LeishMANIAdb
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ATP-binding cassette protein subfamily G, member 6

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-binding cassette protein subfamily G, member 6
Gene product:
ATP-binding cassette protein subfamily G - member 6 - putative
Species:
Leishmania infantum
UniProt:
A4ID77_LEIIN
TriTrypDb:
LINF_360036900
Length:
683

Annotations

LeishMANIAdb annotations

Proteins belonging to the subfamily G of Eukaryotic ABC transporters. Probably functional as dimers, with broad substrate specificity.. Expanded in Kinetoplastids (also in free-living forms)

Annotations by Jardim et al.

Transporters, ATP-binding cassette G, member 6 ABCG6

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4ID77
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID77

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0009987 cellular process 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0005215 transporter activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0015399 primary active transmembrane transporter activity 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0022804 active transmembrane transporter activity 3 12
GO:0022857 transmembrane transporter activity 2 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0042626 ATPase-coupled transmembrane transporter activity 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140359 ABC-type transporter activity 3 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 9 13 PF00656 0.732
CLV_MEL_PAP_1 161 167 PF00089 0.359
CLV_NRD_NRD_1 194 196 PF00675 0.315
CLV_NRD_NRD_1 402 404 PF00675 0.437
CLV_NRD_NRD_1 96 98 PF00675 0.340
CLV_PCSK_KEX2_1 196 198 PF00082 0.254
CLV_PCSK_KEX2_1 402 404 PF00082 0.434
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.254
CLV_PCSK_PC7_1 398 404 PF00082 0.296
CLV_PCSK_SKI1_1 108 112 PF00082 0.325
CLV_PCSK_SKI1_1 259 263 PF00082 0.316
CLV_PCSK_SKI1_1 384 388 PF00082 0.462
CLV_PCSK_SKI1_1 597 601 PF00082 0.447
CLV_PCSK_SKI1_1 606 610 PF00082 0.465
CLV_PCSK_SKI1_1 97 101 PF00082 0.359
CLV_Separin_Metazoa 142 146 PF03568 0.503
DOC_CDC14_PxL_1 204 212 PF14671 0.531
DOC_CYCLIN_RxL_1 532 541 PF00134 0.339
DOC_MAPK_gen_1 455 463 PF00069 0.265
DOC_MAPK_gen_1 650 659 PF00069 0.303
DOC_MAPK_MEF2A_6 237 244 PF00069 0.534
DOC_MAPK_MEF2A_6 455 462 PF00069 0.295
DOC_MAPK_MEF2A_6 653 661 PF00069 0.303
DOC_PP1_RVXF_1 533 540 PF00149 0.295
DOC_PP1_RVXF_1 598 605 PF00149 0.254
DOC_PP2B_LxvP_1 333 336 PF13499 0.721
DOC_USP7_MATH_1 160 164 PF00917 0.507
DOC_USP7_MATH_1 318 322 PF00917 0.626
DOC_USP7_MATH_1 336 340 PF00917 0.575
DOC_USP7_MATH_1 34 38 PF00917 0.733
DOC_USP7_MATH_1 363 367 PF00917 0.580
DOC_USP7_UBL2_3 98 102 PF12436 0.559
DOC_WW_Pin1_4 150 155 PF00397 0.456
DOC_WW_Pin1_4 19 24 PF00397 0.771
DOC_WW_Pin1_4 27 32 PF00397 0.765
DOC_WW_Pin1_4 334 339 PF00397 0.695
DOC_WW_Pin1_4 392 397 PF00397 0.626
LIG_14-3-3_CanoR_1 145 151 PF00244 0.527
LIG_14-3-3_CanoR_1 164 172 PF00244 0.393
LIG_14-3-3_CanoR_1 178 186 PF00244 0.548
LIG_14-3-3_CanoR_1 402 411 PF00244 0.480
LIG_14-3-3_CanoR_1 606 612 PF00244 0.302
LIG_Actin_WH2_2 136 153 PF00022 0.503
LIG_BIR_II_1 1 5 PF00653 0.769
LIG_BRCT_BRCA1_1 208 212 PF00533 0.462
LIG_Clathr_ClatBox_1 210 214 PF01394 0.479
LIG_eIF4E_1 551 557 PF01652 0.387
LIG_FHA_1 104 110 PF00498 0.417
LIG_FHA_1 215 221 PF00498 0.508
LIG_FHA_1 38 44 PF00498 0.549
LIG_FHA_1 385 391 PF00498 0.622
LIG_FHA_1 403 409 PF00498 0.470
LIG_FHA_1 429 435 PF00498 0.419
LIG_FHA_1 438 444 PF00498 0.349
LIG_FHA_1 513 519 PF00498 0.311
LIG_FHA_1 564 570 PF00498 0.527
LIG_FHA_1 86 92 PF00498 0.503
LIG_FHA_2 137 143 PF00498 0.454
LIG_FHA_2 153 159 PF00498 0.507
LIG_FHA_2 216 222 PF00498 0.514
LIG_FHA_2 42 48 PF00498 0.571
LIG_FHA_2 87 93 PF00498 0.454
LIG_LIR_Apic_2 268 274 PF02991 0.495
LIG_LIR_Gen_1 136 144 PF02991 0.495
LIG_LIR_Gen_1 221 231 PF02991 0.515
LIG_LIR_Gen_1 251 262 PF02991 0.525
LIG_LIR_Gen_1 344 354 PF02991 0.620
LIG_LIR_Gen_1 426 435 PF02991 0.349
LIG_LIR_Gen_1 44 52 PF02991 0.587
LIG_LIR_Gen_1 468 478 PF02991 0.313
LIG_LIR_Gen_1 603 612 PF02991 0.359
LIG_LIR_LC3C_4 654 659 PF02991 0.337
LIG_LIR_Nem_3 136 140 PF02991 0.517
LIG_LIR_Nem_3 221 226 PF02991 0.554
LIG_LIR_Nem_3 251 257 PF02991 0.493
LIG_LIR_Nem_3 344 349 PF02991 0.630
LIG_LIR_Nem_3 426 430 PF02991 0.323
LIG_LIR_Nem_3 44 48 PF02991 0.517
LIG_LIR_Nem_3 442 447 PF02991 0.224
LIG_LIR_Nem_3 468 473 PF02991 0.323
LIG_LIR_Nem_3 603 607 PF02991 0.249
LIG_LIR_Nem_3 616 620 PF02991 0.273
LIG_NRBOX 227 233 PF00104 0.596
LIG_NRBOX 569 575 PF00104 0.424
LIG_PCNA_PIPBox_1 530 539 PF02747 0.295
LIG_SH2_PTP2 137 140 PF00017 0.540
LIG_SH2_PTP2 427 430 PF00017 0.427
LIG_SH2_STAP1 495 499 PF00017 0.540
LIG_SH2_STAP1 551 555 PF00017 0.322
LIG_SH2_STAP1 648 652 PF00017 0.421
LIG_SH2_STAT3 127 130 PF00017 0.454
LIG_SH2_STAT3 329 332 PF00017 0.580
LIG_SH2_STAT5 127 130 PF00017 0.454
LIG_SH2_STAT5 137 140 PF00017 0.454
LIG_SH2_STAT5 271 274 PF00017 0.485
LIG_SH2_STAT5 298 301 PF00017 0.590
LIG_SH2_STAT5 427 430 PF00017 0.416
LIG_SH2_STAT5 50 53 PF00017 0.581
LIG_SH2_STAT5 501 504 PF00017 0.344
LIG_SH2_STAT5 524 527 PF00017 0.306
LIG_SH2_STAT5 578 581 PF00017 0.341
LIG_SH2_STAT5 666 669 PF00017 0.330
LIG_SH2_STAT5 671 674 PF00017 0.342
LIG_SH2_STAT5 70 73 PF00017 0.480
LIG_SH3_3 1 7 PF00018 0.743
LIG_SH3_3 112 118 PF00018 0.501
LIG_SH3_3 202 208 PF00018 0.446
LIG_SH3_3 21 27 PF00018 0.775
LIG_SH3_3 28 34 PF00018 0.716
LIG_SH3_3 76 82 PF00018 0.540
LIG_SUMO_SIM_anti_2 238 245 PF11976 0.567
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.342
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.592
LIG_SUMO_SIM_anti_2 571 578 PF11976 0.427
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.461
LIG_SUMO_SIM_anti_2 88 95 PF11976 0.437
LIG_SUMO_SIM_par_1 203 209 PF11976 0.542
LIG_SUMO_SIM_par_1 508 515 PF11976 0.311
LIG_SUMO_SIM_par_1 544 550 PF11976 0.372
LIG_SUMO_SIM_par_1 585 591 PF11976 0.366
LIG_TRAF2_1 139 142 PF00917 0.540
LIG_TRAF2_1 307 310 PF00917 0.611
LIG_TRAF2_2 354 359 PF00917 0.642
LIG_TYR_ITIM 522 527 PF00017 0.322
LIG_TYR_ITIM 664 669 PF00017 0.322
LIG_TYR_ITSM 440 447 PF00017 0.421
LIG_UBA3_1 556 562 PF00899 0.414
LIG_UBA3_1 90 98 PF00899 0.465
LIG_WRC_WIRS_1 220 225 PF05994 0.538
LIG_WRC_WIRS_1 467 472 PF05994 0.427
MOD_CDC14_SPxK_1 395 398 PF00782 0.677
MOD_CDK_SPxK_1 392 398 PF00069 0.686
MOD_CK1_1 136 142 PF00069 0.495
MOD_CK1_1 163 169 PF00069 0.554
MOD_CK1_1 26 32 PF00069 0.741
MOD_CK1_1 289 295 PF00069 0.602
MOD_CK1_1 334 340 PF00069 0.706
MOD_CK1_1 37 43 PF00069 0.562
MOD_CK1_1 429 435 PF00069 0.421
MOD_CK1_1 450 456 PF00069 0.317
MOD_CK1_1 468 474 PF00069 0.241
MOD_CK1_1 558 564 PF00069 0.448
MOD_CK1_1 588 594 PF00069 0.314
MOD_CK1_1 626 632 PF00069 0.422
MOD_CK2_1 136 142 PF00069 0.454
MOD_CK2_1 152 158 PF00069 0.485
MOD_CK2_1 188 194 PF00069 0.446
MOD_CK2_1 19 25 PF00069 0.793
MOD_GlcNHglycan 124 127 PF01048 0.278
MOD_GlcNHglycan 146 149 PF01048 0.334
MOD_GlcNHglycan 183 186 PF01048 0.295
MOD_GlcNHglycan 190 193 PF01048 0.205
MOD_GlcNHglycan 237 240 PF01048 0.402
MOD_GlcNHglycan 288 291 PF01048 0.424
MOD_GlcNHglycan 320 323 PF01048 0.454
MOD_GlcNHglycan 350 353 PF01048 0.441
MOD_GlcNHglycan 431 434 PF01048 0.388
MOD_GlcNHglycan 497 500 PF01048 0.340
MOD_GlcNHglycan 52 55 PF01048 0.461
MOD_GlcNHglycan 636 639 PF01048 0.590
MOD_GlcNHglycan 67 70 PF01048 0.249
MOD_GlcNHglycan 72 75 PF01048 0.250
MOD_GlcNHglycan 82 85 PF01048 0.229
MOD_GSK3_1 146 153 PF00069 0.513
MOD_GSK3_1 177 184 PF00069 0.502
MOD_GSK3_1 19 26 PF00069 0.758
MOD_GSK3_1 215 222 PF00069 0.534
MOD_GSK3_1 227 234 PF00069 0.498
MOD_GSK3_1 285 292 PF00069 0.622
MOD_GSK3_1 33 40 PF00069 0.525
MOD_GSK3_1 348 355 PF00069 0.677
MOD_GSK3_1 380 387 PF00069 0.625
MOD_GSK3_1 388 395 PF00069 0.643
MOD_GSK3_1 46 53 PF00069 0.595
MOD_GSK3_1 465 472 PF00069 0.317
MOD_LATS_1 401 407 PF00433 0.471
MOD_N-GLC_1 103 108 PF02516 0.178
MOD_N-GLC_1 558 563 PF02516 0.270
MOD_N-GLC_2 418 420 PF02516 0.206
MOD_NEK2_1 146 151 PF00069 0.527
MOD_NEK2_1 231 236 PF00069 0.554
MOD_NEK2_1 379 384 PF00069 0.589
MOD_NEK2_1 390 395 PF00069 0.623
MOD_NEK2_1 439 444 PF00069 0.329
MOD_NEK2_1 465 470 PF00069 0.336
MOD_NEK2_1 494 499 PF00069 0.532
MOD_NEK2_1 529 534 PF00069 0.298
MOD_NEK2_1 555 560 PF00069 0.363
MOD_NEK2_1 585 590 PF00069 0.393
MOD_NEK2_1 607 612 PF00069 0.323
MOD_NEK2_2 363 368 PF00069 0.605
MOD_PIKK_1 163 169 PF00454 0.533
MOD_PIKK_1 352 358 PF00454 0.622
MOD_PIKK_1 403 409 PF00454 0.450
MOD_PIKK_1 447 453 PF00454 0.340
MOD_PIKK_1 641 647 PF00454 0.385
MOD_PKA_1 402 408 PF00069 0.463
MOD_PKA_2 144 150 PF00069 0.515
MOD_PKA_2 163 169 PF00069 0.515
MOD_PKA_2 177 183 PF00069 0.548
MOD_PKA_2 380 386 PF00069 0.612
MOD_PKA_2 402 408 PF00069 0.619
MOD_PKA_2 677 683 PF00069 0.668
MOD_Plk_1 46 52 PF00069 0.578
MOD_Plk_4 133 139 PF00069 0.501
MOD_Plk_4 206 212 PF00069 0.462
MOD_Plk_4 227 233 PF00069 0.532
MOD_Plk_4 301 307 PF00069 0.601
MOD_Plk_4 423 429 PF00069 0.339
MOD_Plk_4 439 445 PF00069 0.227
MOD_Plk_4 569 575 PF00069 0.427
MOD_Plk_4 618 624 PF00069 0.407
MOD_Plk_4 86 92 PF00069 0.451
MOD_ProDKin_1 150 156 PF00069 0.456
MOD_ProDKin_1 19 25 PF00069 0.772
MOD_ProDKin_1 27 33 PF00069 0.762
MOD_ProDKin_1 334 340 PF00069 0.695
MOD_ProDKin_1 392 398 PF00069 0.623
TRG_DiLeu_BaEn_1 59 64 PF01217 0.642
TRG_DiLeu_BaEn_4 309 315 PF01217 0.593
TRG_ENDOCYTIC_2 137 140 PF00928 0.465
TRG_ENDOCYTIC_2 254 257 PF00928 0.574
TRG_ENDOCYTIC_2 427 430 PF00928 0.370
TRG_ENDOCYTIC_2 444 447 PF00928 0.162
TRG_ENDOCYTIC_2 524 527 PF00928 0.306
TRG_ENDOCYTIC_2 666 669 PF00928 0.306
TRG_ENDOCYTIC_2 671 674 PF00928 0.306
TRG_ER_diArg_1 249 252 PF00400 0.573
TRG_ER_diArg_1 402 404 PF00400 0.627
TRG_ER_diArg_1 416 419 PF00400 0.531
TRG_ER_diArg_1 454 457 PF00400 0.265
TRG_NES_CRM1_1 297 311 PF08389 0.575
TRG_NES_CRM1_1 359 371 PF08389 0.568
TRG_Pf-PMV_PEXEL_1 280 284 PF00026 0.291
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSP2 Leptomonas seymouri 27% 93%
A0A0N1HZC7 Leptomonas seymouri 68% 100%
A0A0S4IJ55 Bodo saltans 27% 90%
A0A0S4IQG2 Bodo saltans 27% 100%
A0A0S4IUG8 Bodo saltans 26% 100%
A0A0S4IUY5 Bodo saltans 46% 100%
A0A0S4IY23 Bodo saltans 29% 100%
A0A0S4IZ09 Bodo saltans 22% 100%
A0A0S4J724 Bodo saltans 28% 100%
A0A0S4J7U2 Bodo saltans 30% 98%
A0A0S4JPA7 Bodo saltans 29% 91%
A0A1X0NKI4 Trypanosomatidae 49% 100%
A0A1X0NM50 Trypanosomatidae 27% 100%
A0A1X0NTW9 Trypanosomatidae 27% 100%
A0A1X0P4K0 Trypanosomatidae 22% 100%
A0A3Q8IA65 Leishmania donovani 27% 92%
A0A3Q8IHD8 Leishmania donovani 100% 100%
A0A3R7KEQ6 Trypanosoma rangeli 45% 100%
A0A3R7MNM8 Trypanosoma rangeli 27% 100%
A0A3S5H5N0 Leishmania donovani 28% 100%
A0A3S7WPB9 Leishmania donovani 28% 100%
A0A422N4V5 Trypanosoma rangeli 28% 98%
A4H4G9 Leishmania braziliensis 29% 100%
A4H4H6 Leishmania braziliensis 29% 100%
A4H862 Leishmania braziliensis 26% 100%
A4HPF5 Leishmania braziliensis 79% 100%
A4HSQ0 Leishmania infantum 28% 100%
A4HSQ1 Leishmania infantum 28% 100%
A4HWI7 Leishmania infantum 27% 100%
B8ALI0 Oryza sativa subsp. indica 29% 87%
C9ZXW1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A3G8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A3K9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
D3ZCM3 Rattus norvegicus 28% 100%
E9AKN6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AKN7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AQ88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AT67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
H9BZ66 Petunia hybrida 27% 100%
O80946 Arabidopsis thaliana 28% 92%
P10090 Drosophila melanogaster 28% 99%
P45843 Drosophila melanogaster 26% 100%
P45844 Homo sapiens 28% 100%
P58428 Rattus norvegicus 27% 98%
Q05360 Lucilia cuprina 28% 100%
Q09466 Caenorhabditis elegans 26% 100%
Q11180 Caenorhabditis elegans 27% 100%
Q16928 Anopheles albimanus 29% 96%
Q17320 Ceratitis capitata 27% 100%
Q27256 Anopheles gambiae 29% 98%
Q4GZT4 Bos taurus 29% 100%
Q4Q1D0 Leishmania major 93% 98%
Q4QF95 Leishmania major 27% 100%
Q4QJ70 Leishmania major 29% 100%
Q4QJ71 Leishmania major 29% 100%
Q55DA0 Dictyostelium discoideum 28% 100%
Q5MB13 Macaca mulatta 30% 100%
Q64343 Mus musculus 28% 100%
Q7TMS5 Mus musculus 30% 100%
Q7XA72 Arabidopsis thaliana 29% 100%
Q80W57 Rattus norvegicus 30% 100%
Q84TH5 Arabidopsis thaliana 29% 100%
Q8H8V7 Oryza sativa subsp. japonica 29% 87%
Q8MIB3 Sus scrofa 30% 100%
Q8RWI9 Arabidopsis thaliana 31% 99%
Q8RXN0 Arabidopsis thaliana 30% 97%
Q8T686 Dictyostelium discoideum 26% 84%
Q8T689 Dictyostelium discoideum 29% 86%
Q91WA9 Mus musculus 28% 100%
Q93YS4 Arabidopsis thaliana 28% 91%
Q99P81 Mus musculus 26% 100%
Q99PE7 Rattus norvegicus 26% 100%
Q99PE8 Mus musculus 26% 100%
Q9C6W5 Arabidopsis thaliana 28% 100%
Q9C8J8 Arabidopsis thaliana 29% 100%
Q9C8K2 Arabidopsis thaliana 31% 99%
Q9DBM0 Mus musculus 28% 100%
Q9FLX5 Arabidopsis thaliana 27% 100%
Q9FNB5 Arabidopsis thaliana 26% 94%
Q9FT51 Arabidopsis thaliana 28% 93%
Q9H221 Homo sapiens 27% 100%
Q9H222 Homo sapiens 26% 100%
Q9LFG8 Arabidopsis thaliana 28% 92%
Q9LK50 Arabidopsis thaliana 28% 100%
Q9M2V5 Arabidopsis thaliana 27% 96%
Q9M2V6 Arabidopsis thaliana 28% 100%
Q9M2V7 Arabidopsis thaliana 26% 93%
Q9M3D6 Arabidopsis thaliana 28% 94%
Q9SIT6 Arabidopsis thaliana 27% 100%
Q9SW08 Arabidopsis thaliana 27% 100%
Q9SZR9 Arabidopsis thaliana 29% 100%
Q9UNQ0 Homo sapiens 29% 100%
Q9ZU35 Arabidopsis thaliana 30% 94%
Q9ZUT0 Arabidopsis thaliana 27% 90%
Q9ZUU9 Arabidopsis thaliana 22% 94%
V5B0X3 Trypanosoma cruzi 21% 100%
V5BCE1 Trypanosoma cruzi 29% 67%
V5BPQ0 Trypanosoma cruzi 27% 98%
V5D8T8 Trypanosoma cruzi 27% 100%
V5DGN9 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS