LeishMANIAdb
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Serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine protein kinase
Gene product:
serine/threonine protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4IDC2_LEIIN
TriTrypDb:
LINF_360021500
Length:
501

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 76
NetGPI no yes: 0, no: 76
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 77
GO:0006793 phosphorus metabolic process 3 77
GO:0006796 phosphate-containing compound metabolic process 4 77
GO:0006807 nitrogen compound metabolic process 2 77
GO:0008152 metabolic process 1 77
GO:0009987 cellular process 1 77
GO:0016310 phosphorylation 5 77
GO:0019538 protein metabolic process 3 77
GO:0036211 protein modification process 4 77
GO:0043170 macromolecule metabolic process 3 77
GO:0043412 macromolecule modification 4 77
GO:0044237 cellular metabolic process 2 77
GO:0044238 primary metabolic process 2 77
GO:0071704 organic substance metabolic process 2 77
GO:1901564 organonitrogen compound metabolic process 3 77
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 77
GO:0003824 catalytic activity 1 77
GO:0004672 protein kinase activity 3 77
GO:0005488 binding 1 77
GO:0005524 ATP binding 5 77
GO:0016301 kinase activity 4 77
GO:0016740 transferase activity 2 77
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 77
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 77
GO:0017076 purine nucleotide binding 4 77
GO:0030554 adenyl nucleotide binding 5 77
GO:0032553 ribonucleotide binding 3 77
GO:0032555 purine ribonucleotide binding 4 77
GO:0032559 adenyl ribonucleotide binding 5 77
GO:0035639 purine ribonucleoside triphosphate binding 4 77
GO:0036094 small molecule binding 2 77
GO:0043167 ion binding 2 77
GO:0043168 anion binding 3 77
GO:0097159 organic cyclic compound binding 2 77
GO:0097367 carbohydrate derivative binding 2 77
GO:0140096 catalytic activity, acting on a protein 2 77
GO:1901265 nucleoside phosphate binding 3 77
GO:1901363 heterocyclic compound binding 2 77
GO:0004674 protein serine/threonine kinase activity 4 50

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 455 459 PF00656 0.440
CLV_NRD_NRD_1 226 228 PF00675 0.252
CLV_NRD_NRD_1 350 352 PF00675 0.507
CLV_NRD_NRD_1 395 397 PF00675 0.283
CLV_NRD_NRD_1 471 473 PF00675 0.315
CLV_NRD_NRD_1 59 61 PF00675 0.394
CLV_PCSK_KEX2_1 169 171 PF00082 0.336
CLV_PCSK_KEX2_1 225 227 PF00082 0.263
CLV_PCSK_KEX2_1 249 251 PF00082 0.269
CLV_PCSK_KEX2_1 294 296 PF00082 0.378
CLV_PCSK_KEX2_1 349 351 PF00082 0.461
CLV_PCSK_KEX2_1 394 396 PF00082 0.300
CLV_PCSK_KEX2_1 471 473 PF00082 0.295
CLV_PCSK_KEX2_1 59 61 PF00082 0.338
CLV_PCSK_PC1ET2_1 169 171 PF00082 0.182
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.234
CLV_PCSK_PC1ET2_1 294 296 PF00082 0.358
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.306
CLV_PCSK_SKI1_1 174 178 PF00082 0.304
CLV_PCSK_SKI1_1 299 303 PF00082 0.296
CLV_PCSK_SKI1_1 336 340 PF00082 0.410
CLV_PCSK_SKI1_1 383 387 PF00082 0.343
CLV_PCSK_SKI1_1 471 475 PF00082 0.230
CLV_Separin_Metazoa 81 85 PF03568 0.164
DEG_APCC_DBOX_1 39 47 PF00400 0.549
DOC_ANK_TNKS_1 27 34 PF00023 0.696
DOC_CKS1_1 302 307 PF01111 0.276
DOC_CKS1_1 437 442 PF01111 0.307
DOC_CYCLIN_yCln2_LP_2 35 41 PF00134 0.301
DOC_MAPK_gen_1 174 183 PF00069 0.307
DOC_MAPK_gen_1 339 347 PF00069 0.544
DOC_MAPK_gen_1 394 400 PF00069 0.263
DOC_MAPK_MEF2A_6 349 356 PF00069 0.625
DOC_MAPK_MEF2A_6 361 368 PF00069 0.321
DOC_MAPK_RevD_3 155 170 PF00069 0.314
DOC_MAPK_RevD_3 236 250 PF00069 0.295
DOC_PP1_RVXF_1 372 378 PF00149 0.471
DOC_PP1_RVXF_1 469 476 PF00149 0.272
DOC_USP7_MATH_1 2 6 PF00917 0.496
DOC_USP7_MATH_1 202 206 PF00917 0.243
DOC_USP7_UBL2_3 138 142 PF12436 0.281
DOC_WW_Pin1_4 212 217 PF00397 0.314
DOC_WW_Pin1_4 26 31 PF00397 0.642
DOC_WW_Pin1_4 301 306 PF00397 0.260
DOC_WW_Pin1_4 368 373 PF00397 0.509
DOC_WW_Pin1_4 436 441 PF00397 0.311
DOC_WW_Pin1_4 75 80 PF00397 0.295
LIG_14-3-3_CanoR_1 351 357 PF00244 0.535
LIG_14-3-3_CanoR_1 361 365 PF00244 0.528
LIG_14-3-3_CanoR_1 488 494 PF00244 0.326
LIG_APCC_ABBA_1 398 403 PF00400 0.166
LIG_APCC_ABBAyCdc20_2 169 175 PF00400 0.307
LIG_BIR_II_1 1 5 PF00653 0.534
LIG_BIR_III_1 1 5 PF00653 0.342
LIG_BIR_III_3 1 5 PF00653 0.362
LIG_BRCT_BRCA1_1 35 39 PF00533 0.531
LIG_BRCT_BRCA1_1 437 441 PF00533 0.429
LIG_CaM_IQ_9 421 437 PF13499 0.390
LIG_Clathr_ClatBox_1 418 422 PF01394 0.166
LIG_deltaCOP1_diTrp_1 484 493 PF00928 0.358
LIG_FHA_1 17 23 PF00498 0.421
LIG_FHA_1 304 310 PF00498 0.455
LIG_FHA_1 333 339 PF00498 0.507
LIG_FHA_1 361 367 PF00498 0.500
LIG_FHA_1 409 415 PF00498 0.310
LIG_FHA_2 201 207 PF00498 0.325
LIG_FHA_2 22 28 PF00498 0.505
LIG_FHA_2 339 345 PF00498 0.443
LIG_FHA_2 453 459 PF00498 0.444
LIG_FHA_2 76 82 PF00498 0.352
LIG_Integrin_isoDGR_2 469 471 PF01839 0.166
LIG_IRF3_LxIS_1 305 312 PF10401 0.221
LIG_LIR_Apic_2 215 221 PF02991 0.304
LIG_LIR_Gen_1 438 449 PF02991 0.285
LIG_LIR_Gen_1 96 105 PF02991 0.297
LIG_LIR_Nem_3 36 42 PF02991 0.492
LIG_LIR_Nem_3 438 444 PF02991 0.285
LIG_LIR_Nem_3 445 451 PF02991 0.271
LIG_LIR_Nem_3 492 496 PF02991 0.512
LIG_LIR_Nem_3 94 100 PF02991 0.280
LIG_NRBOX 237 243 PF00104 0.249
LIG_PCNA_PIPBox_1 487 496 PF02747 0.166
LIG_PCNA_yPIPBox_3 278 288 PF02747 0.166
LIG_Pex14_1 393 397 PF04695 0.274
LIG_Pex14_2 16 20 PF04695 0.368
LIG_Pex14_2 463 467 PF04695 0.286
LIG_SH2_GRB2like 127 130 PF00017 0.333
LIG_SH2_NCK_1 127 131 PF00017 0.319
LIG_SH2_PTP2 218 221 PF00017 0.316
LIG_SH2_PTP2 310 313 PF00017 0.220
LIG_SH2_PTP2 397 400 PF00017 0.166
LIG_SH2_SRC 127 130 PF00017 0.304
LIG_SH2_STAP1 200 204 PF00017 0.277
LIG_SH2_STAP1 229 233 PF00017 0.326
LIG_SH2_STAP1 57 61 PF00017 0.180
LIG_SH2_STAT3 77 80 PF00017 0.164
LIG_SH2_STAT5 218 221 PF00017 0.303
LIG_SH2_STAT5 310 313 PF00017 0.355
LIG_SH2_STAT5 397 400 PF00017 0.277
LIG_SH2_STAT5 42 45 PF00017 0.349
LIG_SH2_STAT5 454 457 PF00017 0.263
LIG_SH2_STAT5 77 80 PF00017 0.404
LIG_SH2_STAT5 97 100 PF00017 0.340
LIG_SH3_3 361 367 PF00018 0.584
LIG_SUMO_SIM_anti_2 420 425 PF11976 0.336
LIG_SUMO_SIM_par_1 416 422 PF11976 0.317
LIG_TRAF2_1 341 344 PF00917 0.568
LIG_TRAF2_1 78 81 PF00917 0.164
LIG_TYR_ITIM 241 246 PF00017 0.325
LIG_UBA3_1 241 249 PF00899 0.286
LIG_WRC_WIRS_1 490 495 PF05994 0.166
MOD_CDC14_SPxK_1 371 374 PF00782 0.508
MOD_CDK_SPxK_1 368 374 PF00069 0.553
MOD_CDK_SPxxK_3 301 308 PF00069 0.167
MOD_CK1_1 297 303 PF00069 0.172
MOD_CK1_1 324 330 PF00069 0.487
MOD_CK1_1 389 395 PF00069 0.344
MOD_CK1_1 428 434 PF00069 0.341
MOD_CK1_1 452 458 PF00069 0.259
MOD_CK1_1 489 495 PF00069 0.434
MOD_CK1_1 49 55 PF00069 0.278
MOD_CK2_1 26 32 PF00069 0.524
MOD_CK2_1 338 344 PF00069 0.401
MOD_CK2_1 439 445 PF00069 0.312
MOD_CK2_1 75 81 PF00069 0.450
MOD_Cter_Amidation 469 472 PF01082 0.295
MOD_GlcNHglycan 177 180 PF01048 0.321
MOD_GlcNHglycan 284 287 PF01048 0.313
MOD_GlcNHglycan 319 322 PF01048 0.446
MOD_GlcNHglycan 323 326 PF01048 0.485
MOD_GlcNHglycan 48 51 PF01048 0.282
MOD_GlcNHglycan 85 88 PF01048 0.376
MOD_GSK3_1 208 215 PF00069 0.314
MOD_GSK3_1 297 304 PF00069 0.399
MOD_GSK3_1 317 324 PF00069 0.493
MOD_GSK3_1 385 392 PF00069 0.330
MOD_GSK3_1 413 420 PF00069 0.369
MOD_GSK3_1 42 49 PF00069 0.316
MOD_GSK3_1 435 442 PF00069 0.339
MOD_N-GLC_1 138 143 PF02516 0.174
MOD_NEK2_1 182 187 PF00069 0.286
MOD_NEK2_1 194 199 PF00069 0.280
MOD_NEK2_1 261 266 PF00069 0.299
MOD_NEK2_1 309 314 PF00069 0.322
MOD_NEK2_1 360 365 PF00069 0.448
MOD_OFUCOSY 90 95 PF10250 0.164
MOD_PKA_1 294 300 PF00069 0.313
MOD_PKA_2 294 300 PF00069 0.286
MOD_PKA_2 33 39 PF00069 0.609
MOD_PKA_2 360 366 PF00069 0.563
MOD_PKA_2 428 434 PF00069 0.166
MOD_PKA_2 83 89 PF00069 0.164
MOD_PKB_1 225 233 PF00069 0.183
MOD_Plk_1 330 336 PF00069 0.517
MOD_Plk_1 389 395 PF00069 0.311
MOD_Plk_4 116 122 PF00069 0.337
MOD_Plk_4 279 285 PF00069 0.246
MOD_Plk_4 297 303 PF00069 0.202
MOD_Plk_4 42 48 PF00069 0.327
MOD_Plk_4 489 495 PF00069 0.301
MOD_Plk_4 51 57 PF00069 0.310
MOD_ProDKin_1 212 218 PF00069 0.314
MOD_ProDKin_1 26 32 PF00069 0.649
MOD_ProDKin_1 301 307 PF00069 0.260
MOD_ProDKin_1 368 374 PF00069 0.490
MOD_ProDKin_1 436 442 PF00069 0.311
MOD_ProDKin_1 75 81 PF00069 0.295
TRG_DiLeu_BaEn_1 88 93 PF01217 0.329
TRG_ENDOCYTIC_2 243 246 PF00928 0.311
TRG_ENDOCYTIC_2 310 313 PF00928 0.355
TRG_ENDOCYTIC_2 397 400 PF00928 0.306
TRG_ENDOCYTIC_2 401 404 PF00928 0.275
TRG_ENDOCYTIC_2 97 100 PF00928 0.322
TRG_ER_diArg_1 224 227 PF00400 0.277
TRG_ER_diArg_1 349 351 PF00400 0.532
TRG_ER_diArg_1 395 397 PF00400 0.291
TRG_ER_diArg_1 471 473 PF00400 0.322
TRG_ER_diArg_1 59 62 PF00400 0.421
TRG_NLS_MonoExtN_4 292 297 PF00514 0.193
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.486
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.464
TRG_Pf-PMV_PEXEL_1 472 476 PF00026 0.257

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 35% 100%
A0A0N0P953 Leptomonas seymouri 35% 100%
A0A0N1I9A0 Leptomonas seymouri 30% 77%
A0A0N1PD05 Leptomonas seymouri 32% 100%
A0A0N1PE80 Leptomonas seymouri 26% 89%
A0A0S4IMB7 Bodo saltans 38% 100%
A0A0S4IQ75 Bodo saltans 33% 99%
A0A0S4IRZ7 Bodo saltans 33% 100%
A0A0S4IVW1 Bodo saltans 24% 80%
A0A0S4IX86 Bodo saltans 33% 100%
A0A0S4J7K4 Bodo saltans 25% 100%
A0A0S4J804 Bodo saltans 38% 96%
A0A0S4JIJ6 Bodo saltans 28% 89%
A0A0S4JPZ1 Bodo saltans 32% 100%
A0A1X0NFW4 Trypanosomatidae 27% 100%
A0A1X0NIA0 Trypanosomatidae 32% 100%
A0A1X0NIX2 Trypanosomatidae 31% 100%
A0A1X0NUB2 Trypanosomatidae 31% 86%
A0A1X0P527 Trypanosomatidae 33% 100%
A0A1X0P549 Trypanosomatidae 36% 100%
A0A1X0P863 Trypanosomatidae 57% 100%
A0A1X0P994 Trypanosomatidae 56% 100%
A0A3Q8IAQ1 Leishmania donovani 40% 100%
A0A3Q8IFK8 Leishmania donovani 30% 100%
A0A3Q8IFW0 Leishmania donovani 34% 100%
A0A3Q8IIG1 Leishmania donovani 30% 100%
A0A3Q8IJM9 Leishmania donovani 36% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3R7K109 Trypanosoma rangeli 27% 100%
A0A3R7KCZ4 Trypanosoma rangeli 34% 100%
A0A3R7MKG5 Trypanosoma rangeli 31% 100%
A0A3S7X5M4 Leishmania donovani 31% 76%
A0A3S7X6T8 Leishmania donovani 36% 100%
A0A3S7X9R4 Leishmania donovani 28% 100%
A0A3S7X9S2 Leishmania donovani 28% 100%
A0A3S7XAL3 Leishmania donovani 85% 100%
A0A3S7XAT9 Leishmania donovani 100% 100%
A0A422NCP0 Trypanosoma rangeli 57% 100%
A0A422NH41 Trypanosoma rangeli 29% 87%
A0A422NT89 Trypanosoma rangeli 24% 76%
A0A509AHB6 Plasmodium berghei (strain Anka) 28% 96%
A4HCE6 Leishmania braziliensis 39% 100%
A4HED7 Leishmania braziliensis 30% 100%
A4HJT5 Leishmania braziliensis 30% 93%
A4HJW2 Leishmania braziliensis 33% 93%
A4HKG9 Leishmania braziliensis 31% 100%
A4HLR0 Leishmania braziliensis 35% 100%
A4HN71 Leishmania braziliensis 28% 100%
A4HNI1 Leishmania braziliensis 35% 97%
A4HP12 Leishmania braziliensis 58% 100%
A4HP13 Leishmania braziliensis 90% 100%
A4HZW8 Leishmania infantum 40% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I435 Leishmania infantum 30% 100%
A4I7A1 Leishmania infantum 36% 100%
A4I7C4 Leishmania infantum 34% 92%
A4I7Z6 Leishmania infantum 31% 100%
A4I960 Leishmania infantum 36% 100%
A4IBT4 Leishmania infantum 28% 100%
A4IBT9 Leishmania infantum 28% 100%
A4IC37 Leishmania infantum 36% 99%
A4IDC1 Leishmania infantum 58% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 87%
E9AFM1 Leishmania major 27% 100%
E9AFZ2 Leishmania major 35% 96%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 93%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 93%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
O13839 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 69%
P11837 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 72%
Q03428 Trypanosoma brucei brucei 32% 100%
Q08942 Trypanosoma brucei brucei 33% 100%
Q0VD22 Bos taurus 26% 100%
Q4Q1S3 Leishmania major 97% 100%
Q4Q1S4 Leishmania major 58% 100%
Q4Q598 Leishmania major 31% 100%
Q4Q5T9 Leishmania major 34% 92%
Q4Q5W2 Leishmania major 36% 100%
Q4Q7W2 Leishmania major 30% 100%
Q4QBQ2 Leishmania major 39% 100%
Q5KQF5 Oryza sativa subsp. japonica 29% 100%
Q7RAH3 Plasmodium yoelii yoelii 28% 94%
Q9GNR4 Leishmania major 28% 100%
V5BHW8 Trypanosoma cruzi 24% 79%
V5BPJ0 Trypanosoma cruzi 58% 100%
V5D579 Trypanosoma cruzi 33% 100%
V5DFW9 Trypanosoma cruzi 30% 86%
V5DKY9 Trypanosoma cruzi 34% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS