14-3-3 protein-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

14-3-3 protein 1 - putative

Species:

Leishmania infantum

UniProt:

A4IDA9_LEIIN

TriTrypDb:

LINF_360040400

Length:

258

Annotations

Annotations by Jardim et al.

Cell Cycle, 14-3-3 -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 1
Forrest at al. (metacyclic)	yes	yes: 1
Forrest at al. (procyclic)	yes	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDA9

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010639	negative regulation of organelle organization	6	1
GO:0010948	negative regulation of cell cycle process	6	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.421
CLV_NRD_NRD_1	111	113	PF00675	0.323
CLV_NRD_NRD_1	52	54	PF00675	0.322
CLV_NRD_NRD_1	81	83	PF00675	0.309
CLV_PCSK_KEX2_1	111	113	PF00082	0.349
CLV_PCSK_KEX2_1	81	83	PF00082	0.309
CLV_PCSK_SKI1_1	67	71	PF00082	0.391
CLV_PCSK_SKI1_1	8	12	PF00082	0.602
CLV_PCSK_SKI1_1	86	90	PF00082	0.337
DEG_APCC_KENBOX_2	97	101	PF00400	0.425

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P443	Leptomonas seymouri	51%	100%
A0A0N1IJ96	Leptomonas seymouri	95%	100%
A0A0S4IUJ3	Bodo saltans	57%	93%
A0A0S4JJB7	Bodo saltans	72%	99%
A0A1X0NVF8	Trypanosomatidae	53%	100%
A0A1X0P3Q3	Trypanosomatidae	80%	98%
A0A3R7KVM5	Trypanosoma rangeli	52%	100%
A0A3S7WRH0	Leishmania donovani	52%	100%
A0A3S7XB66	Leishmania donovani	100%	100%
A0A422NKL2	Trypanosoma rangeli	78%	98%

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