LeishMANIAdb
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B box-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
B box-type domain-containing protein
Gene product:
predicted tripartite motif protein
Species:
Leishmania infantum
UniProt:
A4IDC4_LEIIN
TriTrypDb:
LINF_360021700
Length:
848

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC4

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0008270 zinc ion binding 6 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0046914 transition metal ion binding 5 7
GO:0003824 catalytic activity 1 1
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0061630 ubiquitin protein ligase activity 5 1
GO:0061659 ubiquitin-like protein ligase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 679 683 PF00656 0.636
CLV_C14_Caspase3-7 783 787 PF00656 0.724
CLV_C14_Caspase3-7 821 825 PF00656 0.641
CLV_NRD_NRD_1 273 275 PF00675 0.583
CLV_NRD_NRD_1 397 399 PF00675 0.533
CLV_NRD_NRD_1 421 423 PF00675 0.571
CLV_NRD_NRD_1 812 814 PF00675 0.799
CLV_NRD_NRD_1 839 841 PF00675 0.734
CLV_PCSK_FUR_1 419 423 PF00082 0.571
CLV_PCSK_KEX2_1 272 274 PF00082 0.581
CLV_PCSK_KEX2_1 3 5 PF00082 0.685
CLV_PCSK_KEX2_1 397 399 PF00082 0.533
CLV_PCSK_KEX2_1 421 423 PF00082 0.571
CLV_PCSK_KEX2_1 498 500 PF00082 0.648
CLV_PCSK_KEX2_1 839 841 PF00082 0.731
CLV_PCSK_PC1ET2_1 3 5 PF00082 0.685
CLV_PCSK_PC1ET2_1 498 500 PF00082 0.640
CLV_PCSK_SKI1_1 374 378 PF00082 0.529
CLV_PCSK_SKI1_1 40 44 PF00082 0.712
CLV_PCSK_SKI1_1 498 502 PF00082 0.638
CLV_PCSK_SKI1_1 596 600 PF00082 0.614
CLV_PCSK_SKI1_1 703 707 PF00082 0.644
CLV_PCSK_SKI1_1 743 747 PF00082 0.572
CLV_PCSK_SKI1_1 774 778 PF00082 0.664
DOC_CKS1_1 597 602 PF01111 0.749
DOC_CYCLIN_RxL_1 771 782 PF00134 0.805
DOC_CYCLIN_RxL_1 803 816 PF00134 0.584
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.521
DOC_MAPK_gen_1 3 11 PF00069 0.700
DOC_MAPK_gen_1 734 742 PF00069 0.775
DOC_MAPK_gen_1 839 846 PF00069 0.730
DOC_MAPK_MEF2A_6 839 848 PF00069 0.725
DOC_MAPK_RevD_3 383 398 PF00069 0.562
DOC_PP2B_LxvP_1 62 65 PF13499 0.714
DOC_PP2B_LxvP_1 827 830 PF13499 0.699
DOC_PP4_FxxP_1 70 73 PF00568 0.483
DOC_USP7_MATH_1 188 192 PF00917 0.495
DOC_USP7_MATH_1 219 223 PF00917 0.698
DOC_USP7_MATH_1 22 26 PF00917 0.709
DOC_USP7_MATH_1 225 229 PF00917 0.497
DOC_USP7_MATH_1 598 602 PF00917 0.735
DOC_USP7_MATH_1 606 610 PF00917 0.678
DOC_USP7_MATH_1 73 77 PF00917 0.610
DOC_USP7_MATH_1 791 795 PF00917 0.737
DOC_USP7_MATH_1 822 826 PF00917 0.782
DOC_WW_Pin1_4 145 150 PF00397 0.734
DOC_WW_Pin1_4 221 226 PF00397 0.585
DOC_WW_Pin1_4 425 430 PF00397 0.549
DOC_WW_Pin1_4 485 490 PF00397 0.674
DOC_WW_Pin1_4 596 601 PF00397 0.749
DOC_WW_Pin1_4 723 728 PF00397 0.583
DOC_WW_Pin1_4 92 97 PF00397 0.739
LIG_14-3-3_CanoR_1 252 260 PF00244 0.615
LIG_14-3-3_CanoR_1 278 285 PF00244 0.474
LIG_14-3-3_CanoR_1 387 395 PF00244 0.548
LIG_14-3-3_CanoR_1 397 406 PF00244 0.481
LIG_14-3-3_CanoR_1 4 11 PF00244 0.562
LIG_14-3-3_CanoR_1 40 47 PF00244 0.715
LIG_14-3-3_CanoR_1 448 454 PF00244 0.547
LIG_14-3-3_CanoR_1 477 482 PF00244 0.649
LIG_14-3-3_CanoR_1 629 636 PF00244 0.814
LIG_14-3-3_CanoR_1 797 807 PF00244 0.723
LIG_14-3-3_CanoR_1 839 846 PF00244 0.725
LIG_Actin_WH2_2 359 376 PF00022 0.511
LIG_Actin_WH2_2 388 405 PF00022 0.638
LIG_APCC_ABBA_1 287 292 PF00400 0.411
LIG_BIR_II_1 1 5 PF00653 0.686
LIG_BIR_III_4 342 346 PF00653 0.512
LIG_BRCT_BRCA1_1 66 70 PF00533 0.648
LIG_deltaCOP1_diTrp_1 118 127 PF00928 0.510
LIG_DLG_GKlike_1 477 484 PF00625 0.646
LIG_EH1_1 406 414 PF00400 0.530
LIG_EVH1_2 642 646 PF00568 0.597
LIG_FHA_1 449 455 PF00498 0.597
LIG_FHA_1 585 591 PF00498 0.791
LIG_FHA_1 597 603 PF00498 0.664
LIG_FHA_1 659 665 PF00498 0.776
LIG_FHA_1 687 693 PF00498 0.816
LIG_FHA_1 799 805 PF00498 0.707
LIG_FHA_1 839 845 PF00498 0.701
LIG_FHA_2 101 107 PF00498 0.672
LIG_FHA_2 166 172 PF00498 0.465
LIG_FHA_2 3 9 PF00498 0.601
LIG_FHA_2 436 442 PF00498 0.553
LIG_FHA_2 486 492 PF00498 0.646
LIG_FHA_2 50 56 PF00498 0.668
LIG_LIR_Apic_2 67 73 PF02991 0.511
LIG_LIR_Gen_1 224 233 PF02991 0.535
LIG_LIR_Gen_1 480 489 PF02991 0.616
LIG_LIR_Gen_1 572 581 PF02991 0.580
LIG_LIR_Nem_3 145 150 PF02991 0.642
LIG_LIR_Nem_3 224 229 PF02991 0.537
LIG_LIR_Nem_3 349 355 PF02991 0.532
LIG_LIR_Nem_3 480 484 PF02991 0.618
LIG_LIR_Nem_3 572 578 PF02991 0.573
LIG_LIR_Nem_3 67 71 PF02991 0.525
LIG_LIR_Nem_3 697 702 PF02991 0.791
LIG_MYND_1 69 73 PF01753 0.483
LIG_MYND_2 747 751 PF01753 0.587
LIG_PDZ_Class_2 843 848 PF00595 0.722
LIG_Pex14_2 348 352 PF04695 0.405
LIG_PTAP_UEV_1 215 220 PF05743 0.778
LIG_SH2_CRK 497 501 PF00017 0.616
LIG_SH2_STAP1 355 359 PF00017 0.607
LIG_SH2_STAP1 662 666 PF00017 0.813
LIG_SH2_STAT5 197 200 PF00017 0.557
LIG_SH2_STAT5 806 809 PF00017 0.697
LIG_SH3_3 210 216 PF00018 0.778
LIG_SH3_3 510 516 PF00018 0.701
LIG_SH3_3 594 600 PF00018 0.825
LIG_SH3_3 637 643 PF00018 0.724
LIG_SH3_3 741 747 PF00018 0.688
LIG_SUMO_SIM_par_1 82 88 PF11976 0.646
LIG_TRAF2_1 438 441 PF00917 0.445
LIG_WRC_WIRS_1 478 483 PF05994 0.655
LIG_WW_3 746 750 PF00397 0.696
MOD_CK1_1 148 154 PF00069 0.617
MOD_CK1_1 204 210 PF00069 0.659
MOD_CK1_1 25 31 PF00069 0.725
MOD_CK1_1 386 392 PF00069 0.487
MOD_CK1_1 428 434 PF00069 0.635
MOD_CK1_1 447 453 PF00069 0.432
MOD_CK1_1 522 528 PF00069 0.817
MOD_CK1_1 632 638 PF00069 0.788
MOD_CK1_1 651 657 PF00069 0.767
MOD_CK1_1 790 796 PF00069 0.670
MOD_CK1_1 825 831 PF00069 0.717
MOD_CK1_1 95 101 PF00069 0.729
MOD_CK2_1 100 106 PF00069 0.681
MOD_CK2_1 2 8 PF00069 0.630
MOD_CK2_1 225 231 PF00069 0.604
MOD_CK2_1 412 418 PF00069 0.531
MOD_CK2_1 435 441 PF00069 0.605
MOD_CK2_1 49 55 PF00069 0.719
MOD_CK2_1 73 79 PF00069 0.585
MOD_CK2_1 760 766 PF00069 0.739
MOD_Cter_Amidation 395 398 PF01082 0.544
MOD_DYRK1A_RPxSP_1 596 600 PF00069 0.614
MOD_GlcNHglycan 121 124 PF01048 0.493
MOD_GlcNHglycan 150 153 PF01048 0.661
MOD_GlcNHglycan 177 180 PF01048 0.637
MOD_GlcNHglycan 216 219 PF01048 0.653
MOD_GlcNHglycan 221 224 PF01048 0.546
MOD_GlcNHglycan 390 394 PF01048 0.493
MOD_GlcNHglycan 403 406 PF01048 0.475
MOD_GlcNHglycan 508 512 PF01048 0.626
MOD_GlcNHglycan 521 524 PF01048 0.628
MOD_GlcNHglycan 631 634 PF01048 0.745
MOD_GlcNHglycan 678 681 PF01048 0.761
MOD_GlcNHglycan 686 689 PF01048 0.713
MOD_GlcNHglycan 75 78 PF01048 0.513
MOD_GlcNHglycan 789 792 PF01048 0.681
MOD_GlcNHglycan 827 830 PF01048 0.650
MOD_GSK3_1 131 138 PF00069 0.683
MOD_GSK3_1 166 173 PF00069 0.519
MOD_GSK3_1 197 204 PF00069 0.646
MOD_GSK3_1 221 228 PF00069 0.578
MOD_GSK3_1 325 332 PF00069 0.531
MOD_GSK3_1 397 404 PF00069 0.494
MOD_GSK3_1 444 451 PF00069 0.611
MOD_GSK3_1 462 469 PF00069 0.400
MOD_GSK3_1 553 560 PF00069 0.627
MOD_GSK3_1 60 67 PF00069 0.686
MOD_GSK3_1 608 615 PF00069 0.770
MOD_GSK3_1 631 638 PF00069 0.718
MOD_GSK3_1 644 651 PF00069 0.752
MOD_GSK3_1 682 689 PF00069 0.691
MOD_GSK3_1 787 794 PF00069 0.679
MOD_GSK3_1 834 841 PF00069 0.697
MOD_GSK3_1 90 97 PF00069 0.685
MOD_N-GLC_1 166 171 PF02516 0.597
MOD_N-GLC_1 629 634 PF02516 0.611
MOD_N-GLC_1 780 785 PF02516 0.700
MOD_N-GLC_2 474 476 PF02516 0.587
MOD_NEK2_1 135 140 PF00069 0.754
MOD_NEK2_1 150 155 PF00069 0.464
MOD_NEK2_1 165 170 PF00069 0.540
MOD_NEK2_1 175 180 PF00069 0.593
MOD_NEK2_1 246 251 PF00069 0.428
MOD_NEK2_1 290 295 PF00069 0.420
MOD_NEK2_1 412 417 PF00069 0.617
MOD_NEK2_1 631 636 PF00069 0.718
MOD_NEK2_1 823 828 PF00069 0.729
MOD_NEK2_2 369 374 PF00069 0.611
MOD_OFUCOSY 163 170 PF10250 0.504
MOD_OFUCOSY 291 297 PF10250 0.411
MOD_PIKK_1 197 203 PF00454 0.683
MOD_PIKK_1 277 283 PF00454 0.474
MOD_PIKK_1 325 331 PF00454 0.586
MOD_PIKK_1 34 40 PF00454 0.746
MOD_PIKK_1 606 612 PF00454 0.646
MOD_PIKK_1 635 641 PF00454 0.769
MOD_PIKK_1 649 655 PF00454 0.802
MOD_PIKK_1 834 840 PF00454 0.833
MOD_PKA_1 397 403 PF00069 0.531
MOD_PKA_1 813 819 PF00069 0.799
MOD_PKA_1 839 845 PF00069 0.730
MOD_PKA_2 195 201 PF00069 0.653
MOD_PKA_2 251 257 PF00069 0.600
MOD_PKA_2 277 283 PF00069 0.419
MOD_PKA_2 386 392 PF00069 0.569
MOD_PKA_2 396 402 PF00069 0.515
MOD_PKA_2 447 453 PF00069 0.550
MOD_PKA_2 590 596 PF00069 0.726
MOD_PKA_2 736 742 PF00069 0.787
MOD_PKA_2 838 844 PF00069 0.669
MOD_PKB_1 621 629 PF00069 0.735
MOD_Plk_1 170 176 PF00069 0.574
MOD_Plk_1 188 194 PF00069 0.695
MOD_Plk_1 389 395 PF00069 0.567
MOD_Plk_1 455 461 PF00069 0.534
MOD_Plk_1 48 54 PF00069 0.732
MOD_Plk_1 584 590 PF00069 0.745
MOD_Plk_1 612 618 PF00069 0.745
MOD_Plk_1 760 766 PF00069 0.739
MOD_Plk_1 780 786 PF00069 0.702
MOD_Plk_1 823 829 PF00069 0.700
MOD_Plk_2-3 49 55 PF00069 0.572
MOD_Plk_2-3 760 766 PF00069 0.739
MOD_Plk_4 142 148 PF00069 0.584
MOD_Plk_4 156 162 PF00069 0.647
MOD_Plk_4 170 176 PF00069 0.488
MOD_Plk_4 188 194 PF00069 0.656
MOD_Plk_4 347 353 PF00069 0.540
MOD_Plk_4 428 434 PF00069 0.451
MOD_Plk_4 477 483 PF00069 0.740
MOD_Plk_4 584 590 PF00069 0.783
MOD_ProDKin_1 145 151 PF00069 0.731
MOD_ProDKin_1 221 227 PF00069 0.565
MOD_ProDKin_1 425 431 PF00069 0.544
MOD_ProDKin_1 485 491 PF00069 0.670
MOD_ProDKin_1 596 602 PF00069 0.751
MOD_ProDKin_1 723 729 PF00069 0.586
MOD_ProDKin_1 92 98 PF00069 0.738
MOD_SUMO_rev_2 228 236 PF00179 0.494
MOD_SUMO_rev_2 350 359 PF00179 0.532
MOD_SUMO_rev_2 697 705 PF00179 0.615
TRG_DiLeu_BaEn_1 585 590 PF01217 0.748
TRG_DiLeu_BaLyEn_6 655 660 PF01217 0.724
TRG_DiLeu_BaLyEn_6 746 751 PF01217 0.583
TRG_ENDOCYTIC_2 497 500 PF00928 0.566
TRG_ER_diArg_1 193 196 PF00400 0.441
TRG_ER_diArg_1 272 274 PF00400 0.581
TRG_ER_diArg_1 419 422 PF00400 0.578
TRG_ER_diArg_1 618 621 PF00400 0.749
TRG_Pf-PMV_PEXEL_1 452 456 PF00026 0.634
TRG_Pf-PMV_PEXEL_1 499 503 PF00026 0.709

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ00 Leptomonas seymouri 35% 97%
A0A3S7XAN9 Leishmania donovani 99% 100%
A4HP15 Leishmania braziliensis 64% 100%
E9ASS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q1S1 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS