LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ID64_LEIIN
TriTrypDb:
LINF_360041800
Length:
408

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005819 spindle 5 1
GO:0005930 axoneme 2 1
GO:0043226 organelle 2 3
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0072686 mitotic spindle 6 1
GO:0110165 cellular anatomical entity 1 3
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4ID64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID64

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0043014 alpha-tubulin binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 120 122 PF00675 0.458
CLV_NRD_NRD_1 364 366 PF00675 0.464
CLV_NRD_NRD_1 64 66 PF00675 0.537
CLV_PCSK_KEX2_1 120 122 PF00082 0.496
CLV_PCSK_KEX2_1 246 248 PF00082 0.595
CLV_PCSK_KEX2_1 364 366 PF00082 0.464
CLV_PCSK_KEX2_1 64 66 PF00082 0.537
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.603
CLV_PCSK_SKI1_1 215 219 PF00082 0.467
CLV_PCSK_SKI1_1 271 275 PF00082 0.527
DOC_CKS1_1 44 49 PF01111 0.530
DOC_CYCLIN_RxL_1 268 276 PF00134 0.585
DOC_MAPK_MEF2A_6 131 138 PF00069 0.588
DOC_PP4_FxxP_1 189 192 PF00568 0.631
DOC_USP7_MATH_1 281 285 PF00917 0.612
DOC_USP7_MATH_1 311 315 PF00917 0.692
DOC_USP7_MATH_1 318 322 PF00917 0.623
DOC_USP7_UBL2_3 226 230 PF12436 0.610
DOC_WW_Pin1_4 43 48 PF00397 0.438
LIG_APCC_ABBAyCdc20_2 96 102 PF00400 0.583
LIG_BIR_II_1 1 5 PF00653 0.571
LIG_BRCT_BRCA1_1 350 354 PF00533 0.397
LIG_FHA_1 103 109 PF00498 0.516
LIG_FHA_1 149 155 PF00498 0.620
LIG_FHA_1 30 36 PF00498 0.584
LIG_FHA_1 324 330 PF00498 0.694
LIG_FHA_1 390 396 PF00498 0.541
LIG_FHA_2 267 273 PF00498 0.696
LIG_FHA_2 29 35 PF00498 0.510
LIG_LIR_Gen_1 380 387 PF02991 0.384
LIG_LIR_Nem_3 113 119 PF02991 0.364
LIG_LIR_Nem_3 380 386 PF02991 0.394
LIG_MLH1_MIPbox_1 350 354 PF16413 0.416
LIG_MYND_1 16 20 PF01753 0.568
LIG_SH2_CRK 158 162 PF00017 0.421
LIG_SH2_GRB2like 4 7 PF00017 0.558
LIG_SH2_PTP2 344 347 PF00017 0.446
LIG_SH2_SRC 4 7 PF00017 0.634
LIG_SH2_STAP1 100 104 PF00017 0.576
LIG_SH2_STAP1 220 224 PF00017 0.452
LIG_SH2_STAT5 116 119 PF00017 0.427
LIG_SH2_STAT5 262 265 PF00017 0.690
LIG_SH2_STAT5 344 347 PF00017 0.386
LIG_SH2_STAT5 353 356 PF00017 0.388
LIG_SH3_1 71 77 PF00018 0.582
LIG_SH3_3 127 133 PF00018 0.521
LIG_SH3_3 160 166 PF00018 0.552
LIG_SH3_3 71 77 PF00018 0.582
LIG_TRAF2_1 394 397 PF00917 0.496
LIG_WRC_WIRS_1 50 55 PF05994 0.577
MOD_CK1_1 150 156 PF00069 0.491
MOD_CK1_1 193 199 PF00069 0.662
MOD_CK1_1 291 297 PF00069 0.716
MOD_CK1_1 321 327 PF00069 0.647
MOD_CK1_1 391 397 PF00069 0.516
MOD_CK2_1 266 272 PF00069 0.592
MOD_CK2_1 28 34 PF00069 0.515
MOD_CK2_1 391 397 PF00069 0.457
MOD_GlcNHglycan 192 195 PF01048 0.661
MOD_GlcNHglycan 207 210 PF01048 0.602
MOD_GlcNHglycan 281 284 PF01048 0.652
MOD_GlcNHglycan 290 293 PF01048 0.647
MOD_GlcNHglycan 312 316 PF01048 0.719
MOD_GlcNHglycan 320 323 PF01048 0.635
MOD_GSK3_1 111 118 PF00069 0.627
MOD_GSK3_1 193 200 PF00069 0.615
MOD_GSK3_1 207 214 PF00069 0.410
MOD_GSK3_1 25 32 PF00069 0.600
MOD_GSK3_1 258 265 PF00069 0.670
MOD_GSK3_1 273 280 PF00069 0.553
MOD_N-GLC_1 205 210 PF02516 0.666
MOD_NEK2_1 141 146 PF00069 0.494
MOD_NEK2_1 205 210 PF00069 0.650
MOD_NEK2_1 228 233 PF00069 0.539
MOD_NEK2_1 253 258 PF00069 0.601
MOD_NEK2_1 273 278 PF00069 0.595
MOD_NEK2_1 35 40 PF00069 0.578
MOD_PIKK_1 111 117 PF00454 0.480
MOD_PIKK_1 141 147 PF00454 0.603
MOD_PIKK_1 148 154 PF00454 0.602
MOD_PIKK_1 182 188 PF00454 0.454
MOD_PIKK_1 207 213 PF00454 0.583
MOD_PIKK_1 4 10 PF00454 0.644
MOD_PK_1 246 252 PF00069 0.560
MOD_PKA_1 246 252 PF00069 0.560
MOD_PKA_2 111 117 PF00069 0.529
MOD_PKA_2 246 252 PF00069 0.644
MOD_Plk_1 220 226 PF00069 0.605
MOD_Plk_2-3 266 272 PF00069 0.592
MOD_Plk_4 150 156 PF00069 0.552
MOD_Plk_4 258 264 PF00069 0.679
MOD_ProDKin_1 43 49 PF00069 0.438
MOD_SUMO_for_1 329 332 PF00179 0.532
MOD_SUMO_rev_2 346 354 PF00179 0.462
MOD_SUMO_rev_2 391 401 PF00179 0.522
TRG_ENDOCYTIC_2 158 161 PF00928 0.672
TRG_ENDOCYTIC_2 344 347 PF00928 0.442
TRG_ER_diArg_1 119 121 PF00400 0.423
TRG_ER_diArg_1 363 365 PF00400 0.448
TRG_Pf-PMV_PEXEL_1 358 362 PF00026 0.402

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6N3 Leptomonas seymouri 64% 100%
A0A0S4J2B8 Bodo saltans 26% 90%
A0A1X0P414 Trypanosomatidae 42% 97%
A0A3Q8IKI9 Leishmania donovani 100% 100%
A0A422NVL8 Trypanosoma rangeli 43% 98%
A4HPK0 Leishmania braziliensis 86% 100%
D0A8L4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 98%
E9ATB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q185 Leishmania major 95% 100%
V5B6X3 Trypanosoma cruzi 41% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS