LeishMANIAdb
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Cullin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cullin-like protein
Gene product:
cullin-like protein
Species:
Leishmania infantum
UniProt:
A4ID94_LEIIN
TriTrypDb:
LINF_360038700
Length:
706

Annotations

Annotations by Jardim et al.

Protein modification, Cullin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ID94
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID94

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 11
GO:0006511 ubiquitin-dependent protein catabolic process 7 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009056 catabolic process 2 11
GO:0009057 macromolecule catabolic process 4 11
GO:0009987 cellular process 1 11
GO:0019538 protein metabolic process 3 11
GO:0019941 modification-dependent protein catabolic process 6 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043632 modification-dependent macromolecule catabolic process 5 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044248 cellular catabolic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044265 obsolete cellular macromolecule catabolic process 4 11
GO:0051603 proteolysis involved in protein catabolic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901575 organic substance catabolic process 3 11
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0019899 enzyme binding 3 11
GO:0031625 ubiquitin protein ligase binding 5 11
GO:0044389 ubiquitin-like protein ligase binding 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 95 99 PF00656 0.535
CLV_NRD_NRD_1 513 515 PF00675 0.286
CLV_NRD_NRD_1 517 519 PF00675 0.266
CLV_NRD_NRD_1 630 632 PF00675 0.625
CLV_NRD_NRD_1 7 9 PF00675 0.631
CLV_PCSK_KEX2_1 286 288 PF00082 0.342
CLV_PCSK_KEX2_1 504 506 PF00082 0.353
CLV_PCSK_KEX2_1 512 514 PF00082 0.328
CLV_PCSK_KEX2_1 9 11 PF00082 0.646
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.365
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.310
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.646
CLV_PCSK_SKI1_1 202 206 PF00082 0.375
CLV_PCSK_SKI1_1 238 242 PF00082 0.253
CLV_PCSK_SKI1_1 289 293 PF00082 0.349
CLV_PCSK_SKI1_1 29 33 PF00082 0.282
CLV_PCSK_SKI1_1 353 357 PF00082 0.329
CLV_PCSK_SKI1_1 452 456 PF00082 0.307
CLV_PCSK_SKI1_1 504 508 PF00082 0.332
CLV_PCSK_SKI1_1 519 523 PF00082 0.264
CLV_PCSK_SKI1_1 648 652 PF00082 0.342
DEG_MDM2_SWIB_1 17 24 PF02201 0.519
DEG_SCF_FBW7_2 393 400 PF00400 0.537
DEG_SPOP_SBC_1 204 208 PF00917 0.510
DOC_CKS1_1 182 187 PF01111 0.565
DOC_CKS1_1 394 399 PF01111 0.537
DOC_CYCLIN_RxL_1 319 328 PF00134 0.514
DOC_MAPK_FxFP_2 315 318 PF00069 0.565
DOC_MAPK_gen_1 466 476 PF00069 0.519
DOC_MAPK_gen_1 518 526 PF00069 0.542
DOC_MAPK_MEF2A_6 407 414 PF00069 0.565
DOC_MAPK_MEF2A_6 468 476 PF00069 0.540
DOC_MAPK_MEF2A_6 677 684 PF00069 0.525
DOC_PP1_RVXF_1 516 523 PF00149 0.462
DOC_PP2B_LxvP_1 494 497 PF13499 0.542
DOC_PP4_FxxP_1 315 318 PF00568 0.565
DOC_USP7_MATH_1 139 143 PF00917 0.542
DOC_USP7_MATH_1 157 161 PF00917 0.542
DOC_USP7_MATH_1 172 176 PF00917 0.388
DOC_USP7_MATH_1 405 409 PF00917 0.532
DOC_USP7_MATH_1 554 558 PF00917 0.548
DOC_USP7_MATH_1 664 668 PF00917 0.553
DOC_USP7_MATH_1 70 74 PF00917 0.565
DOC_USP7_UBL2_3 34 38 PF12436 0.532
DOC_USP7_UBL2_3 607 611 PF12436 0.544
DOC_WW_Pin1_4 181 186 PF00397 0.565
DOC_WW_Pin1_4 341 346 PF00397 0.476
DOC_WW_Pin1_4 393 398 PF00397 0.537
DOC_WW_Pin1_4 468 473 PF00397 0.550
DOC_WW_Pin1_4 671 676 PF00397 0.494
LIG_14-3-3_CanoR_1 129 139 PF00244 0.525
LIG_14-3-3_CanoR_1 43 49 PF00244 0.560
LIG_14-3-3_CanoR_1 452 461 PF00244 0.514
LIG_14-3-3_CanoR_1 601 610 PF00244 0.559
LIG_14-3-3_CanoR_1 638 643 PF00244 0.532
LIG_Actin_WH2_2 225 240 PF00022 0.385
LIG_APCC_ABBA_1 366 371 PF00400 0.542
LIG_BIR_II_1 1 5 PF00653 0.591
LIG_BRCT_BRCA1_1 174 178 PF00533 0.565
LIG_BRCT_BRCA1_1 527 531 PF00533 0.542
LIG_EH1_1 546 554 PF00400 0.542
LIG_EVH1_2 472 476 PF00568 0.565
LIG_FHA_1 182 188 PF00498 0.575
LIG_FHA_1 259 265 PF00498 0.496
LIG_FHA_1 290 296 PF00498 0.540
LIG_FHA_1 363 369 PF00498 0.545
LIG_FHA_1 394 400 PF00498 0.527
LIG_FHA_1 465 471 PF00498 0.534
LIG_FHA_1 480 486 PF00498 0.384
LIG_FHA_1 544 550 PF00498 0.465
LIG_FHA_1 637 643 PF00498 0.427
LIG_FHA_2 14 20 PF00498 0.564
LIG_FHA_2 159 165 PF00498 0.515
LIG_FHA_2 674 680 PF00498 0.542
LIG_FHA_2 692 698 PF00498 0.542
LIG_Integrin_isoDGR_2 516 518 PF01839 0.276
LIG_LIR_Apic_2 312 318 PF02991 0.564
LIG_LIR_Gen_1 13 19 PF02991 0.458
LIG_LIR_Gen_1 228 237 PF02991 0.542
LIG_LIR_Gen_1 239 250 PF02991 0.542
LIG_LIR_Gen_1 276 285 PF02991 0.520
LIG_LIR_Gen_1 346 356 PF02991 0.565
LIG_LIR_Gen_1 40 49 PF02991 0.476
LIG_LIR_Gen_1 475 481 PF02991 0.492
LIG_LIR_Gen_1 579 589 PF02991 0.565
LIG_LIR_Gen_1 655 665 PF02991 0.546
LIG_LIR_Gen_1 66 76 PF02991 0.553
LIG_LIR_Nem_3 13 17 PF02991 0.474
LIG_LIR_Nem_3 18 24 PF02991 0.299
LIG_LIR_Nem_3 227 233 PF02991 0.542
LIG_LIR_Nem_3 239 245 PF02991 0.542
LIG_LIR_Nem_3 276 281 PF02991 0.534
LIG_LIR_Nem_3 314 320 PF02991 0.457
LIG_LIR_Nem_3 346 351 PF02991 0.565
LIG_LIR_Nem_3 40 44 PF02991 0.476
LIG_LIR_Nem_3 430 436 PF02991 0.553
LIG_LIR_Nem_3 475 479 PF02991 0.482
LIG_LIR_Nem_3 483 489 PF02991 0.466
LIG_LIR_Nem_3 579 584 PF02991 0.565
LIG_LIR_Nem_3 655 661 PF02991 0.518
LIG_LIR_Nem_3 66 72 PF02991 0.553
LIG_LIR_Nem_3 92 96 PF02991 0.465
LIG_MLH1_MIPbox_1 174 178 PF16413 0.565
LIG_Pex14_2 17 21 PF04695 0.495
LIG_Pex14_2 278 282 PF04695 0.532
LIG_Pex14_2 402 406 PF04695 0.462
LIG_Pex14_2 599 603 PF04695 0.408
LIG_Pex14_2 89 93 PF04695 0.548
LIG_PTB_Apo_2 108 115 PF02174 0.492
LIG_PTB_Phospho_1 108 114 PF10480 0.492
LIG_SH2_CRK 242 246 PF00017 0.542
LIG_SH2_CRK 416 420 PF00017 0.565
LIG_SH2_CRK 489 493 PF00017 0.513
LIG_SH2_CRK 56 60 PF00017 0.558
LIG_SH2_CRK 658 662 PF00017 0.546
LIG_SH2_GRB2like 109 112 PF00017 0.479
LIG_SH2_GRB2like 370 373 PF00017 0.565
LIG_SH2_GRB2like 489 492 PF00017 0.514
LIG_SH2_NCK_1 489 493 PF00017 0.514
LIG_SH2_PTP2 231 234 PF00017 0.542
LIG_SH2_SRC 370 373 PF00017 0.565
LIG_SH2_STAP1 225 229 PF00017 0.573
LIG_SH2_STAP1 242 246 PF00017 0.444
LIG_SH2_STAT3 194 197 PF00017 0.570
LIG_SH2_STAT5 109 112 PF00017 0.466
LIG_SH2_STAT5 170 173 PF00017 0.528
LIG_SH2_STAT5 177 180 PF00017 0.508
LIG_SH2_STAT5 194 197 PF00017 0.438
LIG_SH2_STAT5 210 213 PF00017 0.405
LIG_SH2_STAT5 231 234 PF00017 0.542
LIG_SH2_STAT5 489 492 PF00017 0.485
LIG_SH2_STAT5 702 705 PF00017 0.380
LIG_SH2_STAT5 85 88 PF00017 0.573
LIG_SH3_3 669 675 PF00018 0.542
LIG_SH3_4 607 614 PF00018 0.534
LIG_SUMO_SIM_anti_2 477 483 PF11976 0.496
LIG_SUMO_SIM_anti_2 562 567 PF11976 0.565
LIG_SUMO_SIM_par_1 477 483 PF11976 0.514
LIG_TRAF2_1 338 341 PF00917 0.540
LIG_TRAF2_1 456 459 PF00917 0.565
LIG_UBA3_1 145 150 PF00899 0.565
LIG_UBA3_1 233 238 PF00899 0.466
LIG_UBA3_1 323 331 PF00899 0.492
LIG_UBA3_1 461 469 PF00899 0.532
LIG_WRC_WIRS_1 14 19 PF05994 0.572
LIG_WRC_WIRS_1 275 280 PF05994 0.532
MOD_CDC14_SPxK_1 674 677 PF00782 0.565
MOD_CDK_SPxK_1 671 677 PF00069 0.565
MOD_CDK_SPxxK_3 343 350 PF00069 0.542
MOD_CK1_1 101 107 PF00069 0.531
MOD_CK1_1 15 21 PF00069 0.501
MOD_CK1_1 248 254 PF00069 0.566
MOD_CK1_1 274 280 PF00069 0.529
MOD_CK1_1 3 9 PF00069 0.624
MOD_CK1_1 37 43 PF00069 0.476
MOD_CK1_1 525 531 PF00069 0.485
MOD_CK1_1 543 549 PF00069 0.542
MOD_CK1_1 627 633 PF00069 0.577
MOD_CK2_1 118 124 PF00069 0.542
MOD_CK2_1 19 25 PF00069 0.393
MOD_CK2_1 249 255 PF00069 0.510
MOD_CK2_1 570 576 PF00069 0.561
MOD_CK2_1 691 697 PF00069 0.568
MOD_Cter_Amidation 516 519 PF01082 0.292
MOD_GlcNHglycan 140 144 PF01048 0.287
MOD_GlcNHglycan 207 210 PF01048 0.371
MOD_GlcNHglycan 238 241 PF01048 0.363
MOD_GlcNHglycan 452 455 PF01048 0.342
MOD_GlcNHglycan 482 485 PF01048 0.314
MOD_GlcNHglycan 542 545 PF01048 0.342
MOD_GlcNHglycan 612 615 PF01048 0.522
MOD_GlcNHglycan 618 621 PF01048 0.588
MOD_GlcNHglycan 666 669 PF01048 0.301
MOD_GlcNHglycan 697 700 PF01048 0.468
MOD_GSK3_1 15 22 PF00069 0.444
MOD_GSK3_1 168 175 PF00069 0.566
MOD_GSK3_1 236 243 PF00069 0.548
MOD_GSK3_1 245 252 PF00069 0.500
MOD_GSK3_1 464 471 PF00069 0.500
MOD_GSK3_1 492 499 PF00069 0.527
MOD_GSK3_1 576 583 PF00069 0.555
MOD_GSK3_1 638 645 PF00069 0.492
MOD_GSK3_1 691 698 PF00069 0.540
MOD_N-GLC_1 357 362 PF02516 0.321
MOD_N-GLC_1 559 564 PF02516 0.312
MOD_N-GLC_1 592 597 PF02516 0.492
MOD_N-GLC_1 96 101 PF02516 0.350
MOD_NEK2_1 131 136 PF00069 0.497
MOD_NEK2_1 145 150 PF00069 0.468
MOD_NEK2_1 205 210 PF00069 0.528
MOD_NEK2_1 241 246 PF00069 0.519
MOD_NEK2_1 362 367 PF00069 0.537
MOD_NEK2_1 4 9 PF00069 0.606
MOD_NEK2_1 479 484 PF00069 0.477
MOD_NEK2_1 522 527 PF00069 0.529
MOD_NEK2_1 548 553 PF00069 0.462
MOD_NEK2_1 603 608 PF00069 0.539
MOD_NEK2_1 642 647 PF00069 0.509
MOD_NEK2_2 158 163 PF00069 0.553
MOD_NEK2_2 225 230 PF00069 0.542
MOD_PIKK_1 576 582 PF00454 0.544
MOD_PIKK_1 98 104 PF00454 0.511
MOD_PKA_2 309 315 PF00069 0.537
MOD_Plk_1 12 18 PF00069 0.585
MOD_Plk_1 158 164 PF00069 0.542
MOD_Plk_1 24 30 PF00069 0.552
MOD_Plk_1 310 316 PF00069 0.563
MOD_Plk_1 357 363 PF00069 0.532
MOD_Plk_1 559 565 PF00069 0.570
MOD_Plk_1 642 648 PF00069 0.527
MOD_Plk_1 96 102 PF00069 0.497
MOD_Plk_2-3 13 19 PF00069 0.546
MOD_Plk_2-3 249 255 PF00069 0.565
MOD_Plk_2-3 652 658 PF00069 0.537
MOD_Plk_4 225 231 PF00069 0.497
MOD_Plk_4 241 247 PF00069 0.520
MOD_Plk_4 274 280 PF00069 0.505
MOD_Plk_4 364 370 PF00069 0.523
MOD_Plk_4 388 394 PF00069 0.565
MOD_Plk_4 436 442 PF00069 0.489
MOD_Plk_4 44 50 PF00069 0.469
MOD_Plk_4 548 554 PF00069 0.464
MOD_Plk_4 55 61 PF00069 0.448
MOD_Plk_4 642 648 PF00069 0.542
MOD_Plk_4 70 76 PF00069 0.510
MOD_Plk_4 81 87 PF00069 0.501
MOD_ProDKin_1 181 187 PF00069 0.565
MOD_ProDKin_1 341 347 PF00069 0.476
MOD_ProDKin_1 393 399 PF00069 0.537
MOD_ProDKin_1 468 474 PF00069 0.550
MOD_ProDKin_1 671 677 PF00069 0.494
MOD_SUMO_for_1 285 288 PF00179 0.565
MOD_SUMO_for_1 32 35 PF00179 0.565
MOD_SUMO_rev_2 459 467 PF00179 0.566
MOD_SUMO_rev_2 674 682 PF00179 0.510
TRG_DiLeu_BaEn_1 475 480 PF01217 0.542
TRG_DiLeu_BaLyEn_6 410 415 PF01217 0.535
TRG_ENDOCYTIC_2 14 17 PF00928 0.582
TRG_ENDOCYTIC_2 231 234 PF00928 0.542
TRG_ENDOCYTIC_2 242 245 PF00928 0.542
TRG_ENDOCYTIC_2 489 492 PF00928 0.484
TRG_ENDOCYTIC_2 56 59 PF00928 0.558
TRG_ENDOCYTIC_2 658 661 PF00928 0.546
TRG_ER_diArg_1 511 514 PF00400 0.542
TRG_ER_diArg_1 8 11 PF00400 0.652
TRG_NES_CRM1_1 235 249 PF08389 0.542
TRG_NLS_MonoExtC_3 7 13 PF00514 0.640
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.314
TRG_Pf-PMV_PEXEL_1 518 523 PF00026 0.342
TRG_Pf-PMV_PEXEL_1 648 652 PF00026 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9C6 Leptomonas seymouri 67% 100%
A0A1X0NKJ9 Trypanosomatidae 27% 100%
A0A3R7LZU1 Trypanosoma rangeli 28% 99%
A0A3S7XB28 Leishmania donovani 99% 100%
A2A432 Mus musculus 21% 73%
A4HPH2 Leishmania braziliensis 89% 100%
D0A3I2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AT84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O14122 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 20% 96%
Q13620 Homo sapiens 21% 77%
Q23639 Caenorhabditis elegans 21% 92%
Q3TCH7 Mus musculus 20% 93%
Q4Q1B3 Leishmania major 97% 100%
Q8LGH4 Arabidopsis thaliana 21% 89%
Q9C9L0 Arabidopsis thaliana 20% 96%
Q9ZVH4 Arabidopsis thaliana 21% 96%
V5B0B0 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS