LeishMANIAdb
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Ribosomal_S5_C domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal_S5_C domain-containing protein
Gene product:
Ribosomal protein S5 - C-terminal domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IDF7_LEIIN
TriTrypDb:
LINF_360025000
Length:
431

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Ribosomal S5, C-terminal domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 12
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDF7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDF7

PDB structure(s): 7ane_a

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 12
GO:0006518 peptide metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009059 macromolecule biosynthetic process 4 12
GO:0009987 cellular process 1 12
GO:0019538 protein metabolic process 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 12
GO:0043043 peptide biosynthetic process 5 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043603 amide metabolic process 3 12
GO:0043604 amide biosynthetic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 12
GO:0005198 structural molecule activity 1 12
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 63 67 PF00656 0.382
CLV_NRD_NRD_1 230 232 PF00675 0.355
CLV_NRD_NRD_1 309 311 PF00675 0.380
CLV_NRD_NRD_1 389 391 PF00675 0.454
CLV_NRD_NRD_1 397 399 PF00675 0.450
CLV_NRD_NRD_1 41 43 PF00675 0.373
CLV_PCSK_KEX2_1 230 232 PF00082 0.270
CLV_PCSK_KEX2_1 308 310 PF00082 0.365
CLV_PCSK_KEX2_1 385 387 PF00082 0.517
CLV_PCSK_KEX2_1 389 391 PF00082 0.440
CLV_PCSK_KEX2_1 397 399 PF00082 0.424
CLV_PCSK_KEX2_1 40 42 PF00082 0.350
CLV_PCSK_KEX2_1 425 427 PF00082 0.394
CLV_PCSK_PC1ET2_1 385 387 PF00082 0.568
CLV_PCSK_PC1ET2_1 425 427 PF00082 0.394
CLV_PCSK_SKI1_1 10 14 PF00082 0.572
CLV_PCSK_SKI1_1 150 154 PF00082 0.270
CLV_PCSK_SKI1_1 195 199 PF00082 0.270
CLV_PCSK_SKI1_1 223 227 PF00082 0.258
CLV_PCSK_SKI1_1 350 354 PF00082 0.352
CLV_PCSK_SKI1_1 382 386 PF00082 0.616
CLV_PCSK_SKI1_1 78 82 PF00082 0.357
DEG_APCC_DBOX_1 388 396 PF00400 0.410
DEG_Nend_Nbox_1 1 3 PF02207 0.560
DOC_ANK_TNKS_1 215 222 PF00023 0.362
DOC_CDC14_PxL_1 298 306 PF14671 0.357
DOC_CDC14_PxL_1 93 101 PF14671 0.339
DOC_CKS1_1 122 127 PF01111 0.372
DOC_MAPK_gen_1 401 411 PF00069 0.406
DOC_MAPK_gen_1 45 53 PF00069 0.390
DOC_MAPK_MEF2A_6 45 53 PF00069 0.390
DOC_PP1_RVXF_1 148 155 PF00149 0.270
DOC_PP4_MxPP_1 316 319 PF00568 0.410
DOC_USP7_MATH_1 278 282 PF00917 0.270
DOC_USP7_MATH_1 384 388 PF00917 0.564
DOC_USP7_MATH_1 74 78 PF00917 0.443
DOC_USP7_UBL2_3 153 157 PF12436 0.286
DOC_USP7_UBL2_3 253 257 PF12436 0.391
DOC_WW_Pin1_4 121 126 PF00397 0.372
DOC_WW_Pin1_4 152 157 PF00397 0.270
DOC_WW_Pin1_4 399 404 PF00397 0.572
LIG_14-3-3_CanoR_1 118 123 PF00244 0.359
LIG_14-3-3_CanoR_1 27 33 PF00244 0.512
LIG_14-3-3_CanoR_1 389 393 PF00244 0.417
LIG_Actin_WH2_2 265 282 PF00022 0.286
LIG_APCC_ABBA_1 300 305 PF00400 0.345
LIG_APCC_ABBA_1 87 92 PF00400 0.344
LIG_BRCT_BRCA1_1 57 61 PF00533 0.378
LIG_deltaCOP1_diTrp_1 345 353 PF00928 0.360
LIG_EH_1 47 51 PF12763 0.384
LIG_EH1_1 235 243 PF00400 0.270
LIG_FHA_1 122 128 PF00498 0.363
LIG_FHA_1 264 270 PF00498 0.286
LIG_FHA_1 3 9 PF00498 0.545
LIG_FHA_2 389 395 PF00498 0.413
LIG_FHA_2 400 406 PF00498 0.416
LIG_Integrin_RGD_1 368 370 PF01839 0.414
LIG_LIR_Apic_2 119 125 PF02991 0.362
LIG_LIR_Apic_2 31 35 PF02991 0.490
LIG_LIR_Gen_1 196 206 PF02991 0.305
LIG_LIR_Gen_1 270 279 PF02991 0.270
LIG_LIR_Nem_3 196 201 PF02991 0.305
LIG_LIR_Nem_3 270 276 PF02991 0.268
LIG_LIR_Nem_3 295 301 PF02991 0.336
LIG_LIR_Nem_3 346 352 PF02991 0.362
LIG_LIR_Nem_3 88 93 PF02991 0.344
LIG_LYPXL_S_1 300 304 PF13949 0.365
LIG_LYPXL_yS_3 301 304 PF13949 0.369
LIG_MLH1_MIPbox_1 57 61 PF16413 0.378
LIG_MYND_1 125 129 PF01753 0.344
LIG_MYND_1 97 101 PF01753 0.340
LIG_Pex14_1 349 353 PF04695 0.356
LIG_Pex14_2 136 140 PF04695 0.317
LIG_SH2_CRK 164 168 PF00017 0.286
LIG_SH2_CRK 93 97 PF00017 0.331
LIG_SH2_NCK_1 344 348 PF00017 0.376
LIG_SH2_SRC 344 347 PF00017 0.371
LIG_SH2_STAP1 147 151 PF00017 0.270
LIG_SH2_STAP1 344 348 PF00017 0.360
LIG_SH2_STAT5 164 167 PF00017 0.273
LIG_SH2_STAT5 168 171 PF00017 0.267
LIG_SH2_STAT5 30 33 PF00017 0.523
LIG_SH2_STAT5 303 306 PF00017 0.348
LIG_SH2_STAT5 428 431 PF00017 0.444
LIG_SH2_STAT5 60 63 PF00017 0.370
LIG_SH3_2 211 216 PF14604 0.356
LIG_SH3_3 1 7 PF00018 0.558
LIG_SH3_3 208 214 PF00018 0.345
LIG_SH3_3 259 265 PF00018 0.270
LIG_SH3_3 408 414 PF00018 0.436
LIG_SUMO_SIM_par_1 199 205 PF11976 0.279
LIG_TRAF2_1 185 188 PF00917 0.286
LIG_UBA3_1 313 321 PF00899 0.404
LIG_WRC_WIRS_1 12 17 PF05994 0.566
MOD_CDK_SPK_2 152 157 PF00069 0.286
MOD_CDK_SPK_2 399 404 PF00069 0.421
MOD_CK1_1 14 20 PF00069 0.433
MOD_CK2_1 182 188 PF00069 0.270
MOD_CK2_1 278 284 PF00069 0.270
MOD_GlcNHglycan 36 39 PF01048 0.463
MOD_GlcNHglycan 66 69 PF01048 0.398
MOD_GSK3_1 10 17 PF00069 0.529
MOD_GSK3_1 384 391 PF00069 0.465
MOD_N-GLC_1 10 15 PF02516 0.545
MOD_NEK2_1 256 261 PF00069 0.270
MOD_NEK2_1 376 381 PF00069 0.574
MOD_PIKK_1 183 189 PF00454 0.286
MOD_PIKK_1 376 382 PF00454 0.619
MOD_PKA_2 2 8 PF00069 0.630
MOD_PKA_2 388 394 PF00069 0.417
MOD_PKA_2 61 67 PF00069 0.381
MOD_Plk_1 10 16 PF00069 0.545
MOD_Plk_4 118 124 PF00069 0.360
MOD_Plk_4 28 34 PF00069 0.465
MOD_Plk_4 292 298 PF00069 0.351
MOD_Plk_4 55 61 PF00069 0.379
MOD_ProDKin_1 121 127 PF00069 0.365
MOD_ProDKin_1 152 158 PF00069 0.270
MOD_ProDKin_1 399 405 PF00069 0.573
MOD_SUMO_rev_2 356 365 PF00179 0.424
MOD_SUMO_rev_2 88 96 PF00179 0.416
TRG_ENDOCYTIC_2 164 167 PF00928 0.286
TRG_ENDOCYTIC_2 30 33 PF00928 0.372
TRG_ENDOCYTIC_2 301 304 PF00928 0.353
TRG_ENDOCYTIC_2 344 347 PF00928 0.357
TRG_ENDOCYTIC_2 93 96 PF00928 0.337
TRG_ER_diArg_1 133 136 PF00400 0.336
TRG_ER_diArg_1 230 232 PF00400 0.355
TRG_ER_diArg_1 307 310 PF00400 0.373
TRG_ER_diArg_1 396 398 PF00400 0.445
TRG_ER_diArg_1 40 42 PF00400 0.355
TRG_Pf-PMV_PEXEL_1 390 394 PF00026 0.415

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I867 Leptomonas seymouri 92% 100%
A0A0S4IX34 Bodo saltans 80% 100%
A0A1X0P7T8 Trypanosomatidae 86% 99%
A0A3Q8INM9 Leishmania donovani 100% 100%
A0A422NLS3 Trypanosoma rangeli 85% 99%
A4HP50 Leishmania braziliensis 97% 100%
D0A335 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 85% 99%
E9ASV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q1N8 Leishmania major 99% 100%
V5BJT0 Trypanosoma cruzi 85% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS