LeishMANIAdb
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KU80 protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
KU80 protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDB9_LEIIN
TriTrypDb:
LINF_360021200
Length:
948

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 317, 318

Expansion

Sequence features

A4IDB9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDB9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 215 219 PF00656 0.522
CLV_C14_Caspase3-7 313 317 PF00656 0.672
CLV_C14_Caspase3-7 407 411 PF00656 0.583
CLV_C14_Caspase3-7 427 431 PF00656 0.313
CLV_C14_Caspase3-7 461 465 PF00656 0.519
CLV_C14_Caspase3-7 513 517 PF00656 0.538
CLV_C14_Caspase3-7 632 636 PF00656 0.591
CLV_C14_Caspase3-7 868 872 PF00656 0.734
CLV_C14_Caspase3-7 873 877 PF00656 0.726
CLV_NRD_NRD_1 298 300 PF00675 0.634
CLV_NRD_NRD_1 697 699 PF00675 0.447
CLV_NRD_NRD_1 754 756 PF00675 0.513
CLV_NRD_NRD_1 825 827 PF00675 0.542
CLV_NRD_NRD_1 840 842 PF00675 0.573
CLV_NRD_NRD_1 887 889 PF00675 0.638
CLV_NRD_NRD_1 904 906 PF00675 0.516
CLV_PCSK_FUR_1 905 909 PF00082 0.635
CLV_PCSK_KEX2_1 262 264 PF00082 0.744
CLV_PCSK_KEX2_1 297 299 PF00082 0.640
CLV_PCSK_KEX2_1 697 699 PF00082 0.469
CLV_PCSK_KEX2_1 754 756 PF00082 0.513
CLV_PCSK_KEX2_1 825 827 PF00082 0.494
CLV_PCSK_KEX2_1 862 864 PF00082 0.726
CLV_PCSK_KEX2_1 889 891 PF00082 0.712
CLV_PCSK_KEX2_1 903 905 PF00082 0.568
CLV_PCSK_KEX2_1 907 909 PF00082 0.544
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.744
CLV_PCSK_PC1ET2_1 862 864 PF00082 0.726
CLV_PCSK_PC1ET2_1 889 891 PF00082 0.776
CLV_PCSK_PC1ET2_1 903 905 PF00082 0.613
CLV_PCSK_PC1ET2_1 907 909 PF00082 0.549
CLV_PCSK_SKI1_1 358 362 PF00082 0.534
CLV_PCSK_SKI1_1 404 408 PF00082 0.541
CLV_PCSK_SKI1_1 435 439 PF00082 0.428
CLV_PCSK_SKI1_1 53 57 PF00082 0.543
CLV_PCSK_SKI1_1 555 559 PF00082 0.643
CLV_PCSK_SKI1_1 660 664 PF00082 0.615
CLV_PCSK_SKI1_1 698 702 PF00082 0.585
CLV_PCSK_SKI1_1 842 846 PF00082 0.607
CLV_PCSK_SKI1_1 85 89 PF00082 0.653
DEG_APCC_DBOX_1 84 92 PF00400 0.635
DEG_SPOP_SBC_1 589 593 PF00917 0.650
DEG_SPOP_SBC_1 788 792 PF00917 0.650
DOC_CKS1_1 437 442 PF01111 0.467
DOC_CYCLIN_RxL_1 432 441 PF00134 0.454
DOC_CYCLIN_RxL_1 550 562 PF00134 0.580
DOC_CYCLIN_yClb5_NLxxxL_5 47 56 PF00134 0.342
DOC_CYCLIN_yClb5_NLxxxL_5 675 684 PF00134 0.473
DOC_MAPK_FxFP_2 545 548 PF00069 0.510
DOC_MAPK_gen_1 614 623 PF00069 0.618
DOC_MAPK_gen_1 82 91 PF00069 0.641
DOC_MAPK_gen_1 845 855 PF00069 0.659
DOC_MAPK_RevD_3 682 698 PF00069 0.501
DOC_PP1_RVXF_1 206 213 PF00149 0.478
DOC_PP1_SILK_1 201 206 PF00149 0.467
DOC_PP2B_LxvP_1 602 605 PF13499 0.642
DOC_PP4_FxxP_1 545 548 PF00568 0.465
DOC_PP4_FxxP_1 55 58 PF00568 0.487
DOC_PP4_FxxP_1 939 942 PF00568 0.536
DOC_USP7_MATH_1 155 159 PF00917 0.497
DOC_USP7_MATH_1 22 26 PF00917 0.565
DOC_USP7_MATH_1 315 319 PF00917 0.699
DOC_USP7_MATH_1 572 576 PF00917 0.581
DOC_USP7_MATH_1 589 593 PF00917 0.720
DOC_USP7_MATH_1 605 609 PF00917 0.713
DOC_USP7_MATH_1 616 620 PF00917 0.581
DOC_USP7_MATH_1 640 644 PF00917 0.659
DOC_USP7_MATH_1 70 74 PF00917 0.501
DOC_USP7_MATH_1 705 709 PF00917 0.654
DOC_USP7_MATH_1 718 722 PF00917 0.758
DOC_USP7_MATH_1 731 735 PF00917 0.598
DOC_USP7_MATH_1 762 766 PF00917 0.761
DOC_USP7_MATH_1 788 792 PF00917 0.745
DOC_USP7_UBL2_3 262 266 PF12436 0.577
DOC_USP7_UBL2_3 420 424 PF12436 0.510
DOC_USP7_UBL2_3 842 846 PF12436 0.616
DOC_USP7_UBL2_3 903 907 PF12436 0.621
DOC_USP7_UBL2_3 915 919 PF12436 0.534
DOC_WW_Pin1_4 11 16 PF00397 0.443
DOC_WW_Pin1_4 436 441 PF00397 0.448
DOC_WW_Pin1_4 504 509 PF00397 0.639
DOC_WW_Pin1_4 668 673 PF00397 0.603
DOC_WW_Pin1_4 734 739 PF00397 0.623
DOC_WW_Pin1_4 811 816 PF00397 0.724
DOC_WW_Pin1_4 926 931 PF00397 0.656
LIG_14-3-3_CanoR_1 251 256 PF00244 0.693
LIG_14-3-3_CanoR_1 518 527 PF00244 0.541
LIG_14-3-3_CanoR_1 543 548 PF00244 0.440
LIG_14-3-3_CanoR_1 614 623 PF00244 0.585
LIG_14-3-3_CanoR_1 697 703 PF00244 0.561
LIG_14-3-3_CanoR_1 848 855 PF00244 0.615
LIG_Actin_WH2_2 481 499 PF00022 0.440
LIG_BIR_III_2 470 474 PF00653 0.593
LIG_BIR_III_2 856 860 PF00653 0.670
LIG_CaM_IQ_9 834 850 PF13499 0.636
LIG_FHA_1 151 157 PF00498 0.444
LIG_FHA_1 378 384 PF00498 0.465
LIG_FHA_1 437 443 PF00498 0.567
LIG_FHA_1 44 50 PF00498 0.439
LIG_FHA_1 505 511 PF00498 0.673
LIG_FHA_1 591 597 PF00498 0.704
LIG_FHA_1 616 622 PF00498 0.578
LIG_FHA_1 629 635 PF00498 0.473
LIG_FHA_1 738 744 PF00498 0.669
LIG_FHA_2 213 219 PF00498 0.492
LIG_FHA_2 366 372 PF00498 0.545
LIG_FHA_2 405 411 PF00498 0.485
LIG_FHA_2 511 517 PF00498 0.504
LIG_FHA_2 871 877 PF00498 0.573
LIG_GBD_Chelix_1 190 198 PF00786 0.442
LIG_IBAR_NPY_1 126 128 PF08397 0.496
LIG_IRF3_LxIS_1 163 170 PF10401 0.478
LIG_LIR_Apic_2 542 548 PF02991 0.463
LIG_LIR_Gen_1 165 172 PF02991 0.349
LIG_LIR_Gen_1 34 43 PF02991 0.343
LIG_LIR_Gen_1 384 393 PF02991 0.357
LIG_LIR_Gen_1 5 11 PF02991 0.451
LIG_LIR_LC3C_4 851 855 PF02991 0.632
LIG_LIR_Nem_3 139 145 PF02991 0.364
LIG_LIR_Nem_3 165 169 PF02991 0.337
LIG_LIR_Nem_3 34 38 PF02991 0.341
LIG_LIR_Nem_3 413 418 PF02991 0.384
LIG_LIR_Nem_3 5 9 PF02991 0.433
LIG_PAM2_1 526 538 PF00658 0.439
LIG_PCNA_yPIPBox_3 614 627 PF02747 0.616
LIG_PTB_Apo_2 452 459 PF02174 0.443
LIG_PTB_Apo_2 487 494 PF02174 0.475
LIG_PTB_Phospho_1 487 493 PF10480 0.474
LIG_SH2_CRK 423 427 PF00017 0.559
LIG_SH2_CRK 493 497 PF00017 0.394
LIG_SH2_NCK_1 468 472 PF00017 0.558
LIG_SH2_NCK_1 646 650 PF00017 0.742
LIG_SH2_SRC 468 471 PF00017 0.561
LIG_SH2_SRC 747 750 PF00017 0.614
LIG_SH2_SRC 809 812 PF00017 0.615
LIG_SH2_STAP1 749 753 PF00017 0.513
LIG_SH2_STAT3 109 112 PF00017 0.456
LIG_SH2_STAT5 128 131 PF00017 0.504
LIG_SH2_STAT5 359 362 PF00017 0.526
LIG_SH2_STAT5 418 421 PF00017 0.393
LIG_SH2_STAT5 487 490 PF00017 0.374
LIG_SH2_STAT5 498 501 PF00017 0.338
LIG_SH2_STAT5 646 649 PF00017 0.624
LIG_SH2_STAT5 683 686 PF00017 0.488
LIG_SH2_STAT5 747 750 PF00017 0.614
LIG_SH3_3 394 400 PF00018 0.525
LIG_SH3_3 470 476 PF00018 0.642
LIG_SH3_3 812 818 PF00018 0.596
LIG_SxIP_EBH_1 773 783 PF03271 0.644
LIG_TRAF2_1 223 226 PF00917 0.589
LIG_TRAF2_1 269 272 PF00917 0.717
LIG_TRAF2_1 476 479 PF00917 0.503
LIG_WRC_WIRS_1 163 168 PF05994 0.386
LIG_WRC_WIRS_1 748 753 PF05994 0.584
MOD_CDK_SPK_2 811 816 PF00069 0.708
MOD_CDK_SPK_2 926 931 PF00069 0.652
MOD_CDK_SPxxK_3 504 511 PF00069 0.577
MOD_CK1_1 13 19 PF00069 0.569
MOD_CK1_1 158 164 PF00069 0.516
MOD_CK1_1 170 176 PF00069 0.368
MOD_CK1_1 189 195 PF00069 0.452
MOD_CK1_1 254 260 PF00069 0.685
MOD_CK1_1 375 381 PF00069 0.415
MOD_CK1_1 441 447 PF00069 0.550
MOD_CK1_1 483 489 PF00069 0.503
MOD_CK1_1 590 596 PF00069 0.725
MOD_CK1_1 619 625 PF00069 0.542
MOD_CK1_1 671 677 PF00069 0.590
MOD_CK1_1 717 723 PF00069 0.714
MOD_CK1_1 734 740 PF00069 0.796
MOD_CK1_1 769 775 PF00069 0.693
MOD_CK1_1 786 792 PF00069 0.742
MOD_CK2_1 221 227 PF00069 0.573
MOD_CK2_1 23 29 PF00069 0.638
MOD_CK2_1 266 272 PF00069 0.694
MOD_CK2_1 344 350 PF00069 0.712
MOD_CK2_1 365 371 PF00069 0.571
MOD_CK2_1 573 579 PF00069 0.623
MOD_CK2_1 589 595 PF00069 0.568
MOD_CK2_1 655 661 PF00069 0.565
MOD_CK2_1 787 793 PF00069 0.708
MOD_Cter_Amidation 859 862 PF01082 0.716
MOD_Cter_Amidation 905 908 PF01082 0.591
MOD_GlcNHglycan 131 134 PF01048 0.383
MOD_GlcNHglycan 15 18 PF01048 0.560
MOD_GlcNHglycan 157 160 PF01048 0.488
MOD_GlcNHglycan 362 366 PF01048 0.637
MOD_GlcNHglycan 410 413 PF01048 0.481
MOD_GlcNHglycan 482 485 PF01048 0.556
MOD_GlcNHglycan 530 533 PF01048 0.491
MOD_GlcNHglycan 561 564 PF01048 0.494
MOD_GlcNHglycan 565 568 PF01048 0.552
MOD_GlcNHglycan 631 634 PF01048 0.579
MOD_GlcNHglycan 638 641 PF01048 0.623
MOD_GlcNHglycan 64 67 PF01048 0.458
MOD_GlcNHglycan 642 645 PF01048 0.729
MOD_GlcNHglycan 652 655 PF01048 0.624
MOD_GlcNHglycan 716 719 PF01048 0.675
MOD_GlcNHglycan 720 723 PF01048 0.657
MOD_GlcNHglycan 726 729 PF01048 0.647
MOD_GlcNHglycan 76 80 PF01048 0.629
MOD_GlcNHglycan 774 777 PF01048 0.787
MOD_GlcNHglycan 793 797 PF01048 0.606
MOD_GlcNHglycan 850 853 PF01048 0.624
MOD_GlcNHglycan 863 866 PF01048 0.697
MOD_GSK3_1 158 165 PF00069 0.443
MOD_GSK3_1 254 261 PF00069 0.691
MOD_GSK3_1 273 280 PF00069 0.680
MOD_GSK3_1 281 288 PF00069 0.600
MOD_GSK3_1 328 335 PF00069 0.775
MOD_GSK3_1 361 368 PF00069 0.617
MOD_GSK3_1 373 380 PF00069 0.426
MOD_GSK3_1 404 411 PF00069 0.670
MOD_GSK3_1 444 451 PF00069 0.491
MOD_GSK3_1 479 486 PF00069 0.540
MOD_GSK3_1 506 513 PF00069 0.578
MOD_GSK3_1 514 521 PF00069 0.510
MOD_GSK3_1 539 546 PF00069 0.357
MOD_GSK3_1 559 566 PF00069 0.518
MOD_GSK3_1 587 594 PF00069 0.696
MOD_GSK3_1 615 622 PF00069 0.573
MOD_GSK3_1 636 643 PF00069 0.648
MOD_GSK3_1 714 721 PF00069 0.667
MOD_GSK3_1 734 741 PF00069 0.695
MOD_GSK3_1 762 769 PF00069 0.654
MOD_GSK3_1 783 790 PF00069 0.783
MOD_GSK3_1 805 812 PF00069 0.643
MOD_GSK3_1 891 898 PF00069 0.748
MOD_GSK3_1 941 948 PF00069 0.558
MOD_N-GLC_1 424 429 PF02516 0.533
MOD_N-GLC_1 572 577 PF02516 0.678
MOD_N-GLC_1 619 624 PF02516 0.603
MOD_N-GLC_1 628 633 PF02516 0.481
MOD_N-GLC_1 895 900 PF02516 0.775
MOD_NEK2_1 212 217 PF00069 0.482
MOD_NEK2_1 305 310 PF00069 0.608
MOD_NEK2_1 372 377 PF00069 0.437
MOD_NEK2_1 458 463 PF00069 0.399
MOD_NEK2_1 510 515 PF00069 0.568
MOD_NEK2_1 520 525 PF00069 0.469
MOD_PIKK_1 70 76 PF00454 0.479
MOD_PIKK_1 762 768 PF00454 0.650
MOD_PIKK_1 809 815 PF00454 0.540
MOD_PKA_1 861 867 PF00069 0.756
MOD_PKA_2 448 454 PF00069 0.454
MOD_PKA_2 616 622 PF00069 0.627
MOD_PKB_1 75 83 PF00069 0.515
MOD_Plk_1 273 279 PF00069 0.714
MOD_Plk_1 619 625 PF00069 0.600
MOD_Plk_1 846 852 PF00069 0.557
MOD_Plk_4 158 164 PF00069 0.517
MOD_Plk_4 199 205 PF00069 0.401
MOD_Plk_4 398 404 PF00069 0.539
MOD_Plk_4 448 454 PF00069 0.415
MOD_Plk_4 458 464 PF00069 0.366
MOD_Plk_4 510 516 PF00069 0.512
MOD_Plk_4 683 689 PF00069 0.452
MOD_ProDKin_1 11 17 PF00069 0.437
MOD_ProDKin_1 436 442 PF00069 0.463
MOD_ProDKin_1 504 510 PF00069 0.641
MOD_ProDKin_1 668 674 PF00069 0.604
MOD_ProDKin_1 734 740 PF00069 0.620
MOD_ProDKin_1 811 817 PF00069 0.722
MOD_ProDKin_1 926 932 PF00069 0.658
MOD_SUMO_for_1 553 556 PF00179 0.591
MOD_SUMO_for_1 710 713 PF00179 0.522
MOD_SUMO_for_1 844 847 PF00179 0.592
MOD_SUMO_rev_2 139 145 PF00179 0.368
MOD_SUMO_rev_2 321 331 PF00179 0.698
MOD_SUMO_rev_2 350 360 PF00179 0.694
MOD_SUMO_rev_2 478 483 PF00179 0.552
TRG_DiLeu_BaEn_1 369 374 PF01217 0.551
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.578
TRG_ENDOCYTIC_2 142 145 PF00928 0.339
TRG_ENDOCYTIC_2 423 426 PF00928 0.469
TRG_ENDOCYTIC_2 493 496 PF00928 0.368
TRG_ER_diArg_1 296 299 PF00400 0.671
TRG_ER_diArg_1 696 698 PF00400 0.469
TRG_ER_diArg_1 753 755 PF00400 0.548
TRG_ER_diArg_1 824 826 PF00400 0.500
TRG_NLS_Bipartite_1 845 865 PF00514 0.637
TRG_NLS_Bipartite_1 888 907 PF00514 0.703
TRG_NLS_MonoCore_2 901 906 PF00514 0.749
TRG_NLS_MonoExtC_3 902 907 PF00514 0.707
TRG_NLS_MonoExtN_4 859 865 PF00514 0.669
TRG_NLS_MonoExtN_4 900 907 PF00514 0.693
TRG_Pf-PMV_PEXEL_1 518 522 PF00026 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4W5 Leptomonas seymouri 60% 98%
A0A0S4JFW1 Bodo saltans 33% 100%
A0A1X0P867 Trypanosomatidae 38% 100%
A0A3S5H820 Leishmania donovani 99% 100%
A4HP10 Leishmania braziliensis 69% 98%
D0A2Z0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9ASS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q1S6 Leishmania major 89% 100%
V5BU47 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS