LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative exoribonuclease 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative exoribonuclease 2
Gene product:
5'-3' exoribonuclease D - putative
Species:
Leishmania infantum
UniProt:
A4IDF0_LEIIN
TriTrypDb:
LINF_360024300
Length:
879

Annotations

Annotations by Jardim et al.

Nucleases, exoribonuclease 2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDF0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDF0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000956 nuclear-transcribed mRNA catabolic process 7 1
GO:0006401 RNA catabolic process 5 1
GO:0006402 mRNA catabolic process 6 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010629 negative regulation of gene expression 6 1
GO:0016071 mRNA metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0046700 heterocycle catabolic process 4 1
GO:0048519 negative regulation of biological process 3 1
GO:0050789 regulation of biological process 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004518 nuclease activity 4 12
GO:0004527 exonuclease activity 5 12
GO:0005488 binding 1 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003723 RNA binding 4 1
GO:0004532 RNA exonuclease activity 5 1
GO:0004534 5'-3' RNA exonuclease activity 7 1
GO:0004540 RNA nuclease activity 4 1
GO:0008409 5'-3' exonuclease activity 6 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.514
CLV_C14_Caspase3-7 24 28 PF00656 0.481
CLV_C14_Caspase3-7 407 411 PF00656 0.517
CLV_MEL_PAP_1 654 660 PF00089 0.440
CLV_NRD_NRD_1 115 117 PF00675 0.244
CLV_NRD_NRD_1 419 421 PF00675 0.359
CLV_NRD_NRD_1 742 744 PF00675 0.739
CLV_NRD_NRD_1 759 761 PF00675 0.440
CLV_NRD_NRD_1 773 775 PF00675 0.711
CLV_NRD_NRD_1 791 793 PF00675 0.720
CLV_NRD_NRD_1 846 848 PF00675 0.759
CLV_NRD_NRD_1 877 879 PF00675 0.699
CLV_PCSK_FUR_1 113 117 PF00082 0.244
CLV_PCSK_FUR_1 771 775 PF00082 0.732
CLV_PCSK_FUR_1 875 879 PF00082 0.579
CLV_PCSK_KEX2_1 115 117 PF00082 0.244
CLV_PCSK_KEX2_1 731 733 PF00082 0.713
CLV_PCSK_KEX2_1 744 746 PF00082 0.490
CLV_PCSK_KEX2_1 759 761 PF00082 0.509
CLV_PCSK_KEX2_1 773 775 PF00082 0.722
CLV_PCSK_KEX2_1 790 792 PF00082 0.680
CLV_PCSK_KEX2_1 821 823 PF00082 0.677
CLV_PCSK_KEX2_1 846 848 PF00082 0.738
CLV_PCSK_KEX2_1 877 879 PF00082 0.683
CLV_PCSK_PC1ET2_1 731 733 PF00082 0.734
CLV_PCSK_PC1ET2_1 744 746 PF00082 0.498
CLV_PCSK_PC1ET2_1 759 761 PF00082 0.567
CLV_PCSK_PC1ET2_1 821 823 PF00082 0.704
CLV_PCSK_SKI1_1 166 170 PF00082 0.330
CLV_PCSK_SKI1_1 186 190 PF00082 0.113
CLV_PCSK_SKI1_1 459 463 PF00082 0.290
CLV_PCSK_SKI1_1 553 557 PF00082 0.305
CLV_PCSK_SKI1_1 707 711 PF00082 0.456
CLV_PCSK_SKI1_1 846 850 PF00082 0.715
CLV_PCSK_SKI1_1 852 856 PF00082 0.603
DEG_SPOP_SBC_1 801 805 PF00917 0.698
DEG_SPOP_SBC_1 806 810 PF00917 0.647
DEG_SPOP_SBC_1 840 844 PF00917 0.757
DOC_CDC14_PxL_1 497 505 PF14671 0.455
DOC_CDC14_PxL_1 530 538 PF14671 0.469
DOC_CKS1_1 156 161 PF01111 0.444
DOC_CYCLIN_RxL_1 88 101 PF00134 0.444
DOC_CYCLIN_yCln2_LP_2 637 643 PF00134 0.572
DOC_MAPK_gen_1 315 323 PF00069 0.455
DOC_MAPK_gen_1 420 428 PF00069 0.467
DOC_MAPK_gen_1 591 599 PF00069 0.549
DOC_MAPK_gen_1 88 98 PF00069 0.444
DOC_MAPK_MEF2A_6 78 87 PF00069 0.468
DOC_MAPK_MEF2A_6 91 100 PF00069 0.404
DOC_MAPK_NFAT4_5 93 101 PF00069 0.444
DOC_PP1_RVXF_1 473 480 PF00149 0.553
DOC_PP2B_LxvP_1 579 582 PF13499 0.455
DOC_PP2B_LxvP_1 637 640 PF13499 0.601
DOC_USP7_MATH_1 310 314 PF00917 0.530
DOC_USP7_MATH_1 389 393 PF00917 0.547
DOC_USP7_MATH_1 400 404 PF00917 0.500
DOC_USP7_MATH_1 414 418 PF00917 0.530
DOC_USP7_MATH_1 461 465 PF00917 0.516
DOC_USP7_MATH_1 626 630 PF00917 0.580
DOC_USP7_MATH_1 724 728 PF00917 0.647
DOC_USP7_MATH_1 801 805 PF00917 0.739
DOC_USP7_MATH_1 806 810 PF00917 0.730
DOC_USP7_MATH_1 840 844 PF00917 0.695
DOC_USP7_MATH_1 848 852 PF00917 0.668
DOC_USP7_MATH_1 867 871 PF00917 0.755
DOC_USP7_UBL2_3 357 361 PF12436 0.502
DOC_USP7_UBL2_3 373 377 PF12436 0.369
DOC_USP7_UBL2_3 731 735 PF12436 0.714
DOC_USP7_UBL2_3 812 816 PF12436 0.738
DOC_WW_Pin1_4 155 160 PF00397 0.444
DOC_WW_Pin1_4 735 740 PF00397 0.742
DOC_WW_Pin1_4 802 807 PF00397 0.696
DOC_WW_Pin1_4 862 867 PF00397 0.608
LIG_14-3-3_CanoR_1 136 144 PF00244 0.521
LIG_14-3-3_CanoR_1 186 191 PF00244 0.505
LIG_14-3-3_CanoR_1 210 216 PF00244 0.495
LIG_14-3-3_CanoR_1 249 258 PF00244 0.536
LIG_14-3-3_CanoR_1 383 391 PF00244 0.505
LIG_14-3-3_CanoR_1 518 522 PF00244 0.503
LIG_14-3-3_CanoR_1 535 539 PF00244 0.353
LIG_BRCT_BRCA1_1 113 117 PF00533 0.444
LIG_BRCT_BRCA1_1 159 163 PF00533 0.444
LIG_Clathr_ClatBox_1 596 600 PF01394 0.548
LIG_deltaCOP1_diTrp_1 181 192 PF00928 0.455
LIG_deltaCOP1_diTrp_1 492 495 PF00928 0.455
LIG_EH1_1 523 531 PF00400 0.444
LIG_eIF4E_1 497 503 PF01652 0.505
LIG_FHA_1 220 226 PF00498 0.455
LIG_FHA_1 314 320 PF00498 0.444
LIG_FHA_1 422 428 PF00498 0.494
LIG_FHA_1 508 514 PF00498 0.462
LIG_FHA_1 61 67 PF00498 0.444
LIG_FHA_1 649 655 PF00498 0.503
LIG_FHA_2 268 274 PF00498 0.442
LIG_FHA_2 383 389 PF00498 0.561
LIG_FHA_2 700 706 PF00498 0.527
LIG_KLC1_Yacidic_2 46 51 PF13176 0.455
LIG_LIR_Apic_2 139 144 PF02991 0.532
LIG_LIR_Apic_2 490 496 PF02991 0.444
LIG_LIR_Gen_1 278 287 PF02991 0.409
LIG_LIR_Gen_1 292 301 PF02991 0.416
LIG_LIR_Gen_1 341 352 PF02991 0.469
LIG_LIR_Gen_1 44 52 PF02991 0.451
LIG_LIR_Gen_1 73 83 PF02991 0.455
LIG_LIR_LC3C_4 424 428 PF02991 0.480
LIG_LIR_Nem_3 182 188 PF02991 0.449
LIG_LIR_Nem_3 278 282 PF02991 0.402
LIG_LIR_Nem_3 292 297 PF02991 0.449
LIG_LIR_Nem_3 341 347 PF02991 0.441
LIG_LIR_Nem_3 363 369 PF02991 0.473
LIG_LIR_Nem_3 44 48 PF02991 0.462
LIG_LIR_Nem_3 490 494 PF02991 0.440
LIG_LIR_Nem_3 574 578 PF02991 0.458
LIG_LIR_Nem_3 705 709 PF02991 0.525
LIG_LIR_Nem_3 77 83 PF02991 0.457
LIG_LYPXL_S_1 559 563 PF13949 0.330
LIG_LYPXL_yS_3 560 563 PF13949 0.530
LIG_MAD2 136 144 PF02301 0.519
LIG_Pex14_1 479 483 PF04695 0.444
LIG_Pex14_1 491 495 PF04695 0.444
LIG_Pex14_2 296 300 PF04695 0.444
LIG_Pex14_2 350 354 PF04695 0.444
LIG_Pex14_2 603 607 PF04695 0.496
LIG_Pex14_2 76 80 PF04695 0.455
LIG_Rb_LxCxE_1 463 485 PF01857 0.485
LIG_Rb_LxCxE_1 605 624 PF01857 0.429
LIG_SH2_CRK 141 145 PF00017 0.549
LIG_SH2_CRK 367 371 PF00017 0.463
LIG_SH2_CRK 499 503 PF00017 0.444
LIG_SH2_CRK 575 579 PF00017 0.444
LIG_SH2_CRK 706 710 PF00017 0.485
LIG_SH2_GRB2like 265 268 PF00017 0.407
LIG_SH2_GRB2like 45 48 PF00017 0.505
LIG_SH2_STAP1 45 49 PF00017 0.505
LIG_SH2_STAP1 661 665 PF00017 0.477
LIG_SH2_STAT3 335 338 PF00017 0.522
LIG_SH2_STAT5 174 177 PF00017 0.530
LIG_SH2_STAT5 208 211 PF00017 0.444
LIG_SH2_STAT5 265 268 PF00017 0.315
LIG_SH2_STAT5 326 329 PF00017 0.444
LIG_SH2_STAT5 335 338 PF00017 0.444
LIG_SH2_STAT5 437 440 PF00017 0.462
LIG_SH2_STAT5 473 476 PF00017 0.443
LIG_SH2_STAT5 484 487 PF00017 0.430
LIG_SH2_STAT5 49 52 PF00017 0.448
LIG_SH2_STAT5 494 497 PF00017 0.444
LIG_SH2_STAT5 609 612 PF00017 0.444
LIG_SH3_1 863 869 PF00018 0.575
LIG_SH3_2 866 871 PF14604 0.564
LIG_SH3_3 153 159 PF00018 0.444
LIG_SH3_3 304 310 PF00018 0.444
LIG_SH3_3 519 525 PF00018 0.444
LIG_SH3_3 546 552 PF00018 0.444
LIG_SH3_3 637 643 PF00018 0.550
LIG_SH3_3 86 92 PF00018 0.457
LIG_SH3_3 863 869 PF00018 0.628
LIG_SH3_5 216 220 PF00018 0.549
LIG_SUMO_SIM_anti_2 81 87 PF11976 0.505
LIG_SUMO_SIM_par_1 310 316 PF11976 0.444
LIG_SUMO_SIM_par_1 409 418 PF11976 0.493
LIG_SUMO_SIM_par_1 562 567 PF11976 0.526
LIG_SUMO_SIM_par_1 595 602 PF11976 0.573
LIG_TYR_ITIM 342 347 PF00017 0.469
LIG_UBA3_1 349 357 PF00899 0.549
LIG_UBA3_1 359 364 PF00899 0.431
LIG_UBA3_1 412 421 PF00899 0.474
LIG_WW_3 738 742 PF00397 0.661
MOD_CDC14_SPxK_1 738 741 PF00782 0.700
MOD_CDK_SPxK_1 735 741 PF00069 0.695
MOD_CDK_SPxK_1 862 868 PF00069 0.610
MOD_CK1_1 313 319 PF00069 0.442
MOD_CK1_1 38 44 PF00069 0.479
MOD_CK1_1 647 653 PF00069 0.539
MOD_CK1_1 727 733 PF00069 0.699
MOD_CK1_1 802 808 PF00069 0.693
MOD_CK1_1 829 835 PF00069 0.732
MOD_CK1_1 842 848 PF00069 0.641
MOD_CK2_1 236 242 PF00069 0.444
MOD_CK2_1 267 273 PF00069 0.443
MOD_CK2_1 277 283 PF00069 0.487
MOD_CK2_1 382 388 PF00069 0.529
MOD_CK2_1 776 782 PF00069 0.753
MOD_CK2_1 820 826 PF00069 0.736
MOD_CK2_1 829 835 PF00069 0.677
MOD_GlcNHglycan 40 43 PF01048 0.297
MOD_GlcNHglycan 417 420 PF01048 0.322
MOD_GlcNHglycan 454 458 PF01048 0.302
MOD_GlcNHglycan 519 522 PF01048 0.329
MOD_GlcNHglycan 628 631 PF01048 0.590
MOD_GSK3_1 123 130 PF00069 0.458
MOD_GSK3_1 186 193 PF00069 0.505
MOD_GSK3_1 31 38 PF00069 0.461
MOD_GSK3_1 644 651 PF00069 0.554
MOD_GSK3_1 786 793 PF00069 0.745
MOD_GSK3_1 795 802 PF00069 0.713
MOD_GSK3_1 808 815 PF00069 0.710
MOD_GSK3_1 820 827 PF00069 0.722
MOD_GSK3_1 858 865 PF00069 0.764
MOD_N-GLC_1 220 225 PF02516 0.330
MOD_N-GLC_1 266 271 PF02516 0.421
MOD_N-GLC_1 352 357 PF02516 0.335
MOD_N-GLC_1 571 576 PF02516 0.297
MOD_N-GLC_2 131 133 PF02516 0.305
MOD_NEK2_1 236 241 PF00069 0.453
MOD_NEK2_1 252 257 PF00069 0.415
MOD_NEK2_1 266 271 PF00069 0.298
MOD_NEK2_1 352 357 PF00069 0.497
MOD_NEK2_1 415 420 PF00069 0.446
MOD_NEK2_1 433 438 PF00069 0.379
MOD_NEK2_1 509 514 PF00069 0.542
MOD_NEK2_1 517 522 PF00069 0.513
MOD_NEK2_1 603 608 PF00069 0.425
MOD_NEK2_1 633 638 PF00069 0.649
MOD_NEK2_1 678 683 PF00069 0.512
MOD_NEK2_1 841 846 PF00069 0.727
MOD_NEK2_2 310 315 PF00069 0.444
MOD_NEK2_2 534 539 PF00069 0.530
MOD_PIKK_1 211 217 PF00454 0.505
MOD_PIKK_1 334 340 PF00454 0.522
MOD_PIKK_1 699 705 PF00454 0.503
MOD_PIKK_1 820 826 PF00454 0.758
MOD_PKA_1 761 767 PF00069 0.770
MOD_PKA_1 790 796 PF00069 0.771
MOD_PKA_1 820 826 PF00069 0.699
MOD_PKA_2 382 388 PF00069 0.549
MOD_PKA_2 517 523 PF00069 0.503
MOD_PKA_2 534 540 PF00069 0.353
MOD_PKA_2 761 767 PF00069 0.764
MOD_PKA_2 790 796 PF00069 0.689
MOD_PKA_2 829 835 PF00069 0.686
MOD_PKA_2 858 864 PF00069 0.775
MOD_PKB_1 760 768 PF00069 0.787
MOD_PKB_1 774 782 PF00069 0.774
MOD_Plk_1 220 226 PF00069 0.505
MOD_Plk_1 266 272 PF00069 0.356
MOD_Plk_1 421 427 PF00069 0.526
MOD_Plk_1 571 577 PF00069 0.497
MOD_Plk_1 611 617 PF00069 0.391
MOD_Plk_4 186 192 PF00069 0.552
MOD_Plk_4 394 400 PF00069 0.557
MOD_Plk_4 551 557 PF00069 0.444
MOD_Plk_4 603 609 PF00069 0.384
MOD_ProDKin_1 155 161 PF00069 0.444
MOD_ProDKin_1 735 741 PF00069 0.744
MOD_ProDKin_1 802 808 PF00069 0.696
MOD_ProDKin_1 862 868 PF00069 0.610
MOD_SUMO_for_1 854 857 PF00179 0.605
MOD_SUMO_rev_2 200 206 PF00179 0.444
MOD_SUMO_rev_2 547 555 PF00179 0.505
MOD_SUMO_rev_2 815 823 PF00179 0.580
MOD_SUMO_rev_2 826 834 PF00179 0.592
TRG_DiLeu_BaEn_1 422 427 PF01217 0.448
TRG_DiLeu_BaLyEn_6 498 503 PF01217 0.444
TRG_ENDOCYTIC_2 265 268 PF00928 0.322
TRG_ENDOCYTIC_2 344 347 PF00928 0.460
TRG_ENDOCYTIC_2 366 369 PF00928 0.460
TRG_ENDOCYTIC_2 45 48 PF00928 0.453
TRG_ENDOCYTIC_2 49 52 PF00928 0.439
TRG_ENDOCYTIC_2 499 502 PF00928 0.452
TRG_ENDOCYTIC_2 560 563 PF00928 0.500
TRG_ENDOCYTIC_2 575 578 PF00928 0.373
TRG_ENDOCYTIC_2 706 709 PF00928 0.486
TRG_ER_diArg_1 113 116 PF00400 0.444
TRG_ER_diArg_1 144 147 PF00400 0.494
TRG_ER_diArg_1 423 426 PF00400 0.469
TRG_ER_diArg_1 740 743 PF00400 0.787
TRG_ER_diArg_1 790 792 PF00400 0.705
TRG_ER_diArg_1 875 878 PF00400 0.734
TRG_NES_CRM1_1 504 516 PF08389 0.502
TRG_NLS_Bipartite_1 731 747 PF00514 0.784
TRG_NLS_MonoCore_2 758 763 PF00514 0.689
TRG_NLS_MonoExtC_3 742 747 PF00514 0.740
TRG_NLS_MonoExtN_4 740 747 PF00514 0.748
TRG_NLS_MonoExtN_4 759 764 PF00514 0.685
TRG_Pf-PMV_PEXEL_1 177 181 PF00026 0.285
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.244
TRG_Pf-PMV_PEXEL_1 594 598 PF00026 0.349

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYA8 Leptomonas seymouri 87% 96%
A0A0S4IWC0 Bodo saltans 54% 100%
A0A1X0P7T7 Trypanosomatidae 59% 100%
A0A3Q8IH53 Leishmania donovani 100% 100%
A0A3R7LZH3 Trypanosoma rangeli 63% 100%
A4HP43 Leishmania braziliensis 86% 100%
D0A327 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9ASV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q1P5 Leishmania major 93% 100%
Q5ZIP4 Gallus gallus 33% 93%
Q60SG7 Caenorhabditis briggsae 32% 90%
Q9FQ02 Arabidopsis thaliana 33% 87%
Q9FQ03 Arabidopsis thaliana 33% 86%
Q9FQ04 Arabidopsis thaliana 34% 93%
Q9U299 Caenorhabditis elegans 32% 90%
Q9VM71 Drosophila melanogaster 34% 97%
V5DKX1 Trypanosoma cruzi 61% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS