LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDE6_LEIIN
TriTrypDb:
LINF_360023900
Length:
550

Annotations

LeishMANIAdb annotations

A membrane-associated WD40 domain protein. Might be a receptor for some unidentified partner molecule.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 7, no: 4
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4IDE6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDE6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 415 417 PF00675 0.513
CLV_NRD_NRD_1 518 520 PF00675 0.413
CLV_NRD_NRD_1 542 544 PF00675 0.427
CLV_PCSK_KEX2_1 415 417 PF00082 0.526
CLV_PCSK_KEX2_1 518 520 PF00082 0.413
CLV_PCSK_KEX2_1 542 544 PF00082 0.427
CLV_PCSK_SKI1_1 190 194 PF00082 0.601
CLV_PCSK_SKI1_1 404 408 PF00082 0.602
DEG_APCC_DBOX_1 119 127 PF00400 0.319
DEG_APCC_KENBOX_2 130 134 PF00400 0.384
DEG_Kelch_Keap1_1 292 297 PF01344 0.403
DOC_ANK_TNKS_1 254 261 PF00023 0.404
DOC_CYCLIN_yCln2_LP_2 136 142 PF00134 0.312
DOC_MAPK_DCC_7 335 343 PF00069 0.400
DOC_MAPK_DCC_7 66 75 PF00069 0.415
DOC_MAPK_gen_1 471 480 PF00069 0.421
DOC_MAPK_gen_1 74 83 PF00069 0.306
DOC_MAPK_HePTP_8 63 75 PF00069 0.407
DOC_MAPK_MEF2A_6 335 343 PF00069 0.397
DOC_MAPK_MEF2A_6 66 75 PF00069 0.415
DOC_PP2B_LxvP_1 302 305 PF13499 0.370
DOC_PP2B_PxIxI_1 338 344 PF00149 0.377
DOC_PP4_FxxP_1 336 339 PF00568 0.311
DOC_SPAK_OSR1_1 335 339 PF12202 0.403
DOC_USP7_MATH_1 178 182 PF00917 0.552
DOC_USP7_MATH_1 225 229 PF00917 0.414
DOC_USP7_MATH_1 3 7 PF00917 0.698
DOC_USP7_MATH_1 94 98 PF00917 0.416
DOC_WW_Pin1_4 170 175 PF00397 0.459
DOC_WW_Pin1_4 247 252 PF00397 0.280
DOC_WW_Pin1_4 303 308 PF00397 0.285
DOC_WW_Pin1_4 387 392 PF00397 0.456
DOC_WW_Pin1_4 419 424 PF00397 0.283
DOC_WW_Pin1_4 432 437 PF00397 0.303
DOC_WW_Pin1_4 534 539 PF00397 0.725
LIG_14-3-3_CanoR_1 166 174 PF00244 0.343
LIG_14-3-3_CanoR_1 315 324 PF00244 0.327
LIG_14-3-3_CanoR_1 4 12 PF00244 0.544
LIG_14-3-3_CanoR_1 415 421 PF00244 0.306
LIG_Actin_WH2_2 49 67 PF00022 0.412
LIG_BRCT_BRCA1_1 227 231 PF00533 0.376
LIG_BRCT_BRCA1_1 263 267 PF00533 0.412
LIG_BRCT_BRCA1_1 79 83 PF00533 0.398
LIG_BRCT_BRCA1_1 98 102 PF00533 0.189
LIG_deltaCOP1_diTrp_1 48 53 PF00928 0.334
LIG_EH_1 132 136 PF12763 0.342
LIG_EH1_1 450 458 PF00400 0.376
LIG_FHA_1 167 173 PF00498 0.484
LIG_FHA_1 285 291 PF00498 0.383
LIG_FHA_1 35 41 PF00498 0.350
LIG_FHA_2 111 117 PF00498 0.410
LIG_FHA_2 123 129 PF00498 0.294
LIG_FHA_2 342 348 PF00498 0.288
LIG_FHA_2 453 459 PF00498 0.318
LIG_GBD_Chelix_1 12 20 PF00786 0.320
LIG_GBD_Chelix_1 489 497 PF00786 0.388
LIG_HCF-1_HBM_1 137 140 PF13415 0.307
LIG_Integrin_isoDGR_2 413 415 PF01839 0.549
LIG_IRF3_LxIS_1 244 250 PF10401 0.318
LIG_LIR_Apic_2 333 339 PF02991 0.313
LIG_LIR_Apic_2 419 423 PF02991 0.280
LIG_LIR_Gen_1 121 130 PF02991 0.444
LIG_LIR_Gen_1 274 283 PF02991 0.360
LIG_LIR_Gen_1 337 347 PF02991 0.344
LIG_LIR_Gen_1 52 60 PF02991 0.398
LIG_LIR_Gen_1 97 104 PF02991 0.361
LIG_LIR_Nem_3 121 127 PF02991 0.426
LIG_LIR_Nem_3 162 167 PF02991 0.280
LIG_LIR_Nem_3 273 279 PF02991 0.322
LIG_LIR_Nem_3 337 343 PF02991 0.318
LIG_LIR_Nem_3 435 440 PF02991 0.381
LIG_LIR_Nem_3 472 478 PF02991 0.313
LIG_LIR_Nem_3 500 504 PF02991 0.427
LIG_LIR_Nem_3 52 56 PF02991 0.391
LIG_LIR_Nem_3 97 101 PF02991 0.367
LIG_Pex14_1 235 239 PF04695 0.318
LIG_Pex14_2 185 189 PF04695 0.361
LIG_Pex14_2 231 235 PF04695 0.302
LIG_Pex14_2 373 377 PF04695 0.438
LIG_Pex14_2 437 441 PF04695 0.316
LIG_PTB_Apo_2 311 318 PF02174 0.271
LIG_PTB_Apo_2 506 513 PF02174 0.494
LIG_PTB_Phospho_1 311 317 PF10480 0.263
LIG_PTB_Phospho_1 506 512 PF10480 0.494
LIG_REV1ctd_RIR_1 438 445 PF16727 0.387
LIG_SH2_CRK 420 424 PF00017 0.306
LIG_SH2_CRK 504 508 PF00017 0.619
LIG_SH2_CRK 98 102 PF00017 0.300
LIG_SH2_GRB2like 399 402 PF00017 0.302
LIG_SH2_NCK_1 420 424 PF00017 0.324
LIG_SH2_NCK_1 98 102 PF00017 0.300
LIG_SH2_PTP2 340 343 PF00017 0.344
LIG_SH2_PTP2 477 480 PF00017 0.354
LIG_SH2_SRC 340 343 PF00017 0.344
LIG_SH2_SRC 399 402 PF00017 0.302
LIG_SH2_STAP1 140 144 PF00017 0.305
LIG_SH2_STAP1 399 403 PF00017 0.391
LIG_SH2_STAP1 98 102 PF00017 0.300
LIG_SH2_STAT5 122 125 PF00017 0.322
LIG_SH2_STAT5 152 155 PF00017 0.388
LIG_SH2_STAT5 164 167 PF00017 0.350
LIG_SH2_STAT5 277 280 PF00017 0.266
LIG_SH2_STAT5 317 320 PF00017 0.500
LIG_SH2_STAT5 340 343 PF00017 0.291
LIG_SH2_STAT5 384 387 PF00017 0.265
LIG_SH2_STAT5 41 44 PF00017 0.299
LIG_SH2_STAT5 428 431 PF00017 0.432
LIG_SH2_STAT5 477 480 PF00017 0.343
LIG_SH2_STAT5 522 525 PF00017 0.675
LIG_SH2_STAT5 59 62 PF00017 0.248
LIG_SH2_STAT5 90 93 PF00017 0.279
LIG_SH3_1 443 449 PF00018 0.367
LIG_SH3_3 215 221 PF00018 0.476
LIG_SH3_3 248 254 PF00018 0.286
LIG_SH3_3 287 293 PF00018 0.368
LIG_SH3_3 301 307 PF00018 0.240
LIG_SH3_3 443 449 PF00018 0.313
LIG_Sin3_3 13 20 PF02671 0.377
LIG_SUMO_SIM_anti_2 405 411 PF11976 0.370
LIG_SUMO_SIM_par_1 405 411 PF11976 0.309
LIG_SUMO_SIM_par_1 494 500 PF11976 0.415
LIG_TRAF2_1 113 116 PF00917 0.460
LIG_TRAF2_1 201 204 PF00917 0.494
LIG_TRAF2_1 207 210 PF00917 0.491
LIG_TRAF2_1 213 216 PF00917 0.430
LIG_TYR_ITIM 338 343 PF00017 0.348
LIG_TYR_ITIM 502 507 PF00017 0.524
LIG_UBA3_1 123 131 PF00899 0.302
LIG_WRC_WIRS_1 498 503 PF05994 0.449
LIG_WRC_WIRS_1 50 55 PF05994 0.363
LIG_WW_3 1 5 PF00397 0.586
MOD_CDK_SPK_2 170 175 PF00069 0.456
MOD_CK1_1 233 239 PF00069 0.345
MOD_CK1_1 240 246 PF00069 0.307
MOD_CK1_1 284 290 PF00069 0.387
MOD_CK1_1 319 325 PF00069 0.413
MOD_CK1_1 419 425 PF00069 0.321
MOD_CK1_1 485 491 PF00069 0.426
MOD_CK1_1 52 58 PF00069 0.386
MOD_CK1_1 533 539 PF00069 0.721
MOD_CK2_1 110 116 PF00069 0.414
MOD_CK2_1 122 128 PF00069 0.294
MOD_CK2_1 204 210 PF00069 0.528
MOD_CK2_1 341 347 PF00069 0.317
MOD_CK2_1 452 458 PF00069 0.307
MOD_Cter_Amidation 413 416 PF01082 0.528
MOD_Cter_Amidation 540 543 PF01082 0.422
MOD_GlcNHglycan 104 107 PF01048 0.513
MOD_GlcNHglycan 206 209 PF01048 0.702
MOD_GlcNHglycan 212 215 PF01048 0.671
MOD_GlcNHglycan 226 230 PF01048 0.556
MOD_GlcNHglycan 25 28 PF01048 0.705
MOD_GlcNHglycan 263 266 PF01048 0.654
MOD_GlcNHglycan 294 297 PF01048 0.651
MOD_GlcNHglycan 326 329 PF01048 0.653
MOD_GlcNHglycan 395 398 PF01048 0.496
MOD_GlcNHglycan 400 404 PF01048 0.521
MOD_GlcNHglycan 429 432 PF01048 0.573
MOD_GlcNHglycan 524 530 PF01048 0.489
MOD_GlcNHglycan 532 535 PF01048 0.506
MOD_GlcNHglycan 92 95 PF01048 0.486
MOD_GSK3_1 151 158 PF00069 0.337
MOD_GSK3_1 162 169 PF00069 0.388
MOD_GSK3_1 204 211 PF00069 0.540
MOD_GSK3_1 230 237 PF00069 0.332
MOD_GSK3_1 267 274 PF00069 0.424
MOD_GSK3_1 30 37 PF00069 0.412
MOD_GSK3_1 316 323 PF00069 0.447
MOD_GSK3_1 419 426 PF00069 0.299
MOD_GSK3_1 530 537 PF00069 0.714
MOD_GSK3_1 90 97 PF00069 0.363
MOD_N-GLC_1 110 115 PF02516 0.585
MOD_N-GLC_1 116 121 PF02516 0.540
MOD_N-GLC_1 270 275 PF02516 0.604
MOD_NEK2_1 102 107 PF00069 0.275
MOD_NEK2_1 151 156 PF00069 0.343
MOD_NEK2_1 21 26 PF00069 0.634
MOD_NEK2_1 230 235 PF00069 0.307
MOD_NEK2_1 324 329 PF00069 0.367
MOD_NEK2_1 451 456 PF00069 0.290
MOD_NEK2_1 530 535 PF00069 0.727
MOD_NEK2_1 89 94 PF00069 0.296
MOD_NEK2_2 140 145 PF00069 0.332
MOD_PIKK_1 178 184 PF00454 0.506
MOD_PIKK_1 330 336 PF00454 0.352
MOD_PKA_2 162 168 PF00069 0.411
MOD_PKA_2 3 9 PF00069 0.670
MOD_PKA_2 354 360 PF00069 0.424
MOD_PKA_2 94 100 PF00069 0.373
MOD_Plk_1 140 146 PF00069 0.352
MOD_Plk_1 202 208 PF00069 0.527
MOD_Plk_1 214 220 PF00069 0.480
MOD_Plk_1 270 276 PF00069 0.401
MOD_Plk_1 319 325 PF00069 0.400
MOD_Plk_1 525 531 PF00069 0.716
MOD_Plk_4 214 220 PF00069 0.492
MOD_Plk_4 271 277 PF00069 0.366
MOD_Plk_4 36 42 PF00069 0.402
MOD_Plk_4 452 458 PF00069 0.350
MOD_Plk_4 482 488 PF00069 0.354
MOD_Plk_4 497 503 PF00069 0.318
MOD_ProDKin_1 170 176 PF00069 0.463
MOD_ProDKin_1 247 253 PF00069 0.280
MOD_ProDKin_1 303 309 PF00069 0.283
MOD_ProDKin_1 387 393 PF00069 0.453
MOD_ProDKin_1 419 425 PF00069 0.291
MOD_ProDKin_1 432 438 PF00069 0.305
MOD_ProDKin_1 534 540 PF00069 0.726
MOD_SUMO_rev_2 468 475 PF00179 0.453
TRG_DiLeu_BaLyEn_6 248 253 PF01217 0.329
TRG_DiLeu_BaLyEn_6 535 540 PF01217 0.727
TRG_ENDOCYTIC_2 276 279 PF00928 0.286
TRG_ENDOCYTIC_2 340 343 PF00928 0.300
TRG_ENDOCYTIC_2 477 480 PF00928 0.351
TRG_ENDOCYTIC_2 504 507 PF00928 0.620
TRG_ENDOCYTIC_2 98 101 PF00928 0.303
TRG_ER_diArg_1 415 417 PF00400 0.315
TRG_ER_diArg_1 518 521 PF00400 0.623
TRG_Pf-PMV_PEXEL_1 255 259 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 521 525 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7G1 Leptomonas seymouri 67% 100%
A0A0S4ISR8 Bodo saltans 42% 100%
A0A1X0P7T5 Trypanosomatidae 53% 100%
A0A3Q8IKI2 Leishmania donovani 99% 100%
A0A3R7NQT8 Trypanosoma rangeli 49% 100%
A4HP39 Leishmania braziliensis 79% 99%
D0A322 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9ASU7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 99%
Q4Q1P9 Leishmania major 93% 99%
V5BJV5 Trypanosoma cruzi 46% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS