LeishMANIAdb
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Tetratricopeptide repeat-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tetratricopeptide repeat-containing protein
Gene product:
Tetratricopeptide repeat/TPR repeat - putative
Species:
Leishmania infantum
UniProt:
A4IDE9_LEIIN
TriTrypDb:
LINF_360024200
Length:
745

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDE9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDE9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 266 270 PF00656 0.512
CLV_C14_Caspase3-7 394 398 PF00656 0.546
CLV_C14_Caspase3-7 497 501 PF00656 0.511
CLV_NRD_NRD_1 101 103 PF00675 0.521
CLV_NRD_NRD_1 345 347 PF00675 0.515
CLV_NRD_NRD_1 385 387 PF00675 0.683
CLV_NRD_NRD_1 445 447 PF00675 0.423
CLV_NRD_NRD_1 564 566 PF00675 0.484
CLV_NRD_NRD_1 646 648 PF00675 0.788
CLV_NRD_NRD_1 655 657 PF00675 0.664
CLV_NRD_NRD_1 683 685 PF00675 0.737
CLV_NRD_NRD_1 712 714 PF00675 0.724
CLV_NRD_NRD_1 735 737 PF00675 0.640
CLV_NRD_NRD_1 85 87 PF00675 0.408
CLV_PCSK_KEX2_1 101 103 PF00082 0.521
CLV_PCSK_KEX2_1 384 386 PF00082 0.706
CLV_PCSK_KEX2_1 445 447 PF00082 0.439
CLV_PCSK_KEX2_1 646 648 PF00082 0.788
CLV_PCSK_KEX2_1 654 656 PF00082 0.679
CLV_PCSK_KEX2_1 682 684 PF00082 0.705
CLV_PCSK_KEX2_1 712 714 PF00082 0.781
CLV_PCSK_KEX2_1 718 720 PF00082 0.734
CLV_PCSK_KEX2_1 735 737 PF00082 0.542
CLV_PCSK_KEX2_1 85 87 PF00082 0.408
CLV_PCSK_PC1ET2_1 654 656 PF00082 0.725
CLV_PCSK_PC1ET2_1 718 720 PF00082 0.706
CLV_PCSK_SKI1_1 342 346 PF00082 0.444
CLV_PCSK_SKI1_1 349 353 PF00082 0.424
CLV_PCSK_SKI1_1 406 410 PF00082 0.494
CLV_PCSK_SKI1_1 461 465 PF00082 0.428
CLV_PCSK_SKI1_1 565 569 PF00082 0.499
CLV_PCSK_SKI1_1 608 612 PF00082 0.465
CLV_PCSK_SKI1_1 85 89 PF00082 0.501
DEG_APCC_DBOX_1 233 241 PF00400 0.453
DEG_APCC_DBOX_1 607 615 PF00400 0.483
DEG_APCC_DBOX_1 84 92 PF00400 0.408
DEG_SPOP_SBC_1 5 9 PF00917 0.632
DOC_CYCLIN_RxL_1 346 356 PF00134 0.443
DOC_CYCLIN_RxL_1 403 411 PF00134 0.550
DOC_CYCLIN_RxL_1 82 90 PF00134 0.490
DOC_MAPK_gen_1 28 37 PF00069 0.529
DOC_MAPK_gen_1 346 352 PF00069 0.516
DOC_MAPK_gen_1 445 451 PF00069 0.492
DOC_MAPK_gen_1 510 519 PF00069 0.510
DOC_MAPK_gen_1 82 91 PF00069 0.437
DOC_MAPK_MEF2A_6 512 520 PF00069 0.454
DOC_PP2B_LxvP_1 219 222 PF13499 0.681
DOC_USP7_MATH_1 116 120 PF00917 0.621
DOC_USP7_MATH_1 170 174 PF00917 0.654
DOC_USP7_MATH_1 18 22 PF00917 0.562
DOC_USP7_MATH_1 398 402 PF00917 0.417
DOC_USP7_MATH_1 420 424 PF00917 0.517
DOC_USP7_MATH_1 5 9 PF00917 0.726
DOC_USP7_MATH_1 641 645 PF00917 0.788
DOC_USP7_MATH_1 658 662 PF00917 0.590
DOC_USP7_MATH_1 689 693 PF00917 0.739
DOC_USP7_UBL2_3 26 30 PF12436 0.547
DOC_USP7_UBL2_3 457 461 PF12436 0.477
DOC_WW_Pin1_4 124 129 PF00397 0.749
DOC_WW_Pin1_4 171 176 PF00397 0.799
DOC_WW_Pin1_4 284 289 PF00397 0.629
DOC_WW_Pin1_4 646 651 PF00397 0.702
LIG_14-3-3_CanoR_1 139 147 PF00244 0.607
LIG_14-3-3_CanoR_1 155 164 PF00244 0.481
LIG_14-3-3_CanoR_1 195 203 PF00244 0.719
LIG_14-3-3_CanoR_1 328 336 PF00244 0.440
LIG_14-3-3_CanoR_1 384 389 PF00244 0.686
LIG_14-3-3_CanoR_1 446 452 PF00244 0.493
LIG_14-3-3_CanoR_1 555 560 PF00244 0.554
LIG_14-3-3_CanoR_1 712 717 PF00244 0.738
LIG_14-3-3_CanoR_1 86 92 PF00244 0.438
LIG_Actin_WH2_2 244 261 PF00022 0.461
LIG_APCC_ABBA_1 47 52 PF00400 0.556
LIG_BIR_III_4 242 246 PF00653 0.541
LIG_BIR_III_4 397 401 PF00653 0.513
LIG_BRCT_BRCA1_1 286 290 PF00533 0.532
LIG_BRCT_BRCA1_1 436 440 PF00533 0.484
LIG_deltaCOP1_diTrp_1 561 568 PF00928 0.432
LIG_DLG_GKlike_1 555 562 PF00625 0.553
LIG_eIF4E_1 44 50 PF01652 0.456
LIG_FHA_1 106 112 PF00498 0.664
LIG_FHA_1 17 23 PF00498 0.615
LIG_FHA_1 216 222 PF00498 0.709
LIG_FHA_1 293 299 PF00498 0.492
LIG_FHA_1 329 335 PF00498 0.449
LIG_FHA_1 416 422 PF00498 0.493
LIG_FHA_1 428 434 PF00498 0.359
LIG_FHA_1 480 486 PF00498 0.418
LIG_FHA_1 579 585 PF00498 0.483
LIG_FHA_1 702 708 PF00498 0.812
LIG_FHA_2 108 114 PF00498 0.711
LIG_FHA_2 156 162 PF00498 0.782
LIG_FHA_2 227 233 PF00498 0.567
LIG_FHA_2 468 474 PF00498 0.497
LIG_FHA_2 525 531 PF00498 0.495
LIG_GBD_Chelix_1 404 412 PF00786 0.490
LIG_HP1_1 63 67 PF01393 0.469
LIG_Integrin_RGD_1 522 524 PF01839 0.430
LIG_LIR_Apic_2 12 18 PF02991 0.639
LIG_LIR_Gen_1 318 329 PF02991 0.524
LIG_LIR_Gen_1 437 447 PF02991 0.464
LIG_LIR_Gen_1 524 532 PF02991 0.413
LIG_LIR_Gen_1 538 545 PF02991 0.440
LIG_LIR_Gen_1 69 77 PF02991 0.452
LIG_LIR_Nem_3 318 324 PF02991 0.496
LIG_LIR_Nem_3 410 416 PF02991 0.417
LIG_LIR_Nem_3 437 443 PF02991 0.527
LIG_LIR_Nem_3 462 467 PF02991 0.422
LIG_LIR_Nem_3 538 542 PF02991 0.394
LIG_LIR_Nem_3 69 74 PF02991 0.429
LIG_Pex14_2 440 444 PF04695 0.452
LIG_PTAP_UEV_1 621 626 PF05743 0.498
LIG_PTB_Apo_2 587 594 PF02174 0.521
LIG_Rb_LxCxE_1 613 623 PF01857 0.521
LIG_SH2_GRB2like 436 439 PF00017 0.485
LIG_SH2_NCK_1 44 48 PF00017 0.561
LIG_SH2_PTP2 71 74 PF00017 0.455
LIG_SH2_SRC 303 306 PF00017 0.352
LIG_SH2_SRC 634 637 PF00017 0.579
LIG_SH2_STAP1 436 440 PF00017 0.484
LIG_SH2_STAP1 505 509 PF00017 0.414
LIG_SH2_STAP1 539 543 PF00017 0.566
LIG_SH2_STAT5 303 306 PF00017 0.405
LIG_SH2_STAT5 339 342 PF00017 0.409
LIG_SH2_STAT5 407 410 PF00017 0.491
LIG_SH2_STAT5 526 529 PF00017 0.410
LIG_SH2_STAT5 634 637 PF00017 0.657
LIG_SH2_STAT5 71 74 PF00017 0.455
LIG_SH2_STAT5 99 102 PF00017 0.680
LIG_SH3_1 634 640 PF00018 0.580
LIG_SH3_2 125 130 PF14604 0.598
LIG_SH3_3 119 125 PF00018 0.651
LIG_SH3_3 387 393 PF00018 0.664
LIG_SH3_3 619 625 PF00018 0.472
LIG_SH3_3 634 640 PF00018 0.561
LIG_SH3_3 737 743 PF00018 0.564
LIG_SUMO_SIM_anti_2 263 269 PF11976 0.461
LIG_SUMO_SIM_anti_2 476 483 PF11976 0.449
LIG_SUMO_SIM_anti_2 514 520 PF11976 0.496
LIG_SUMO_SIM_par_1 63 69 PF11976 0.471
LIG_TRAF2_1 354 357 PF00917 0.453
LIG_TYR_ITIM 42 47 PF00017 0.556
LIG_UBA3_1 88 94 PF00899 0.512
MOD_CDC14_SPxK_1 127 130 PF00782 0.703
MOD_CDK_SPxK_1 124 130 PF00069 0.691
MOD_CK1_1 166 172 PF00069 0.689
MOD_CK1_1 173 179 PF00069 0.760
MOD_CK1_1 20 26 PF00069 0.450
MOD_CK1_1 206 212 PF00069 0.695
MOD_CK1_1 284 290 PF00069 0.674
MOD_CK1_1 391 397 PF00069 0.654
MOD_CK1_1 434 440 PF00069 0.482
MOD_CK1_1 701 707 PF00069 0.728
MOD_CK1_1 8 14 PF00069 0.690
MOD_CK2_1 107 113 PF00069 0.576
MOD_CK2_1 420 426 PF00069 0.518
MOD_CK2_1 467 473 PF00069 0.494
MOD_CK2_1 524 530 PF00069 0.495
MOD_CK2_1 613 619 PF00069 0.529
MOD_CK2_1 669 675 PF00069 0.576
MOD_Cter_Amidation 563 566 PF01082 0.479
MOD_GlcNHglycan 112 117 PF01048 0.729
MOD_GlcNHglycan 168 171 PF01048 0.603
MOD_GlcNHglycan 208 211 PF01048 0.757
MOD_GlcNHglycan 381 384 PF01048 0.773
MOD_GlcNHglycan 394 397 PF01048 0.393
MOD_GlcNHglycan 719 722 PF01048 0.729
MOD_GlcNHglycan 78 81 PF01048 0.457
MOD_GSK3_1 112 119 PF00069 0.663
MOD_GSK3_1 124 131 PF00069 0.767
MOD_GSK3_1 16 23 PF00069 0.586
MOD_GSK3_1 166 173 PF00069 0.698
MOD_GSK3_1 199 206 PF00069 0.693
MOD_GSK3_1 384 391 PF00069 0.726
MOD_GSK3_1 4 11 PF00069 0.704
MOD_GSK3_1 427 434 PF00069 0.483
MOD_GSK3_1 480 487 PF00069 0.439
MOD_GSK3_1 685 692 PF00069 0.817
MOD_N-GLC_1 105 110 PF02516 0.557
MOD_NEK2_1 244 249 PF00069 0.544
MOD_NEK2_1 6 11 PF00069 0.748
MOD_NEK2_2 116 121 PF00069 0.625
MOD_NEK2_2 505 510 PF00069 0.481
MOD_NEK2_2 689 694 PF00069 0.654
MOD_NEK2_2 729 734 PF00069 0.634
MOD_NEK2_2 87 92 PF00069 0.489
MOD_PIKK_1 641 647 PF00454 0.798
MOD_PK_1 431 437 PF00069 0.514
MOD_PKA_1 384 390 PF00069 0.639
MOD_PKA_1 683 689 PF00069 0.605
MOD_PKA_1 712 718 PF00069 0.697
MOD_PKA_1 735 741 PF00069 0.586
MOD_PKA_2 138 144 PF00069 0.777
MOD_PKA_2 194 200 PF00069 0.701
MOD_PKA_2 258 264 PF00069 0.455
MOD_PKA_2 384 390 PF00069 0.673
MOD_PKA_2 467 473 PF00069 0.592
MOD_PKA_2 683 689 PF00069 0.820
MOD_PKA_2 712 718 PF00069 0.694
MOD_PKA_2 735 741 PF00069 0.738
MOD_PKB_1 326 334 PF00069 0.330
MOD_PKB_1 553 561 PF00069 0.563
MOD_Plk_1 128 134 PF00069 0.763
MOD_Plk_1 176 182 PF00069 0.720
MOD_Plk_1 425 431 PF00069 0.464
MOD_Plk_1 51 57 PF00069 0.519
MOD_Plk_1 689 695 PF00069 0.744
MOD_Plk_4 244 250 PF00069 0.461
MOD_Plk_4 431 437 PF00069 0.510
MOD_Plk_4 480 486 PF00069 0.398
MOD_Plk_4 500 506 PF00069 0.551
MOD_Plk_4 51 57 PF00069 0.437
MOD_ProDKin_1 124 130 PF00069 0.754
MOD_ProDKin_1 171 177 PF00069 0.799
MOD_ProDKin_1 284 290 PF00069 0.617
MOD_ProDKin_1 646 652 PF00069 0.700
MOD_SUMO_rev_2 353 360 PF00179 0.594
MOD_SUMO_rev_2 469 477 PF00179 0.537
TRG_DiLeu_BaEn_1 263 268 PF01217 0.469
TRG_DiLeu_BaEn_1 312 317 PF01217 0.489
TRG_DiLeu_BaEn_2 68 74 PF01217 0.490
TRG_DiLeu_BaEn_4 675 681 PF01217 0.602
TRG_DiLeu_BaLyEn_6 33 38 PF01217 0.513
TRG_ENDOCYTIC_2 44 47 PF00928 0.555
TRG_ENDOCYTIC_2 526 529 PF00928 0.410
TRG_ENDOCYTIC_2 539 542 PF00928 0.373
TRG_ENDOCYTIC_2 71 74 PF00928 0.455
TRG_ER_diArg_1 233 236 PF00400 0.477
TRG_ER_diArg_1 384 386 PF00400 0.574
TRG_ER_diArg_1 444 446 PF00400 0.439
TRG_ER_diArg_1 552 555 PF00400 0.572
TRG_ER_diArg_1 682 684 PF00400 0.812
TRG_ER_diArg_1 84 86 PF00400 0.403
TRG_Pf-PMV_PEXEL_1 349 353 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 565 570 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6L1 Leptomonas seymouri 53% 89%
A0A1X0P7U7 Trypanosomatidae 34% 100%
A0A3S7XAR1 Leishmania donovani 100% 100%
A4HP42 Leishmania braziliensis 70% 100%
D0A326 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9ASV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q1P6 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS