Putative ADP-ribosylation factor GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein - putative

Species:

Leishmania infantum

UniProt:

A4IDA3_LEIIN

TriTrypDb:

LINF_360039700

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDA3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.513
CLV_NRD_NRD_1	15	17	PF00675	0.411
CLV_NRD_NRD_1	5	7	PF00675	0.550
CLV_PCSK_KEX2_1	117	119	PF00082	0.513
CLV_PCSK_SKI1_1	111	115	PF00082	0.416
CLV_PCSK_SKI1_1	117	121	PF00082	0.515
CLV_PCSK_SKI1_1	12	16	PF00082	0.478
CLV_PCSK_SKI1_1	62	66	PF00082	0.513
CLV_PCSK_SKI1_1	84	88	PF00082	0.323
CLV_Separin_Metazoa	13	17	PF03568	0.436
DEG_Nend_UBRbox_3	1	3	PF02207	0.598
DEG_SPOP_SBC_1	193	197	PF00917	0.637
DOC_CKS1_1	304	309	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.599
DOC_MAPK_MEF2A_6	107	114	PF00069	0.436
DOC_PP1_RVXF_1	109	115	PF00149	0.338
DOC_PP2B_LxvP_1	215	218	PF13499	0.607
DOC_PP4_FxxP_1	330	333	PF00568	0.620
DOC_SPAK_OSR1_1	76	80	PF12202	0.513
DOC_USP7_MATH_1	151	155	PF00917	0.663
DOC_USP7_MATH_1	280	284	PF00917	0.724
DOC_USP7_MATH_1	331	335	PF00917	0.614
DOC_USP7_MATH_1	401	405	PF00917	0.602
DOC_USP7_MATH_1	417	421	PF00917	0.539
DOC_WW_Pin1_4	195	200	PF00397	0.795
DOC_WW_Pin1_4	303	308	PF00397	0.587
DOC_WW_Pin1_4	413	418	PF00397	0.691
LIG_14-3-3_CanoR_1	4	14	PF00244	0.506
LIG_14-3-3_CanoR_1	76	80	PF00244	0.436
LIG_BRCT_BRCA1_1	388	392	PF00533	0.680
LIG_FHA_1	228	234	PF00498	0.776
LIG_FHA_2	63	69	PF00498	0.472
LIG_IBAR_NPY_1	339	341	PF08397	0.625
LIG_LIR_Apic_2	327	333	PF02991	0.613
LIG_LIR_Apic_2	352	356	PF02991	0.709
LIG_LIR_Gen_1	182	193	PF02991	0.785
LIG_LIR_Nem_3	182	188	PF02991	0.678
LIG_LIR_Nem_3	235	240	PF02991	0.723
LIG_LIR_Nem_3	40	45	PF02991	0.513
LIG_Pex14_1	89	93	PF04695	0.411
LIG_Pex14_2	185	189	PF04695	0.679
LIG_PTAP_UEV_1	332	337	PF05743	0.575
LIG_SH2_CRK	251	255	PF00017	0.798
LIG_SH2_CRK	381	385	PF00017	0.746
LIG_SH2_NCK_1	381	385	PF00017	0.746
LIG_SH2_STAT3	297	300	PF00017	0.726
LIG_SH2_STAT3	341	344	PF00017	0.701
LIG_SH2_STAT5	37	40	PF00017	0.411
LIG_SH3_1	381	387	PF00018	0.571
LIG_SH3_2	173	178	PF14604	0.744
LIG_SH3_3	145	151	PF00018	0.745
LIG_SH3_3	157	163	PF00018	0.500
LIG_SH3_3	167	173	PF00018	0.632
LIG_SH3_3	205	211	PF00018	0.663
LIG_SH3_3	215	221	PF00018	0.633
LIG_SH3_3	237	243	PF00018	0.685
LIG_SH3_3	312	318	PF00018	0.600
LIG_SH3_3	330	336	PF00018	0.605
LIG_SH3_3	381	387	PF00018	0.595
LIG_SH3_3	419	425	PF00018	0.725
LIG_SH3_3	456	462	PF00018	0.685
LIG_SUMO_SIM_par_1	144	149	PF11976	0.626
LIG_SUMO_SIM_par_1	445	450	PF11976	0.733
LIG_SxIP_EBH_1	433	445	PF03271	0.577
LIG_TRAF2_1	179	182	PF00917	0.767
LIG_TRAF2_1	424	427	PF00917	0.762
LIG_TRFH_1	413	417	PF08558	0.551
LIG_WRC_WIRS_1	90	95	PF05994	0.513
MOD_CK1_1	155	161	PF00069	0.690
MOD_CK1_1	171	177	PF00069	0.725
MOD_CK1_1	187	193	PF00069	0.596
MOD_CK1_1	195	201	PF00069	0.590
MOD_CK1_1	266	272	PF00069	0.596
MOD_CK1_1	374	380	PF00069	0.655
MOD_CK1_1	432	438	PF00069	0.613
MOD_CK1_1	48	54	PF00069	0.459
MOD_CK1_1	67	73	PF00069	0.513
MOD_CK2_1	155	161	PF00069	0.690
MOD_CK2_1	62	68	PF00069	0.411
MOD_GlcNHglycan	124	128	PF01048	0.590
MOD_GlcNHglycan	170	173	PF01048	0.715
MOD_GlcNHglycan	189	192	PF01048	0.717
MOD_GlcNHglycan	251	254	PF01048	0.788
MOD_GlcNHglycan	310	313	PF01048	0.597
MOD_GlcNHglycan	333	336	PF01048	0.611
MOD_GlcNHglycan	374	377	PF01048	0.734
MOD_GlcNHglycan	393	396	PF01048	0.474
MOD_GlcNHglycan	403	406	PF01048	0.692
MOD_GlcNHglycan	47	50	PF01048	0.410
MOD_GlcNHglycan	99	102	PF01048	0.323
MOD_GSK3_1	151	158	PF00069	0.740
MOD_GSK3_1	189	196	PF00069	0.677
MOD_GSK3_1	285	292	PF00069	0.743
MOD_GSK3_1	319	326	PF00069	0.550
MOD_GSK3_1	397	404	PF00069	0.713
MOD_GSK3_1	413	420	PF00069	0.680
MOD_GSK3_1	431	438	PF00069	0.512
MOD_N-GLC_1	23	28	PF02516	0.377
MOD_N-GLC_1	274	279	PF02516	0.795
MOD_N-GLC_1	435	440	PF02516	0.583
MOD_NEK2_1	146	151	PF00069	0.793
MOD_NEK2_1	189	194	PF00069	0.578
MOD_NEK2_1	290	295	PF00069	0.812
MOD_NEK2_1	371	376	PF00069	0.734
MOD_NEK2_1	449	454	PF00069	0.746
MOD_NEK2_1	45	50	PF00069	0.387
MOD_NEK2_2	211	216	PF00069	0.603
MOD_NEK2_2	23	28	PF00069	0.377
MOD_NEK2_2	89	94	PF00069	0.474
MOD_PIKK_1	137	143	PF00454	0.759
MOD_PIKK_1	16	22	PF00454	0.513
MOD_PIKK_1	274	280	PF00454	0.747
MOD_PIKK_1	285	291	PF00454	0.636
MOD_PIKK_1	319	325	PF00454	0.588
MOD_PIKK_1	356	362	PF00454	0.552
MOD_PKA_1	16	22	PF00069	0.411
MOD_PKA_2	5	11	PF00069	0.612
MOD_PKA_2	75	81	PF00069	0.436
MOD_Plk_1	123	129	PF00069	0.622
MOD_Plk_1	152	158	PF00069	0.622
MOD_Plk_1	23	29	PF00069	0.377
MOD_Plk_1	435	441	PF00069	0.579
MOD_Plk_4	184	190	PF00069	0.565
MOD_Plk_4	228	234	PF00069	0.776
MOD_Plk_4	280	286	PF00069	0.662
MOD_ProDKin_1	195	201	PF00069	0.796
MOD_ProDKin_1	303	309	PF00069	0.583
MOD_ProDKin_1	413	419	PF00069	0.690
TRG_DiLeu_BaEn_2	114	120	PF01217	0.299
TRG_DiLeu_BaEn_4	115	121	PF01217	0.299
TRG_ER_diArg_1	117	119	PF00400	0.436
TRG_ER_diArg_1	3	6	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3S6	Trypanosomatidae	39%	100%
A0A3S7XB38	Leishmania donovani	99%	100%
A4HPI1	Leishmania braziliensis	70%	100%
E9AT93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1A4	Leishmania major	76%	89%