Queuosine salvage protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2419) - putative

Species:

Leishmania infantum

UniProt:

A4IDD8_LEIIN

TriTrypDb:

LINF_360023100

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDD8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0101030	tRNA-guanine transglycosylation	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.483
CLV_NRD_NRD_1	99	101	PF00675	0.439
CLV_PCSK_KEX2_1	406	408	PF00082	0.415
CLV_PCSK_KEX2_1	99	101	PF00082	0.434
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.415
CLV_PCSK_SKI1_1	346	350	PF00082	0.492
CLV_PCSK_SKI1_1	361	365	PF00082	0.438
CLV_PCSK_SKI1_1	423	427	PF00082	0.503
DOC_ANK_TNKS_1	211	218	PF00023	0.597
DOC_CKS1_1	375	380	PF01111	0.492
DOC_CYCLIN_RxL_1	367	377	PF00134	0.492
DOC_MAPK_gen_1	150	159	PF00069	0.446
DOC_MAPK_gen_1	326	335	PF00069	0.433
DOC_MAPK_gen_1	406	414	PF00069	0.492
DOC_MAPK_MEF2A_6	150	159	PF00069	0.415
DOC_MAPK_NFAT4_5	152	160	PF00069	0.432
DOC_PP1_RVXF_1	128	134	PF00149	0.466
DOC_PP1_RVXF_1	368	375	PF00149	0.393
DOC_PP2B_LxvP_1	144	147	PF13499	0.527
DOC_PP2B_LxvP_1	181	184	PF13499	0.487
DOC_PP2B_LxvP_1	349	352	PF13499	0.438
DOC_PP4_FxxP_1	63	66	PF00568	0.647
DOC_USP7_MATH_1	124	128	PF00917	0.546
DOC_USP7_MATH_1	21	25	PF00917	0.458
DOC_USP7_MATH_1	260	264	PF00917	0.571
DOC_USP7_MATH_1	278	282	PF00917	0.517
DOC_USP7_MATH_1	302	306	PF00917	0.661
DOC_WW_Pin1_4	139	144	PF00397	0.456
DOC_WW_Pin1_4	226	231	PF00397	0.482
DOC_WW_Pin1_4	265	270	PF00397	0.609
DOC_WW_Pin1_4	374	379	PF00397	0.475
LIG_14-3-3_CanoR_1	166	171	PF00244	0.506
LIG_14-3-3_CanoR_1	298	302	PF00244	0.546
LIG_14-3-3_CanoR_1	361	366	PF00244	0.438
LIG_14-3-3_CanoR_1	381	386	PF00244	0.418
LIG_14-3-3_CanoR_1	407	412	PF00244	0.390
LIG_APCC_ABBA_1	333	338	PF00400	0.492
LIG_APCC_ABBA_1	60	65	PF00400	0.500
LIG_BRCT_BRCA1_1	306	310	PF00533	0.486
LIG_CSL_BTD_1	144	147	PF09270	0.445
LIG_DLG_GKlike_1	166	173	PF00625	0.522
LIG_FHA_1	124	130	PF00498	0.430
LIG_FHA_1	51	57	PF00498	0.659
LIG_FHA_2	226	232	PF00498	0.565
LIG_FHA_2	298	304	PF00498	0.544
LIG_FHA_2	390	396	PF00498	0.429
LIG_Integrin_RGD_1	119	121	PF01839	0.598
LIG_LIR_Apic_2	321	325	PF02991	0.357
LIG_LIR_Apic_2	61	66	PF02991	0.659
LIG_LIR_Gen_1	209	218	PF02991	0.624
LIG_LIR_Nem_3	168	174	PF02991	0.414
LIG_LIR_Nem_3	209	213	PF02991	0.579
LIG_LIR_Nem_3	30	35	PF02991	0.496
LIG_PAM2_1	273	285	PF00658	0.699
LIG_Pex14_2	110	114	PF04695	0.516
LIG_PTAP_UEV_1	274	279	PF05743	0.757
LIG_RPA_C_Fungi	161	173	PF08784	0.518
LIG_SH2_CRK	171	175	PF00017	0.470
LIG_SH2_CRK	322	326	PF00017	0.357
LIG_SH2_CRK	424	428	PF00017	0.438
LIG_SH2_NCK_1	36	40	PF00017	0.499
LIG_SH2_SRC	322	325	PF00017	0.391
LIG_SH2_SRC	336	339	PF00017	0.391
LIG_SH2_STAP1	207	211	PF00017	0.485
LIG_SH2_STAP1	336	340	PF00017	0.438
LIG_SH2_STAP1	416	420	PF00017	0.438
LIG_SH2_STAT5	420	423	PF00017	0.401
LIG_SH2_STAT5	96	99	PF00017	0.464
LIG_SH3_1	272	278	PF00018	0.651
LIG_SH3_3	212	218	PF00018	0.595
LIG_SH3_3	272	278	PF00018	0.742
LIG_SH3_3	36	42	PF00018	0.502
LIG_SH3_3	394	400	PF00018	0.477
LIG_SUMO_SIM_anti_2	151	158	PF11976	0.491
LIG_SUMO_SIM_par_1	1	6	PF11976	0.480
LIG_SUMO_SIM_par_1	154	161	PF11976	0.439
LIG_SUMO_SIM_par_1	58	65	PF11976	0.495
LIG_TRAF2_1	354	357	PF00917	0.438
MOD_CDK_SPxxK_3	265	272	PF00069	0.546
MOD_CDK_SPxxK_3	374	381	PF00069	0.454
MOD_CK1_1	241	247	PF00069	0.478
MOD_CK1_1	262	268	PF00069	0.648
MOD_CK1_1	281	287	PF00069	0.454
MOD_CK1_1	297	303	PF00069	0.769
MOD_CK1_1	304	310	PF00069	0.385
MOD_CK1_1	43	49	PF00069	0.634
MOD_CK2_1	21	27	PF00069	0.539
MOD_CK2_1	290	296	PF00069	0.580
MOD_CK2_1	297	303	PF00069	0.605
MOD_CK2_1	351	357	PF00069	0.492
MOD_CK2_1	389	395	PF00069	0.429
MOD_GlcNHglycan	126	129	PF01048	0.547
MOD_GlcNHglycan	262	265	PF01048	0.569
MOD_GlcNHglycan	275	278	PF01048	0.696
MOD_GlcNHglycan	292	295	PF01048	0.557
MOD_GlcNHglycan	306	309	PF01048	0.410
MOD_GlcNHglycan	312	315	PF01048	0.382
MOD_GlcNHglycan	353	356	PF01048	0.415
MOD_GlcNHglycan	45	48	PF01048	0.639
MOD_GlcNHglycan	67	70	PF01048	0.737
MOD_GlcNHglycan	90	93	PF01048	0.505
MOD_GSK3_1	119	126	PF00069	0.490
MOD_GSK3_1	17	24	PF00069	0.528
MOD_GSK3_1	222	229	PF00069	0.664
MOD_GSK3_1	259	266	PF00069	0.556
MOD_GSK3_1	290	297	PF00069	0.685
MOD_GSK3_1	310	317	PF00069	0.203
MOD_GSK3_1	61	68	PF00069	0.683
MOD_NEK2_1	155	160	PF00069	0.430
MOD_NEK2_1	238	243	PF00069	0.465
MOD_NEK2_1	310	315	PF00069	0.395
MOD_NEK2_1	434	439	PF00069	0.350
MOD_NEK2_1	88	93	PF00069	0.457
MOD_PIKK_1	238	244	PF00454	0.473
MOD_PK_1	407	413	PF00069	0.317
MOD_PKA_2	165	171	PF00069	0.510
MOD_PKA_2	297	303	PF00069	0.544
MOD_PKA_2	380	386	PF00069	0.371
MOD_PKA_2	88	94	PF00069	0.419
MOD_PKB_1	117	125	PF00069	0.488
MOD_Plk_1	302	308	PF00069	0.685
MOD_Plk_1	356	362	PF00069	0.393
MOD_Plk_4	166	172	PF00069	0.432
MOD_Plk_4	196	202	PF00069	0.473
MOD_Plk_4	278	284	PF00069	0.656
MOD_Plk_4	361	367	PF00069	0.430
MOD_Plk_4	407	413	PF00069	0.317
MOD_Plk_4	83	89	PF00069	0.548
MOD_ProDKin_1	139	145	PF00069	0.457
MOD_ProDKin_1	226	232	PF00069	0.468
MOD_ProDKin_1	265	271	PF00069	0.613
MOD_ProDKin_1	374	380	PF00069	0.475
TRG_DiLeu_BaEn_1	151	156	PF01217	0.492
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.438
TRG_ENDOCYTIC_2	170	173	PF00928	0.485
TRG_ENDOCYTIC_2	207	210	PF00928	0.433
TRG_ENDOCYTIC_2	36	39	PF00928	0.409
TRG_ER_diArg_1	98	100	PF00400	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P722	Leptomonas seymouri	52%	83%
A0A1X0P849	Trypanosomatidae	34%	100%
A0A3Q8INL6	Leishmania donovani	99%	81%
A4HP31	Leishmania braziliensis	76%	100%
D0A314	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	88%
E9AST9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1Q7	Leishmania major	92%	100%