LeishMANIAdb
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Protein kinase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase
Gene product:
serine/threonine protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4IDC1_LEIIN
TriTrypDb:
LINF_360021400
Length:
510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 85
NetGPI no yes: 0, no: 85
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0005930 axoneme 2 2
GO:0005952 cAMP-dependent protein kinase complex 3 2
GO:0031974 membrane-enclosed lumen 2 3
GO:0031981 nuclear lumen 5 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 3
GO:0032991 protein-containing complex 1 2
GO:0043233 organelle lumen 3 3
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 2
GO:0070013 intracellular organelle lumen 4 3
GO:0097014 ciliary plasm 5 3
GO:0099568 cytoplasmic region 3 3
GO:0110165 cellular anatomical entity 1 3
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:1902554 serine/threonine protein kinase complex 6 2
GO:1902911 protein kinase complex 5 2
GO:1990234 transferase complex 3 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDC1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDC1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 86
GO:0006793 phosphorus metabolic process 3 86
GO:0006796 phosphate-containing compound metabolic process 4 86
GO:0006807 nitrogen compound metabolic process 2 86
GO:0008152 metabolic process 1 86
GO:0009987 cellular process 1 86
GO:0016310 phosphorylation 5 86
GO:0019538 protein metabolic process 3 86
GO:0036211 protein modification process 4 86
GO:0043170 macromolecule metabolic process 3 86
GO:0043412 macromolecule modification 4 86
GO:0044237 cellular metabolic process 2 86
GO:0044238 primary metabolic process 2 86
GO:0071704 organic substance metabolic process 2 86
GO:1901564 organonitrogen compound metabolic process 3 86
GO:0007165 signal transduction 2 2
GO:0018105 peptidyl-serine phosphorylation 6 3
GO:0018193 peptidyl-amino acid modification 5 3
GO:0018209 peptidyl-serine modification 6 3
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 86
GO:0003824 catalytic activity 1 86
GO:0004672 protein kinase activity 3 86
GO:0005488 binding 1 86
GO:0005524 ATP binding 5 86
GO:0016301 kinase activity 4 86
GO:0016740 transferase activity 2 86
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 86
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 86
GO:0017076 purine nucleotide binding 4 86
GO:0030554 adenyl nucleotide binding 5 86
GO:0032553 ribonucleotide binding 3 86
GO:0032555 purine ribonucleotide binding 4 86
GO:0032559 adenyl ribonucleotide binding 5 86
GO:0035639 purine ribonucleoside triphosphate binding 4 86
GO:0036094 small molecule binding 2 86
GO:0043167 ion binding 2 86
GO:0043168 anion binding 3 86
GO:0097159 organic cyclic compound binding 2 86
GO:0097367 carbohydrate derivative binding 2 86
GO:0140096 catalytic activity, acting on a protein 2 86
GO:1901265 nucleoside phosphate binding 3 86
GO:1901363 heterocyclic compound binding 2 86
GO:0004674 protein serine/threonine kinase activity 4 56
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 2
GO:0004691 cAMP-dependent protein kinase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.408
CLV_NRD_NRD_1 220 222 PF00675 0.234
CLV_NRD_NRD_1 289 291 PF00675 0.376
CLV_PCSK_KEX2_1 104 106 PF00082 0.372
CLV_PCSK_KEX2_1 220 222 PF00082 0.247
CLV_PCSK_KEX2_1 244 246 PF00082 0.256
CLV_PCSK_KEX2_1 289 291 PF00082 0.364
CLV_PCSK_KEX2_1 335 337 PF00082 0.407
CLV_PCSK_KEX2_1 342 344 PF00082 0.416
CLV_PCSK_KEX2_1 395 397 PF00082 0.360
CLV_PCSK_KEX2_1 470 472 PF00082 0.375
CLV_PCSK_KEX2_1 54 56 PF00082 0.329
CLV_PCSK_PC1ET2_1 104 106 PF00082 0.154
CLV_PCSK_PC1ET2_1 244 246 PF00082 0.220
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.397
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.359
CLV_PCSK_PC1ET2_1 395 397 PF00082 0.365
CLV_PCSK_PC1ET2_1 470 472 PF00082 0.344
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.281
CLV_PCSK_SKI1_1 169 173 PF00082 0.297
CLV_PCSK_SKI1_1 303 307 PF00082 0.364
CLV_PCSK_SKI1_1 335 339 PF00082 0.391
DEG_SCF_FBW7_2 436 442 PF00400 0.392
DEG_SPOP_SBC_1 358 362 PF00917 0.484
DEG_SPOP_SBC_1 369 373 PF00917 0.374
DOC_CKS1_1 436 441 PF01111 0.407
DOC_CYCLIN_RxL_1 467 478 PF00134 0.396
DOC_MAPK_gen_1 169 178 PF00069 0.299
DOC_MAPK_gen_1 394 400 PF00069 0.311
DOC_MAPK_gen_1 416 424 PF00069 0.333
DOC_MAPK_MEF2A_6 418 426 PF00069 0.332
DOC_MAPK_RevD_3 231 245 PF00069 0.288
DOC_PP1_RVXF_1 468 475 PF00149 0.334
DOC_PP2B_LxvP_1 297 300 PF13499 0.280
DOC_PP4_FxxP_1 447 450 PF00568 0.305
DOC_USP7_MATH_1 266 270 PF00917 0.346
DOC_USP7_MATH_1 291 295 PF00917 0.204
DOC_WW_Pin1_4 207 212 PF00397 0.306
DOC_WW_Pin1_4 269 274 PF00397 0.249
DOC_WW_Pin1_4 365 370 PF00397 0.464
DOC_WW_Pin1_4 435 440 PF00397 0.402
LIG_14-3-3_CanoR_1 137 143 PF00244 0.297
LIG_14-3-3_CanoR_1 289 299 PF00244 0.264
LIG_14-3-3_CanoR_1 336 345 PF00244 0.515
LIG_14-3-3_CanoR_1 471 475 PF00244 0.444
LIG_14-3-3_CanoR_1 55 62 PF00244 0.314
LIG_AP2alpha_1 18 22 PF02296 0.326
LIG_APCC_ABBAyCdc20_2 164 170 PF00400 0.292
LIG_BIR_II_1 1 5 PF00653 0.691
LIG_BIR_III_2 445 449 PF00653 0.217
LIG_BRCT_BRCA1_1 436 440 PF00533 0.523
LIG_BRCT_BRCA1_1 458 462 PF00533 0.355
LIG_FHA_1 278 284 PF00498 0.316
LIG_FHA_1 332 338 PF00498 0.521
LIG_FHA_1 359 365 PF00498 0.493
LIG_FHA_1 369 375 PF00498 0.448
LIG_FHA_1 45 51 PF00498 0.332
LIG_FHA_2 139 145 PF00498 0.372
LIG_FHA_2 196 202 PF00498 0.318
LIG_FHA_2 26 32 PF00498 0.445
LIG_FHA_2 360 366 PF00498 0.445
LIG_FHA_2 376 382 PF00498 0.299
LIG_FHA_2 407 413 PF00498 0.490
LIG_FHA_2 439 445 PF00498 0.383
LIG_FHA_2 474 480 PF00498 0.387
LIG_IRF3_LxIS_1 420 427 PF10401 0.386
LIG_LIR_Apic_2 210 216 PF02991 0.294
LIG_LIR_Apic_2 444 450 PF02991 0.330
LIG_LIR_Gen_1 188 199 PF02991 0.236
LIG_LIR_Gen_1 437 448 PF02991 0.359
LIG_LIR_Gen_1 91 100 PF02991 0.291
LIG_LIR_Nem_3 437 443 PF02991 0.374
LIG_LIR_Nem_3 91 96 PF02991 0.269
LIG_NRBOX 151 157 PF00104 0.156
LIG_NRBOX 232 238 PF00104 0.239
LIG_NRBOX 305 311 PF00104 0.494
LIG_PCNA_yPIPBox_3 104 116 PF02747 0.246
LIG_PCNA_yPIPBox_3 295 305 PF02747 0.259
LIG_PCNA_yPIPBox_3 77 88 PF02747 0.232
LIG_Pex14_1 393 397 PF04695 0.331
LIG_Pex14_2 18 22 PF04695 0.368
LIG_Pex14_2 462 466 PF04695 0.290
LIG_PTB_Apo_2 411 418 PF02174 0.520
LIG_PTB_Apo_2 86 93 PF02174 0.263
LIG_SH2_GRB2like 122 125 PF00017 0.323
LIG_SH2_GRB2like 195 198 PF00017 0.421
LIG_SH2_NCK_1 122 126 PF00017 0.300
LIG_SH2_PTP2 213 216 PF00017 0.304
LIG_SH2_SRC 122 125 PF00017 0.282
LIG_SH2_STAP1 195 199 PF00017 0.261
LIG_SH2_STAP1 224 228 PF00017 0.313
LIG_SH2_STAT5 213 216 PF00017 0.292
LIG_SH2_STAT5 397 400 PF00017 0.288
LIG_SH2_STAT5 453 456 PF00017 0.333
LIG_SUMO_SIM_par_1 421 427 PF11976 0.349
LIG_TYR_ITIM 236 241 PF00017 0.321
LIG_UBA3_1 236 244 PF00899 0.276
LIG_UBA3_1 296 303 PF00899 0.229
MOD_CDK_SPxxK_3 269 276 PF00069 0.413
MOD_CK1_1 269 275 PF00069 0.289
MOD_CK1_1 352 358 PF00069 0.520
MOD_CK1_1 427 433 PF00069 0.426
MOD_CK1_1 44 50 PF00069 0.269
MOD_CK1_1 473 479 PF00069 0.450
MOD_CK2_1 138 144 PF00069 0.359
MOD_CK2_1 25 31 PF00069 0.414
MOD_CK2_1 359 365 PF00069 0.460
MOD_CK2_1 375 381 PF00069 0.291
MOD_CK2_1 438 444 PF00069 0.389
MOD_CK2_1 473 479 PF00069 0.330
MOD_CK2_1 54 60 PF00069 0.224
MOD_Cter_Amidation 287 290 PF01082 0.149
MOD_Cter_Amidation 468 471 PF01082 0.378
MOD_GlcNHglycan 1 4 PF01048 0.663
MOD_GlcNHglycan 172 175 PF01048 0.309
MOD_GlcNHglycan 283 286 PF01048 0.285
MOD_GlcNHglycan 306 309 PF01048 0.309
MOD_GlcNHglycan 350 355 PF01048 0.497
MOD_GlcNHglycan 43 46 PF01048 0.272
MOD_GlcNHglycan 500 506 PF01048 0.661
MOD_GSK3_1 131 138 PF00069 0.382
MOD_GSK3_1 203 210 PF00069 0.302
MOD_GSK3_1 277 284 PF00069 0.302
MOD_GSK3_1 349 356 PF00069 0.480
MOD_GSK3_1 365 372 PF00069 0.504
MOD_GSK3_1 434 441 PF00069 0.411
MOD_N-GLC_1 269 274 PF02516 0.348
MOD_N-GLC_1 456 461 PF02516 0.316
MOD_NEK2_1 177 182 PF00069 0.274
MOD_NEK2_1 189 194 PF00069 0.270
MOD_NEK2_1 256 261 PF00069 0.289
MOD_NEK2_1 304 309 PF00069 0.297
MOD_NEK2_1 323 328 PF00069 0.394
MOD_NEK2_1 349 354 PF00069 0.418
MOD_NEK2_1 370 375 PF00069 0.413
MOD_NEK2_2 375 380 PF00069 0.311
MOD_PIKK_1 312 318 PF00454 0.379
MOD_PKA_1 289 295 PF00069 0.296
MOD_PKA_1 385 391 PF00069 0.359
MOD_PKA_1 470 476 PF00069 0.220
MOD_PKA_1 54 60 PF00069 0.323
MOD_PKA_2 289 295 PF00069 0.276
MOD_PKA_2 323 329 PF00069 0.412
MOD_PKA_2 470 476 PF00069 0.487
MOD_PKA_2 54 60 PF00069 0.288
MOD_Plk_1 456 462 PF00069 0.532
MOD_Plk_1 501 507 PF00069 0.425
MOD_Plk_2-3 406 412 PF00069 0.530
MOD_Plk_2-3 70 76 PF00069 0.298
MOD_Plk_4 359 365 PF00069 0.450
MOD_Plk_4 406 412 PF00069 0.509
MOD_Plk_4 456 462 PF00069 0.371
MOD_Plk_4 46 52 PF00069 0.293
MOD_ProDKin_1 207 213 PF00069 0.306
MOD_ProDKin_1 269 275 PF00069 0.249
MOD_ProDKin_1 365 371 PF00069 0.472
MOD_ProDKin_1 435 441 PF00069 0.408
MOD_SUMO_for_1 23 26 PF00179 0.379
MOD_SUMO_rev_2 127 134 PF00179 0.311
MOD_SUMO_rev_2 328 337 PF00179 0.398
TRG_DiLeu_BaEn_1 333 338 PF01217 0.480
TRG_DiLeu_BaEn_1 83 88 PF01217 0.333
TRG_DiLeu_BaLyEn_6 292 297 PF01217 0.420
TRG_DiLeu_LyEn_5 333 338 PF01217 0.256
TRG_ENDOCYTIC_2 238 241 PF00928 0.303
TRG_ENDOCYTIC_2 397 400 PF00928 0.315
TRG_ER_diArg_1 219 221 PF00400 0.256
TRG_ER_diArg_1 289 291 PF00400 0.350
TRG_NES_CRM1_1 111 121 PF08389 0.156
TRG_Pf-PMV_PEXEL_1 336 341 PF00026 0.440
TRG_Pf-PMV_PEXEL_1 482 487 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 34% 100%
A0A0N0P953 Leptomonas seymouri 34% 100%
A0A0N1I9A0 Leptomonas seymouri 30% 78%
A0A0N1PD05 Leptomonas seymouri 35% 100%
A0A0S4IMB7 Bodo saltans 37% 100%
A0A0S4IRZ7 Bodo saltans 34% 100%
A0A0S4IVW1 Bodo saltans 27% 81%
A0A0S4IX86 Bodo saltans 37% 100%
A0A0S4J804 Bodo saltans 37% 98%
A0A0S4JIJ6 Bodo saltans 27% 90%
A0A0S4JPZ1 Bodo saltans 32% 100%
A0A0S4JWD5 Bodo saltans 24% 100%
A0A1X0NIA0 Trypanosomatidae 38% 100%
A0A1X0NIX2 Trypanosomatidae 34% 100%
A0A1X0NTL6 Trypanosomatidae 33% 100%
A0A1X0NUB2 Trypanosomatidae 30% 88%
A0A1X0NUQ4 Trypanosomatidae 25% 100%
A0A1X0P022 Trypanosomatidae 25% 79%
A0A1X0P527 Trypanosomatidae 37% 100%
A0A1X0P549 Trypanosomatidae 37% 100%
A0A1X0P863 Trypanosomatidae 76% 100%
A0A1X0P994 Trypanosomatidae 70% 100%
A0A3Q8IAQ1 Leishmania donovani 42% 100%
A0A3Q8IC87 Leishmania donovani 26% 100%
A0A3Q8IFK8 Leishmania donovani 34% 100%
A0A3Q8IFW0 Leishmania donovani 34% 100%
A0A3Q8IIG1 Leishmania donovani 32% 100%
A0A3Q8IJM9 Leishmania donovani 35% 100%
A0A3R7KCZ4 Trypanosoma rangeli 36% 100%
A0A3R7KDE9 Trypanosoma rangeli 25% 70%
A0A3R7MKG5 Trypanosoma rangeli 35% 100%
A0A3S5H528 Leishmania donovani 27% 100%
A0A3S7WTN9 Leishmania donovani 26% 100%
A0A3S7X2W3 Leishmania donovani 26% 100%
A0A3S7X5M4 Leishmania donovani 30% 78%
A0A3S7X6T8 Leishmania donovani 36% 100%
A0A3S7X9R4 Leishmania donovani 29% 100%
A0A3S7X9S2 Leishmania donovani 29% 100%
A0A3S7XAL3 Leishmania donovani 73% 100%
A0A3S7XAT9 Leishmania donovani 58% 100%
A0A422NCP0 Trypanosoma rangeli 75% 100%
A0A422NH41 Trypanosoma rangeli 30% 89%
A4H3J3 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 26% 100%
A4HCE6 Leishmania braziliensis 40% 100%
A4HFA1 Leishmania braziliensis 26% 100%
A4HH03 Leishmania braziliensis 31% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HJT5 Leishmania braziliensis 34% 95%
A4HJW2 Leishmania braziliensis 34% 91%
A4HKG9 Leishmania braziliensis 30% 100%
A4HLR0 Leishmania braziliensis 35% 97%
A4HN71 Leishmania braziliensis 28% 100%
A4HNI1 Leishmania braziliensis 34% 97%
A4HP12 Leishmania braziliensis 97% 100%
A4HP13 Leishmania braziliensis 59% 100%
A4HRT2 Leishmania infantum 27% 100%
A4HWP5 Leishmania infantum 26% 100%
A4HZV1 Leishmania infantum 26% 100%
A4HZW8 Leishmania infantum 42% 100%
A4I435 Leishmania infantum 31% 100%
A4I7A1 Leishmania infantum 34% 95%
A4I7C4 Leishmania infantum 34% 92%
A4I7Z6 Leishmania infantum 30% 100%
A4I960 Leishmania infantum 35% 97%
A4IBT4 Leishmania infantum 27% 100%
A4IBT9 Leishmania infantum 29% 100%
A4IC37 Leishmania infantum 35% 98%
A4IDC2 Leishmania infantum 58% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZUU2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 77%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 89%
E9ACG8 Leishmania major 27% 100%
E9AFM1 Leishmania major 29% 100%
E9AFZ2 Leishmania major 34% 97%
E9AII8 Leishmania braziliensis 25% 98%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 95%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 91%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 97%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 99%
P28867 Mus musculus 28% 76%
P45894 Caenorhabditis elegans 28% 87%
Q03428 Trypanosoma brucei brucei 35% 100%
Q05655 Homo sapiens 28% 75%
Q08942 Trypanosoma brucei brucei 36% 100%
Q4Q1S3 Leishmania major 58% 100%
Q4Q1S4 Leishmania major 98% 100%
Q4Q3Y9 Leishmania major 35% 97%
Q4Q598 Leishmania major 31% 100%
Q4Q5T9 Leishmania major 34% 92%
Q4Q5W2 Leishmania major 34% 95%
Q4Q7W2 Leishmania major 31% 100%
Q4Q9K2 Leishmania major 32% 100%
Q4QBQ2 Leishmania major 41% 100%
Q4QBR6 Leishmania major 26% 100%
Q4QF23 Leishmania major 26% 100%
Q5PU49 Canis lupus familiaris 28% 76%
Q8RXT4 Arabidopsis thaliana 26% 92%
Q9CAU7 Arabidopsis thaliana 25% 84%
Q9GNR4 Leishmania major 29% 100%
V5BC28 Trypanosoma cruzi 33% 100%
V5BL06 Trypanosoma cruzi 24% 79%
V5BPJ0 Trypanosoma cruzi 75% 100%
V5D579 Trypanosoma cruzi 36% 100%
V5DFW9 Trypanosoma cruzi 32% 87%
V5DKY9 Trypanosoma cruzi 34% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS