Conserved oligomeric Golgi complex subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDE4_LEIIN

TriTrypDb:

LINF_360023700

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005801	cis-Golgi network	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0017119	Golgi transport complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4IDE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDE4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.262
CLV_C14_Caspase3-7	415	419	PF00656	0.612
CLV_C14_Caspase3-7	599	603	PF00656	0.646
CLV_C14_Caspase3-7	663	667	PF00656	0.538
CLV_C14_Caspase3-7	685	689	PF00656	0.569
CLV_C14_Caspase3-7	855	859	PF00656	0.600
CLV_C14_Caspase3-7	943	947	PF00656	0.591
CLV_NRD_NRD_1	170	172	PF00675	0.328
CLV_NRD_NRD_1	345	347	PF00675	0.436
CLV_NRD_NRD_1	706	708	PF00675	0.574
CLV_PCSK_FUR_1	704	708	PF00082	0.711
CLV_PCSK_KEX2_1	345	347	PF00082	0.436
CLV_PCSK_KEX2_1	706	708	PF00082	0.622
CLV_PCSK_SKI1_1	103	107	PF00082	0.613
CLV_PCSK_SKI1_1	125	129	PF00082	0.601
CLV_PCSK_SKI1_1	171	175	PF00082	0.421
CLV_PCSK_SKI1_1	179	183	PF00082	0.353
CLV_PCSK_SKI1_1	232	236	PF00082	0.381
CLV_PCSK_SKI1_1	274	278	PF00082	0.429
CLV_PCSK_SKI1_1	558	562	PF00082	0.382
CLV_PCSK_SKI1_1	668	672	PF00082	0.461
CLV_PCSK_SKI1_1	830	834	PF00082	0.697
CLV_Separin_Metazoa	176	180	PF03568	0.449
DEG_APCC_DBOX_1	102	110	PF00400	0.602
DEG_APCC_DBOX_1	443	451	PF00400	0.612
DEG_APCC_DBOX_1	507	515	PF00400	0.409
DEG_SPOP_SBC_1	820	824	PF00917	0.726
DOC_CYCLIN_RxL_1	703	714	PF00134	0.701
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.652
DOC_MAPK_FxFP_2	31	34	PF00069	0.651
DOC_MAPK_gen_1	100	108	PF00069	0.615
DOC_MAPK_gen_1	171	177	PF00069	0.423
DOC_MAPK_gen_1	232	241	PF00069	0.449
DOC_MAPK_gen_1	30	37	PF00069	0.614
DOC_MAPK_gen_1	715	725	PF00069	0.601
DOC_MAPK_MEF2A_6	18	27	PF00069	0.608
DOC_MAPK_MEF2A_6	235	243	PF00069	0.432
DOC_MAPK_MEF2A_6	391	398	PF00069	0.444
DOC_PP1_RVXF_1	556	562	PF00149	0.388
DOC_PP1_RVXF_1	617	624	PF00149	0.517
DOC_PP1_RVXF_1	769	776	PF00149	0.546
DOC_PP2B_LxvP_1	23	26	PF13499	0.620
DOC_PP2B_LxvP_1	35	38	PF13499	0.643
DOC_PP4_FxxP_1	31	34	PF00568	0.619
DOC_PP4_FxxP_1	609	612	PF00568	0.529
DOC_PP4_FxxP_1	867	870	PF00568	0.691
DOC_PP4_FxxP_1	905	908	PF00568	0.721
DOC_USP7_MATH_1	285	289	PF00917	0.747
DOC_USP7_MATH_1	472	476	PF00917	0.446
DOC_USP7_MATH_1	596	600	PF00917	0.679
DOC_USP7_MATH_1	69	73	PF00917	0.789
DOC_USP7_MATH_1	748	752	PF00917	0.572
DOC_USP7_MATH_1	799	803	PF00917	0.569
DOC_USP7_MATH_1	820	824	PF00917	0.805
DOC_USP7_MATH_1	853	857	PF00917	0.766
DOC_USP7_MATH_1	86	90	PF00917	0.498
DOC_USP7_MATH_1	876	880	PF00917	0.765
DOC_USP7_MATH_1	881	885	PF00917	0.771
DOC_USP7_MATH_1	940	944	PF00917	0.805
DOC_WW_Pin1_4	267	272	PF00397	0.525
DOC_WW_Pin1_4	287	292	PF00397	0.448
DOC_WW_Pin1_4	295	300	PF00397	0.680
DOC_WW_Pin1_4	433	438	PF00397	0.676
DOC_WW_Pin1_4	572	577	PF00397	0.512
DOC_WW_Pin1_4	58	63	PF00397	0.721
DOC_WW_Pin1_4	904	909	PF00397	0.797
DOC_WW_Pin1_4	925	930	PF00397	0.755
LIG_14-3-3_CanoR_1	100	109	PF00244	0.596
LIG_14-3-3_CanoR_1	125	134	PF00244	0.551
LIG_14-3-3_CanoR_1	139	145	PF00244	0.339
LIG_14-3-3_CanoR_1	210	215	PF00244	0.385
LIG_14-3-3_CanoR_1	257	261	PF00244	0.398
LIG_14-3-3_CanoR_1	294	299	PF00244	0.753
LIG_14-3-3_CanoR_1	400	406	PF00244	0.518
LIG_14-3-3_CanoR_1	413	421	PF00244	0.542
LIG_14-3-3_CanoR_1	529	533	PF00244	0.539
LIG_14-3-3_CanoR_1	562	566	PF00244	0.379
LIG_14-3-3_CanoR_1	568	572	PF00244	0.421
LIG_14-3-3_CanoR_1	830	839	PF00244	0.694
LIG_14-3-3_CanoR_1	912	916	PF00244	0.815
LIG_14-3-3_CanoR_1	941	950	PF00244	0.769
LIG_Actin_WH2_2	337	353	PF00022	0.572
LIG_Actin_WH2_2	651	667	PF00022	0.541
LIG_APCC_ABBA_1	633	638	PF00400	0.381
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	207	211	PF00533	0.449
LIG_BRCT_BRCA1_1	269	273	PF00533	0.549
LIG_BRCT_BRCA1_1	666	670	PF00533	0.529
LIG_Clathr_ClatBox_1	511	515	PF01394	0.414
LIG_deltaCOP1_diTrp_1	622	630	PF00928	0.536
LIG_EH_1	200	204	PF12763	0.449
LIG_EVH1_1	905	909	PF00568	0.771
LIG_EVH1_2	863	867	PF00568	0.579
LIG_FHA_1	149	155	PF00498	0.341
LIG_FHA_1	275	281	PF00498	0.536
LIG_FHA_1	575	581	PF00498	0.541
LIG_FHA_1	739	745	PF00498	0.565
LIG_FHA_1	908	914	PF00498	0.815
LIG_FHA_2	188	194	PF00498	0.400
LIG_FHA_2	249	255	PF00498	0.390
LIG_FHA_2	4	10	PF00498	0.734
LIG_FHA_2	40	46	PF00498	0.691
LIG_FHA_2	661	667	PF00498	0.572
LIG_FHA_2	690	696	PF00498	0.522
LIG_FHA_2	780	786	PF00498	0.558
LIG_GBD_Chelix_1	459	467	PF00786	0.414
LIG_GBD_Chelix_1	543	551	PF00786	0.524
LIG_LIR_Apic_2	606	612	PF02991	0.556
LIG_LIR_Apic_2	622	626	PF02991	0.530
LIG_LIR_Apic_2	72	77	PF02991	0.658
LIG_LIR_Apic_2	858	863	PF02991	0.653
LIG_LIR_Apic_2	866	870	PF02991	0.595
LIG_LIR_Apic_2	932	936	PF02991	0.705
LIG_LIR_Gen_1	208	219	PF02991	0.385
LIG_LIR_Gen_1	322	330	PF02991	0.510
LIG_LIR_Gen_1	339	348	PF02991	0.567
LIG_LIR_Gen_1	545	552	PF02991	0.462
LIG_LIR_Gen_1	627	637	PF02991	0.421
LIG_LIR_Gen_1	734	744	PF02991	0.566
LIG_LIR_Gen_1	888	899	PF02991	0.727
LIG_LIR_Nem_3	208	214	PF02991	0.385
LIG_LIR_Nem_3	322	326	PF02991	0.511
LIG_LIR_Nem_3	339	344	PF02991	0.447
LIG_LIR_Nem_3	404	409	PF02991	0.448
LIG_LIR_Nem_3	501	507	PF02991	0.380
LIG_LIR_Nem_3	622	628	PF02991	0.407
LIG_LIR_Nem_3	629	633	PF02991	0.384
LIG_LIR_Nem_3	734	740	PF02991	0.559
LIG_LIR_Nem_3	888	894	PF02991	0.725
LIG_LYPXL_S_1	624	628	PF13949	0.373
LIG_LYPXL_yS_3	625	628	PF13949	0.380
LIG_MYND_1	493	497	PF01753	0.537
LIG_NRBOX	19	25	PF00104	0.620
LIG_NRBOX	785	791	PF00104	0.567
LIG_PCNA_PIPBox_1	769	778	PF02747	0.551
LIG_PCNA_yPIPBox_3	783	793	PF02747	0.596
LIG_PDZ_Class_3	946	951	PF00595	0.787
LIG_Rb_LxCxE_1	722	741	PF01857	0.544
LIG_SH2_CRK	860	864	PF00017	0.578
LIG_SH2_CRK	933	937	PF00017	0.714
LIG_SH2_NCK_1	74	78	PF00017	0.656
LIG_SH2_NCK_1	915	919	PF00017	0.723
LIG_SH2_NCK_1	933	937	PF00017	0.503
LIG_SH2_SRC	408	411	PF00017	0.525
LIG_SH2_SRC	610	613	PF00017	0.402
LIG_SH2_SRC	74	77	PF00017	0.694
LIG_SH2_SRC	776	779	PF00017	0.552
LIG_SH2_STAP1	237	241	PF00017	0.328
LIG_SH2_STAT3	566	569	PF00017	0.554
LIG_SH2_STAT5	387	390	PF00017	0.497
LIG_SH2_STAT5	408	411	PF00017	0.521
LIG_SH2_STAT5	566	569	PF00017	0.505
LIG_SH2_STAT5	584	587	PF00017	0.525
LIG_SH2_STAT5	592	595	PF00017	0.586
LIG_SH2_STAT5	610	613	PF00017	0.402
LIG_SH2_STAT5	776	779	PF00017	0.564
LIG_SH3_1	900	906	PF00018	0.697
LIG_SH3_2	809	814	PF14604	0.628
LIG_SH3_3	299	305	PF00018	0.691
LIG_SH3_3	391	397	PF00018	0.418
LIG_SH3_3	56	62	PF00018	0.766
LIG_SH3_3	737	743	PF00018	0.482
LIG_SH3_3	806	812	PF00018	0.593
LIG_SH3_3	834	840	PF00018	0.820
LIG_SH3_3	896	902	PF00018	0.784
LIG_SH3_3	903	909	PF00018	0.787
LIG_SH3_5	929	933	PF00018	0.680
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.622
LIG_SUMO_SIM_anti_2	644	649	PF11976	0.496
LIG_TRAF2_1	10	13	PF00917	0.609
LIG_TRAF2_1	322	325	PF00917	0.466
LIG_UBA3_1	214	220	PF00899	0.475
MOD_CDK_SPxK_1	572	578	PF00069	0.515
MOD_CDK_SPxxK_3	267	274	PF00069	0.398
MOD_CDK_SPxxK_3	287	294	PF00069	0.550
MOD_CK1_1	142	148	PF00069	0.441
MOD_CK1_1	259	265	PF00069	0.355
MOD_CK1_1	290	296	PF00069	0.707
MOD_CK1_1	298	304	PF00069	0.646
MOD_CK1_1	337	343	PF00069	0.348
MOD_CK1_1	572	578	PF00069	0.546
MOD_CK1_1	631	637	PF00069	0.419
MOD_CK1_1	660	666	PF00069	0.560
MOD_CK1_1	714	720	PF00069	0.497
MOD_CK1_1	856	862	PF00069	0.789
MOD_CK1_1	907	913	PF00069	0.797
MOD_CK2_1	319	325	PF00069	0.557
MOD_CK2_1	355	361	PF00069	0.530
MOD_CK2_1	383	389	PF00069	0.498
MOD_CK2_1	39	45	PF00069	0.631
MOD_CK2_1	495	501	PF00069	0.491
MOD_CK2_1	689	695	PF00069	0.514
MOD_CK2_1	710	716	PF00069	0.544
MOD_CK2_1	748	754	PF00069	0.579
MOD_CK2_1	815	821	PF00069	0.601
MOD_CK2_1	828	834	PF00069	0.811
MOD_GlcNHglycan	103	106	PF01048	0.526
MOD_GlcNHglycan	144	147	PF01048	0.427
MOD_GlcNHglycan	165	168	PF01048	0.348
MOD_GlcNHglycan	207	210	PF01048	0.358
MOD_GlcNHglycan	232	235	PF01048	0.413
MOD_GlcNHglycan	248	251	PF01048	0.312
MOD_GlcNHglycan	282	286	PF01048	0.688
MOD_GlcNHglycan	336	339	PF01048	0.561
MOD_GlcNHglycan	357	360	PF01048	0.613
MOD_GlcNHglycan	447	450	PF01048	0.696
MOD_GlcNHglycan	744	747	PF01048	0.503
MOD_GlcNHglycan	830	833	PF01048	0.793
MOD_GlcNHglycan	843	846	PF01048	0.760
MOD_GlcNHglycan	855	858	PF01048	0.763
MOD_GlcNHglycan	878	881	PF01048	0.776
MOD_GlcNHglycan	88	91	PF01048	0.778
MOD_GlcNHglycan	883	886	PF01048	0.789
MOD_GlcNHglycan	916	919	PF01048	0.759
MOD_GSK3_1	155	162	PF00069	0.355
MOD_GSK3_1	205	212	PF00069	0.344
MOD_GSK3_1	226	233	PF00069	0.362
MOD_GSK3_1	244	251	PF00069	0.354
MOD_GSK3_1	255	262	PF00069	0.363
MOD_GSK3_1	281	288	PF00069	0.648
MOD_GSK3_1	290	297	PF00069	0.664
MOD_GSK3_1	300	307	PF00069	0.711
MOD_GSK3_1	433	440	PF00069	0.731
MOD_GSK3_1	538	545	PF00069	0.532
MOD_GSK3_1	586	593	PF00069	0.479
MOD_GSK3_1	624	631	PF00069	0.428
MOD_GSK3_1	660	667	PF00069	0.552
MOD_GSK3_1	710	717	PF00069	0.542
MOD_GSK3_1	726	733	PF00069	0.429
MOD_GSK3_1	738	745	PF00069	0.401
MOD_GSK3_1	815	822	PF00069	0.684
MOD_GSK3_1	86	93	PF00069	0.717
MOD_GSK3_1	881	888	PF00069	0.734
MOD_GSK3_1	907	914	PF00069	0.756
MOD_GSK3_1	941	948	PF00069	0.817
MOD_N-GLC_1	163	168	PF02516	0.328
MOD_N-GLC_1	689	694	PF02516	0.503
MOD_NEK2_1	101	106	PF00069	0.664
MOD_NEK2_1	224	229	PF00069	0.404
MOD_NEK2_1	355	360	PF00069	0.595
MOD_NEK2_1	467	472	PF00069	0.499
MOD_NEK2_1	506	511	PF00069	0.529
MOD_NEK2_1	533	538	PF00069	0.589
MOD_NEK2_1	561	566	PF00069	0.386
MOD_NEK2_1	567	572	PF00069	0.411
MOD_NEK2_1	628	633	PF00069	0.431
MOD_NEK2_1	664	669	PF00069	0.496
MOD_NEK2_1	680	685	PF00069	0.472
MOD_NEK2_1	710	715	PF00069	0.661
MOD_NEK2_1	828	833	PF00069	0.790
MOD_PIKK_1	125	131	PF00454	0.588
MOD_PIKK_1	226	232	PF00454	0.428
MOD_PIKK_1	274	280	PF00454	0.588
MOD_PIKK_1	412	418	PF00454	0.563
MOD_PIKK_1	538	544	PF00454	0.505
MOD_PIKK_1	552	558	PF00454	0.336
MOD_PIKK_1	738	744	PF00454	0.546
MOD_PIKK_1	779	785	PF00454	0.603
MOD_PIKK_1	821	827	PF00454	0.670
MOD_PIKK_1	941	947	PF00454	0.774
MOD_PKA_2	140	146	PF00069	0.492
MOD_PKA_2	148	154	PF00069	0.343
MOD_PKA_2	209	215	PF00069	0.385
MOD_PKA_2	256	262	PF00069	0.398
MOD_PKA_2	293	299	PF00069	0.761
MOD_PKA_2	412	418	PF00069	0.553
MOD_PKA_2	528	534	PF00069	0.523
MOD_PKA_2	561	567	PF00069	0.383
MOD_PKA_2	664	670	PF00069	0.500
MOD_PKA_2	714	720	PF00069	0.507
MOD_PKA_2	911	917	PF00069	0.816
MOD_PKA_2	940	946	PF00069	0.726
MOD_PKB_1	939	947	PF00069	0.711
MOD_Plk_1	11	17	PF00069	0.588
MOD_Plk_1	163	169	PF00069	0.344
MOD_Plk_1	281	287	PF00069	0.651
MOD_Plk_1	628	634	PF00069	0.420
MOD_Plk_1	689	695	PF00069	0.530
MOD_Plk_1	799	805	PF00069	0.603
MOD_Plk_4	12	18	PF00069	0.619
MOD_Plk_4	210	216	PF00069	0.340
MOD_Plk_4	401	407	PF00069	0.521
MOD_Plk_4	528	534	PF00069	0.601
MOD_Plk_4	561	567	PF00069	0.383
MOD_Plk_4	579	585	PF00069	0.501
MOD_ProDKin_1	267	273	PF00069	0.522
MOD_ProDKin_1	287	293	PF00069	0.450
MOD_ProDKin_1	295	301	PF00069	0.680
MOD_ProDKin_1	433	439	PF00069	0.675
MOD_ProDKin_1	572	578	PF00069	0.515
MOD_ProDKin_1	58	64	PF00069	0.727
MOD_ProDKin_1	904	910	PF00069	0.799
MOD_ProDKin_1	925	931	PF00069	0.757
MOD_SUMO_for_1	173	176	PF00179	0.413
MOD_SUMO_rev_2	415	422	PF00179	0.637
MOD_SUMO_rev_2	660	670	PF00179	0.535
TRG_DiLeu_BaEn_1	12	17	PF01217	0.656
TRG_DiLeu_BaEn_1	754	759	PF01217	0.594
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.388
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.444
TRG_ENDOCYTIC_2	134	137	PF00928	0.449
TRG_ENDOCYTIC_2	504	507	PF00928	0.366
TRG_ENDOCYTIC_2	625	628	PF00928	0.358
TRG_ER_diArg_1	344	346	PF00400	0.430
TRG_ER_diArg_1	507	510	PF00400	0.445
TRG_ER_diArg_1	703	706	PF00400	0.572
TRG_ER_diArg_1	939	942	PF00400	0.637
TRG_NES_CRM1_1	325	339	PF08389	0.454
TRG_NLS_MonoExtC_3	170	176	PF00514	0.328
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	706	711	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I905	Leptomonas seymouri	67%	99%
A0A0S4J053	Bodo saltans	30%	100%
A0A1X0P8U2	Trypanosomatidae	35%	100%
A0A3R7KGY7	Trypanosoma rangeli	34%	100%
A0A3S7XAQ6	Leishmania donovani	100%	100%
A4HP37	Leishmania braziliensis	79%	100%
D0A320	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1Q1	Leishmania major	94%	100%
V5DKX4	Trypanosoma cruzi	35%	100%