MCM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4ID78_LEIIN

TriTrypDb:

Length:

903

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4ID78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID78

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0032392	DNA geometric change	7	3
GO:0032508	DNA duplex unwinding	8	3
GO:0051276	chromosome organization	5	3
GO:0071103	DNA conformation change	6	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.468
CLV_NRD_NRD_1	217	219	PF00675	0.549
CLV_NRD_NRD_1	256	258	PF00675	0.534
CLV_NRD_NRD_1	33	35	PF00675	0.492
CLV_NRD_NRD_1	357	359	PF00675	0.294
CLV_NRD_NRD_1	453	455	PF00675	0.604
CLV_NRD_NRD_1	604	606	PF00675	0.519
CLV_NRD_NRD_1	625	627	PF00675	0.555
CLV_NRD_NRD_1	750	752	PF00675	0.532
CLV_NRD_NRD_1	895	897	PF00675	0.513
CLV_PCSK_KEX2_1	217	219	PF00082	0.549
CLV_PCSK_KEX2_1	256	258	PF00082	0.534
CLV_PCSK_KEX2_1	33	35	PF00082	0.492
CLV_PCSK_KEX2_1	357	359	PF00082	0.294
CLV_PCSK_KEX2_1	453	455	PF00082	0.674
CLV_PCSK_KEX2_1	604	606	PF00082	0.519
CLV_PCSK_KEX2_1	625	627	PF00082	0.555
CLV_PCSK_KEX2_1	750	752	PF00082	0.528
CLV_PCSK_KEX2_1	834	836	PF00082	0.470
CLV_PCSK_KEX2_1	895	897	PF00082	0.513
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.504
CLV_PCSK_PC7_1	621	627	PF00082	0.432
CLV_PCSK_SKI1_1	186	190	PF00082	0.571
CLV_PCSK_SKI1_1	26	30	PF00082	0.415
CLV_PCSK_SKI1_1	321	325	PF00082	0.520
CLV_PCSK_SKI1_1	335	339	PF00082	0.345
CLV_PCSK_SKI1_1	370	374	PF00082	0.255
CLV_PCSK_SKI1_1	409	413	PF00082	0.261
CLV_PCSK_SKI1_1	711	715	PF00082	0.452
CLV_PCSK_SKI1_1	837	841	PF00082	0.497
CLV_Separin_Metazoa	718	722	PF03568	0.464
CLV_Separin_Metazoa	765	769	PF03568	0.564
DEG_APCC_DBOX_1	217	225	PF00400	0.502
DEG_APCC_DBOX_1	393	401	PF00400	0.461
DEG_APCC_DBOX_1	834	842	PF00400	0.512
DOC_CDC14_PxL_1	221	229	PF14671	0.529
DOC_CDC14_PxL_1	6	14	PF14671	0.445
DOC_CKS1_1	48	53	PF01111	0.502
DOC_CKS1_1	828	833	PF01111	0.512
DOC_CYCLIN_RxL_1	180	191	PF00134	0.567
DOC_CYCLIN_RxL_1	708	718	PF00134	0.518
DOC_MAPK_FxFP_2	7	10	PF00069	0.443
DOC_MAPK_gen_1	21	29	PF00069	0.407
DOC_MAPK_gen_1	217	226	PF00069	0.502
DOC_MAPK_gen_1	833	841	PF00069	0.419
DOC_MAPK_MEF2A_6	173	181	PF00069	0.484
DOC_MAPK_MEF2A_6	273	281	PF00069	0.389
DOC_MAPK_MEF2A_6	370	378	PF00069	0.446
DOC_MAPK_MEF2A_6	394	401	PF00069	0.468
DOC_MAPK_NFAT4_5	370	378	PF00069	0.444
DOC_MAPK_RevD_3	882	896	PF00069	0.415
DOC_PP1_RVXF_1	166	172	PF00149	0.479
DOC_PP1_RVXF_1	24	30	PF00149	0.415
DOC_PP1_RVXF_1	835	841	PF00149	0.505
DOC_PP2B_LxvP_1	668	671	PF13499	0.675
DOC_PP2B_LxvP_1	850	853	PF13499	0.437
DOC_PP4_FxxP_1	139	142	PF00568	0.514
DOC_PP4_FxxP_1	7	10	PF00568	0.443
DOC_PP4_FxxP_1	876	879	PF00568	0.451
DOC_USP7_MATH_1	127	131	PF00917	0.511
DOC_USP7_MATH_1	13	17	PF00917	0.434
DOC_USP7_MATH_1	159	163	PF00917	0.715
DOC_USP7_MATH_1	308	312	PF00917	0.612
DOC_USP7_MATH_1	389	393	PF00917	0.546
DOC_USP7_MATH_1	441	445	PF00917	0.646
DOC_USP7_MATH_1	546	550	PF00917	0.547
DOC_USP7_MATH_1	566	570	PF00917	0.365
DOC_USP7_MATH_1	589	593	PF00917	0.663
DOC_USP7_MATH_1	596	600	PF00917	0.681
DOC_USP7_MATH_1	660	664	PF00917	0.683
DOC_USP7_MATH_1	686	690	PF00917	0.634
DOC_USP7_MATH_1	757	761	PF00917	0.693
DOC_USP7_MATH_1	815	819	PF00917	0.753
DOC_USP7_UBL2_3	829	833	PF12436	0.481
DOC_WW_Pin1_4	133	138	PF00397	0.534
DOC_WW_Pin1_4	47	52	PF00397	0.471
DOC_WW_Pin1_4	585	590	PF00397	0.643
DOC_WW_Pin1_4	827	832	PF00397	0.540
DOC_WW_Pin1_4	94	99	PF00397	0.475
LIG_14-3-3_CanoR_1	15	23	PF00244	0.413
LIG_14-3-3_CanoR_1	453	459	PF00244	0.523
LIG_14-3-3_CanoR_1	572	578	PF00244	0.604
LIG_14-3-3_CanoR_1	614	622	PF00244	0.667
LIG_14-3-3_CanoR_1	750	758	PF00244	0.534
LIG_14-3-3_CanoR_1	768	773	PF00244	0.429
LIG_14-3-3_CanoR_1	847	853	PF00244	0.486
LIG_BIR_III_4	778	782	PF00653	0.539
LIG_BRCT_BRCA1_1	135	139	PF00533	0.488
LIG_BRCT_BRCA1_1	166	170	PF00533	0.443
LIG_BRCT_BRCA1_1	773	777	PF00533	0.546
LIG_BRCT_BRCA1_1	872	876	PF00533	0.471
LIG_Clathr_ClatBox_1	419	423	PF01394	0.457
LIG_Clathr_ClatBox_1	838	842	PF01394	0.503
LIG_CSL_BTD_1	824	827	PF09270	0.606
LIG_deltaCOP1_diTrp_1	104	111	PF00928	0.535
LIG_EVH1_2	794	798	PF00568	0.485
LIG_FHA_1	141	147	PF00498	0.479
LIG_FHA_1	183	189	PF00498	0.494
LIG_FHA_1	245	251	PF00498	0.393
LIG_FHA_1	466	472	PF00498	0.498
LIG_FHA_1	545	551	PF00498	0.481
LIG_FHA_1	632	638	PF00498	0.350
LIG_FHA_2	142	148	PF00498	0.490
LIG_FHA_2	189	195	PF00498	0.513
LIG_FHA_2	614	620	PF00498	0.548
LIG_FHA_2	99	105	PF00498	0.466
LIG_LIR_Apic_2	136	142	PF02991	0.507
LIG_LIR_Apic_2	873	879	PF02991	0.458
LIG_LIR_Nem_3	116	121	PF02991	0.462
LIG_LIR_Nem_3	62	68	PF02991	0.395
LIG_LIR_Nem_3	731	737	PF02991	0.419
LIG_LIR_Nem_3	864	870	PF02991	0.483
LIG_LYPXL_S_1	8	12	PF13949	0.442
LIG_LYPXL_yS_3	9	12	PF13949	0.466
LIG_MLH1_MIPbox_1	773	777	PF16413	0.549
LIG_NRBOX	118	124	PF00104	0.371
LIG_NRBOX	84	90	PF00104	0.415
LIG_NRBOX	865	871	PF00104	0.419
LIG_Pex14_1	772	776	PF04695	0.524
LIG_Rb_LxCxE_1	311	331	PF01857	0.493
LIG_RPA_C_Fungi	252	264	PF08784	0.425
LIG_SH2_NCK_1	286	290	PF00017	0.382
LIG_SH2_NCK_1	347	351	PF00017	0.364
LIG_SH2_NCK_1	68	72	PF00017	0.421
LIG_SH2_STAP1	643	647	PF00017	0.460
LIG_SH2_STAT5	118	121	PF00017	0.370
LIG_SH2_STAT5	251	254	PF00017	0.413
LIG_SH2_STAT5	286	289	PF00017	0.474
LIG_SH2_STAT5	379	382	PF00017	0.385
LIG_SH2_STAT5	537	540	PF00017	0.449
LIG_SH2_STAT5	6	9	PF00017	0.548
LIG_SH2_STAT5	622	625	PF00017	0.551
LIG_SH3_2	10	15	PF14604	0.454
LIG_SH3_3	238	244	PF00018	0.509
LIG_SH3_3	7	13	PF00018	0.453
LIG_SUMO_SIM_anti_2	371	377	PF11976	0.212
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.460
LIG_SUMO_SIM_anti_2	878	885	PF11976	0.530
LIG_SUMO_SIM_par_1	467	472	PF11976	0.493
LIG_SUMO_SIM_par_1	693	699	PF11976	0.568
LIG_TRAF2_1	524	527	PF00917	0.537
LIG_TRFH_1	6	10	PF08558	0.468
MOD_CDK_SPxK_1	827	833	PF00069	0.525
MOD_CDK_SPxxK_3	827	834	PF00069	0.518
MOD_CK1_1	130	136	PF00069	0.485
MOD_CK1_1	444	450	PF00069	0.558
MOD_CK1_1	462	468	PF00069	0.562
MOD_CK1_1	47	53	PF00069	0.451
MOD_CK1_1	568	574	PF00069	0.564
MOD_CK1_1	579	585	PF00069	0.579
MOD_CK1_1	594	600	PF00069	0.573
MOD_CK1_1	609	615	PF00069	0.652
MOD_CK1_1	635	641	PF00069	0.583
MOD_CK1_1	684	690	PF00069	0.540
MOD_CK1_1	752	758	PF00069	0.661
MOD_CK1_1	771	777	PF00069	0.534
MOD_CK1_1	796	802	PF00069	0.732
MOD_CK1_1	94	100	PF00069	0.439
MOD_CK2_1	188	194	PF00069	0.536
MOD_CK2_1	285	291	PF00069	0.394
MOD_CK2_1	382	388	PF00069	0.207
MOD_CK2_1	814	820	PF00069	0.581
MOD_CK2_1	858	864	PF00069	0.527
MOD_Cter_Amidation	31	34	PF01082	0.484
MOD_GlcNHglycan	104	109	PF01048	0.489
MOD_GlcNHglycan	129	132	PF01048	0.521
MOD_GlcNHglycan	161	164	PF01048	0.648
MOD_GlcNHglycan	287	290	PF01048	0.391
MOD_GlcNHglycan	310	313	PF01048	0.672
MOD_GlcNHglycan	409	412	PF01048	0.291
MOD_GlcNHglycan	436	439	PF01048	0.614
MOD_GlcNHglycan	446	449	PF01048	0.497
MOD_GlcNHglycan	454	457	PF01048	0.592
MOD_GlcNHglycan	461	464	PF01048	0.534
MOD_GlcNHglycan	526	530	PF01048	0.556
MOD_GlcNHglycan	584	587	PF01048	0.661
MOD_GlcNHglycan	593	596	PF01048	0.646
MOD_GlcNHglycan	607	611	PF01048	0.518
MOD_GlcNHglycan	671	674	PF01048	0.615
MOD_GlcNHglycan	683	686	PF01048	0.588
MOD_GlcNHglycan	69	72	PF01048	0.492
MOD_GlcNHglycan	754	757	PF01048	0.680
MOD_GlcNHglycan	798	801	PF01048	0.641
MOD_GlcNHglycan	850	853	PF01048	0.613
MOD_GlcNHglycan	873	876	PF01048	0.436
MOD_GlcNHglycan	93	96	PF01048	0.501
MOD_GSK3_1	13	20	PF00069	0.417
MOD_GSK3_1	155	162	PF00069	0.492
MOD_GSK3_1	188	195	PF00069	0.469
MOD_GSK3_1	427	434	PF00069	0.480
MOD_GSK3_1	43	50	PF00069	0.526
MOD_GSK3_1	546	553	PF00069	0.497
MOD_GSK3_1	561	568	PF00069	0.556
MOD_GSK3_1	572	579	PF00069	0.590
MOD_GSK3_1	585	592	PF00069	0.649
MOD_GSK3_1	594	601	PF00069	0.702
MOD_GSK3_1	609	616	PF00069	0.651
MOD_GSK3_1	631	638	PF00069	0.494
MOD_GSK3_1	767	774	PF00069	0.593
MOD_GSK3_1	94	101	PF00069	0.538
MOD_LATS_1	570	576	PF00433	0.607
MOD_NEK2_1	188	193	PF00069	0.487
MOD_NEK2_1	284	289	PF00069	0.469
MOD_NEK2_1	427	432	PF00069	0.510
MOD_NEK2_1	452	457	PF00069	0.628
MOD_NEK2_1	459	464	PF00069	0.586
MOD_NEK2_1	550	555	PF00069	0.535
MOD_NEK2_1	584	589	PF00069	0.651
MOD_NEK2_1	632	637	PF00069	0.535
MOD_NEK2_1	767	772	PF00069	0.624
MOD_NEK2_1	870	875	PF00069	0.522
MOD_NEK2_1	91	96	PF00069	0.445
MOD_NEK2_2	686	691	PF00069	0.649
MOD_NEK2_2	772	777	PF00069	0.525
MOD_PIKK_1	130	136	PF00454	0.548
MOD_PIKK_1	192	198	PF00454	0.548
MOD_PIKK_1	228	234	PF00454	0.454
MOD_PIKK_1	554	560	PF00454	0.473
MOD_PIKK_1	579	585	PF00454	0.697
MOD_PIKK_1	589	595	PF00454	0.671
MOD_PIKK_1	596	602	PF00454	0.576
MOD_PIKK_1	882	888	PF00454	0.580
MOD_PKA_2	14	20	PF00069	0.411
MOD_PKA_2	32	38	PF00069	0.415
MOD_PKA_2	452	458	PF00069	0.539
MOD_PKA_2	566	572	PF00069	0.582
MOD_PKA_2	579	585	PF00069	0.598
MOD_PKA_2	613	619	PF00069	0.652
MOD_PKA_2	749	755	PF00069	0.544
MOD_PKA_2	767	773	PF00069	0.488
MOD_PKA_2	796	802	PF00069	0.627
MOD_PKA_2	848	854	PF00069	0.550
MOD_Plk_1	38	44	PF00069	0.716
MOD_Plk_1	427	433	PF00069	0.540
MOD_Plk_1	550	556	PF00069	0.559
MOD_Plk_4	427	433	PF00069	0.470
MOD_Plk_4	465	471	PF00069	0.496
MOD_Plk_4	516	522	PF00069	0.580
MOD_Plk_4	632	638	PF00069	0.505
MOD_Plk_4	772	778	PF00069	0.624
MOD_ProDKin_1	133	139	PF00069	0.534
MOD_ProDKin_1	47	53	PF00069	0.467
MOD_ProDKin_1	585	591	PF00069	0.643
MOD_ProDKin_1	827	833	PF00069	0.525
MOD_ProDKin_1	94	100	PF00069	0.478
TRG_DiLeu_BaEn_1	371	376	PF01217	0.256
TRG_DiLeu_BaEn_1	415	420	PF01217	0.426
TRG_DiLeu_BaEn_1	715	720	PF01217	0.408
TRG_DiLeu_BaEn_1	87	92	PF01217	0.454
TRG_DiLeu_BaEn_1	889	894	PF01217	0.478
TRG_DiLeu_BaEn_4	889	895	PF01217	0.530
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.564
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.491
TRG_ENDOCYTIC_2	251	254	PF00928	0.430
TRG_ENDOCYTIC_2	537	540	PF00928	0.449
TRG_ENDOCYTIC_2	643	646	PF00928	0.511
TRG_ENDOCYTIC_2	9	12	PF00928	0.557
TRG_ER_diArg_1	217	220	PF00400	0.521
TRG_ER_diArg_1	357	359	PF00400	0.349
TRG_ER_diArg_1	452	454	PF00400	0.614
TRG_ER_diArg_1	604	606	PF00400	0.519
TRG_ER_diArg_1	624	626	PF00400	0.476
TRG_ER_diArg_1	709	712	PF00400	0.337
TRG_ER_diArg_1	835	838	PF00400	0.518
TRG_ER_diArg_1	844	847	PF00400	0.507
TRG_ER_diArg_1	894	896	PF00400	0.485
TRG_NLS_MonoExtC_3	832	837	PF00514	0.530
TRG_NLS_MonoExtN_4	831	838	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P797	Leptomonas seymouri	46%	100%
A0A1X0NKL2	Trypanosomatidae	25%	100%
A0A3R7LZS8	Trypanosoma rangeli	27%	100%
A0A3S5H829	Leishmania donovani	99%	100%
A4HPF6	Leishmania braziliensis	75%	100%
E9AT68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1C9	Leishmania major	90%	100%
V5B0C2	Trypanosoma cruzi	26%	100%