LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative translation elongation factor 1-beta

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative translation elongation factor 1-beta
Gene product:
translation elongation factor 1-beta - putative
Species:
Leishmania infantum
UniProt:
A4IDB2_LEIIN
TriTrypDb:
LINF_360020500
Length:
211

Annotations

Annotations by Jardim et al.

Translation, translation elongation factor 1-beta

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 22
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005853 eukaryotic translation elongation factor 1 complex 2 21
GO:0032991 protein-containing complex 1 21
GO:0005829 cytosol 2 2
GO:0110165 cellular anatomical entity 1 2
GO:0005737 cytoplasm 2 1

Phosphorylation

Amastigote: 18, 21, 24

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDB2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDB2

Function

Biological processes
Term Name Level Count
GO:0006414 translational elongation 5 2
GO:0008152 metabolic process 1 2
GO:0009058 biosynthetic process 2 2
GO:0009059 macromolecule biosynthetic process 4 2
GO:0009987 cellular process 1 2
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0044237 cellular metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:1901576 organic substance biosynthetic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 21
GO:0003746 translation elongation factor activity 4 21
GO:0005488 binding 1 21
GO:0008135 translation factor activity, RNA binding 3 21
GO:0045182 translation regulator activity 1 21
GO:0090079 translation regulator activity, nucleic acid binding 2 21
GO:0097159 organic cyclic compound binding 2 21
GO:1901363 heterocyclic compound binding 2 21
GO:0005085 guanyl-nucleotide exchange factor activity 3 2
GO:0030234 enzyme regulator activity 2 2
GO:0030695 GTPase regulator activity 4 2
GO:0060589 nucleoside-triphosphatase regulator activity 3 2
GO:0098772 molecular function regulator activity 1 2
GO:0140677 molecular function activator activity 2 2
GO:0140678 molecular function inhibitor activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 102 106 PF00082 0.515
CLV_PCSK_SKI1_1 108 112 PF00082 0.547
CLV_PCSK_SKI1_1 116 120 PF00082 0.480
CLV_PCSK_SKI1_1 65 69 PF00082 0.612
DOC_MAPK_gen_1 171 179 PF00069 0.270
DOC_USP7_MATH_1 124 128 PF00917 0.341
DOC_USP7_MATH_1 15 19 PF00917 0.340
DOC_USP7_MATH_1 67 71 PF00917 0.504
DOC_USP7_UBL2_3 111 115 PF12436 0.505
DOC_WW_Pin1_4 18 23 PF00397 0.405
LIG_14-3-3_CanoR_1 46 51 PF00244 0.413
LIG_APCC_ABBA_1 91 96 PF00400 0.509
LIG_BIR_II_1 1 5 PF00653 0.435
LIG_BRCT_BRCA1_1 126 130 PF00533 0.282
LIG_CaM_IQ_9 38 54 PF13499 0.338
LIG_Clathr_ClatBox_1 176 180 PF01394 0.270
LIG_FHA_1 118 124 PF00498 0.483
LIG_FHA_1 136 142 PF00498 0.259
LIG_FHA_2 1 7 PF00498 0.462
LIG_FHA_2 95 101 PF00498 0.497
LIG_Integrin_isoDGR_2 8 10 PF01839 0.367
LIG_PCNA_yPIPBox_3 37 46 PF02747 0.362
LIG_Pex14_2 16 20 PF04695 0.423
LIG_Pex14_2 30 34 PF04695 0.271
LIG_PTB_Apo_2 28 35 PF02174 0.278
LIG_SUMO_SIM_par_1 136 142 PF11976 0.271
LIG_SUMO_SIM_par_1 175 182 PF11976 0.270
LIG_TRAF2_1 84 87 PF00917 0.602
LIG_TRAF2_1 97 100 PF00917 0.445
LIG_UBA3_1 128 133 PF00899 0.368
LIG_UBA3_1 176 183 PF00899 0.266
MOD_CK1_1 18 24 PF00069 0.411
MOD_CK2_1 94 100 PF00069 0.514
MOD_GlcNHglycan 17 20 PF01048 0.398
MOD_GlcNHglycan 184 187 PF01048 0.282
MOD_GlcNHglycan 69 72 PF01048 0.654
MOD_NEK2_1 33 38 PF00069 0.310
MOD_PKA_1 65 71 PF00069 0.443
MOD_Plk_1 135 141 PF00069 0.275
MOD_Plk_2-3 199 205 PF00069 0.282
MOD_Plk_4 124 130 PF00069 0.270
MOD_Plk_4 46 52 PF00069 0.435
MOD_ProDKin_1 18 24 PF00069 0.407
MOD_SUMO_rev_2 112 118 PF00179 0.497
MOD_SUMO_rev_2 126 134 PF00179 0.236
MOD_SUMO_rev_2 154 164 PF00179 0.279
MOD_SUMO_rev_2 180 185 PF00179 0.270
MOD_SUMO_rev_2 96 104 PF00179 0.563
TRG_DiLeu_BaEn_4 100 106 PF01217 0.495
TRG_NLS_MonoExtC_3 115 121 PF00514 0.517
TRG_NLS_MonoExtN_4 115 120 PF00514 0.599

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4W7 Leptomonas seymouri 82% 100%
A0A0N1HZF7 Leptomonas seymouri 61% 89%
A0A0S4JC29 Bodo saltans 70% 100%
A0A0S4JK70 Bodo saltans 54% 86%
A0A1X0P9D3 Trypanosomatidae 75% 100%
A0A1X0PA37 Trypanosomatidae 62% 92%
A0A3Q8IVV7 Leishmania donovani 99% 100%
A0A3R7MFZ8 Trypanosoma rangeli 69% 100%
A0A3S5H7W1 Leishmania donovani 64% 88%
A0A422N8N9 Trypanosoma rangeli 61% 93%
A4HAJ1 Leishmania braziliensis 64% 100%
A4HAJ3 Leishmania braziliensis 64% 100%
A4HAJ7 Leishmania braziliensis 61% 100%
A4HP03 Leishmania braziliensis 86% 99%
A4I9P1 Leishmania infantum 67% 100%
D0A2X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9ASR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
E9B4Q3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
O70251 Mus musculus 38% 94%
O74173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 99%
O81918 Beta vulgaris 36% 91%
O96827 Drosophila melanogaster 42% 95%
P12262 Artemia salina 37% 100%
P24534 Homo sapiens 38% 94%
P29522 Bombyx mori 41% 95%
P29693 Xenopus laevis 47% 80%
P30151 Xenopus laevis 40% 93%
P32192 Artemia salina 56% 89%
P34460 Caenorhabditis elegans 41% 99%
P34826 Oryctolagus cuniculus 38% 94%
P34827 Trypanosoma cruzi 62% 95%
P48006 Arabidopsis thaliana 39% 91%
P57776 Mus musculus 48% 75%
P78590 Candida albicans (strain WO-1) 33% 99%
P93447 Spuriopimpinella brachycarpa 37% 93%
Q40680 Oryza sativa subsp. japonica 35% 92%
Q40682 Oryza sativa subsp. japonica 37% 93%
Q4Q3C1 Leishmania major 69% 100%
Q5E983 Bos taurus 38% 94%
Q66NE2 Leishmania major 98% 100%
Q68FR9 Rattus norvegicus 49% 75%
Q69BZ7 Penicillium citrinum 33% 93%
Q6DET9 Xenopus tropicalis 37% 93%
Q84WM9 Arabidopsis thaliana 34% 93%
Q9GRF8 Dictyostelium discoideum 42% 98%
Q9SI20 Arabidopsis thaliana 38% 91%
Q9YGQ1 Gallus gallus 39% 94%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS