LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CBF domain-containing protein
Gene product:
Nucleolar complex-associated protein/CBF/Mak21 family - putative
Species:
Leishmania infantum
UniProt:
A4IDF9_LEIIN
TriTrypDb:
LINF_360025200
Length:
633

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 11
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4IDF9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDF9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006270 DNA replication initiation 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003682 chromatin binding 2 1
GO:0005488 binding 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 152 156 PF00656 0.344
CLV_C14_Caspase3-7 320 324 PF00656 0.697
CLV_NRD_NRD_1 174 176 PF00675 0.365
CLV_NRD_NRD_1 231 233 PF00675 0.433
CLV_NRD_NRD_1 477 479 PF00675 0.245
CLV_NRD_NRD_1 619 621 PF00675 0.425
CLV_NRD_NRD_1 64 66 PF00675 0.492
CLV_NRD_NRD_1 91 93 PF00675 0.337
CLV_NRD_NRD_1 95 97 PF00675 0.370
CLV_PCSK_KEX2_1 176 178 PF00082 0.492
CLV_PCSK_KEX2_1 212 214 PF00082 0.520
CLV_PCSK_KEX2_1 231 233 PF00082 0.433
CLV_PCSK_KEX2_1 477 479 PF00082 0.245
CLV_PCSK_KEX2_1 621 623 PF00082 0.415
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.542
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.467
CLV_PCSK_PC1ET2_1 621 623 PF00082 0.412
CLV_PCSK_PC7_1 172 178 PF00082 0.503
CLV_PCSK_SKI1_1 112 116 PF00082 0.400
CLV_PCSK_SKI1_1 212 216 PF00082 0.549
CLV_PCSK_SKI1_1 331 335 PF00082 0.406
CLV_PCSK_SKI1_1 352 356 PF00082 0.260
CLV_PCSK_SKI1_1 500 504 PF00082 0.307
DEG_Nend_UBRbox_3 1 3 PF02207 0.489
DEG_SPOP_SBC_1 385 389 PF00917 0.390
DOC_MAPK_gen_1 240 250 PF00069 0.343
DOC_MAPK_MEF2A_6 184 192 PF00069 0.317
DOC_MAPK_MEF2A_6 247 255 PF00069 0.282
DOC_MAPK_MEF2A_6 280 289 PF00069 0.353
DOC_PP2B_LxvP_1 380 383 PF13499 0.245
DOC_USP7_MATH_1 104 108 PF00917 0.320
DOC_USP7_MATH_1 356 360 PF00917 0.287
DOC_USP7_MATH_1 385 389 PF00917 0.390
DOC_USP7_MATH_1 482 486 PF00917 0.243
DOC_USP7_MATH_1 538 542 PF00917 0.245
DOC_USP7_UBL2_3 208 212 PF12436 0.468
DOC_USP7_UBL2_3 215 219 PF12436 0.425
DOC_USP7_UBL2_3 298 302 PF12436 0.490
DOC_USP7_UBL2_3 566 570 PF12436 0.500
DOC_USP7_UBL2_3 93 97 PF12436 0.396
DOC_WW_Pin1_4 260 265 PF00397 0.465
LIG_14-3-3_CanoR_1 112 121 PF00244 0.403
LIG_14-3-3_CanoR_1 175 180 PF00244 0.417
LIG_14-3-3_CanoR_1 471 479 PF00244 0.260
LIG_14-3-3_CanoR_1 51 57 PF00244 0.562
LIG_14-3-3_CanoR_1 96 100 PF00244 0.413
LIG_Actin_WH2_2 241 256 PF00022 0.353
LIG_Actin_WH2_2 542 560 PF00022 0.362
LIG_APCC_ABBA_1 197 202 PF00400 0.605
LIG_BRCT_BRCA1_1 422 426 PF00533 0.245
LIG_Clathr_ClatBox_1 284 288 PF01394 0.342
LIG_deltaCOP1_diTrp_1 360 368 PF00928 0.260
LIG_deltaCOP1_diTrp_1 445 448 PF00928 0.260
LIG_EH1_1 164 172 PF00400 0.400
LIG_eIF4E_1 367 373 PF01652 0.260
LIG_FHA_1 161 167 PF00498 0.314
LIG_FHA_1 240 246 PF00498 0.411
LIG_FHA_1 266 272 PF00498 0.353
LIG_FHA_1 335 341 PF00498 0.342
LIG_FHA_1 445 451 PF00498 0.238
LIG_FHA_1 471 477 PF00498 0.276
LIG_FHA_1 541 547 PF00498 0.285
LIG_FHA_1 581 587 PF00498 0.375
LIG_FHA_1 6 12 PF00498 0.366
LIG_FHA_1 83 89 PF00498 0.450
LIG_FHA_2 23 29 PF00498 0.385
LIG_FHA_2 355 361 PF00498 0.279
LIG_FHA_2 392 398 PF00498 0.278
LIG_LIR_Gen_1 288 297 PF02991 0.360
LIG_LIR_Gen_1 366 376 PF02991 0.245
LIG_LIR_Gen_1 82 91 PF02991 0.321
LIG_LIR_Nem_3 28 32 PF02991 0.369
LIG_LIR_Nem_3 288 293 PF02991 0.365
LIG_LIR_Nem_3 366 371 PF02991 0.245
LIG_LIR_Nem_3 82 87 PF02991 0.318
LIG_NRBOX 184 190 PF00104 0.315
LIG_NRBOX 545 551 PF00104 0.189
LIG_PCNA_PIPBox_1 12 21 PF02747 0.473
LIG_PCNA_yPIPBox_3 12 24 PF02747 0.497
LIG_PCNA_yPIPBox_3 141 154 PF02747 0.392
LIG_PCNA_yPIPBox_3 175 189 PF02747 0.370
LIG_PTB_Apo_2 4 11 PF02174 0.388
LIG_PTB_Phospho_1 4 10 PF10480 0.398
LIG_SH2_CRK 290 294 PF00017 0.355
LIG_SH2_CRK 568 572 PF00017 0.425
LIG_SH2_SRC 598 601 PF00017 0.397
LIG_SH2_STAP1 84 88 PF00017 0.298
LIG_SH2_STAT3 71 74 PF00017 0.378
LIG_SH2_STAT5 10 13 PF00017 0.344
LIG_SH2_STAT5 252 255 PF00017 0.333
LIG_SH2_STAT5 367 370 PF00017 0.260
LIG_SH2_STAT5 4 7 PF00017 0.425
LIG_SH2_STAT5 84 87 PF00017 0.408
LIG_SH3_3 139 145 PF00018 0.334
LIG_SH3_3 481 487 PF00018 0.309
LIG_SH3_3 604 610 PF00018 0.410
LIG_Sin3_3 124 131 PF02671 0.324
LIG_SUMO_SIM_anti_2 458 463 PF11976 0.246
LIG_SUMO_SIM_anti_2 545 550 PF11976 0.256
LIG_SUMO_SIM_par_1 342 348 PF11976 0.245
LIG_SUMO_SIM_par_1 458 463 PF11976 0.260
LIG_TRAF2_1 394 397 PF00917 0.267
LIG_TYR_ITIM 250 255 PF00017 0.283
LIG_UBA3_1 170 176 PF00899 0.361
LIG_UBA3_1 293 302 PF00899 0.343
LIG_UBA3_1 459 465 PF00899 0.245
LIG_UBA3_1 90 97 PF00899 0.347
MOD_CK1_1 160 166 PF00069 0.332
MOD_CK1_1 17 23 PF00069 0.457
MOD_CK1_1 335 341 PF00069 0.342
MOD_CK1_1 384 390 PF00069 0.390
MOD_CK1_1 411 417 PF00069 0.245
MOD_CK1_1 420 426 PF00069 0.245
MOD_CK1_1 540 546 PF00069 0.279
MOD_CK1_1 95 101 PF00069 0.517
MOD_CK2_1 114 120 PF00069 0.332
MOD_CK2_1 354 360 PF00069 0.304
MOD_CK2_1 391 397 PF00069 0.250
MOD_CK2_1 51 57 PF00069 0.467
MOD_CK2_1 95 101 PF00069 0.404
MOD_GlcNHglycan 116 119 PF01048 0.436
MOD_GlcNHglycan 383 386 PF01048 0.354
MOD_GlcNHglycan 389 392 PF01048 0.325
MOD_GlcNHglycan 416 419 PF01048 0.245
MOD_GlcNHglycan 534 537 PF01048 0.308
MOD_GSK3_1 256 263 PF00069 0.326
MOD_GSK3_1 331 338 PF00069 0.353
MOD_GSK3_1 352 359 PF00069 0.304
MOD_GSK3_1 381 388 PF00069 0.315
MOD_GSK3_1 408 415 PF00069 0.245
MOD_GSK3_1 420 427 PF00069 0.245
MOD_GSK3_1 440 447 PF00069 0.260
MOD_GSK3_1 46 53 PF00069 0.450
MOD_GSK3_1 540 547 PF00069 0.292
MOD_GSK3_1 549 556 PF00069 0.251
MOD_LATS_1 329 335 PF00433 0.417
MOD_N-GLC_1 22 27 PF02516 0.385
MOD_N-GLC_1 440 445 PF02516 0.260
MOD_N-GLC_1 6 11 PF02516 0.367
MOD_NEK2_1 113 118 PF00069 0.471
MOD_NEK2_1 134 139 PF00069 0.459
MOD_NEK2_1 225 230 PF00069 0.413
MOD_NEK2_1 460 465 PF00069 0.271
MOD_NEK2_1 5 10 PF00069 0.389
MOD_NEK2_1 549 554 PF00069 0.299
MOD_PIKK_1 408 414 PF00454 0.245
MOD_PIKK_1 420 426 PF00454 0.245
MOD_PIKK_1 430 436 PF00454 0.245
MOD_PIKK_1 460 466 PF00454 0.294
MOD_PIKK_1 79 85 PF00454 0.449
MOD_PKA_1 175 181 PF00069 0.407
MOD_PKA_1 92 98 PF00069 0.513
MOD_PKA_2 470 476 PF00069 0.260
MOD_PKA_2 50 56 PF00069 0.551
MOD_PKA_2 95 101 PF00069 0.403
MOD_Plk_1 22 28 PF00069 0.383
MOD_Plk_1 363 369 PF00069 0.250
MOD_Plk_1 38 44 PF00069 0.375
MOD_Plk_1 444 450 PF00069 0.245
MOD_Plk_1 538 544 PF00069 0.245
MOD_Plk_1 6 12 PF00069 0.366
MOD_Plk_2-3 317 323 PF00069 0.578
MOD_Plk_4 14 20 PF00069 0.347
MOD_Plk_4 363 369 PF00069 0.307
MOD_Plk_4 38 44 PF00069 0.338
MOD_Plk_4 433 439 PF00069 0.445
MOD_Plk_4 490 496 PF00069 0.279
MOD_Plk_4 544 550 PF00069 0.298
MOD_Plk_4 6 12 PF00069 0.366
MOD_ProDKin_1 260 266 PF00069 0.465
MOD_SUMO_for_1 214 217 PF00179 0.449
MOD_SUMO_for_1 615 618 PF00179 0.551
MOD_SUMO_rev_2 202 209 PF00179 0.507
MOD_SUMO_rev_2 599 608 PF00179 0.513
TRG_DiLeu_BaEn_1 545 550 PF01217 0.189
TRG_DiLeu_BaEn_4 38 44 PF01217 0.429
TRG_DiLeu_BaLyEn_6 475 480 PF01217 0.359
TRG_ENDOCYTIC_2 252 255 PF00928 0.333
TRG_ENDOCYTIC_2 29 32 PF00928 0.365
TRG_ENDOCYTIC_2 290 293 PF00928 0.360
TRG_ENDOCYTIC_2 568 571 PF00928 0.420
TRG_ENDOCYTIC_2 592 595 PF00928 0.382
TRG_ENDOCYTIC_2 84 87 PF00928 0.305
TRG_ER_diArg_1 174 177 PF00400 0.453
TRG_ER_diArg_1 308 311 PF00400 0.685
TRG_ER_diArg_1 476 478 PF00400 0.245
TRG_ER_diArg_1 619 622 PF00400 0.503
TRG_NES_CRM1_1 370 386 PF08389 0.339
TRG_NLS_MonoExtC_3 211 216 PF00514 0.454
TRG_NLS_MonoExtC_3 619 624 PF00514 0.470
TRG_NLS_MonoExtN_4 172 179 PF00514 0.503
TRG_NLS_MonoExtN_4 210 216 PF00514 0.457
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.245
TRG_Pf-PMV_PEXEL_1 477 481 PF00026 0.245

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6K8 Leptomonas seymouri 88% 100%
A0A0S4J058 Bodo saltans 62% 100%
A0A1X0P7S6 Trypanosomatidae 71% 100%
A0A3R7JWC9 Trypanosoma rangeli 70% 100%
A0A3S7XAS0 Leishmania donovani 100% 100%
A4HP52 Leishmania braziliensis 93% 100%
D0A338 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9ASW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O94288 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 85%
Q4Q1N6 Leishmania major 97% 100%
V5DKS9 Trypanosoma cruzi 70% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS