LeishMANIAdb
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Major vault protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Major vault protein
Gene product:
major vault protein - putative
Species:
Leishmania infantum
UniProt:
A4IDF8_LEIIN
TriTrypDb:
LINF_360025100
Length:
876

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0005737 cytoplasm 2 11
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 11

Expansion

Sequence features

A4IDF8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDF8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.522
CLV_C14_Caspase3-7 192 196 PF00656 0.487
CLV_C14_Caspase3-7 357 361 PF00656 0.467
CLV_C14_Caspase3-7 408 412 PF00656 0.495
CLV_NRD_NRD_1 147 149 PF00675 0.286
CLV_NRD_NRD_1 260 262 PF00675 0.460
CLV_NRD_NRD_1 317 319 PF00675 0.386
CLV_NRD_NRD_1 402 404 PF00675 0.526
CLV_NRD_NRD_1 470 472 PF00675 0.690
CLV_NRD_NRD_1 633 635 PF00675 0.327
CLV_NRD_NRD_1 727 729 PF00675 0.465
CLV_PCSK_KEX2_1 147 149 PF00082 0.263
CLV_PCSK_KEX2_1 290 292 PF00082 0.479
CLV_PCSK_KEX2_1 317 319 PF00082 0.383
CLV_PCSK_KEX2_1 402 404 PF00082 0.526
CLV_PCSK_KEX2_1 633 635 PF00082 0.327
CLV_PCSK_KEX2_1 727 729 PF00082 0.531
CLV_PCSK_KEX2_1 789 791 PF00082 0.504
CLV_PCSK_PC1ET2_1 290 292 PF00082 0.471
CLV_PCSK_PC1ET2_1 789 791 PF00082 0.520
CLV_PCSK_SKI1_1 120 124 PF00082 0.318
CLV_PCSK_SKI1_1 153 157 PF00082 0.278
CLV_PCSK_SKI1_1 226 230 PF00082 0.473
CLV_PCSK_SKI1_1 257 261 PF00082 0.591
CLV_PCSK_SKI1_1 287 291 PF00082 0.444
CLV_PCSK_SKI1_1 318 322 PF00082 0.392
CLV_PCSK_SKI1_1 471 475 PF00082 0.657
CLV_PCSK_SKI1_1 489 493 PF00082 0.144
CLV_PCSK_SKI1_1 503 507 PF00082 0.251
CLV_PCSK_SKI1_1 510 514 PF00082 0.272
CLV_PCSK_SKI1_1 634 638 PF00082 0.327
CLV_PCSK_SKI1_1 680 684 PF00082 0.466
CLV_PCSK_SKI1_1 727 731 PF00082 0.484
CLV_PCSK_SKI1_1 771 775 PF00082 0.537
CLV_PCSK_SKI1_1 789 793 PF00082 0.398
DEG_SCF_FBW7_1 583 588 PF00400 0.551
DEG_SCF_FBW7_2 250 256 PF00400 0.572
DOC_CKS1_1 250 255 PF01111 0.563
DOC_CYCLIN_RxL_1 725 735 PF00134 0.474
DOC_CYCLIN_RxL_1 771 781 PF00134 0.587
DOC_CYCLIN_RxL_1 787 797 PF00134 0.467
DOC_CYCLIN_yCln2_LP_2 650 656 PF00134 0.551
DOC_MAPK_gen_1 680 688 PF00069 0.502
DOC_MAPK_HePTP_8 563 575 PF00069 0.447
DOC_MAPK_MEF2A_6 120 127 PF00069 0.551
DOC_MAPK_MEF2A_6 566 575 PF00069 0.447
DOC_MAPK_MEF2A_6 680 688 PF00069 0.460
DOC_PP1_RVXF_1 501 507 PF00149 0.499
DOC_PP4_FxxP_1 156 159 PF00568 0.461
DOC_PP4_FxxP_1 217 220 PF00568 0.467
DOC_PP4_FxxP_1 326 329 PF00568 0.447
DOC_PP4_FxxP_1 551 554 PF00568 0.447
DOC_USP7_MATH_1 134 138 PF00917 0.539
DOC_USP7_MATH_1 220 224 PF00917 0.437
DOC_USP7_MATH_1 34 38 PF00917 0.516
DOC_USP7_MATH_1 354 358 PF00917 0.467
DOC_USP7_MATH_1 487 491 PF00917 0.447
DOC_USP7_MATH_1 615 619 PF00917 0.449
DOC_USP7_MATH_1 739 743 PF00917 0.503
DOC_USP7_UBL2_3 536 540 PF12436 0.464
DOC_WW_Pin1_4 139 144 PF00397 0.535
DOC_WW_Pin1_4 249 254 PF00397 0.520
DOC_WW_Pin1_4 361 366 PF00397 0.527
DOC_WW_Pin1_4 524 529 PF00397 0.484
DOC_WW_Pin1_4 581 586 PF00397 0.527
DOC_WW_Pin1_4 858 863 PF00397 0.506
LIG_14-3-3_CanoR_1 291 301 PF00244 0.459
LIG_14-3-3_CanoR_1 317 327 PF00244 0.426
LIG_14-3-3_CanoR_1 33 43 PF00244 0.531
LIG_14-3-3_CanoR_1 480 485 PF00244 0.312
LIG_14-3-3_CanoR_1 489 497 PF00244 0.411
LIG_14-3-3_CanoR_1 815 819 PF00244 0.635
LIG_APCC_ABBA_1 100 105 PF00400 0.461
LIG_APCC_ABBA_1 729 734 PF00400 0.476
LIG_APCC_ABBAyCdc20_2 728 734 PF00400 0.479
LIG_BIR_III_4 79 83 PF00653 0.527
LIG_BRCT_BRCA1_1 189 193 PF00533 0.508
LIG_BRCT_BRCA1_1 617 621 PF00533 0.447
LIG_CaM_IQ_9 782 798 PF13499 0.570
LIG_deltaCOP1_diTrp_1 578 581 PF00928 0.499
LIG_deltaCOP1_diTrp_1 90 100 PF00928 0.527
LIG_EVH1_2 44 48 PF00568 0.528
LIG_FHA_1 192 198 PF00498 0.534
LIG_FHA_1 21 27 PF00498 0.425
LIG_FHA_1 268 274 PF00498 0.457
LIG_FHA_1 362 368 PF00498 0.527
LIG_FHA_1 418 424 PF00498 0.462
LIG_FHA_1 44 50 PF00498 0.521
LIG_FHA_1 500 506 PF00498 0.462
LIG_FHA_1 540 546 PF00498 0.506
LIG_FHA_1 556 562 PF00498 0.440
LIG_FHA_1 68 74 PF00498 0.523
LIG_FHA_2 186 192 PF00498 0.454
LIG_FHA_2 244 250 PF00498 0.563
LIG_FHA_2 395 401 PF00498 0.544
LIG_FHA_2 433 439 PF00498 0.551
LIG_FHA_2 582 588 PF00498 0.527
LIG_FHA_2 63 69 PF00498 0.532
LIG_FHA_2 658 664 PF00498 0.472
LIG_FHA_2 779 785 PF00498 0.527
LIG_FHA_2 828 834 PF00498 0.508
LIG_LIR_Apic_2 129 134 PF02991 0.481
LIG_LIR_Apic_2 244 250 PF02991 0.509
LIG_LIR_Apic_2 438 444 PF02991 0.527
LIG_LIR_Apic_2 483 487 PF02991 0.466
LIG_LIR_Apic_2 92 98 PF02991 0.518
LIG_LIR_Gen_1 12 19 PF02991 0.449
LIG_LIR_Gen_1 205 215 PF02991 0.456
LIG_LIR_Gen_1 297 306 PF02991 0.408
LIG_LIR_Gen_1 46 56 PF02991 0.320
LIG_LIR_Gen_1 516 524 PF02991 0.447
LIG_LIR_Gen_1 618 629 PF02991 0.461
LIG_LIR_Nem_3 12 16 PF02991 0.436
LIG_LIR_Nem_3 161 166 PF02991 0.481
LIG_LIR_Nem_3 205 211 PF02991 0.446
LIG_LIR_Nem_3 297 302 PF02991 0.402
LIG_LIR_Nem_3 321 327 PF02991 0.390
LIG_LIR_Nem_3 46 51 PF02991 0.411
LIG_LIR_Nem_3 516 522 PF02991 0.447
LIG_LIR_Nem_3 54 59 PF02991 0.461
LIG_LIR_Nem_3 578 583 PF02991 0.482
LIG_LIR_Nem_3 618 624 PF02991 0.447
LIG_LIR_Nem_3 79 84 PF02991 0.497
LIG_LYPXL_L_2 102 111 PF13949 0.527
LIG_LYPXL_yS_3 163 166 PF13949 0.499
LIG_Pex14_2 217 221 PF04695 0.480
LIG_REV1ctd_RIR_1 322 328 PF16727 0.483
LIG_SH2_CRK 131 135 PF00017 0.527
LIG_SH2_CRK 208 212 PF00017 0.503
LIG_SH2_CRK 282 286 PF00017 0.468
LIG_SH2_CRK 299 303 PF00017 0.286
LIG_SH2_CRK 484 488 PF00017 0.450
LIG_SH2_CRK 56 60 PF00017 0.551
LIG_SH2_CRK 81 85 PF00017 0.518
LIG_SH2_PTP2 462 465 PF00017 0.689
LIG_SH2_SRC 247 250 PF00017 0.545
LIG_SH2_STAP1 282 286 PF00017 0.437
LIG_SH2_STAP1 299 303 PF00017 0.325
LIG_SH2_STAP1 577 581 PF00017 0.447
LIG_SH2_STAP1 807 811 PF00017 0.564
LIG_SH2_STAT3 497 500 PF00017 0.527
LIG_SH2_STAT5 154 157 PF00017 0.474
LIG_SH2_STAT5 177 180 PF00017 0.515
LIG_SH2_STAT5 210 213 PF00017 0.392
LIG_SH2_STAT5 342 345 PF00017 0.447
LIG_SH2_STAT5 405 408 PF00017 0.454
LIG_SH2_STAT5 414 417 PF00017 0.416
LIG_SH2_STAT5 432 435 PF00017 0.447
LIG_SH2_STAT5 462 465 PF00017 0.639
LIG_SH2_STAT5 544 547 PF00017 0.512
LIG_SH2_STAT5 56 59 PF00017 0.478
LIG_SH2_STAT5 580 583 PF00017 0.461
LIG_SH2_STAT5 607 610 PF00017 0.521
LIG_SH2_STAT5 854 857 PF00017 0.474
LIG_SH3_1 247 253 PF00018 0.524
LIG_SH3_2 250 255 PF14604 0.563
LIG_SH3_2 528 533 PF14604 0.503
LIG_SH3_3 247 253 PF00018 0.519
LIG_SH3_3 275 281 PF00018 0.393
LIG_SH3_3 374 380 PF00018 0.499
LIG_SH3_3 38 44 PF00018 0.471
LIG_SH3_3 398 404 PF00018 0.560
LIG_SH3_3 46 52 PF00018 0.322
LIG_SH3_3 502 508 PF00018 0.527
LIG_SH3_3 525 531 PF00018 0.466
LIG_SH3_3 56 62 PF00018 0.428
LIG_SH3_3 95 101 PF00018 0.453
LIG_SUMO_SIM_par_1 520 525 PF11976 0.470
LIG_TRAF2_1 234 237 PF00917 0.522
LIG_TRAF2_1 435 438 PF00917 0.463
LIG_TRAF2_1 620 623 PF00917 0.527
LIG_TRAF2_1 722 725 PF00917 0.551
LIG_TRAF2_1 794 797 PF00917 0.559
LIG_TRAF2_1 88 91 PF00917 0.527
LIG_TRAF2_2 366 371 PF00917 0.495
LIG_TRFH_1 100 104 PF08558 0.461
LIG_TRFH_1 277 281 PF08558 0.407
LIG_TRFH_1 325 329 PF08558 0.444
LIG_TYR_ITIM 486 491 PF00017 0.527
LIG_TYR_ITSM 159 166 PF00017 0.499
LIG_TYR_ITSM 52 59 PF00017 0.495
LIG_UBA3_1 388 396 PF00899 0.350
LIG_WRC_WIRS_1 355 360 PF05994 0.467
MOD_CDC14_SPxK_1 144 147 PF00782 0.495
MOD_CDK_SPxK_1 141 147 PF00069 0.495
MOD_CDK_SPxK_1 249 255 PF00069 0.558
MOD_CDK_SPxxK_3 141 148 PF00069 0.551
MOD_CK1_1 139 145 PF00069 0.534
MOD_CK1_1 361 367 PF00069 0.551
MOD_CK1_1 37 43 PF00069 0.506
MOD_CK1_1 555 561 PF00069 0.495
MOD_CK1_1 661 667 PF00069 0.461
MOD_CK1_1 743 749 PF00069 0.516
MOD_CK1_1 754 760 PF00069 0.545
MOD_CK1_1 761 767 PF00069 0.485
MOD_CK2_1 185 191 PF00069 0.481
MOD_CK2_1 231 237 PF00069 0.503
MOD_CK2_1 394 400 PF00069 0.538
MOD_CK2_1 432 438 PF00069 0.551
MOD_CK2_1 587 593 PF00069 0.398
MOD_CK2_1 754 760 PF00069 0.519
MOD_CK2_1 778 784 PF00069 0.512
MOD_CK2_1 827 833 PF00069 0.520
MOD_CK2_1 85 91 PF00069 0.527
MOD_GlcNHglycan 117 120 PF01048 0.303
MOD_GlcNHglycan 136 139 PF01048 0.247
MOD_GlcNHglycan 182 185 PF01048 0.496
MOD_GlcNHglycan 294 297 PF01048 0.502
MOD_GlcNHglycan 339 342 PF01048 0.439
MOD_GlcNHglycan 524 527 PF01048 0.261
MOD_GlcNHglycan 627 630 PF01048 0.278
MOD_GlcNHglycan 742 745 PF01048 0.476
MOD_GlcNHglycan 869 872 PF01048 0.637
MOD_GlcNHglycan 87 90 PF01048 0.309
MOD_GSK3_1 134 141 PF00069 0.535
MOD_GSK3_1 14 21 PF00069 0.480
MOD_GSK3_1 185 192 PF00069 0.494
MOD_GSK3_1 285 292 PF00069 0.549
MOD_GSK3_1 350 357 PF00069 0.515
MOD_GSK3_1 379 386 PF00069 0.551
MOD_GSK3_1 428 435 PF00069 0.541
MOD_GSK3_1 520 527 PF00069 0.450
MOD_GSK3_1 539 546 PF00069 0.436
MOD_GSK3_1 581 588 PF00069 0.548
MOD_GSK3_1 603 610 PF00069 0.499
MOD_GSK3_1 657 664 PF00069 0.478
MOD_GSK3_1 739 746 PF00069 0.480
MOD_GSK3_1 754 761 PF00069 0.543
MOD_GSK3_1 854 861 PF00069 0.543
MOD_N-GLC_1 21 26 PF02516 0.429
MOD_N-GLC_1 555 560 PF02516 0.278
MOD_NEK2_1 1 6 PF00069 0.597
MOD_NEK2_1 185 190 PF00069 0.459
MOD_NEK2_1 193 198 PF00069 0.522
MOD_NEK2_1 285 290 PF00069 0.477
MOD_NEK2_1 358 363 PF00069 0.544
MOD_NEK2_1 657 662 PF00069 0.461
MOD_NEK2_1 678 683 PF00069 0.458
MOD_NEK2_1 778 783 PF00069 0.496
MOD_NEK2_1 845 850 PF00069 0.527
MOD_PIKK_1 294 300 PF00454 0.484
MOD_PIKK_1 489 495 PF00454 0.447
MOD_PIKK_1 496 502 PF00454 0.447
MOD_PIKK_1 51 57 PF00454 0.527
MOD_PIKK_1 661 667 PF00454 0.478
MOD_PKA_2 180 186 PF00069 0.499
MOD_PKA_2 814 820 PF00069 0.625
MOD_Plk_1 172 178 PF00069 0.514
MOD_Plk_1 761 767 PF00069 0.550
MOD_Plk_2-3 593 599 PF00069 0.551
MOD_Plk_4 1 7 PF00069 0.599
MOD_Plk_4 158 164 PF00069 0.461
MOD_Plk_4 379 385 PF00069 0.487
MOD_Plk_4 428 434 PF00069 0.479
MOD_Plk_4 603 609 PF00069 0.461
MOD_Plk_4 814 820 PF00069 0.614
MOD_ProDKin_1 139 145 PF00069 0.535
MOD_ProDKin_1 249 255 PF00069 0.525
MOD_ProDKin_1 361 367 PF00069 0.527
MOD_ProDKin_1 524 530 PF00069 0.484
MOD_ProDKin_1 581 587 PF00069 0.527
MOD_ProDKin_1 858 864 PF00069 0.506
MOD_SUMO_for_1 109 112 PF00179 0.549
MOD_SUMO_rev_2 112 117 PF00179 0.515
MOD_SUMO_rev_2 308 313 PF00179 0.398
MOD_SUMO_rev_2 464 474 PF00179 0.677
MOD_SUMO_rev_2 795 801 PF00179 0.565
TRG_DiLeu_BaEn_2 212 218 PF01217 0.494
TRG_DiLeu_BaLyEn_6 787 792 PF01217 0.541
TRG_ENDOCYTIC_2 13 16 PF00928 0.387
TRG_ENDOCYTIC_2 163 166 PF00928 0.499
TRG_ENDOCYTIC_2 208 211 PF00928 0.424
TRG_ENDOCYTIC_2 282 285 PF00928 0.401
TRG_ENDOCYTIC_2 299 302 PF00928 0.307
TRG_ENDOCYTIC_2 462 465 PF00928 0.656
TRG_ENDOCYTIC_2 488 491 PF00928 0.497
TRG_ENDOCYTIC_2 56 59 PF00928 0.461
TRG_ENDOCYTIC_2 580 583 PF00928 0.461
TRG_ENDOCYTIC_2 779 782 PF00928 0.527
TRG_ENDOCYTIC_2 81 84 PF00928 0.527
TRG_ER_diArg_1 317 319 PF00400 0.407
TRG_ER_diArg_1 401 403 PF00400 0.491
TRG_ER_diArg_1 632 634 PF00400 0.527
TRG_ER_diArg_1 709 712 PF00400 0.569
TRG_ER_diArg_1 714 717 PF00400 0.582
TRG_ER_diArg_1 727 729 PF00400 0.442
TRG_NES_CRM1_1 840 852 PF08389 0.504
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.295
TRG_Pf-PMV_PEXEL_1 451 455 PF00026 0.327
TRG_Pf-PMV_PEXEL_1 510 514 PF00026 0.278
TRG_Pf-PMV_PEXEL_1 790 795 PF00026 0.569
TRG_Pf-PMV_PEXEL_1 809 813 PF00026 0.598

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Z8 Leptomonas seymouri 71% 97%
A0A0N1I3S9 Leptomonas seymouri 35% 100%
A0A0S4ISQ0 Bodo saltans 44% 100%
A0A0S4JL46 Bodo saltans 37% 100%
A0A1X0NXD4 Trypanosomatidae 36% 100%
A0A1X0P2V2 Trypanosomatidae 36% 100%
A0A1X0P8P2 Trypanosomatidae 48% 100%
A0A3Q8IKW2 Leishmania donovani 31% 91%
A0A3S7WNY9 Leishmania donovani 35% 100%
A0A3S7XAQ4 Leishmania donovani 100% 100%
A0A422NIL8 Trypanosoma rangeli 36% 100%
A0A422NLE5 Trypanosoma rangeli 48% 100%
A0A422NYK3 Trypanosoma rangeli 36% 100%
A4H452 Leishmania braziliensis 36% 93%
A4HP51 Leishmania braziliensis 90% 100%
A4HSC9 Leishmania infantum 36% 94%
A4HZA7 Leishmania infantum 31% 91%
C9ZPY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A1L3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
D0A336 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AKB0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 94%
E9ASV9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9AUY7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 98%
P34118 Dictyostelium discoideum 37% 100%
P54659 Dictyostelium discoideum 35% 100%
Q14764 Homo sapiens 37% 98%
Q3SYU9 Bos taurus 37% 98%
Q4CUM2 Trypanosoma cruzi (strain CL Brener) 36% 100%
Q4Q1N7 Leishmania major 96% 100%
Q4QCJ5 Leishmania major 31% 99%
Q4QJJ7 Leishmania major 36% 94%
Q57Z03 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 35% 100%
Q5EAJ7 Strongylocentrotus purpuratus 37% 100%
Q5R9N2 Pongo abelii 38% 98%
Q5ZMI4 Gallus gallus 38% 100%
Q62667 Rattus norvegicus 37% 100%
Q6P3L0 Danio rerio 37% 100%
Q6PF69 Xenopus laevis 38% 100%
Q90405 Diplobatis ommata 37% 100%
Q9DGM7 Ictalurus punctatus 37% 100%
Q9EQK5 Mus musculus 37% 100%
V5AUX6 Trypanosoma cruzi 36% 100%
V5B0K2 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS