LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDA0_LEIIN
TriTrypDb:
LINF_360039400
Length:
568

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0031514 motile cilium 5 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A4IDA0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDA0

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044782 cilium organization 5 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 4
GO:0005509 calcium ion binding 5 4
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.405
CLV_NRD_NRD_1 349 351 PF00675 0.495
CLV_NRD_NRD_1 357 359 PF00675 0.432
CLV_NRD_NRD_1 543 545 PF00675 0.549
CLV_PCSK_FUR_1 347 351 PF00082 0.467
CLV_PCSK_KEX2_1 349 351 PF00082 0.461
CLV_PCSK_KEX2_1 548 550 PF00082 0.472
CLV_PCSK_PC1ET2_1 548 550 PF00082 0.554
CLV_PCSK_PC7_1 544 550 PF00082 0.436
CLV_PCSK_SKI1_1 16 20 PF00082 0.342
CLV_PCSK_SKI1_1 240 244 PF00082 0.383
CLV_PCSK_SKI1_1 349 353 PF00082 0.475
CLV_PCSK_SKI1_1 50 54 PF00082 0.518
CLV_PCSK_SKI1_1 517 521 PF00082 0.398
CLV_PCSK_SKI1_1 545 549 PF00082 0.431
CLV_PCSK_SKI1_1 557 561 PF00082 0.403
CLV_PCSK_SKI1_1 58 62 PF00082 0.379
DEG_SPOP_SBC_1 290 294 PF00917 0.707
DOC_CYCLIN_yCln2_LP_2 367 373 PF00134 0.277
DOC_MAPK_DCC_7 363 373 PF00069 0.284
DOC_MAPK_FxFP_2 213 216 PF00069 0.423
DOC_MAPK_gen_1 262 269 PF00069 0.580
DOC_MAPK_gen_1 318 326 PF00069 0.358
DOC_MAPK_gen_1 358 366 PF00069 0.501
DOC_MAPK_gen_1 544 552 PF00069 0.388
DOC_MAPK_HePTP_8 88 100 PF00069 0.396
DOC_MAPK_MEF2A_6 333 341 PF00069 0.465
DOC_MAPK_MEF2A_6 359 368 PF00069 0.487
DOC_MAPK_MEF2A_6 80 88 PF00069 0.358
DOC_MAPK_MEF2A_6 91 100 PF00069 0.397
DOC_PP1_MyPhoNE_1 30 37 PF00149 0.526
DOC_PP1_RVXF_1 327 333 PF00149 0.351
DOC_PP4_FxxP_1 213 216 PF00568 0.467
DOC_USP7_MATH_1 290 294 PF00917 0.554
DOC_USP7_MATH_1 487 491 PF00917 0.459
DOC_USP7_MATH_1 505 509 PF00917 0.493
DOC_WW_Pin1_4 366 371 PF00397 0.402
DOC_WW_Pin1_4 482 487 PF00397 0.337
LIG_14-3-3_CanoR_1 126 132 PF00244 0.367
LIG_14-3-3_CanoR_1 144 152 PF00244 0.441
LIG_14-3-3_CanoR_1 180 188 PF00244 0.447
LIG_14-3-3_CanoR_1 240 246 PF00244 0.398
LIG_14-3-3_CanoR_1 299 306 PF00244 0.600
LIG_14-3-3_CanoR_1 517 522 PF00244 0.417
LIG_Actin_WH2_2 164 182 PF00022 0.424
LIG_Actin_WH2_2 543 559 PF00022 0.440
LIG_BIR_II_1 1 5 PF00653 0.553
LIG_BRCT_BRCA1_1 422 426 PF00533 0.453
LIG_eIF4E_1 14 20 PF01652 0.396
LIG_FHA_1 126 132 PF00498 0.379
LIG_FHA_1 281 287 PF00498 0.581
LIG_FHA_1 398 404 PF00498 0.440
LIG_FHA_1 469 475 PF00498 0.399
LIG_FHA_1 51 57 PF00498 0.500
LIG_FHA_1 526 532 PF00498 0.436
LIG_FHA_1 67 73 PF00498 0.517
LIG_FHA_1 90 96 PF00498 0.379
LIG_FHA_2 204 210 PF00498 0.610
LIG_FHA_2 437 443 PF00498 0.523
LIG_FHA_2 471 477 PF00498 0.385
LIG_FHA_2 520 526 PF00498 0.609
LIG_LIR_Apic_2 210 216 PF02991 0.570
LIG_LIR_Apic_2 501 505 PF02991 0.392
LIG_LIR_Gen_1 127 136 PF02991 0.481
LIG_LIR_Gen_1 166 175 PF02991 0.334
LIG_LIR_Gen_1 479 487 PF02991 0.398
LIG_LIR_Gen_1 491 498 PF02991 0.369
LIG_LIR_Nem_3 127 132 PF02991 0.529
LIG_LIR_Nem_3 166 171 PF02991 0.328
LIG_LIR_Nem_3 475 480 PF02991 0.331
LIG_LIR_Nem_3 491 497 PF02991 0.449
LIG_NRBOX 363 369 PF00104 0.369
LIG_PCNA_PIPBox_1 373 382 PF02747 0.278
LIG_Pex14_2 457 461 PF04695 0.319
LIG_SH2_CRK 413 417 PF00017 0.468
LIG_SH2_GRB2like 8 11 PF00017 0.473
LIG_SH2_NCK_1 481 485 PF00017 0.315
LIG_SH2_NCK_1 8 12 PF00017 0.462
LIG_SH2_SRC 481 484 PF00017 0.381
LIG_SH2_STAP1 255 259 PF00017 0.553
LIG_SH2_STAT3 37 40 PF00017 0.479
LIG_SH2_STAT3 411 414 PF00017 0.474
LIG_SH2_STAT5 113 116 PF00017 0.503
LIG_SH2_STAT5 170 173 PF00017 0.328
LIG_SH2_STAT5 255 258 PF00017 0.550
LIG_SH2_STAT5 259 262 PF00017 0.597
LIG_SH2_STAT5 276 279 PF00017 0.374
LIG_SH2_STAT5 510 513 PF00017 0.535
LIG_SH2_STAT5 85 88 PF00017 0.442
LIG_SH3_3 265 271 PF00018 0.510
LIG_SH3_3 42 48 PF00018 0.617
LIG_SH3_3 528 534 PF00018 0.578
LIG_SUMO_SIM_anti_2 221 228 PF11976 0.413
LIG_SUMO_SIM_par_1 221 228 PF11976 0.425
LIG_SUMO_SIM_par_1 470 476 PF11976 0.400
LIG_SUMO_SIM_par_1 517 522 PF11976 0.503
LIG_SUMO_SIM_par_1 94 99 PF11976 0.325
LIG_TRAF2_1 486 489 PF00917 0.455
MOD_CK1_1 107 113 PF00069 0.614
MOD_CK1_1 127 133 PF00069 0.510
MOD_CK1_1 173 179 PF00069 0.509
MOD_CK1_1 298 304 PF00069 0.621
MOD_CK2_1 366 372 PF00069 0.543
MOD_CK2_1 470 476 PF00069 0.455
MOD_CK2_1 482 488 PF00069 0.355
MOD_CK2_1 60 66 PF00069 0.522
MOD_GlcNHglycan 115 118 PF01048 0.571
MOD_GlcNHglycan 163 166 PF01048 0.415
MOD_GlcNHglycan 176 179 PF01048 0.413
MOD_GlcNHglycan 277 280 PF01048 0.440
MOD_GlcNHglycan 300 303 PF01048 0.562
MOD_GlcNHglycan 507 510 PF01048 0.513
MOD_GlcNHglycan 511 514 PF01048 0.523
MOD_GSK3_1 107 114 PF00069 0.549
MOD_GSK3_1 170 177 PF00069 0.434
MOD_GSK3_1 199 206 PF00069 0.542
MOD_GSK3_1 249 256 PF00069 0.378
MOD_GSK3_1 291 298 PF00069 0.591
MOD_GSK3_1 505 512 PF00069 0.449
MOD_GSK3_1 56 63 PF00069 0.473
MOD_GSK3_1 560 567 PF00069 0.536
MOD_N-GLC_1 138 143 PF02516 0.578
MOD_N-GLC_1 144 149 PF02516 0.579
MOD_N-GLC_1 161 166 PF02516 0.331
MOD_N-GLC_2 192 194 PF02516 0.419
MOD_NEK2_1 115 120 PF00069 0.472
MOD_NEK2_1 199 204 PF00069 0.402
MOD_NEK2_1 225 230 PF00069 0.425
MOD_NEK2_1 275 280 PF00069 0.470
MOD_NEK2_1 304 309 PF00069 0.489
MOD_NEK2_1 380 385 PF00069 0.441
MOD_NEK2_1 397 402 PF00069 0.404
MOD_NEK2_1 498 503 PF00069 0.451
MOD_NEK2_1 562 567 PF00069 0.436
MOD_NEK2_1 6 11 PF00069 0.526
MOD_NEK2_1 60 65 PF00069 0.528
MOD_NEK2_2 527 532 PF00069 0.630
MOD_PIKK_1 105 111 PF00454 0.533
MOD_PIKK_1 538 544 PF00454 0.521
MOD_PIKK_1 60 66 PF00454 0.570
MOD_PIKK_1 89 95 PF00454 0.469
MOD_PK_1 333 339 PF00069 0.460
MOD_PKA_2 125 131 PF00069 0.364
MOD_PKA_2 143 149 PF00069 0.470
MOD_PKA_2 179 185 PF00069 0.477
MOD_PKA_2 290 296 PF00069 0.723
MOD_PKA_2 298 304 PF00069 0.531
MOD_PKA_2 397 403 PF00069 0.485
MOD_PKA_2 420 426 PF00069 0.462
MOD_PKB_1 289 297 PF00069 0.565
MOD_Plk_1 138 144 PF00069 0.586
MOD_Plk_1 560 566 PF00069 0.416
MOD_Plk_4 428 434 PF00069 0.434
MOD_Plk_4 533 539 PF00069 0.516
MOD_Plk_4 67 73 PF00069 0.519
MOD_ProDKin_1 366 372 PF00069 0.399
MOD_ProDKin_1 482 488 PF00069 0.336
MOD_SUMO_for_1 269 272 PF00179 0.438
MOD_SUMO_rev_2 419 429 PF00179 0.444
MOD_SUMO_rev_2 540 547 PF00179 0.404
TRG_DiLeu_BaEn_1 372 377 PF01217 0.474
TRG_DiLeu_BaEn_1 514 519 PF01217 0.434
TRG_DiLeu_BaLyEn_6 546 551 PF01217 0.497
TRG_DiLeu_LyEn_5 514 519 PF01217 0.434
TRG_ENDOCYTIC_2 413 416 PF00928 0.416
TRG_ENDOCYTIC_2 481 484 PF00928 0.316
TRG_ENDOCYTIC_2 85 88 PF00928 0.537
TRG_ER_diArg_1 155 158 PF00400 0.421
TRG_ER_diArg_1 288 291 PF00400 0.719
TRG_ER_diArg_1 347 350 PF00400 0.568
TRG_NES_CRM1_1 392 407 PF08389 0.402
TRG_Pf-PMV_PEXEL_1 549 553 PF00026 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HW03 Leptomonas seymouri 61% 99%
A0A0S4JII0 Bodo saltans 28% 97%
A0A1X0P3R1 Trypanosomatidae 44% 100%
A0A3Q8IJI1 Leishmania donovani 100% 100%
A0A422NKK1 Trypanosoma rangeli 44% 100%
A4HPH8 Leishmania braziliensis 84% 100%
D0A8E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 86%
E9AT90 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q1A7 Leishmania major 95% 100%
V5AU55 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS