LeishMANIAdb
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Nucleic acid binding protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleic acid binding protein
Gene product:
nucleic acid binding protein - putative
Species:
Leishmania infantum
UniProt:
A4IDA7_LEIIN
TriTrypDb:
LINF_360040200
Length:
566

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDA7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDA7

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0034250 positive regulation of amide metabolic process 6 1
GO:0045727 positive regulation of translation 7 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
GO:2000765 regulation of cytoplasmic translation 7 1
GO:2000767 positive regulation of cytoplasmic translation 8 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0005488 binding 1 11
GO:0008270 zinc ion binding 6 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003723 RNA binding 4 1
GO:0003727 single-stranded RNA binding 5 1
GO:0003729 mRNA binding 5 1
GO:0045182 translation regulator activity 1 1
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004540 RNA nuclease activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 350 352 PF00675 0.581
CLV_NRD_NRD_1 415 417 PF00675 0.434
CLV_NRD_NRD_1 502 504 PF00675 0.454
CLV_NRD_NRD_1 55 57 PF00675 0.355
CLV_NRD_NRD_1 73 75 PF00675 0.419
CLV_PCSK_KEX2_1 329 331 PF00082 0.544
CLV_PCSK_KEX2_1 350 352 PF00082 0.568
CLV_PCSK_KEX2_1 417 419 PF00082 0.466
CLV_PCSK_KEX2_1 442 444 PF00082 0.542
CLV_PCSK_KEX2_1 502 504 PF00082 0.454
CLV_PCSK_KEX2_1 55 57 PF00082 0.342
CLV_PCSK_KEX2_1 67 69 PF00082 0.321
CLV_PCSK_KEX2_1 73 75 PF00082 0.368
CLV_PCSK_KEX2_1 82 84 PF00082 0.541
CLV_PCSK_PC1ET2_1 329 331 PF00082 0.531
CLV_PCSK_PC1ET2_1 417 419 PF00082 0.466
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.542
CLV_PCSK_PC1ET2_1 67 69 PF00082 0.454
CLV_PCSK_PC1ET2_1 82 84 PF00082 0.585
CLV_PCSK_PC7_1 51 57 PF00082 0.493
CLV_PCSK_SKI1_1 360 364 PF00082 0.518
CLV_PCSK_SKI1_1 418 422 PF00082 0.443
CLV_PCSK_SKI1_1 445 449 PF00082 0.582
CLV_PCSK_SKI1_1 539 543 PF00082 0.552
DOC_CYCLIN_RxL_1 536 546 PF00134 0.556
DOC_CYCLIN_yClb5_NLxxxL_5 62 69 PF00134 0.480
DOC_MAPK_gen_1 329 338 PF00069 0.440
DOC_MAPK_MEF2A_6 329 338 PF00069 0.459
DOC_PP1_RVXF_1 550 557 PF00149 0.566
DOC_USP7_MATH_1 179 183 PF00917 0.589
DOC_USP7_MATH_1 284 288 PF00917 0.750
DOC_USP7_MATH_1 293 297 PF00917 0.730
DOC_USP7_MATH_1 311 315 PF00917 0.643
DOC_USP7_MATH_2 276 282 PF00917 0.647
DOC_WW_Pin1_4 289 294 PF00397 0.732
LIG_14-3-3_CanoR_1 102 106 PF00244 0.315
LIG_14-3-3_CanoR_1 174 180 PF00244 0.442
LIG_14-3-3_CanoR_1 271 276 PF00244 0.811
LIG_14-3-3_CanoR_1 310 320 PF00244 0.655
LIG_14-3-3_CanoR_1 350 356 PF00244 0.590
LIG_14-3-3_CanoR_1 360 368 PF00244 0.430
LIG_14-3-3_CanoR_1 445 452 PF00244 0.627
LIG_14-3-3_CanoR_1 544 554 PF00244 0.603
LIG_14-3-3_CanoR_1 83 88 PF00244 0.762
LIG_APCC_ABBA_1 470 475 PF00400 0.499
LIG_BRCT_BRCA1_1 558 562 PF00533 0.590
LIG_Clathr_ClatBox_1 9 13 PF01394 0.793
LIG_FHA_1 231 237 PF00498 0.526
LIG_FHA_1 361 367 PF00498 0.457
LIG_FHA_1 392 398 PF00498 0.376
LIG_FHA_1 465 471 PF00498 0.393
LIG_FHA_1 532 538 PF00498 0.624
LIG_FHA_1 556 562 PF00498 0.540
LIG_FHA_2 290 296 PF00498 0.730
LIG_FHA_2 457 463 PF00498 0.430
LIG_GBD_Chelix_1 433 441 PF00786 0.442
LIG_LIR_Gen_1 390 401 PF02991 0.519
LIG_LIR_Nem_3 390 396 PF02991 0.475
LIG_LIR_Nem_3 490 495 PF02991 0.430
LIG_LIR_Nem_3 559 565 PF02991 0.634
LIG_LYPXL_S_1 491 495 PF13949 0.400
LIG_LYPXL_yS_3 492 495 PF13949 0.404
LIG_MYND_1 7 11 PF01753 0.786
LIG_PCNA_PIPBox_1 530 539 PF02747 0.621
LIG_PCNA_yPIPBox_3 525 537 PF02747 0.638
LIG_Pex14_2 382 386 PF04695 0.469
LIG_SH2_CRK 258 262 PF00017 0.731
LIG_SH2_PTP2 322 325 PF00017 0.654
LIG_SH2_STAP1 368 372 PF00017 0.475
LIG_SH2_STAT3 527 530 PF00017 0.661
LIG_SH2_STAT5 322 325 PF00017 0.621
LIG_SH2_STAT5 342 345 PF00017 0.235
LIG_SH2_STAT5 368 371 PF00017 0.424
LIG_SH2_STAT5 372 375 PF00017 0.398
LIG_SH2_STAT5 419 422 PF00017 0.533
LIG_SH2_STAT5 497 500 PF00017 0.448
LIG_SH3_3 314 320 PF00018 0.664
LIG_TRAF2_1 11 14 PF00917 0.794
LIG_TRAF2_1 91 94 PF00917 0.675
LIG_TYR_ITIM 121 126 PF00017 0.605
MOD_CDK_SPK_2 289 294 PF00069 0.608
MOD_CK1_1 27 33 PF00069 0.767
MOD_CK1_1 274 280 PF00069 0.745
MOD_CK1_1 287 293 PF00069 0.589
MOD_CK1_1 36 42 PF00069 0.704
MOD_CK1_1 426 432 PF00069 0.539
MOD_CK2_1 338 344 PF00069 0.505
MOD_CK2_1 543 549 PF00069 0.551
MOD_GlcNHglycan 170 173 PF01048 0.553
MOD_GlcNHglycan 26 29 PF01048 0.768
MOD_GlcNHglycan 269 274 PF01048 0.698
MOD_GlcNHglycan 280 283 PF01048 0.566
MOD_GlcNHglycan 289 292 PF01048 0.638
MOD_GlcNHglycan 425 428 PF01048 0.552
MOD_GSK3_1 137 144 PF00069 0.432
MOD_GSK3_1 148 155 PF00069 0.414
MOD_GSK3_1 168 175 PF00069 0.487
MOD_GSK3_1 24 31 PF00069 0.792
MOD_GSK3_1 265 272 PF00069 0.754
MOD_GSK3_1 274 281 PF00069 0.596
MOD_GSK3_1 289 296 PF00069 0.602
MOD_GSK3_1 32 39 PF00069 0.698
MOD_GSK3_1 387 394 PF00069 0.415
MOD_GSK3_1 497 504 PF00069 0.529
MOD_GSK3_1 517 524 PF00069 0.342
MOD_LATS_1 228 234 PF00433 0.567
MOD_N-GLC_1 287 292 PF02516 0.690
MOD_N-GLC_1 32 37 PF02516 0.715
MOD_N-GLC_1 351 356 PF02516 0.622
MOD_N-GLC_2 225 227 PF02516 0.486
MOD_N-GLC_2 64 66 PF02516 0.442
MOD_NEK2_1 137 142 PF00069 0.488
MOD_NEK2_1 152 157 PF00069 0.389
MOD_NEK2_1 166 171 PF00069 0.392
MOD_NEK2_1 501 506 PF00069 0.528
MOD_NEK2_2 497 502 PF00069 0.574
MOD_PIKK_1 153 159 PF00454 0.406
MOD_PIKK_1 16 22 PF00454 0.788
MOD_PIKK_1 28 34 PF00454 0.763
MOD_PK_1 83 89 PF00069 0.686
MOD_PKA_1 502 508 PF00069 0.584
MOD_PKA_2 101 107 PF00069 0.622
MOD_PKA_2 173 179 PF00069 0.421
MOD_PKA_2 265 271 PF00069 0.776
MOD_PKA_2 293 299 PF00069 0.706
MOD_PKA_2 501 507 PF00069 0.471
MOD_PKA_2 543 549 PF00069 0.594
MOD_PKB_1 416 424 PF00069 0.555
MOD_PKB_1 443 451 PF00069 0.620
MOD_Plk_1 397 403 PF00069 0.441
MOD_Plk_1 411 417 PF00069 0.397
MOD_Plk_2-3 265 271 PF00069 0.710
MOD_Plk_4 338 344 PF00069 0.505
MOD_Plk_4 39 45 PF00069 0.573
MOD_ProDKin_1 289 295 PF00069 0.732
TRG_DiLeu_BaLyEn_6 536 541 PF01217 0.642
TRG_ENDOCYTIC_2 123 126 PF00928 0.589
TRG_ENDOCYTIC_2 322 325 PF00928 0.654
TRG_ENDOCYTIC_2 359 362 PF00928 0.501
TRG_ENDOCYTIC_2 492 495 PF00928 0.458
TRG_ER_diArg_1 307 310 PF00400 0.697
TRG_ER_diArg_1 349 351 PF00400 0.699
TRG_ER_diArg_1 415 418 PF00400 0.453
TRG_ER_diArg_1 501 503 PF00400 0.524
TRG_ER_diArg_1 54 56 PF00400 0.346
TRG_ER_diArg_1 72 74 PF00400 0.445
TRG_NLS_Bipartite_1 67 86 PF00514 0.443
TRG_Pf-PMV_PEXEL_1 360 364 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 418 422 PF00026 0.446
TRG_Pf-PMV_PEXEL_1 539 543 PF00026 0.552

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIN4 Leptomonas seymouri 75% 100%
A0A1X0P496 Trypanosomatidae 54% 100%
A0A3Q8IKH2 Leishmania donovani 100% 100%
A0A3R7MHM2 Trypanosoma rangeli 53% 100%
A4HPI5 Leishmania braziliensis 86% 100%
D0A8E8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AT97 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q1A0 Leishmania major 96% 100%
V5DA56 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS