TSPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ID72_LEIIN

TriTrypDb:

LINF_360040800

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4ID72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	811	815	PF00656	0.447
CLV_NRD_NRD_1	243	245	PF00675	0.617
CLV_NRD_NRD_1	31	33	PF00675	0.707
CLV_NRD_NRD_1	721	723	PF00675	0.645
CLV_PCSK_FUR_1	29	33	PF00082	0.723
CLV_PCSK_KEX2_1	243	245	PF00082	0.617
CLV_PCSK_KEX2_1	29	31	PF00082	0.740
CLV_PCSK_KEX2_1	721	723	PF00082	0.645
CLV_PCSK_SKI1_1	639	643	PF00082	0.536
DEG_APCC_KENBOX_2	705	709	PF00400	0.362
DEG_Nend_UBRbox_2	1	3	PF02207	0.564
DEG_SCF_FBW7_1	537	543	PF00400	0.534
DEG_SCF_FBW7_1	804	810	PF00400	0.526
DEG_SCF_FBW7_2	744	750	PF00400	0.451
DEG_SPOP_SBC_1	541	545	PF00917	0.504
DOC_ANK_TNKS_1	149	156	PF00023	0.401
DOC_ANK_TNKS_1	816	823	PF00023	0.440
DOC_CKS1_1	358	363	PF01111	0.384
DOC_CKS1_1	537	542	PF01111	0.534
DOC_CKS1_1	744	749	PF01111	0.451
DOC_CKS1_1	804	809	PF01111	0.523
DOC_CYCLIN_yCln2_LP_2	818	821	PF00134	0.435
DOC_MAPK_DCC_7	289	299	PF00069	0.404
DOC_PP2B_LxvP_1	365	368	PF13499	0.451
DOC_PP2B_LxvP_1	818	821	PF13499	0.435
DOC_USP7_MATH_1	126	130	PF00917	0.443
DOC_USP7_MATH_1	191	195	PF00917	0.450
DOC_USP7_MATH_1	196	200	PF00917	0.390
DOC_USP7_MATH_1	518	522	PF00917	0.605
DOC_USP7_MATH_1	524	528	PF00917	0.570
DOC_USP7_MATH_1	540	544	PF00917	0.487
DOC_USP7_MATH_1	808	812	PF00917	0.464
DOC_USP7_MATH_2	679	685	PF00917	0.359
DOC_WW_Pin1_4	324	329	PF00397	0.533
DOC_WW_Pin1_4	357	362	PF00397	0.413
DOC_WW_Pin1_4	412	417	PF00397	0.456
DOC_WW_Pin1_4	536	541	PF00397	0.534
DOC_WW_Pin1_4	743	748	PF00397	0.443
DOC_WW_Pin1_4	803	808	PF00397	0.520
LIG_14-3-3_CanoR_1	124	134	PF00244	0.382
LIG_14-3-3_CanoR_1	289	294	PF00244	0.361
LIG_14-3-3_CanoR_1	492	498	PF00244	0.537
LIG_14-3-3_CanoR_1	639	647	PF00244	0.376
LIG_14-3-3_CanoR_1	768	773	PF00244	0.461
LIG_APCC_ABBAyCdc20_2	41	47	PF00400	0.504
LIG_BRCT_BRCA1_1	193	197	PF00533	0.466
LIG_BRCT_BRCA1_1	214	218	PF00533	0.433
LIG_BRCT_BRCA1_1	69	73	PF00533	0.433
LIG_BRCT_BRCA1_1	832	836	PF00533	0.364
LIG_Clathr_ClatBox_1	332	336	PF01394	0.423
LIG_DLG_GKlike_1	768	776	PF00625	0.373
LIG_eIF4E_1	830	836	PF01652	0.446
LIG_FHA_1	118	124	PF00498	0.440
LIG_FHA_1	129	135	PF00498	0.371
LIG_FHA_1	181	187	PF00498	0.370
LIG_FHA_1	325	331	PF00498	0.474
LIG_FHA_1	384	390	PF00498	0.473
LIG_FHA_1	558	564	PF00498	0.568
LIG_FHA_1	610	616	PF00498	0.359
LIG_FHA_1	629	635	PF00498	0.424
LIG_FHA_1	711	717	PF00498	0.425
LIG_FHA_1	735	741	PF00498	0.465
LIG_FHA_1	774	780	PF00498	0.377
LIG_FHA_1	804	810	PF00498	0.573
LIG_FHA_1	811	817	PF00498	0.498
LIG_FHA_1	822	828	PF00498	0.338
LIG_FHA_1	86	92	PF00498	0.477
LIG_FHA_2	55	61	PF00498	0.467
LIG_FHA_2	702	708	PF00498	0.396
LIG_LIR_Apic_2	290	296	PF02991	0.370
LIG_LIR_Apic_2	355	361	PF02991	0.383
LIG_LIR_Apic_2	654	660	PF02991	0.386
LIG_LIR_Apic_2	675	679	PF02991	0.423
LIG_LIR_Gen_1	143	153	PF02991	0.419
LIG_LIR_Gen_1	164	173	PF02991	0.412
LIG_LIR_Gen_1	407	417	PF02991	0.443
LIG_LIR_Gen_1	595	600	PF02991	0.366
LIG_LIR_Gen_1	70	80	PF02991	0.433
LIG_LIR_Gen_1	738	747	PF02991	0.424
LIG_LIR_Gen_1	748	759	PF02991	0.365
LIG_LIR_Nem_3	164	169	PF02991	0.407
LIG_LIR_Nem_3	183	187	PF02991	0.221
LIG_LIR_Nem_3	199	205	PF02991	0.299
LIG_LIR_Nem_3	360	365	PF02991	0.450
LIG_LIR_Nem_3	407	412	PF02991	0.425
LIG_LIR_Nem_3	463	468	PF02991	0.398
LIG_LIR_Nem_3	478	483	PF02991	0.260
LIG_LIR_Nem_3	595	599	PF02991	0.387
LIG_LIR_Nem_3	70	76	PF02991	0.468
LIG_LIR_Nem_3	738	744	PF02991	0.426
LIG_LIR_Nem_3	748	754	PF02991	0.369
LIG_LIR_Nem_3	785	791	PF02991	0.427
LIG_LIR_Nem_3	833	839	PF02991	0.393
LIG_LYPXL_S_1	36	40	PF13949	0.712
LIG_LYPXL_yS_3	37	40	PF13949	0.517
LIG_MYND_1	115	119	PF01753	0.502
LIG_Pex14_1	273	277	PF04695	0.362
LIG_Pex14_1	358	362	PF04695	0.452
LIG_Pex14_1	657	661	PF04695	0.439
LIG_Pex14_2	173	177	PF04695	0.424
LIG_PTB_Apo_2	39	46	PF02174	0.507
LIG_PTB_Phospho_1	39	45	PF10480	0.514
LIG_REV1ctd_RIR_1	93	101	PF16727	0.490
LIG_SH2_CRK	187	191	PF00017	0.434
LIG_SH2_CRK	400	404	PF00017	0.423
LIG_SH2_CRK	596	600	PF00017	0.373
LIG_SH2_CRK	741	745	PF00017	0.448
LIG_SH2_NCK_1	187	191	PF00017	0.346
LIG_SH2_NCK_1	483	487	PF00017	0.401
LIG_SH2_NCK_1	596	600	PF00017	0.429
LIG_SH2_NCK_1	759	763	PF00017	0.436
LIG_SH2_PTP2	676	679	PF00017	0.423
LIG_SH2_SRC	646	649	PF00017	0.402
LIG_SH2_SRC	676	679	PF00017	0.423
LIG_SH2_STAP1	304	308	PF00017	0.409
LIG_SH2_STAP1	519	523	PF00017	0.510
LIG_SH2_STAP1	596	600	PF00017	0.373
LIG_SH2_STAP1	98	102	PF00017	0.486
LIG_SH2_STAT3	246	249	PF00017	0.392
LIG_SH2_STAT3	98	101	PF00017	0.491
LIG_SH2_STAT5	184	187	PF00017	0.391
LIG_SH2_STAT5	219	222	PF00017	0.428
LIG_SH2_STAT5	246	249	PF00017	0.450
LIG_SH2_STAT5	293	296	PF00017	0.395
LIG_SH2_STAT5	480	483	PF00017	0.407
LIG_SH2_STAT5	596	599	PF00017	0.401
LIG_SH2_STAT5	646	649	PF00017	0.423
LIG_SH2_STAT5	661	664	PF00017	0.355
LIG_SH2_STAT5	676	679	PF00017	0.291
LIG_SH2_STAT5	68	71	PF00017	0.497
LIG_SH2_STAT5	687	690	PF00017	0.312
LIG_SH2_STAT5	703	706	PF00017	0.306
LIG_SH2_STAT5	717	720	PF00017	0.332
LIG_SH2_STAT5	75	78	PF00017	0.435
LIG_SH2_STAT5	803	806	PF00017	0.517
LIG_SH2_STAT5	830	833	PF00017	0.529
LIG_SH3_3	562	568	PF00018	0.524
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.382
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.326
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.531
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.478
LIG_SUMO_SIM_par_1	253	260	PF11976	0.435
LIG_SUMO_SIM_par_1	331	336	PF11976	0.426
LIG_SUMO_SIM_par_1	414	420	PF11976	0.477
LIG_SUMO_SIM_par_1	51	58	PF11976	0.531
LIG_SUMO_SIM_par_1	563	569	PF11976	0.496
LIG_TRAF2_1	46	49	PF00917	0.496
LIG_TYR_ITIM	398	403	PF00017	0.435
LIG_TYR_ITIM	779	784	PF00017	0.419
LIG_UBA3_1	91	97	PF00899	0.484
LIG_WRC_WIRS_1	127	132	PF05994	0.441
LIG_WRC_WIRS_1	349	354	PF05994	0.449
MOD_CK1_1	125	131	PF00069	0.384
MOD_CK1_1	209	215	PF00069	0.402
MOD_CK1_1	221	227	PF00069	0.318
MOD_CK1_1	256	262	PF00069	0.437
MOD_CK1_1	378	384	PF00069	0.408
MOD_CK1_1	407	413	PF00069	0.424
MOD_CK1_1	478	484	PF00069	0.456
MOD_CK1_1	491	497	PF00069	0.471
MOD_CK1_1	500	506	PF00069	0.493
MOD_CK1_1	527	533	PF00069	0.516
MOD_CK1_1	573	579	PF00069	0.572
MOD_CK1_1	598	604	PF00069	0.453
MOD_CK1_1	609	615	PF00069	0.384
MOD_CK1_1	632	638	PF00069	0.399
MOD_CK1_1	664	670	PF00069	0.419
MOD_CK1_1	680	686	PF00069	0.299
MOD_CK2_1	126	132	PF00069	0.442
MOD_CK2_1	348	354	PF00069	0.385
MOD_CK2_1	417	423	PF00069	0.470
MOD_CK2_1	43	49	PF00069	0.500
MOD_CK2_1	578	584	PF00069	0.487
MOD_CK2_1	701	707	PF00069	0.369
MOD_Cter_Amidation	241	244	PF01082	0.621
MOD_GlcNHglycan	124	127	PF01048	0.651
MOD_GlcNHglycan	159	162	PF01048	0.605
MOD_GlcNHglycan	264	267	PF01048	0.643
MOD_GlcNHglycan	269	272	PF01048	0.609
MOD_GlcNHglycan	442	445	PF01048	0.633
MOD_GlcNHglycan	494	497	PF01048	0.784
MOD_GlcNHglycan	5	8	PF01048	0.682
MOD_GlcNHglycan	520	523	PF01048	0.764
MOD_GlcNHglycan	526	529	PF01048	0.718
MOD_GlcNHglycan	530	533	PF01048	0.706
MOD_GlcNHglycan	578	581	PF01048	0.766
MOD_GlcNHglycan	623	626	PF01048	0.662
MOD_GlcNHglycan	634	637	PF01048	0.548
MOD_GlcNHglycan	664	667	PF01048	0.660
MOD_GlcNHglycan	69	72	PF01048	0.630
MOD_GlcNHglycan	755	758	PF01048	0.673
MOD_GlcNHglycan	759	762	PF01048	0.635
MOD_GlcNHglycan	810	813	PF01048	0.663
MOD_GSK3_1	122	129	PF00069	0.453
MOD_GSK3_1	157	164	PF00069	0.439
MOD_GSK3_1	191	198	PF00069	0.498
MOD_GSK3_1	218	225	PF00069	0.394
MOD_GSK3_1	228	235	PF00069	0.404
MOD_GSK3_1	253	260	PF00069	0.422
MOD_GSK3_1	267	274	PF00069	0.318
MOD_GSK3_1	348	355	PF00069	0.474
MOD_GSK3_1	407	414	PF00069	0.437
MOD_GSK3_1	471	478	PF00069	0.428
MOD_GSK3_1	481	488	PF00069	0.425
MOD_GSK3_1	490	497	PF00069	0.494
MOD_GSK3_1	499	506	PF00069	0.459
MOD_GSK3_1	523	530	PF00069	0.503
MOD_GSK3_1	536	543	PF00069	0.499
MOD_GSK3_1	570	577	PF00069	0.522
MOD_GSK3_1	594	601	PF00069	0.411
MOD_GSK3_1	628	635	PF00069	0.426
MOD_GSK3_1	647	654	PF00069	0.396
MOD_GSK3_1	664	671	PF00069	0.384
MOD_GSK3_1	677	684	PF00069	0.321
MOD_GSK3_1	723	730	PF00069	0.451
MOD_GSK3_1	753	760	PF00069	0.385
MOD_GSK3_1	762	769	PF00069	0.365
MOD_GSK3_1	803	810	PF00069	0.548
MOD_N-GLC_1	209	214	PF02516	0.669
MOD_N-GLC_1	322	327	PF02516	0.581
MOD_N-GLC_1	339	344	PF02516	0.552
MOD_N-GLC_1	389	394	PF02516	0.663
MOD_N-GLC_1	570	575	PF02516	0.702
MOD_N-GLC_1	609	614	PF02516	0.550
MOD_N-GLC_1	621	626	PF02516	0.523
MOD_N-GLC_1	668	673	PF02516	0.668
MOD_N-GLC_1	710	715	PF02516	0.601
MOD_NEK2_1	173	178	PF00069	0.424
MOD_NEK2_1	267	272	PF00069	0.436
MOD_NEK2_1	352	357	PF00069	0.460
MOD_NEK2_1	375	380	PF00069	0.385
MOD_NEK2_1	389	394	PF00069	0.322
MOD_NEK2_1	40	45	PF00069	0.510
MOD_NEK2_1	411	416	PF00069	0.437
MOD_NEK2_1	417	422	PF00069	0.421
MOD_NEK2_1	479	484	PF00069	0.360
MOD_NEK2_1	485	490	PF00069	0.437
MOD_NEK2_1	606	611	PF00069	0.388
MOD_NEK2_1	616	621	PF00069	0.370
MOD_NEK2_1	634	639	PF00069	0.430
MOD_NEK2_1	641	646	PF00069	0.374
MOD_NEK2_1	662	667	PF00069	0.429
MOD_NEK2_1	701	706	PF00069	0.407
MOD_NEK2_1	727	732	PF00069	0.440
MOD_NEK2_1	845	850	PF00069	0.674
MOD_NEK2_1	85	90	PF00069	0.482
MOD_NEK2_2	119	124	PF00069	0.464
MOD_NEK2_2	284	289	PF00069	0.403
MOD_NEK2_2	600	605	PF00069	0.345
MOD_PIKK_1	471	477	PF00454	0.373
MOD_PIKK_1	629	635	PF00454	0.410
MOD_PIKK_1	641	647	PF00454	0.315
MOD_PKA_2	149	155	PF00069	0.432
MOD_PKA_2	491	497	PF00069	0.533
MOD_PKA_2	574	580	PF00069	0.533
MOD_PKA_2	662	668	PF00069	0.432
MOD_Plk_1	212	218	PF00069	0.448
MOD_Plk_1	222	228	PF00069	0.353
MOD_Plk_1	311	317	PF00069	0.414
MOD_Plk_1	352	358	PF00069	0.463
MOD_Plk_1	570	576	PF00069	0.537
MOD_Plk_1	629	635	PF00069	0.365
MOD_Plk_1	668	674	PF00069	0.462
MOD_Plk_1	766	772	PF00069	0.452
MOD_Plk_4	165	171	PF00069	0.359
MOD_Plk_4	173	179	PF00069	0.361
MOD_Plk_4	180	186	PF00069	0.266
MOD_Plk_4	352	358	PF00069	0.463
MOD_Plk_4	375	381	PF00069	0.409
MOD_Plk_4	389	395	PF00069	0.380
MOD_Plk_4	40	46	PF00069	0.503
MOD_Plk_4	401	407	PF00069	0.326
MOD_Plk_4	475	481	PF00069	0.425
MOD_Plk_4	509	515	PF00069	0.505
MOD_Plk_4	616	622	PF00069	0.436
MOD_Plk_4	668	674	PF00069	0.456
MOD_Plk_4	723	729	PF00069	0.433
MOD_Plk_4	774	780	PF00069	0.474
MOD_Plk_4	830	836	PF00069	0.492
MOD_Plk_4	86	92	PF00069	0.388
MOD_ProDKin_1	324	330	PF00069	0.526
MOD_ProDKin_1	357	363	PF00069	0.406
MOD_ProDKin_1	412	418	PF00069	0.459
MOD_ProDKin_1	536	542	PF00069	0.534
MOD_ProDKin_1	743	749	PF00069	0.446
MOD_ProDKin_1	803	809	PF00069	0.519
TRG_DiLeu_BaEn_4	132	138	PF01217	0.428
TRG_DiLeu_BaLyEn_6	814	819	PF01217	0.499
TRG_ENDOCYTIC_2	349	352	PF00928	0.420
TRG_ENDOCYTIC_2	362	365	PF00928	0.360
TRG_ENDOCYTIC_2	37	40	PF00928	0.517
TRG_ENDOCYTIC_2	400	403	PF00928	0.419
TRG_ENDOCYTIC_2	596	599	PF00928	0.371
TRG_ENDOCYTIC_2	741	744	PF00928	0.502
TRG_ENDOCYTIC_2	781	784	PF00928	0.424
TRG_ER_diArg_1	28	31	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XB55	Leishmania donovani	100%	100%
A4HPJ1	Leishmania braziliensis	68%	100%
E9ATA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%