_MATH_1 371 375 PF00917 0.332
DOC_USP7_MATH_1 47 51 PF00917 0.359
DOC_USP7_UBL2_3 276 280 PF12436 0.367
DOC_WW_Pin1_4 401 406 PF00397 0.441
DOC_WW_Pin1_4 458 463 PF00397 0.430
DOC_WW_Pin1_4 69 74 PF00397 0.421
DOC_WW_Pin1_4 97 102 PF00397 0.367
LIG_14-3-3_CanoR_1 335 339 PF00244 0.525
LIG_Actin_WH2_2 387 404 PF00022 0.333
LIG_BRCT_BRCA1_1 297 301 PF00533 0.352
LIG_EH_1 233 237 PF12763 0.450
LIG_eIF4E_1 31 37 PF01652 0.309
LIG_eIF4E_1 437 443 PF01652 0.314
LIG_FHA_1 160 166 PF00498 0.470
LIG_FHA_1 266 272 PF00498 0.552
LIG_FHA_1 31 37 PF00498 0.302
LIG_FHA_1 322 328 PF00498 0.434
LIG_FHA_1 356 362 PF00498 0.287
LIG_FHA_1 377 383 PF00498 0.323
LIG_FHA_1 43 49 PF00498 0.255
LIG_FHA_1 459 465 PF00498 0.412
LIG_FHA_2 200 206 PF00498 0.167
LIG_FHA_2 22 28 PF00498 0.479
LIG_FHA_2 326 332 PF00498 0.470
LIG_IRF3_LxIS_1 203 210 PF10401 0.169
LIG_LIR_Gen_1 201 209 PF02991 0.262
LIG_LIR_Gen_1 30 39 PF02991 0.272
LIG_LIR_Gen_1 337 347 PF02991 0.515
LIG_LIR_Gen_1 354 364 PF02991 0.221
LIG_LIR_Gen_1 374 385 PF02991 0.304
LIG_LIR_LC3C_4 122 125 PF02991 0.164
LIG_LIR_Nem_3 201 206 PF02991 0.270
LIG_LIR_Nem_3 210 216 PF02991 0.195
LIG_LIR_Nem_3 27 31 PF02991 0.439
LIG_LIR_Nem_3 33 37 PF02991 0.289
LIG_LIR_Nem_3 337 342 PF02991 0.488
LIG_LIR_Nem_3 354 360 PF02991 0.237
LIG_LIR_Nem_3 374 380 PF02991 0.264
LIG_LIR_Nem_3 412 416 PF02991 0.322
LIG_LIR_Nem_3 56 61 PF02991 0.300
LIG_LYPXL_S_1 345 349 PF13949 0.323
LIG_LYPXL_yS_3 346 349 PF13949 0.523
LIG_PCNA_PIPBox_1 378 387 PF02747 0.282
LIG_Pex14_2 169 173 PF04695 0.412
LIG_Pex14_2 353 357 PF04695 0.247
LIG_Pex14_2 363 367 PF04695 0.228
LIG_PTB_Apo_2 444 451 PF02174 0.297
LIG_SH2_CRK 377 381 PF00017 0.229
LIG_SH2_PTP2 437 440 PF00017 0.376
LIG_SH2_STAP1 88 92 PF00017 0.366
LIG_SH2_STAT3 88 91 PF00017 0.405
LIG_SH2_STAT5 213 216 PF00017 0.264
LIG_SH2_STAT5 240 243 PF00017 0.472
LIG_SH2_STAT5 31 34 PF00017 0.296
LIG_SH2_STAT5 437 440 PF00017 0.303
LIG_SH2_STAT5 449 452 PF00017 0.293
LIG_SH2_STAT5 58 61 PF00017 0.282
LIG_SH3_3 397 403 PF00018 0.453
LIG_SH3_3 430 436 PF00018 0.256
LIG_SH3_3 456 462 PF00018 0.505
LIG_SUMO_SIM_anti_2 122 128 PF11976 0.288
LIG_SUMO_SIM_par_1 205 210 PF11976 0.289
LIG_SUMO_SIM_par_1 316 322 PF11976 0.478
LIG_SUMO_SIM_par_1 378 383 PF11976 0.348
LIG_SUMO_SIM_par_1 406 412 PF11976 0.475
LIG_TRAF2_1 286 289 PF00917 0.327
LIG_TRFH_1 367 371 PF08558 0.289
LIG_TYR_ITIM 435 440 PF00017 0.295
LIG_UBA3_1 149 155 PF00899 0.264
LIG_UBA3_1 397 406 PF00899 0.468
LIG_WRC_WIRS_1 31 36 PF05994 0.233
LIG_WRC_WIRS_1 410 415 PF05994 0.200
MOD_CDK_SPK_2 401 406 PF00069 0.408
MOD_CDK_SPxxK_3 97 104 PF00069 0.364
MOD_CK1_1 198 204 PF00069 0.211
MOD_CK1_1 260 266 PF00069 0.459
MOD_CK1_1 337 343 PF00069 0.476
MOD_CK1_1 46 52 PF00069 0.362
MOD_CK1_1 489 495 PF00069 0.305
MOD_CK2_1 21 27 PF00069 0.494
MOD_CK2_1 325 331 PF00069 0.487
MOD_GlcNHglycan 12 15 PF01048 0.391
MOD_GlcNHglycan 304 307 PF01048 0.339
MOD_GlcNHglycan 373 376 PF01048 0.475
MOD_GlcNHglycan 4 7 PF01048 0.348
MOD_GlcNHglycan 45 48 PF01048 0.324
MOD_GlcNHglycan 49 52 PF01048 0.528
MOD_GSK3_1 195 202 PF00069 0.252
MOD_GSK3_1 321 328 PF00069 0.492
MOD_GSK3_1 351 358 PF00069 0.342
MOD_GSK3_1 376 383 PF00069 0.332
MOD_GSK3_1 42 49 PF00069 0.301
MOD_GSK3_1 489 496 PF00069 0.396
MOD_GSK3_1 91 98 PF00069 0.330
MOD_N-GLC_1 325 330 PF02516 0.258
MOD_N-GLC_1 489 494 PF02516 0.389
MOD_NEK2_1 102 107 PF00069 0.485
MOD_NEK2_1 157 162 PF00069 0.299
MOD_NEK2_1 186 191 PF00069 0.301
MOD_NEK2_1 195 200 PF00069 0.230
MOD_NEK2_1 207 212 PF00069 0.202
MOD_NEK2_1 321 326 PF00069 0.493
MOD_NEK2_1 334 339 PF00069 0.458
MOD_NEK2_1 356 361 PF00069 0.327
MOD_NEK2_1 37 42 PF00069 0.282
MOD_NEK2_1 43 48 PF00069 0.296
MOD_NEK2_1 443 448 PF00069 0.357
MOD_NEK2_1 493 498 PF00069 0.414
MOD_NEK2_2 351 356 PF00069 0.366
MOD_PIKK_1 133 139 PF00454 0.338
MOD_PIKK_1 257 263 PF00454 0.473
MOD_PKA_2 334 340 PF00069 0.501
MOD_Plk_1 280 286 PF00069 0.475
MOD_Plk_1 468 474 PF00069 0.444
MOD_Plk_1 489 495 PF00069 0.399
MOD_Plk_4 179 185 PF00069 0.319
MOD_Plk_4 186 192 PF00069 0.288
MOD_Plk_4 27 33 PF00069 0.442
MOD_Plk_4 334 340 PF00069 0.433
MOD_Plk_4 356 362 PF00069 0.276
MOD_Plk_4 37 43 PF00069 0.310
MOD_Plk_4 376 382 PF00069 0.295
MOD_Plk_4 78 84 PF00069 0.263
MOD_ProDKin_1 401 407 PF00069 0.441
MOD_ProDKin_1 458 464 PF00069 0.430
MOD_ProDKin_1 69 75 PF00069 0.416
MOD_ProDKin_1 97 103 PF00069 0.364
MOD_SUMO_rev_2 256 266 PF00179 0.449
TRG_DiLeu_BaLyEn_6 417 422 PF01217 0.342
TRG_ENDOCYTIC_2 213 216 PF00928 0.240
TRG_ENDOCYTIC_2 233 236 PF00928 0.451
TRG_ENDOCYTIC_2 31 34 PF00928 0.296
TRG_ENDOCYTIC_2 346 349 PF00928 0.503
TRG_ENDOCYTIC_2 377 380 PF00928 0.199
TRG_ENDOCYTIC_2 437 440 PF00928 0.343
TRG_ER_diArg_1 249 252 PF00400 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 31% 100%
A0A0N0P6Z5 Leptomonas seymouri 68% 100%
A0A0N1I1J0 Leptomonas seymouri 30% 100%
A0A0N1I8E8 Leptomonas seymouri 25% 100%
A0A0N1PBQ1 Leptomonas seymouri 34% 99%
A0A0S4JBS4 Bodo saltans 31% 100%
A0A1X0NN91 Trypanosomatidae 32% 100%
A0A1X0NPL0 Trypanosomatidae 34% 100%
A0A1X0NV38 Trypanosomatidae 33% 100%
A0A1X0NWJ5 Trypanosomatidae 32% 100%
A0A3Q8ICX7 Leishmania donovani 33% 100%
A0A3R7NQR3 Trypanosoma rangeli 33% 100%
A0A3S7WTL0 Leishmania donovani 31% 100%
A0A3S7XAS5 Leishmania donovani 100% 100%
A0A422MQ08 Trypanosoma rangeli 33% 100%
A0A422N8M2 Trypanosoma rangeli 45% 100%
A0A422NHH9 Trypanosoma rangeli 46% 100%
A0A422NR81 Trypanosoma rangeli 27% 100%
A1L272 Danio rerio 23% 96%
A4H6I0 Leishmania braziliensis 31% 100%
A4H7A5 Leishmania braziliensis 34% 100%
A4HG96 Leishmania braziliensis 26% 100%
A4HP60 Leishmania braziliensis 80% 100%
A4HUW2 Leishmania infantum 33% 100%
A4HVP9 Leishmania infantum 33% 99%
A4HWK9 Leishmania infantum 31% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AGM5 Leishmania infantum 31% 100%
E9AGM6 Leishmania infantum 31% 100%
E9AGM7 Leishmania infantum 31% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O76343 Leishmania donovani 31% 100%
Q4Q1M9 Leishmania major 95% 100%
Q4QF58 Leishmania major 32% 100%
Q4QF59 Leishmania major 32% 100%
Q4QG33 Leishmania major 32% 100%
Q4QH25 Leishmania major 31% 100%
Q7RTT9 Homo sapiens 22% 94%
Q8R139 Mus musculus 23% 95%
V5BGB1 Trypanosoma cruzi 33% 100%
V5BRM5 Trypanosoma cruzi 31% 100%
V5DSF4 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS