LeishMANIAdb
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ECH_2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ECH_2 domain-containing protein
Gene product:
Enoyl-CoA hydratase/isomerase family/2-enoyl-CoA Hydratase C-terminal region containing protein - putative
Species:
Leishmania infantum
UniProt:
A4ID68_LEIIN
TriTrypDb:
LINF_360041200
Length:
1170

Annotations

Annotations by Jardim et al.

Hydrolase, Enoyl-CoA hydratase/isomerase family

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4ID68
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID68

PDB structure(s): 7ane_z

Function

Biological processes
TermNameLevelCount
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006635 fatty acid beta-oxidation 6 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009062 fatty acid catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0016042 lipid catabolic process 4 1
GO:0016054 organic acid catabolic process 4 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 2
GO:0004300 enoyl-CoA hydratase activity 5 1
GO:0016829 lyase activity 2 1
GO:0016835 carbon-oxygen lyase activity 3 1
GO:0016836 hydro-lyase activity 4 1
GO:0016853 isomerase activity 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1165 1169 PF00656 0.777
CLV_C14_Caspase3-7 354 358 PF00656 0.449
CLV_NRD_NRD_1 1068 1070 PF00675 0.477
CLV_NRD_NRD_1 1114 1116 PF00675 0.761
CLV_NRD_NRD_1 168 170 PF00675 0.523
CLV_NRD_NRD_1 225 227 PF00675 0.545
CLV_NRD_NRD_1 320 322 PF00675 0.475
CLV_NRD_NRD_1 34 36 PF00675 0.719
CLV_NRD_NRD_1 4 6 PF00675 0.592
CLV_NRD_NRD_1 613 615 PF00675 0.515
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I608 Leptomonas seymouri 78% 100%
A0A0S4IPV3 Bodo saltans 52% 88%
A0A1X0P399 Trypanosomatidae 62% 96%
A0A3S5IS05 Trypanosoma rangeli 61% 99%
A0A3S7XB51 Leishmania donovani 100% 100%
A4HPJ5 Leishmania braziliensis 90% 100%
D0A8M0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9ATA7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q190 Leishmania major 96% 100%
V5BMG1 Trypanosoma cruzi 62% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS