Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2 - putative

Species:

Leishmania infantum

UniProt:

A4IDC3_LEIIN

TriTrypDb:

LINF_360021600

Length:

936

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.619
CLV_C14_Caspase3-7	458	462	PF00656	0.689
CLV_NRD_NRD_1	14	16	PF00675	0.513
CLV_NRD_NRD_1	197	199	PF00675	0.767
CLV_NRD_NRD_1	451	453	PF00675	0.690
CLV_NRD_NRD_1	558	560	PF00675	0.423
CLV_NRD_NRD_1	676	678	PF00675	0.353
CLV_NRD_NRD_1	913	915	PF00675	0.547
CLV_PCSK_KEX2_1	14	16	PF00082	0.510
CLV_PCSK_KEX2_1	197	199	PF00082	0.766
CLV_PCSK_KEX2_1	451	453	PF00082	0.690
CLV_PCSK_KEX2_1	558	560	PF00082	0.429
CLV_PCSK_KEX2_1	676	678	PF00082	0.353
CLV_PCSK_KEX2_1	787	789	PF00082	0.416
CLV_PCSK_KEX2_1	828	830	PF00082	0.353
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.333
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.353
CLV_PCSK_SKI1_1	661	665	PF00082	0.454
CLV_PCSK_SKI1_1	676	680	PF00082	0.270
DEG_APCC_DBOX_1	633	641	PF00400	0.660
DEG_APCC_DBOX_1	675	683	PF00400	0.334
DEG_COP1_1	267	276	PF00400	0.578
DEG_SPOP_SBC_1	23	27	PF00917	0.634
DEG_SPOP_SBC_1	338	342	PF00917	0.616
DEG_SPOP_SBC_1	421	425	PF00917	0.615
DEG_SPOP_SBC_1	576	580	PF00917	0.697
DEG_SPOP_SBC_1	704	708	PF00917	0.388
DEG_SPOP_SBC_1	709	713	PF00917	0.301
DOC_CKS1_1	299	304	PF01111	0.715
DOC_CYCLIN_RxL_1	369	382	PF00134	0.538
DOC_CYCLIN_RxL_1	674	681	PF00134	0.449
DOC_CYCLIN_yClb1_LxF_4	792	798	PF00134	0.317
DOC_MAPK_DCC_7	790	800	PF00069	0.317
DOC_MAPK_gen_1	429	436	PF00069	0.531
DOC_MAPK_gen_1	661	670	PF00069	0.446
DOC_MAPK_gen_1	676	682	PF00069	0.270
DOC_MAPK_gen_1	787	797	PF00069	0.398
DOC_MAPK_GRA24_9	784	800	PF00069	0.283
DOC_MAPK_HePTP_8	784	800	PF00069	0.283
DOC_MAPK_MEF2A_6	539	546	PF00069	0.472
DOC_MAPK_MEF2A_6	664	672	PF00069	0.449
DOC_PP2B_LxvP_1	178	181	PF13499	0.764
DOC_PP2B_LxvP_1	411	414	PF13499	0.558
DOC_PP4_FxxP_1	171	174	PF00568	0.627
DOC_USP7_MATH_1	104	108	PF00917	0.720
DOC_USP7_MATH_1	118	122	PF00917	0.612
DOC_USP7_MATH_1	23	27	PF00917	0.760
DOC_USP7_MATH_1	247	251	PF00917	0.740
DOC_USP7_MATH_1	257	261	PF00917	0.620
DOC_USP7_MATH_1	282	286	PF00917	0.661
DOC_USP7_MATH_1	345	349	PF00917	0.660
DOC_USP7_MATH_1	379	383	PF00917	0.603
DOC_USP7_MATH_1	444	448	PF00917	0.702
DOC_USP7_MATH_1	460	464	PF00917	0.670
DOC_USP7_MATH_1	576	580	PF00917	0.549
DOC_USP7_MATH_1	622	626	PF00917	0.630
DOC_USP7_MATH_1	627	631	PF00917	0.709
DOC_USP7_MATH_1	662	666	PF00917	0.369
DOC_USP7_MATH_1	691	695	PF00917	0.375
DOC_USP7_MATH_1	704	708	PF00917	0.350
DOC_USP7_MATH_1	710	714	PF00917	0.317
DOC_USP7_MATH_1	846	850	PF00917	0.416
DOC_USP7_MATH_1	871	875	PF00917	0.283
DOC_USP7_UBL2_3	911	915	PF12436	0.558
DOC_WW_Pin1_4	125	130	PF00397	0.709
DOC_WW_Pin1_4	234	239	PF00397	0.668
DOC_WW_Pin1_4	298	303	PF00397	0.630
DOC_WW_Pin1_4	309	314	PF00397	0.630
DOC_WW_Pin1_4	341	346	PF00397	0.678
DOC_WW_Pin1_4	466	471	PF00397	0.704
DOC_WW_Pin1_4	60	65	PF00397	0.644
DOC_WW_Pin1_4	700	705	PF00397	0.381
DOC_WW_Pin1_4	769	774	PF00397	0.421
DOC_WW_Pin1_4	828	833	PF00397	0.326
LIG_14-3-3_CanoR_1	151	156	PF00244	0.719
LIG_14-3-3_CanoR_1	206	212	PF00244	0.595
LIG_14-3-3_CanoR_1	265	274	PF00244	0.696
LIG_14-3-3_CanoR_1	479	483	PF00244	0.690
LIG_14-3-3_CanoR_1	575	584	PF00244	0.674
LIG_14-3-3_CanoR_1	614	619	PF00244	0.727
LIG_14-3-3_CanoR_1	661	670	PF00244	0.458
LIG_14-3-3_CanoR_1	677	683	PF00244	0.235
LIG_14-3-3_CanoR_1	695	705	PF00244	0.366
LIG_Actin_WH2_2	901	916	PF00022	0.554
LIG_APCC_ABBA_1	865	870	PF00400	0.334
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_4	360	364	PF00653	0.593
LIG_BIR_III_4	561	565	PF00653	0.482
LIG_BIR_III_4	810	814	PF00653	0.334
LIG_BRCT_BRCA1_1	345	349	PF00533	0.693
LIG_BRCT_BRCA1_1	719	723	PF00533	0.449
LIG_BRCT_BRCA1_1	94	98	PF00533	0.671
LIG_EVH1_1	178	182	PF00568	0.688
LIG_EVH1_2	542	546	PF00568	0.381
LIG_FHA_1	170	176	PF00498	0.578
LIG_FHA_1	238	244	PF00498	0.706
LIG_FHA_1	267	273	PF00498	0.695
LIG_FHA_1	413	419	PF00498	0.636
LIG_FHA_1	421	427	PF00498	0.656
LIG_FHA_1	552	558	PF00498	0.523
LIG_FHA_1	685	691	PF00498	0.334
LIG_FHA_1	733	739	PF00498	0.334
LIG_FHA_1	803	809	PF00498	0.334
LIG_FHA_2	348	354	PF00498	0.716
LIG_FHA_2	365	371	PF00498	0.500
LIG_FHA_2	543	549	PF00498	0.388
LIG_FHA_2	831	837	PF00498	0.283
LIG_Integrin_RGD_1	559	561	PF01839	0.459
LIG_LIR_Apic_2	169	174	PF02991	0.623
LIG_LIR_Gen_1	102	112	PF02991	0.620
LIG_LIR_Gen_1	210	218	PF02991	0.578
LIG_LIR_Gen_1	246	255	PF02991	0.731
LIG_LIR_Gen_1	48	57	PF02991	0.636
LIG_LIR_Gen_1	548	557	PF02991	0.440
LIG_LIR_Gen_1	681	691	PF02991	0.334
LIG_LIR_Gen_1	794	804	PF02991	0.334
LIG_LIR_Nem_3	162	168	PF02991	0.727
LIG_LIR_Nem_3	210	214	PF02991	0.572
LIG_LIR_Nem_3	246	251	PF02991	0.733
LIG_LIR_Nem_3	41	47	PF02991	0.630
LIG_LIR_Nem_3	465	471	PF02991	0.658
LIG_LIR_Nem_3	48	53	PF02991	0.596
LIG_LIR_Nem_3	545	550	PF02991	0.398
LIG_LIR_Nem_3	681	686	PF02991	0.334
LIG_LIR_Nem_3	748	753	PF02991	0.323
LIG_LIR_Nem_3	794	800	PF02991	0.334
LIG_LIR_Nem_3	900	904	PF02991	0.539
LIG_LYPXL_S_1	43	47	PF13949	0.691
LIG_LYPXL_yS_3	44	47	PF13949	0.739
LIG_MYND_1	190	194	PF01753	0.693
LIG_Pex14_2	868	872	PF04695	0.334
LIG_SH2_STAP1	547	551	PF00017	0.578
LIG_SH2_STAT3	17	20	PF00017	0.578
LIG_SH2_STAT5	165	168	PF00017	0.647
LIG_SH2_STAT5	550	553	PF00017	0.584
LIG_SH2_STAT5	745	748	PF00017	0.334
LIG_SH2_STAT5	861	864	PF00017	0.468
LIG_SH3_3	141	147	PF00018	0.644
LIG_SH3_3	171	177	PF00018	0.634
LIG_SH3_3	178	184	PF00018	0.653
LIG_SH3_3	228	234	PF00018	0.672
LIG_SH3_3	296	302	PF00018	0.627
LIG_SH3_3	316	322	PF00018	0.478
LIG_SH3_3	581	587	PF00018	0.601
LIG_SH3_3	647	653	PF00018	0.544
LIG_SH3_3	925	931	PF00018	0.519
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.586
LIG_Sin3_3	804	811	PF02671	0.323
LIG_SUMO_SIM_par_1	321	327	PF11976	0.703
LIG_TRAF2_1	215	218	PF00917	0.753
LIG_TRAF2_1	334	337	PF00917	0.709
LIG_WRC_WIRS_1	505	510	PF05994	0.592
MOD_CDK_SPK_2	64	69	PF00069	0.669
MOD_CDK_SPxxK_3	62	69	PF00069	0.584
MOD_CK1_1	121	127	PF00069	0.635
MOD_CK1_1	212	218	PF00069	0.625
MOD_CK1_1	229	235	PF00069	0.606
MOD_CK1_1	237	243	PF00069	0.586
MOD_CK1_1	339	345	PF00069	0.631
MOD_CK1_1	347	353	PF00069	0.632
MOD_CK1_1	396	402	PF00069	0.744
MOD_CK1_1	416	422	PF00069	0.557
MOD_CK1_1	432	438	PF00069	0.652
MOD_CK1_1	447	453	PF00069	0.622
MOD_CK1_1	469	475	PF00069	0.632
MOD_CK1_1	613	619	PF00069	0.694
MOD_CK1_1	699	705	PF00069	0.469
MOD_CK1_1	708	714	PF00069	0.301
MOD_CK1_1	831	837	PF00069	0.366
MOD_CK1_1	92	98	PF00069	0.705
MOD_CK2_1	212	218	PF00069	0.749
MOD_CK2_1	24	30	PF00069	0.720
MOD_CK2_1	272	278	PF00069	0.698
MOD_CK2_1	331	337	PF00069	0.643
MOD_CK2_1	347	353	PF00069	0.612
MOD_CK2_1	364	370	PF00069	0.508
MOD_CK2_1	542	548	PF00069	0.398
MOD_CK2_1	830	836	PF00069	0.394
MOD_CMANNOS	208	211	PF00535	0.566
MOD_Cter_Amidation	195	198	PF01082	0.746
MOD_Cter_Amidation	826	829	PF01082	0.399
MOD_GlcNHglycan	213	217	PF01048	0.769
MOD_GlcNHglycan	228	231	PF01048	0.597
MOD_GlcNHglycan	269	272	PF01048	0.745
MOD_GlcNHglycan	332	336	PF01048	0.692
MOD_GlcNHglycan	395	398	PF01048	0.718
MOD_GlcNHglycan	430	434	PF01048	0.789
MOD_GlcNHglycan	438	441	PF01048	0.645
MOD_GlcNHglycan	471	474	PF01048	0.603
MOD_GlcNHglycan	508	511	PF01048	0.715
MOD_GlcNHglycan	610	613	PF01048	0.557
MOD_GlcNHglycan	629	632	PF01048	0.597
MOD_GlcNHglycan	635	640	PF01048	0.715
MOD_GlcNHglycan	647	650	PF01048	0.504
MOD_GlcNHglycan	91	94	PF01048	0.664
MOD_GlcNHglycan	95	98	PF01048	0.614
MOD_GSK3_1	110	117	PF00069	0.686
MOD_GSK3_1	118	125	PF00069	0.581
MOD_GSK3_1	145	152	PF00069	0.672
MOD_GSK3_1	222	229	PF00069	0.780
MOD_GSK3_1	232	239	PF00069	0.685
MOD_GSK3_1	272	279	PF00069	0.683
MOD_GSK3_1	294	301	PF00069	0.614
MOD_GSK3_1	336	343	PF00069	0.626
MOD_GSK3_1	345	352	PF00069	0.606
MOD_GSK3_1	412	419	PF00069	0.626
MOD_GSK3_1	421	428	PF00069	0.648
MOD_GSK3_1	432	439	PF00069	0.641
MOD_GSK3_1	504	511	PF00069	0.709
MOD_GSK3_1	60	67	PF00069	0.656
MOD_GSK3_1	610	617	PF00069	0.579
MOD_GSK3_1	623	630	PF00069	0.629
MOD_GSK3_1	662	669	PF00069	0.320
MOD_GSK3_1	678	685	PF00069	0.383
MOD_GSK3_1	696	703	PF00069	0.396
MOD_GSK3_1	704	711	PF00069	0.307
MOD_GSK3_1	723	730	PF00069	0.317
MOD_GSK3_1	767	774	PF00069	0.380
MOD_GSK3_1	878	885	PF00069	0.336
MOD_GSK3_1	88	95	PF00069	0.693
MOD_LATS_1	427	433	PF00433	0.580
MOD_N-GLC_1	110	115	PF02516	0.627
MOD_N-GLC_1	169	174	PF02516	0.571
MOD_N-GLC_1	444	449	PF02516	0.682
MOD_N-GLC_1	511	516	PF02516	0.555
MOD_N-GLC_1	697	702	PF02516	0.357
MOD_N-GLC_1	802	807	PF02516	0.317
MOD_NEK2_1	294	299	PF00069	0.676
MOD_NEK2_1	436	441	PF00069	0.648
MOD_NEK2_1	506	511	PF00069	0.600
MOD_NEK2_1	551	556	PF00069	0.504
MOD_NEK2_1	670	675	PF00069	0.373
MOD_NEK2_1	678	683	PF00069	0.445
MOD_NEK2_1	723	728	PF00069	0.399
MOD_NEK2_1	802	807	PF00069	0.350
MOD_NEK2_1	886	891	PF00069	0.591
MOD_NEK2_1	98	103	PF00069	0.733
MOD_NEK2_2	104	109	PF00069	0.705
MOD_PIKK_1	224	230	PF00454	0.654
MOD_PIKK_1	662	668	PF00454	0.416
MOD_PIKK_1	74	80	PF00454	0.710
MOD_PK_1	664	670	PF00069	0.316
MOD_PK_1	717	723	PF00069	0.449
MOD_PKA_2	145	151	PF00069	0.741
MOD_PKA_2	219	225	PF00069	0.656
MOD_PKA_2	23	29	PF00069	0.723
MOD_PKA_2	264	270	PF00069	0.748
MOD_PKA_2	436	442	PF00069	0.594
MOD_PKA_2	478	484	PF00069	0.689
MOD_PKA_2	613	619	PF00069	0.607
MOD_PKA_2	732	738	PF00069	0.334
MOD_PKA_2	789	795	PF00069	0.317
MOD_PKA_2	894	900	PF00069	0.477
MOD_Plk_1	38	44	PF00069	0.665
MOD_Plk_1	429	435	PF00069	0.811
MOD_Plk_1	511	517	PF00069	0.554
MOD_Plk_1	74	80	PF00069	0.660
MOD_Plk_1	802	808	PF00069	0.317
MOD_Plk_2-3	30	36	PF00069	0.695
MOD_Plk_4	406	412	PF00069	0.718
MOD_Plk_4	413	419	PF00069	0.644
MOD_Plk_4	577	583	PF00069	0.662
MOD_Plk_4	678	684	PF00069	0.414
MOD_ProDKin_1	125	131	PF00069	0.706
MOD_ProDKin_1	234	240	PF00069	0.667
MOD_ProDKin_1	298	304	PF00069	0.632
MOD_ProDKin_1	309	315	PF00069	0.630
MOD_ProDKin_1	341	347	PF00069	0.677
MOD_ProDKin_1	466	472	PF00069	0.703
MOD_ProDKin_1	60	66	PF00069	0.644
MOD_ProDKin_1	700	706	PF00069	0.381
MOD_ProDKin_1	769	775	PF00069	0.421
MOD_ProDKin_1	828	834	PF00069	0.326
MOD_SUMO_for_1	716	719	PF00179	0.449
MOD_SUMO_rev_2	357	366	PF00179	0.716
MOD_SUMO_rev_2	897	906	PF00179	0.439
TRG_ENDOCYTIC_2	165	168	PF00928	0.681
TRG_ENDOCYTIC_2	44	47	PF00928	0.739
TRG_ENDOCYTIC_2	482	485	PF00928	0.690
TRG_ENDOCYTIC_2	550	553	PF00928	0.416
TRG_ENDOCYTIC_2	750	753	PF00928	0.339
TRG_ENDOCYTIC_2	851	854	PF00928	0.506
TRG_ER_diArg_1	13	15	PF00400	0.498
TRG_ER_diArg_1	451	453	PF00400	0.745
TRG_ER_diArg_1	557	559	PF00400	0.401
TRG_ER_diArg_1	676	678	PF00400	0.353
TRG_ER_diArg_1	788	791	PF00400	0.395
TRG_ER_diArg_1	872	875	PF00400	0.348
TRG_NLS_MonoExtC_3	10	15	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	661	666	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB6	Leptomonas seymouri	33%	98%
A0A3S7XAP8	Leishmania donovani	100%	100%
A4HP14	Leishmania braziliensis	59%	100%
E9ASS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1S2	Leishmania major	86%	100%