Intu_longin_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fungal domain of unknown function (DUF1712) - putative

Species:

Leishmania infantum

UniProt:

A4ID71_LEIIN

TriTrypDb:

LINF_360040900

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ID71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID71

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.713
CLV_MEL_PAP_1	61	67	PF00089	0.383
CLV_NRD_NRD_1	138	140	PF00675	0.750
CLV_NRD_NRD_1	71	73	PF00675	0.490
CLV_NRD_NRD_1	75	77	PF00675	0.471
CLV_PCSK_KEX2_1	71	73	PF00082	0.519
CLV_PCSK_SKI1_1	168	172	PF00082	0.527
CLV_PCSK_SKI1_1	177	181	PF00082	0.468
CLV_PCSK_SKI1_1	247	251	PF00082	0.695
CLV_PCSK_SKI1_1	372	376	PF00082	0.708
CLV_PCSK_SKI1_1	509	513	PF00082	0.541
CLV_Separin_Metazoa	244	248	PF03568	0.640
DEG_SPOP_SBC_1	458	462	PF00917	0.647
DOC_ANK_TNKS_1	435	442	PF00023	0.676
DOC_CKS1_1	152	157	PF01111	0.782
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.674
DOC_MAPK_FxFP_2	37	40	PF00069	0.513
DOC_MAPK_gen_1	76	84	PF00069	0.416
DOC_MAPK_MEF2A_6	232	239	PF00069	0.685
DOC_PP1_RVXF_1	245	252	PF00149	0.592
DOC_PP2B_LxvP_1	130	133	PF13499	0.650
DOC_PP2B_LxvP_1	307	310	PF13499	0.579
DOC_PP2B_LxvP_1	409	412	PF13499	0.676
DOC_PP2B_LxvP_1	455	458	PF13499	0.708
DOC_PP2B_LxvP_1	512	515	PF13499	0.710
DOC_PP4_FxxP_1	222	225	PF00568	0.761
DOC_PP4_FxxP_1	279	282	PF00568	0.612
DOC_PP4_FxxP_1	37	40	PF00568	0.513
DOC_SPAK_OSR1_1	64	68	PF12202	0.383
DOC_USP7_MATH_1	160	164	PF00917	0.707
DOC_USP7_MATH_1	166	170	PF00917	0.606
DOC_USP7_MATH_1	205	209	PF00917	0.667
DOC_USP7_MATH_1	218	222	PF00917	0.650
DOC_USP7_MATH_1	312	316	PF00917	0.548
DOC_USP7_MATH_1	414	418	PF00917	0.707
DOC_USP7_MATH_1	57	61	PF00917	0.411
DOC_USP7_UBL2_3	406	410	PF12436	0.752
DOC_WW_Pin1_4	151	156	PF00397	0.789
DOC_WW_Pin1_4	354	359	PF00397	0.636
DOC_WW_Pin1_4	430	435	PF00397	0.682
DOC_WW_Pin1_4	83	88	PF00397	0.411
LIG_14-3-3_CanoR_1	177	182	PF00244	0.590
LIG_14-3-3_CanoR_1	227	235	PF00244	0.695
LIG_14-3-3_CanoR_1	365	375	PF00244	0.640
LIG_14-3-3_CanoR_1	471	476	PF00244	0.525
LIG_14-3-3_CanoR_1	76	85	PF00244	0.424
LIG_APCC_ABBA_1	341	346	PF00400	0.570
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.524
LIG_EH1_1	504	512	PF00400	0.509
LIG_eIF4E_1	505	511	PF01652	0.637
LIG_FHA_1	105	111	PF00498	0.416
LIG_FHA_1	346	352	PF00498	0.683
LIG_FHA_1	461	467	PF00498	0.628
LIG_FHA_2	3	9	PF00498	0.757
LIG_FHA_2	381	387	PF00498	0.585
LIG_FHA_2	426	432	PF00498	0.621
LIG_GBD_Chelix_1	297	305	PF00786	0.641
LIG_LIR_Apic_2	219	225	PF02991	0.745
LIG_LIR_Gen_1	389	400	PF02991	0.503
LIG_LIR_Gen_1	470	479	PF02991	0.507
LIG_LIR_Nem_3	300	306	PF02991	0.608
LIG_LIR_Nem_3	433	438	PF02991	0.625
LIG_LIR_Nem_3	470	475	PF02991	0.522
LIG_NRBOX	116	122	PF00104	0.411
LIG_REV1ctd_RIR_1	172	181	PF16727	0.494
LIG_SH2_CRK	19	23	PF00017	0.513
LIG_SH2_CRK	308	312	PF00017	0.567
LIG_SH2_NCK_1	308	312	PF00017	0.567
LIG_SH2_SRC	308	311	PF00017	0.562
LIG_SH2_STAP1	451	455	PF00017	0.490
LIG_SH2_STAT3	505	508	PF00017	0.636
LIG_SH2_STAT5	19	22	PF00017	0.513
LIG_SH2_STAT5	304	307	PF00017	0.547
LIG_SH2_STAT5	38	41	PF00017	0.199
LIG_SH2_STAT5	445	448	PF00017	0.631
LIG_SH2_STAT5	478	481	PF00017	0.487
LIG_SH3_3	149	155	PF00018	0.843
LIG_SH3_3	15	21	PF00018	0.364
LIG_SH3_3	6	12	PF00018	0.682
LIG_TYR_ITIM	301	306	PF00017	0.645
LIG_WRC_WIRS_1	171	176	PF05994	0.489
MOD_CDK_SPxK_1	430	436	PF00069	0.685
MOD_CK1_1	123	129	PF00069	0.633
MOD_CK1_1	150	156	PF00069	0.736
MOD_CK1_1	162	168	PF00069	0.586
MOD_CK1_1	459	465	PF00069	0.597
MOD_CK2_1	227	233	PF00069	0.774
MOD_CK2_1	356	362	PF00069	0.608
MOD_CK2_1	380	386	PF00069	0.594
MOD_CK2_1	425	431	PF00069	0.613
MOD_CK2_1	461	467	PF00069	0.689
MOD_CK2_1	83	89	PF00069	0.499
MOD_CMANNOS	469	472	PF00535	0.516
MOD_Cter_Amidation	137	140	PF01082	0.748
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.655
MOD_GlcNHglycan	122	125	PF01048	0.645
MOD_GlcNHglycan	168	171	PF01048	0.402
MOD_GlcNHglycan	202	205	PF01048	0.739
MOD_GlcNHglycan	207	210	PF01048	0.659
MOD_GlcNHglycan	216	219	PF01048	0.472
MOD_GlcNHglycan	416	419	PF01048	0.674
MOD_GlcNHglycan	93	96	PF01048	0.375
MOD_GSK3_1	142	149	PF00069	0.725
MOD_GSK3_1	150	157	PF00069	0.728
MOD_GSK3_1	162	169	PF00069	0.398
MOD_GSK3_1	177	184	PF00069	0.465
MOD_GSK3_1	214	221	PF00069	0.672
MOD_GSK3_1	456	463	PF00069	0.667
MOD_GSK3_1	467	474	PF00069	0.455
MOD_GSK3_1	67	74	PF00069	0.411
MOD_LATS_1	363	369	PF00433	0.595
MOD_NEK2_1	1	6	PF00069	0.784
MOD_NEK2_1	111	116	PF00069	0.411
MOD_NEK2_1	128	133	PF00069	0.318
MOD_NEK2_1	181	186	PF00069	0.594
MOD_NEK2_1	200	205	PF00069	0.496
MOD_NEK2_1	288	293	PF00069	0.610
MOD_NEK2_1	425	430	PF00069	0.617
MOD_NEK2_1	449	454	PF00069	0.555
MOD_NEK2_1	91	96	PF00069	0.411
MOD_NEK2_2	170	175	PF00069	0.591
MOD_NEK2_2	270	275	PF00069	0.629
MOD_NEK2_2	391	396	PF00069	0.571
MOD_NEK2_2	405	410	PF00069	0.670
MOD_PKA_1	71	77	PF00069	0.397
MOD_PKA_2	270	276	PF00069	0.625
MOD_PKA_2	425	431	PF00069	0.613
MOD_PKA_2	71	77	PF00069	0.419
MOD_PKA_2	78	84	PF00069	0.450
MOD_Plk_1	218	224	PF00069	0.606
MOD_Plk_4	123	129	PF00069	0.505
MOD_Plk_4	177	183	PF00069	0.589
MOD_Plk_4	356	362	PF00069	0.579
MOD_Plk_4	425	431	PF00069	0.613
MOD_Plk_4	461	467	PF00069	0.629
MOD_Plk_4	471	477	PF00069	0.451
MOD_ProDKin_1	151	157	PF00069	0.788
MOD_ProDKin_1	354	360	PF00069	0.625
MOD_ProDKin_1	430	436	PF00069	0.687
MOD_ProDKin_1	83	89	PF00069	0.411
MOD_SUMO_rev_2	384	390	PF00179	0.593
TRG_DiLeu_BaEn_1	370	375	PF01217	0.476
TRG_DiLeu_BaEn_1	506	511	PF01217	0.632
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.364
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.604
TRG_DiLeu_LyEn_5	506	511	PF01217	0.535
TRG_ENDOCYTIC_2	19	22	PF00928	0.513
TRG_ENDOCYTIC_2	303	306	PF00928	0.541
TRG_ENDOCYTIC_2	308	311	PF00928	0.584
TRG_ENDOCYTIC_2	404	407	PF00928	0.747
TRG_ENDOCYTIC_2	478	481	PF00928	0.487
TRG_ER_diArg_1	423	426	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW11	Leptomonas seymouri	43%	100%
A0A3Q8IR86	Leishmania donovani	100%	100%
A4HPJ2	Leishmania braziliensis	77%	100%
E9ATA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q193	Leishmania major	92%	100%