Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2 - putative

Species:

Leishmania infantum

UniProt:

A4IDC3_LEIIN

TriTrypDb:

LINF_360021600

Length:

936

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IDC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.619
CLV_C14_Caspase3-7	458	462	PF00656	0.689
CLV_NRD_NRD_1	14	16	PF00675	0.513
CLV_NRD_NRD_1	197	199	PF00675	0.767
CLV_NRD_NRD_1	451	453	PF00675	0.690
CLV_NRD_NRD_1	558	560	PF00675	0.423
CLV_NRD_NRD_1	676	678	PF00675	0.353
CLV_NRD_NRD_1	913	915	PF00675	0.547
CLV_PCSK_KEX2_1	14	16	PF00082	0.510
CLV_PCSK_KEX2_1	197	199	PF00082	0.766

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB6	Leptomonas seymouri	33%	98%
A0A3S7XAP8	Leishmania donovani	100%	100%
A4HP14	Leishmania braziliensis	59%	100%
E9ASS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1S2	Leishmania major	86%	100%

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