TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ID84_LEIIN

TriTrypDb:

LINF_360037600

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4ID84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.503
CLV_PCSK_SKI1_1	84	88	PF00082	0.490
DEG_APCC_DBOX_1	83	91	PF00400	0.321
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_CYCLIN_RxL_1	68	78	PF00134	0.345
DOC_MAPK_MEF2A_6	84	91	PF00069	0.243
DOC_MAPK_NFAT4_5	84	92	PF00069	0.244
LIG_Actin_WH2_2	9	25	PF00022	0.509
LIG_BRCT_BRCA1_1	59	63	PF00533	0.319
LIG_EH1_1	120	128	PF00400	0.461
LIG_FHA_1	101	107	PF00498	0.291
LIG_FHA_1	6	12	PF00498	0.565
LIG_FHA_2	76	82	PF00498	0.349
LIG_GBD_Chelix_1	45	53	PF00786	0.367
LIG_LIR_Gen_1	109	116	PF02991	0.405
LIG_LIR_Gen_1	15	25	PF02991	0.555
LIG_LIR_Gen_1	60	69	PF02991	0.372
LIG_LIR_Nem_3	109	114	PF02991	0.463
LIG_LIR_Nem_3	15	20	PF02991	0.574
LIG_LIR_Nem_3	60	66	PF02991	0.419
LIG_NRBOX	61	67	PF00104	0.307
LIG_NRBOX	86	92	PF00104	0.329
LIG_Pex14_2	2	6	PF04695	0.538
LIG_SH2_CRK	50	54	PF00017	0.367
LIG_SH2_STAP1	7	11	PF00017	0.506
LIG_SH2_STAT3	116	119	PF00017	0.413
LIG_SH2_STAT5	121	124	PF00017	0.539
LIG_SH2_STAT5	7	10	PF00017	0.553
LIG_SH2_STAT5	88	91	PF00017	0.335
LIG_SUMO_SIM_par_1	102	107	PF11976	0.325
LIG_SUMO_SIM_par_1	72	78	PF11976	0.353
LIG_TYR_ITIM	86	91	PF00017	0.375
LIG_UBA3_1	123	132	PF00899	0.527
LIG_WRC_WIRS_1	105	110	PF05994	0.393
MOD_CK1_1	96	102	PF00069	0.387
MOD_CK2_1	75	81	PF00069	0.386
MOD_GlcNHglycan	95	98	PF01048	0.633
MOD_GSK3_1	106	113	PF00069	0.408
MOD_GSK3_1	96	103	PF00069	0.349
MOD_NEK2_1	106	111	PF00069	0.409
MOD_NEK2_1	57	62	PF00069	0.398
MOD_NEK2_1	75	80	PF00069	0.240
MOD_NEK2_1	90	95	PF00069	0.418
MOD_PIKK_1	90	96	PF00454	0.404
MOD_Plk_4	100	106	PF00069	0.258
MOD_Plk_4	110	116	PF00069	0.281
MOD_Plk_4	31	37	PF00069	0.543
TRG_DiLeu_BaEn_1	81	86	PF01217	0.342
TRG_ENDOCYTIC_2	120	123	PF00928	0.506
TRG_ENDOCYTIC_2	17	20	PF00928	0.611
TRG_ENDOCYTIC_2	50	53	PF00928	0.357
TRG_ENDOCYTIC_2	88	91	PF00928	0.397
TRG_NES_CRM1_1	81	94	PF08389	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z5	Leptomonas seymouri	55%	100%
A0A1X0NKL9	Trypanosomatidae	38%	99%
A0A3Q8IP15	Leishmania donovani	99%	100%
A0A3R7KH99	Trypanosoma rangeli	39%	100%
A4HPG2	Leishmania braziliensis	80%	100%
E9AT74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q1C3	Leishmania major	94%	100%