LeishMANIAdb
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Leucine_Rich_repeat

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine_Rich_repeat
Gene product:
Leucine rich repeat/Leucine Rich Repeat - putative
Species:
Leishmania infantum
UniProt:
A4IDC5_LEIIN
TriTrypDb:
LINF_360021800
Length:
503

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 8
GO:0120025 plasma membrane bounded cell projection 3 7
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1

Expansion

Sequence features

A4IDC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.497
CLV_C14_Caspase3-7 177 181 PF00656 0.475
CLV_C14_Caspase3-7 352 356 PF00656 0.566
CLV_C14_Caspase3-7 90 94 PF00656 0.580
CLV_NRD_NRD_1 385 387 PF00675 0.629
CLV_NRD_NRD_1 432 434 PF00675 0.749
CLV_PCSK_KEX2_1 385 387 PF00082 0.652
CLV_PCSK_KEX2_1 432 434 PF00082 0.749
CLV_PCSK_SKI1_1 263 267 PF00082 0.473
CLV_PCSK_SKI1_1 269 273 PF00082 0.336
CLV_PCSK_SKI1_1 390 394 PF00082 0.684
CLV_PCSK_SKI1_1 445 449 PF00082 0.694
CLV_PCSK_SKI1_1 482 486 PF00082 0.606
CLV_PCSK_SKI1_1 498 502 PF00082 0.517
DEG_SPOP_SBC_1 358 362 PF00917 0.655
DOC_CDC14_PxL_1 143 151 PF14671 0.338
DOC_CDC14_PxL_1 237 245 PF14671 0.444
DOC_CDC14_PxL_1 461 469 PF14671 0.528
DOC_CDC14_PxL_1 67 75 PF14671 0.451
DOC_CKS1_1 22 27 PF01111 0.560
DOC_CKS1_1 405 410 PF01111 0.560
DOC_CYCLIN_RxL_1 195 203 PF00134 0.383
DOC_MAPK_gen_1 107 117 PF00069 0.436
DOC_MAPK_gen_1 263 273 PF00069 0.473
DOC_MAPK_gen_1 432 439 PF00069 0.700
DOC_MAPK_MEF2A_6 110 119 PF00069 0.431
DOC_MAPK_MEF2A_6 238 245 PF00069 0.445
DOC_MAPK_MEF2A_6 432 441 PF00069 0.664
DOC_PP1_RVXF_1 267 274 PF00149 0.456
DOC_PP2B_LxvP_1 448 451 PF13499 0.605
DOC_USP7_MATH_1 26 30 PF00917 0.657
DOC_USP7_MATH_1 358 362 PF00917 0.776
DOC_WW_Pin1_4 21 26 PF00397 0.605
DOC_WW_Pin1_4 398 403 PF00397 0.608
DOC_WW_Pin1_4 404 409 PF00397 0.676
LIG_14-3-3_CanoR_1 110 119 PF00244 0.495
LIG_14-3-3_CanoR_1 174 179 PF00244 0.413
LIG_14-3-3_CanoR_1 231 240 PF00244 0.563
LIG_14-3-3_CanoR_1 269 274 PF00244 0.451
LIG_14-3-3_CanoR_1 336 344 PF00244 0.555
LIG_14-3-3_CanoR_1 404 408 PF00244 0.643
LIG_Actin_WH2_2 28 43 PF00022 0.509
LIG_BIR_III_4 380 384 PF00653 0.597
LIG_BRCT_BRCA1_1 112 116 PF00533 0.437
LIG_BRCT_BRCA1_1 208 212 PF00533 0.458
LIG_BRCT_BRCA1_1 327 331 PF00533 0.539
LIG_FHA_1 110 116 PF00498 0.437
LIG_FHA_1 183 189 PF00498 0.450
LIG_FHA_1 192 198 PF00498 0.342
LIG_FHA_1 339 345 PF00498 0.678
LIG_FHA_1 387 393 PF00498 0.683
LIG_FHA_1 458 464 PF00498 0.581
LIG_FHA_2 136 142 PF00498 0.472
LIG_FHA_2 242 248 PF00498 0.380
LIG_FHA_2 302 308 PF00498 0.780
LIG_FHA_2 34 40 PF00498 0.482
LIG_FHA_2 350 356 PF00498 0.585
LIG_FHA_2 473 479 PF00498 0.633
LIG_FHA_2 490 496 PF00498 0.533
LIG_FHA_2 88 94 PF00498 0.565
LIG_IBAR_NPY_1 50 52 PF08397 0.548
LIG_Integrin_isoDGR_2 471 473 PF01839 0.587
LIG_Integrin_RGD_1 16 18 PF01839 0.648
LIG_LIR_Gen_1 113 124 PF02991 0.395
LIG_LIR_Gen_1 410 418 PF02991 0.658
LIG_LIR_Nem_3 113 119 PF02991 0.374
LIG_LIR_Nem_3 410 416 PF02991 0.688
LIG_LIR_Nem_3 46 52 PF02991 0.479
LIG_Pex14_2 148 152 PF04695 0.416
LIG_SH2_NCK_1 214 218 PF00017 0.395
LIG_SH2_PTP2 413 416 PF00017 0.628
LIG_SH2_PTP2 76 79 PF00017 0.432
LIG_SH2_STAP1 306 310 PF00017 0.682
LIG_SH2_STAT3 97 100 PF00017 0.528
LIG_SH2_STAT5 413 416 PF00017 0.628
LIG_SH2_STAT5 457 460 PF00017 0.536
LIG_SH2_STAT5 57 60 PF00017 0.501
LIG_SH2_STAT5 76 79 PF00017 0.432
LIG_SH3_3 17 23 PF00018 0.640
LIG_SH3_3 402 408 PF00018 0.563
LIG_SUMO_SIM_anti_2 460 465 PF11976 0.525
LIG_SUMO_SIM_par_1 198 203 PF11976 0.377
LIG_TRAF2_1 36 39 PF00917 0.496
LIG_TRAF2_1 451 454 PF00917 0.587
LIG_TRAF2_1 492 495 PF00917 0.730
LIG_TYR_ITIM 411 416 PF00017 0.489
MOD_CDC14_SPxK_1 401 404 PF00782 0.569
MOD_CDK_SPxK_1 398 404 PF00069 0.567
MOD_CK1_1 366 372 PF00069 0.696
MOD_CK1_1 397 403 PF00069 0.616
MOD_CK1_1 42 48 PF00069 0.412
MOD_CK1_1 427 433 PF00069 0.522
MOD_CK2_1 310 316 PF00069 0.670
MOD_CK2_1 33 39 PF00069 0.489
MOD_CK2_1 414 420 PF00069 0.453
MOD_CK2_1 472 478 PF00069 0.660
MOD_CK2_1 489 495 PF00069 0.575
MOD_DYRK1A_RPxSP_1 404 408 PF00069 0.643
MOD_GlcNHglycan 233 236 PF01048 0.562
MOD_GlcNHglycan 252 256 PF01048 0.334
MOD_GlcNHglycan 28 31 PF01048 0.667
MOD_GlcNHglycan 327 330 PF01048 0.636
MOD_GlcNHglycan 345 348 PF01048 0.720
MOD_GlcNHglycan 366 369 PF01048 0.721
MOD_GlcNHglycan 415 419 PF01048 0.448
MOD_GlcNHglycan 429 432 PF01048 0.615
MOD_GlcNHglycan 9 12 PF01048 0.526
MOD_GSK3_1 297 304 PF00069 0.646
MOD_GSK3_1 334 341 PF00069 0.741
MOD_GSK3_1 359 366 PF00069 0.670
MOD_GSK3_1 386 393 PF00069 0.747
MOD_GSK3_1 394 401 PF00069 0.658
MOD_GSK3_1 403 410 PF00069 0.548
MOD_GSK3_1 414 421 PF00069 0.478
MOD_GSK3_1 57 64 PF00069 0.464
MOD_LATS_1 108 114 PF00433 0.444
MOD_LATS_1 229 235 PF00433 0.421
MOD_N-GLC_2 6 8 PF02516 0.693
MOD_NEK2_1 150 155 PF00069 0.464
MOD_NEK2_1 191 196 PF00069 0.400
MOD_NEK2_1 200 205 PF00069 0.298
MOD_NEK2_1 212 217 PF00069 0.334
MOD_NEK2_1 297 302 PF00069 0.594
MOD_NEK2_1 364 369 PF00069 0.640
MOD_NEK2_1 40 45 PF00069 0.568
MOD_NEK2_1 424 429 PF00069 0.545
MOD_NEK2_1 55 60 PF00069 0.501
MOD_PKA_2 109 115 PF00069 0.559
MOD_PKA_2 335 341 PF00069 0.634
MOD_PKA_2 403 409 PF00069 0.643
MOD_PKA_2 472 478 PF00069 0.585
MOD_PKB_1 172 180 PF00069 0.377
MOD_Plk_1 33 39 PF00069 0.547
MOD_Plk_4 241 247 PF00069 0.447
MOD_Plk_4 459 465 PF00069 0.525
MOD_ProDKin_1 21 27 PF00069 0.601
MOD_ProDKin_1 398 404 PF00069 0.611
MOD_SUMO_rev_2 34 43 PF00179 0.475
TRG_DiLeu_BaEn_2 143 149 PF01217 0.430
TRG_DiLeu_BaEn_2 419 425 PF01217 0.622
TRG_ENDOCYTIC_2 413 416 PF00928 0.683
TRG_ENDOCYTIC_2 52 55 PF00928 0.553
TRG_ENDOCYTIC_2 76 79 PF00928 0.377
TRG_ER_diArg_1 156 159 PF00400 0.490
TRG_NES_CRM1_1 239 252 PF08389 0.443

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P712 Leptomonas seymouri 47% 100%
A0A1X0P7V7 Trypanosomatidae 28% 100%
A0A3Q8IIX2 Leishmania donovani 99% 100%
E9AIX7 Leishmania braziliensis 67% 100%
E9ASS6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q1S0 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS