LeishMANIAdb
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Acetolactate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acetolactate synthase
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ID93_LEIIN
TriTrypDb:
LINF_360038600
Length:
142

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
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Expansion

Sequence features

A4ID93
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID93

Function

Biological processes
TermNameLevelCount
GO:0006996 organelle organization 4 11
GO:0007031 peroxisome organization 5 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0071840 cellular component organization or biogenesis 2 11
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_KEX2_1 109 111 PF00082 0.524
CLV_PCSK_KEX2_1 58 60 PF00082 0.479
CLV_PCSK_PC1ET2_1 109 111 PF00082 0.517
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.463
CLV_PCSK_SKI1_1 59 63 PF00082 0.423
CLV_PCSK_SKI1_1 75 79 PF00082 0.364
CLV_Separin_Metazoa 35 39 PF03568 0.324
DEG_APCC_DBOX_1 58 66 PF00400 0.312
DOC_CYCLIN_RxL_1 72 82 PF00134 0.449
DOC_MAPK_gen_1 109 117 PF00069 0.475
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7N3 Leptomonas seymouri 73% 68%
A0A0S4JN26 Bodo saltans 28% 73%
A0A1X0NKF5 Trypanosomatidae 48% 72%
A0A3S7XB48 Leishmania donovani 100% 100%
A0A422NM43 Trypanosoma rangeli 43% 71%
A4HPH1 Leishmania braziliensis 92% 100%
D0A3I1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 72%
E9AT83 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q1B4 Leishmania major 96% 100%
V5BKE1 Trypanosoma cruzi 43% 71%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS