LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDC6_LEIIN
TriTrypDb:
LINF_360021900
Length:
476

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDC6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 116 118 PF00675 0.472
CLV_NRD_NRD_1 196 198 PF00675 0.665
CLV_NRD_NRD_1 205 207 PF00675 0.539
CLV_NRD_NRD_1 229 231 PF00675 0.621
CLV_NRD_NRD_1 256 258 PF00675 0.720
CLV_NRD_NRD_1 339 341 PF00675 0.791
CLV_NRD_NRD_1 457 459 PF00675 0.474
CLV_NRD_NRD_1 80 82 PF00675 0.553
CLV_NRD_NRD_1 92 94 PF00675 0.504
CLV_PCSK_KEX2_1 116 118 PF00082 0.497
CLV_PCSK_KEX2_1 195 197 PF00082 0.661
CLV_PCSK_KEX2_1 205 207 PF00082 0.538
CLV_PCSK_KEX2_1 229 231 PF00082 0.662
CLV_PCSK_KEX2_1 339 341 PF00082 0.791
CLV_PCSK_KEX2_1 457 459 PF00082 0.476
CLV_PCSK_KEX2_1 82 84 PF00082 0.547
CLV_PCSK_KEX2_1 92 94 PF00082 0.527
CLV_PCSK_PC1ET2_1 82 84 PF00082 0.547
CLV_PCSK_SKI1_1 155 159 PF00082 0.435
CLV_PCSK_SKI1_1 249 253 PF00082 0.623
CLV_PCSK_SKI1_1 389 393 PF00082 0.616
CLV_PCSK_SKI1_1 411 415 PF00082 0.530
CLV_PCSK_SKI1_1 457 461 PF00082 0.458
CLV_PCSK_SKI1_1 466 470 PF00082 0.377
CLV_Separin_Metazoa 386 390 PF03568 0.481
CLV_Separin_Metazoa 89 93 PF03568 0.533
DEG_APCC_DBOX_1 115 123 PF00400 0.414
DEG_APCC_DBOX_1 364 372 PF00400 0.487
DOC_CYCLIN_RxL_1 454 464 PF00134 0.500
DOC_MAPK_gen_1 133 141 PF00069 0.490
DOC_MAPK_gen_1 406 412 PF00069 0.404
DOC_MAPK_gen_1 454 462 PF00069 0.550
DOC_MAPK_gen_1 81 90 PF00069 0.567
DOC_MAPK_MEF2A_6 155 162 PF00069 0.546
DOC_MAPK_MEF2A_6 17 24 PF00069 0.635
DOC_MAPK_MEF2A_6 174 183 PF00069 0.504
DOC_USP7_MATH_1 228 232 PF00917 0.668
DOC_USP7_MATH_1 290 294 PF00917 0.722
DOC_USP7_MATH_1 3 7 PF00917 0.743
DOC_USP7_MATH_1 314 318 PF00917 0.600
DOC_USP7_MATH_1 327 331 PF00917 0.706
DOC_USP7_MATH_1 347 351 PF00917 0.656
DOC_USP7_MATH_1 36 40 PF00917 0.466
DOC_USP7_MATH_1 428 432 PF00917 0.564
DOC_USP7_UBL2_3 407 411 PF12436 0.540
DOC_WW_Pin1_4 257 262 PF00397 0.606
DOC_WW_Pin1_4 333 338 PF00397 0.689
DOC_WW_Pin1_4 442 447 PF00397 0.696
LIG_14-3-3_CanoR_1 229 233 PF00244 0.731
LIG_14-3-3_CanoR_1 235 240 PF00244 0.628
LIG_14-3-3_CanoR_1 353 360 PF00244 0.472
LIG_14-3-3_CanoR_1 381 388 PF00244 0.594
LIG_BIR_II_1 1 5 PF00653 0.588
LIG_CaM_IQ_9 34 50 PF13499 0.397
LIG_Clathr_ClatBox_1 159 163 PF01394 0.542
LIG_EH1_1 396 404 PF00400 0.504
LIG_FHA_1 234 240 PF00498 0.516
LIG_FHA_1 25 31 PF00498 0.516
LIG_FHA_1 352 358 PF00498 0.501
LIG_FHA_2 186 192 PF00498 0.482
LIG_FHA_2 21 27 PF00498 0.629
LIG_FHA_2 353 359 PF00498 0.475
LIG_GBD_Chelix_1 461 469 PF00786 0.455
LIG_LIR_Apic_2 238 244 PF02991 0.600
LIG_LIR_Gen_1 188 198 PF02991 0.556
LIG_LIR_Nem_3 188 193 PF02991 0.516
LIG_MAD2 280 288 PF02301 0.619
LIG_NRBOX 464 470 PF00104 0.456
LIG_NRBOX 86 92 PF00104 0.483
LIG_SH2_CRK 241 245 PF00017 0.567
LIG_SH2_NCK_1 267 271 PF00017 0.593
LIG_SH2_SRC 241 244 PF00017 0.587
LIG_SH2_SRC 267 270 PF00017 0.669
LIG_SH2_STAP1 375 379 PF00017 0.559
LIG_SH2_STAP1 55 59 PF00017 0.426
LIG_SH3_3 343 349 PF00018 0.699
LIG_SH3_CIN85_PxpxPR_1 200 205 PF14604 0.539
LIG_SUMO_SIM_anti_2 86 92 PF11976 0.536
LIG_SUMO_SIM_par_1 158 163 PF11976 0.560
LIG_TRAF2_1 301 304 PF00917 0.618
LIG_TRAF2_1 383 386 PF00917 0.523
LIG_TRAF2_1 94 97 PF00917 0.465
LIG_WW_3 242 246 PF00397 0.589
MOD_CDC14_SPxK_1 336 339 PF00782 0.781
MOD_CDK_SPxK_1 333 339 PF00069 0.762
MOD_CDK_SPxxK_3 333 340 PF00069 0.746
MOD_CK1_1 10 16 PF00069 0.570
MOD_CK1_1 18 24 PF00069 0.557
MOD_CK1_1 210 216 PF00069 0.663
MOD_CK1_1 233 239 PF00069 0.662
MOD_CK1_1 293 299 PF00069 0.733
MOD_CK1_1 429 435 PF00069 0.597
MOD_CK1_1 445 451 PF00069 0.586
MOD_CK2_1 122 128 PF00069 0.506
MOD_CK2_1 185 191 PF00069 0.552
MOD_CK2_1 298 304 PF00069 0.617
MOD_CK2_1 3 9 PF00069 0.705
MOD_CK2_1 380 386 PF00069 0.671
MOD_GlcNHglycan 1 4 PF01048 0.685
MOD_GlcNHglycan 105 108 PF01048 0.458
MOD_GlcNHglycan 17 20 PF01048 0.490
MOD_GlcNHglycan 209 212 PF01048 0.660
MOD_GlcNHglycan 232 235 PF01048 0.610
MOD_GlcNHglycan 249 252 PF01048 0.536
MOD_GlcNHglycan 292 295 PF01048 0.797
MOD_GlcNHglycan 316 319 PF01048 0.697
MOD_GlcNHglycan 331 334 PF01048 0.780
MOD_GlcNHglycan 348 352 PF01048 0.646
MOD_GlcNHglycan 399 402 PF01048 0.528
MOD_GlcNHglycan 426 429 PF01048 0.674
MOD_GlcNHglycan 9 12 PF01048 0.613
MOD_GSK3_1 11 18 PF00069 0.512
MOD_GSK3_1 128 135 PF00069 0.491
MOD_GSK3_1 20 27 PF00069 0.614
MOD_GSK3_1 206 213 PF00069 0.683
MOD_GSK3_1 290 297 PF00069 0.692
MOD_GSK3_1 3 10 PF00069 0.609
MOD_GSK3_1 323 330 PF00069 0.757
MOD_GSK3_1 347 354 PF00069 0.568
MOD_GSK3_1 36 43 PF00069 0.516
MOD_GSK3_1 422 429 PF00069 0.502
MOD_N-GLC_1 294 299 PF02516 0.703
MOD_N-GLC_1 434 439 PF02516 0.747
MOD_NEK2_1 1 6 PF00069 0.711
MOD_NEK2_1 101 106 PF00069 0.436
MOD_NEK2_1 15 20 PF00069 0.560
MOD_NEK2_1 247 252 PF00069 0.518
MOD_NEK2_1 298 303 PF00069 0.735
MOD_NEK2_1 426 431 PF00069 0.690
MOD_NEK2_1 7 12 PF00069 0.611
MOD_NEK2_2 294 299 PF00069 0.612
MOD_PIKK_1 1 7 PF00454 0.560
MOD_PIKK_1 128 134 PF00454 0.558
MOD_PIKK_1 298 304 PF00454 0.782
MOD_PKA_2 132 138 PF00069 0.553
MOD_PKA_2 228 234 PF00069 0.702
MOD_PKA_2 352 358 PF00069 0.485
MOD_PKA_2 380 386 PF00069 0.597
MOD_PKA_2 397 403 PF00069 0.473
MOD_PKA_2 429 435 PF00069 0.605
MOD_Plk_1 101 107 PF00069 0.495
MOD_Plk_1 294 300 PF00069 0.658
MOD_Plk_1 375 381 PF00069 0.569
MOD_Plk_1 434 440 PF00069 0.748
MOD_Plk_4 26 32 PF00069 0.438
MOD_Plk_4 271 277 PF00069 0.662
MOD_ProDKin_1 257 263 PF00069 0.605
MOD_ProDKin_1 333 339 PF00069 0.725
MOD_ProDKin_1 442 448 PF00069 0.692
MOD_SUMO_for_1 148 151 PF00179 0.550
MOD_SUMO_for_1 165 168 PF00179 0.496
MOD_SUMO_rev_2 128 137 PF00179 0.544
MOD_SUMO_rev_2 21 30 PF00179 0.498
TRG_DiLeu_BaEn_1 408 413 PF01217 0.402
TRG_DiLeu_BaEn_1 464 469 PF01217 0.458
TRG_DiLeu_BaEn_4 96 102 PF01217 0.548
TRG_ENDOCYTIC_2 190 193 PF00928 0.523
TRG_ER_diArg_1 115 117 PF00400 0.621
TRG_ER_diArg_1 195 197 PF00400 0.685
TRG_ER_diArg_1 204 206 PF00400 0.529
TRG_ER_diArg_1 228 230 PF00400 0.675
TRG_ER_diArg_1 339 341 PF00400 0.677
TRG_ER_diArg_1 91 93 PF00400 0.505
TRG_Pf-PMV_PEXEL_1 117 121 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 411 415 PF00026 0.460
TRG_Pf-PMV_PEXEL_1 42 46 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 466 471 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7F5 Leptomonas seymouri 58% 98%
A0A0S4ISW4 Bodo saltans 34% 100%
A0A1X0P856 Trypanosomatidae 40% 100%
A0A3Q8INJ9 Leishmania donovani 99% 100%
A0A3R7RIJ2 Trypanosoma rangeli 37% 100%
A4HP16 Leishmania braziliensis 78% 100%
E9ASS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q1R9 Leishmania major 93% 100%
V5BU44 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS