Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ID73_LEIIN

TriTrypDb:

LINF_360040700

Length:

226

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized (Fragment)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4ID73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.531
CLV_PCSK_KEX2_1	140	142	PF00082	0.537
CLV_PCSK_KEX2_1	180	182	PF00082	0.394
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.335
CLV_PCSK_SKI1_1	180	184	PF00082	0.319
CLV_PCSK_SKI1_1	91	95	PF00082	0.315
DEG_Nend_UBRbox_2	1	3	PF02207	0.513
DOC_ANK_TNKS_1	139	146	PF00023	0.361
DOC_PP1_RVXF_1	133	139	PF00149	0.333
DOC_PP4_MxPP_1	217	220	PF00568	0.621
DOC_USP7_MATH_1	143	147	PF00917	0.380
DOC_USP7_MATH_1	175	179	PF00917	0.525
DOC_USP7_MATH_1	54	58	PF00917	0.501
LIG_14-3-3_CanoR_1	181	189	PF00244	0.624
LIG_Actin_WH2_2	185	203	PF00022	0.538
LIG_APCC_ABBA_1	19	24	PF00400	0.500
LIG_BRCT_BRCA1_1	2	6	PF00533	0.621
LIG_FHA_1	115	121	PF00498	0.332
LIG_FHA_1	154	160	PF00498	0.297
LIG_FHA_1	195	201	PF00498	0.639
LIG_FHA_1	33	39	PF00498	0.579
LIG_FHA_1	61	67	PF00498	0.534
LIG_FHA_1	94	100	PF00498	0.553
LIG_LIR_Apic_2	49	54	PF02991	0.519
LIG_LIR_Gen_1	110	119	PF02991	0.302
LIG_LIR_Nem_3	27	33	PF02991	0.499
LIG_LIR_Nem_3	49	53	PF02991	0.537
LIG_LIR_Nem_3	85	90	PF02991	0.510
LIG_MLH1_MIPbox_1	2	6	PF16413	0.621
LIG_Pex14_1	107	111	PF04695	0.553
LIG_SH2_CRK	87	91	PF00017	0.482
LIG_SH2_CRK	92	96	PF00017	0.461
LIG_SH2_GRB2like	50	53	PF00017	0.481
LIG_SH2_PTP2	72	75	PF00017	0.498
LIG_SH2_STAT5	198	201	PF00017	0.540
LIG_SH2_STAT5	5	8	PF00017	0.544
LIG_SH2_STAT5	59	62	PF00017	0.547
LIG_SH2_STAT5	72	75	PF00017	0.493
LIG_SH3_3	215	221	PF00018	0.635
LIG_SUMO_SIM_par_1	116	122	PF11976	0.327
LIG_TRAF2_1	220	223	PF00917	0.635
LIG_TYR_ITIM	90	95	PF00017	0.468
LIG_WRC_WIRS_1	128	133	PF05994	0.509
LIG_WRC_WIRS_1	148	153	PF05994	0.426
MOD_GlcNHglycan	24	29	PF01048	0.323
MOD_GlcNHglycan	56	59	PF01048	0.321
MOD_GlcNHglycan	96	99	PF01048	0.292
MOD_GSK3_1	110	117	PF00069	0.346
MOD_GSK3_1	143	150	PF00069	0.393
MOD_LATS_1	179	185	PF00433	0.487
MOD_N-GLC_1	114	119	PF02516	0.329
MOD_NEK2_1	114	119	PF00069	0.235
MOD_NEK2_1	155	160	PF00069	0.363
MOD_NEK2_1	60	65	PF00069	0.525
MOD_NEK2_1	83	88	PF00069	0.527
MOD_NEK2_1	94	99	PF00069	0.492
MOD_Plk_1	114	120	PF00069	0.330
MOD_Plk_4	143	149	PF00069	0.325
MOD_Plk_4	155	161	PF00069	0.274
MOD_SUMO_rev_2	204	208	PF00179	0.627
MOD_SUMO_rev_2	76	81	PF00179	0.588
TRG_ENDOCYTIC_2	109	112	PF00928	0.519
TRG_ENDOCYTIC_2	30	33	PF00928	0.502
TRG_ENDOCYTIC_2	50	53	PF00928	0.489
TRG_ENDOCYTIC_2	72	75	PF00928	0.502
TRG_ENDOCYTIC_2	87	90	PF00928	0.479
TRG_ENDOCYTIC_2	92	95	PF00928	0.464
TRG_ER_diArg_1	133	136	PF00400	0.330
TRG_ER_diArg_1	139	141	PF00400	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P459	Leptomonas seymouri	84%	74%
A0A0S4JIL7	Bodo saltans	54%	74%
A0A1X0P3F8	Trypanosomatidae	64%	75%
A0A3R7NG42	Trypanosoma rangeli	62%	91%
A0A3S5H831	Leishmania donovani	100%	74%
A4HPJ0	Leishmania braziliensis	90%	100%
D0A8F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	76%
E9ATA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q195	Leishmania major	96%	100%
V5BIN2	Trypanosoma cruzi	60%	75%