LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4ID54_LEIIN
TriTrypDb:
LINF_360042900
Length:
792

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ID54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 397 401 PF00656 0.556
CLV_MEL_PAP_1 298 304 PF00089 0.523
CLV_NRD_NRD_1 176 178 PF00675 0.482
CLV_NRD_NRD_1 219 221 PF00675 0.295
CLV_NRD_NRD_1 292 294 PF00675 0.436
CLV_NRD_NRD_1 295 297 PF00675 0.471
CLV_NRD_NRD_1 41 43 PF00675 0.437
CLV_NRD_NRD_1 516 518 PF00675 0.594
CLV_NRD_NRD_1 564 566 PF00675 0.417
CLV_NRD_NRD_1 575 577 PF00675 0.541
CLV_NRD_NRD_1 692 694 PF00675 0.620
CLV_NRD_NRD_1 93 95 PF00675 0.408
CLV_PCSK_FUR_1 293 297 PF00082 0.404
CLV_PCSK_KEX2_1 176 178 PF00082 0.360
CLV_PCSK_KEX2_1 219 221 PF00082 0.295
CLV_PCSK_KEX2_1 292 294 PF00082 0.436
CLV_PCSK_KEX2_1 295 297 PF00082 0.471
CLV_PCSK_KEX2_1 41 43 PF00082 0.437
CLV_PCSK_KEX2_1 425 427 PF00082 0.654
CLV_PCSK_KEX2_1 516 518 PF00082 0.594
CLV_PCSK_KEX2_1 564 566 PF00082 0.486
CLV_PCSK_KEX2_1 577 579 PF00082 0.390
CLV_PCSK_KEX2_1 634 636 PF00082 0.707
CLV_PCSK_KEX2_1 652 654 PF00082 0.461
CLV_PCSK_KEX2_1 692 694 PF00082 0.620
CLV_PCSK_PC1ET2_1 425 427 PF00082 0.654
CLV_PCSK_PC1ET2_1 577 579 PF00082 0.436
CLV_PCSK_PC1ET2_1 634 636 PF00082 0.728
CLV_PCSK_PC1ET2_1 652 654 PF00082 0.508
CLV_PCSK_PC1ET2_1 692 694 PF00082 0.620
CLV_PCSK_SKI1_1 151 155 PF00082 0.354
CLV_PCSK_SKI1_1 219 223 PF00082 0.295
CLV_PCSK_SKI1_1 330 334 PF00082 0.598
CLV_PCSK_SKI1_1 52 56 PF00082 0.408
CLV_PCSK_SKI1_1 577 581 PF00082 0.448
CLV_PCSK_SKI1_1 653 657 PF00082 0.652
CLV_Separin_Metazoa 216 220 PF03568 0.295
DEG_APCC_DBOX_1 159 167 PF00400 0.363
DEG_APCC_DBOX_1 603 611 PF00400 0.452
DEG_SPOP_SBC_1 338 342 PF00917 0.609
DEG_SPOP_SBC_1 382 386 PF00917 0.742
DOC_ANK_TNKS_1 294 301 PF00023 0.464
DOC_ANK_TNKS_1 596 603 PF00023 0.497
DOC_CYCLIN_RxL_1 216 226 PF00134 0.290
DOC_MAPK_DCC_7 131 139 PF00069 0.354
DOC_MAPK_DCC_7 250 260 PF00069 0.238
DOC_MAPK_gen_1 176 187 PF00069 0.353
DOC_MAPK_gen_1 235 245 PF00069 0.354
DOC_MAPK_gen_1 50 57 PF00069 0.433
DOC_MAPK_gen_1 516 524 PF00069 0.518
DOC_MAPK_gen_1 571 581 PF00069 0.403
DOC_MAPK_gen_1 604 611 PF00069 0.445
DOC_MAPK_gen_1 634 644 PF00069 0.584
DOC_MAPK_gen_1 692 700 PF00069 0.584
DOC_MAPK_HePTP_8 632 644 PF00069 0.573
DOC_MAPK_MEF2A_6 131 139 PF00069 0.374
DOC_MAPK_MEF2A_6 235 243 PF00069 0.354
DOC_MAPK_MEF2A_6 366 373 PF00069 0.511
DOC_MAPK_MEF2A_6 604 611 PF00069 0.445
DOC_MAPK_MEF2A_6 635 644 PF00069 0.588
DOC_PP1_RVXF_1 218 225 PF00149 0.294
DOC_PP1_RVXF_1 246 252 PF00149 0.354
DOC_PP1_RVXF_1 694 701 PF00149 0.588
DOC_PP2B_LxvP_1 502 505 PF13499 0.401
DOC_SPAK_OSR1_1 71 75 PF12202 0.338
DOC_USP7_MATH_1 27 31 PF00917 0.461
DOC_USP7_MATH_1 309 313 PF00917 0.592
DOC_USP7_MATH_1 401 405 PF00917 0.653
DOC_USP7_MATH_1 445 449 PF00917 0.633
DOC_USP7_MATH_1 456 460 PF00917 0.576
DOC_USP7_MATH_1 481 485 PF00917 0.456
DOC_USP7_MATH_1 534 538 PF00917 0.601
DOC_USP7_MATH_1 658 662 PF00917 0.653
DOC_USP7_MATH_1 702 706 PF00917 0.622
DOC_USP7_MATH_1 714 718 PF00917 0.607
DOC_USP7_MATH_1 776 780 PF00917 0.590
DOC_USP7_UBL2_3 692 696 PF12436 0.601
DOC_USP7_UBL2_3 744 748 PF12436 0.497
DOC_WW_Pin1_4 10 15 PF00397 0.488
DOC_WW_Pin1_4 113 118 PF00397 0.476
DOC_WW_Pin1_4 137 142 PF00397 0.346
DOC_WW_Pin1_4 300 305 PF00397 0.523
DOC_WW_Pin1_4 339 344 PF00397 0.584
DOC_WW_Pin1_4 347 352 PF00397 0.584
DOC_WW_Pin1_4 412 417 PF00397 0.654
DOC_WW_Pin1_4 430 435 PF00397 0.634
DOC_WW_Pin1_4 686 691 PF00397 0.628
LIG_14-3-3_CanoR_1 180 184 PF00244 0.338
LIG_14-3-3_CanoR_1 322 328 PF00244 0.607
LIG_14-3-3_CanoR_1 576 582 PF00244 0.340
LIG_14-3-3_CanoR_1 92 102 PF00244 0.557
LIG_Actin_WH2_2 188 206 PF00022 0.370
LIG_APCC_ABBA_1 54 59 PF00400 0.412
LIG_BRCT_BRCA1_1 32 36 PF00533 0.471
LIG_BRCT_BRCA1_1 696 700 PF00533 0.591
LIG_CaM_NSCaTE_8 675 682 PF13499 0.626
LIG_FHA_1 180 186 PF00498 0.354
LIG_FHA_1 197 203 PF00498 0.354
LIG_FHA_1 255 261 PF00498 0.269
LIG_FHA_1 323 329 PF00498 0.595
LIG_FHA_1 339 345 PF00498 0.626
LIG_FHA_1 376 382 PF00498 0.603
LIG_FHA_1 455 461 PF00498 0.839
LIG_FHA_1 639 645 PF00498 0.621
LIG_FHA_1 727 733 PF00498 0.544
LIG_FHA_2 11 17 PF00498 0.549
LIG_FHA_2 456 462 PF00498 0.575
LIG_FHA_2 505 511 PF00498 0.581
LIG_Integrin_isoDGR_2 672 674 PF01839 0.569
LIG_LIR_Gen_1 169 178 PF02991 0.295
LIG_LIR_Gen_1 580 590 PF02991 0.459
LIG_LIR_Gen_1 678 688 PF02991 0.623
LIG_LIR_Gen_1 89 97 PF02991 0.417
LIG_LIR_Nem_3 169 174 PF02991 0.295
LIG_LIR_Nem_3 231 237 PF02991 0.349
LIG_LIR_Nem_3 427 431 PF02991 0.625
LIG_LIR_Nem_3 580 585 PF02991 0.442
LIG_LIR_Nem_3 623 628 PF02991 0.416
LIG_LIR_Nem_3 67 73 PF02991 0.325
LIG_LIR_Nem_3 678 683 PF02991 0.622
LIG_LIR_Nem_3 739 745 PF02991 0.424
LIG_LIR_Nem_3 89 93 PF02991 0.415
LIG_LYPXL_yS_3 214 217 PF13949 0.295
LIG_MYND_1 519 523 PF01753 0.586
LIG_Pex14_1 17 21 PF04695 0.450
LIG_Pex14_2 224 228 PF04695 0.295
LIG_Pex14_2 514 518 PF04695 0.558
LIG_SH2_CRK 428 432 PF00017 0.649
LIG_SH2_CRK 582 586 PF00017 0.441
LIG_SH2_CRK 70 74 PF00017 0.326
LIG_SH2_CRK 90 94 PF00017 0.244
LIG_SH2_NCK_1 503 507 PF00017 0.422
LIG_SH2_NCK_1 582 586 PF00017 0.441
LIG_SH2_PTP2 171 174 PF00017 0.340
LIG_SH2_SRC 503 506 PF00017 0.433
LIG_SH2_SRC 599 602 PF00017 0.475
LIG_SH2_STAP1 21 25 PF00017 0.452
LIG_SH2_STAT5 171 174 PF00017 0.422
LIG_SH2_STAT5 183 186 PF00017 0.290
LIG_SH2_STAT5 264 267 PF00017 0.363
LIG_SH2_STAT5 488 491 PF00017 0.455
LIG_SH2_STAT5 568 571 PF00017 0.416
LIG_SH2_STAT5 599 602 PF00017 0.475
LIG_SH3_3 111 117 PF00018 0.416
LIG_SH3_3 209 215 PF00018 0.363
LIG_SH3_3 233 239 PF00018 0.295
LIG_SH3_3 279 285 PF00018 0.421
LIG_SH3_3 311 317 PF00018 0.604
LIG_SH3_3 428 434 PF00018 0.655
LIG_SH3_3 535 541 PF00018 0.505
LIG_SH3_3 606 612 PF00018 0.455
LIG_SH3_3 637 643 PF00018 0.594
LIG_SH3_3 684 690 PF00018 0.509
LIG_SH3_3 705 711 PF00018 0.654
LIG_SUMO_SIM_anti_2 199 204 PF11976 0.340
LIG_SUMO_SIM_anti_2 257 262 PF11976 0.269
LIG_SUMO_SIM_par_1 256 262 PF11976 0.238
LIG_SUMO_SIM_par_1 471 476 PF11976 0.478
LIG_SUMO_SIM_par_1 8 13 PF11976 0.537
LIG_TRAF2_1 37 40 PF00917 0.420
LIG_TYR_ITIM 212 217 PF00017 0.354
LIG_TYR_ITIM 68 73 PF00017 0.319
LIG_TYR_ITSM 578 585 PF00017 0.408
LIG_UBA3_1 146 151 PF00899 0.295
MOD_CDC14_SPxK_1 689 692 PF00782 0.588
MOD_CDK_SPxK_1 686 692 PF00069 0.591
MOD_CDK_SPxxK_3 113 120 PF00069 0.416
MOD_CDK_SPxxK_3 430 437 PF00069 0.649
MOD_CDK_SPxxK_3 686 693 PF00069 0.593
MOD_CK1_1 113 119 PF00069 0.477
MOD_CK1_1 30 36 PF00069 0.573
MOD_CK1_1 318 324 PF00069 0.728
MOD_CK1_1 337 343 PF00069 0.550
MOD_CK1_1 375 381 PF00069 0.600
MOD_CK1_1 385 391 PF00069 0.616
MOD_CK1_1 399 405 PF00069 0.530
MOD_CK1_1 433 439 PF00069 0.622
MOD_CK1_1 525 531 PF00069 0.695
MOD_CK1_1 614 620 PF00069 0.588
MOD_CK1_1 661 667 PF00069 0.620
MOD_CK1_1 717 723 PF00069 0.554
MOD_CK1_1 779 785 PF00069 0.631
MOD_CK2_1 12 18 PF00069 0.497
MOD_CK2_1 34 40 PF00069 0.462
MOD_CK2_1 400 406 PF00069 0.767
MOD_CK2_1 455 461 PF00069 0.705
MOD_DYRK1A_RPxSP_1 686 690 PF00069 0.569
MOD_GlcNHglycan 230 233 PF01048 0.361
MOD_GlcNHglycan 252 255 PF01048 0.295
MOD_GlcNHglycan 278 281 PF01048 0.431
MOD_GlcNHglycan 30 33 PF01048 0.517
MOD_GlcNHglycan 374 377 PF01048 0.569
MOD_GlcNHglycan 387 390 PF01048 0.592
MOD_GlcNHglycan 403 406 PF01048 0.641
MOD_GlcNHglycan 438 442 PF01048 0.667
MOD_GlcNHglycan 485 488 PF01048 0.402
MOD_GlcNHglycan 5 8 PF01048 0.624
MOD_GlcNHglycan 508 514 PF01048 0.593
MOD_GlcNHglycan 702 705 PF01048 0.591
MOD_GlcNHglycan 715 719 PF01048 0.583
MOD_GSK3_1 162 169 PF00069 0.318
MOD_GSK3_1 250 257 PF00069 0.295
MOD_GSK3_1 270 277 PF00069 0.171
MOD_GSK3_1 30 37 PF00069 0.434
MOD_GSK3_1 318 325 PF00069 0.746
MOD_GSK3_1 334 341 PF00069 0.541
MOD_GSK3_1 343 350 PF00069 0.575
MOD_GSK3_1 381 388 PF00069 0.590
MOD_GSK3_1 396 403 PF00069 0.521
MOD_GSK3_1 433 440 PF00069 0.707
MOD_GSK3_1 441 448 PF00069 0.647
MOD_GSK3_1 456 463 PF00069 0.690
MOD_GSK3_1 611 618 PF00069 0.486
MOD_GSK3_1 630 637 PF00069 0.447
MOD_GSK3_1 654 661 PF00069 0.735
MOD_GSK3_1 663 670 PF00069 0.606
MOD_GSK3_1 696 703 PF00069 0.776
MOD_GSK3_1 722 729 PF00069 0.524
MOD_GSK3_1 743 750 PF00069 0.581
MOD_GSK3_1 759 766 PF00069 0.382
MOD_GSK3_1 779 786 PF00069 0.514
MOD_N-GLC_1 614 619 PF02516 0.648
MOD_NEK2_1 166 171 PF00069 0.439
MOD_NEK2_1 274 279 PF00069 0.453
MOD_NEK2_1 381 386 PF00069 0.693
MOD_NEK2_1 394 399 PF00069 0.569
MOD_NEK2_1 524 529 PF00069 0.509
MOD_NEK2_1 648 653 PF00069 0.766
MOD_NEK2_1 667 672 PF00069 0.478
MOD_NEK2_1 700 705 PF00069 0.599
MOD_NEK2_2 675 680 PF00069 0.631
MOD_PIKK_1 461 467 PF00454 0.547
MOD_PIKK_1 522 528 PF00454 0.604
MOD_PIKK_1 667 673 PF00454 0.588
MOD_PIKK_1 726 732 PF00454 0.510
MOD_PIKK_1 759 765 PF00454 0.395
MOD_PK_1 694 700 PF00069 0.586
MOD_PKA_1 577 583 PF00069 0.406
MOD_PKA_1 634 640 PF00069 0.626
MOD_PKA_2 179 185 PF00069 0.338
MOD_PKA_2 315 321 PF00069 0.722
MOD_PKA_2 570 576 PF00069 0.476
MOD_PKA_2 577 583 PF00069 0.436
MOD_PKA_2 634 640 PF00069 0.625
MOD_PKA_2 661 667 PF00069 0.582
MOD_PKA_2 93 99 PF00069 0.558
MOD_Plk_1 166 172 PF00069 0.295
MOD_Plk_1 394 400 PF00069 0.596
MOD_Plk_1 509 515 PF00069 0.575
MOD_Plk_1 726 732 PF00069 0.505
MOD_Plk_2-3 722 728 PF00069 0.583
MOD_Plk_4 110 116 PF00069 0.388
MOD_Plk_4 179 185 PF00069 0.354
MOD_Plk_4 30 36 PF00069 0.443
MOD_Plk_4 309 315 PF00069 0.625
MOD_Plk_4 323 329 PF00069 0.615
MOD_Plk_4 331 337 PF00069 0.594
MOD_Plk_4 517 523 PF00069 0.640
MOD_Plk_4 525 531 PF00069 0.540
MOD_Plk_4 577 583 PF00069 0.594
MOD_Plk_4 675 681 PF00069 0.619
MOD_ProDKin_1 10 16 PF00069 0.474
MOD_ProDKin_1 113 119 PF00069 0.477
MOD_ProDKin_1 137 143 PF00069 0.346
MOD_ProDKin_1 300 306 PF00069 0.527
MOD_ProDKin_1 339 345 PF00069 0.585
MOD_ProDKin_1 347 353 PF00069 0.586
MOD_ProDKin_1 412 418 PF00069 0.653
MOD_ProDKin_1 430 436 PF00069 0.635
MOD_ProDKin_1 686 692 PF00069 0.629
MOD_SUMO_for_1 249 252 PF00179 0.354
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.354
TRG_ENDOCYTIC_2 171 174 PF00928 0.340
TRG_ENDOCYTIC_2 214 217 PF00928 0.295
TRG_ENDOCYTIC_2 428 431 PF00928 0.650
TRG_ENDOCYTIC_2 582 585 PF00928 0.448
TRG_ENDOCYTIC_2 70 73 PF00928 0.321
TRG_ENDOCYTIC_2 90 93 PF00928 0.250
TRG_ER_diArg_1 176 178 PF00400 0.446
TRG_ER_diArg_1 218 220 PF00400 0.295
TRG_ER_diArg_1 291 293 PF00400 0.434
TRG_ER_diArg_1 294 296 PF00400 0.446
TRG_ER_diArg_1 515 517 PF00400 0.592
TRG_ER_diArg_1 564 567 PF00400 0.423
TRG_ER_diArg_1 575 578 PF00400 0.401
TRG_NLS_Bipartite_1 564 580 PF00514 0.412
TRG_NLS_MonoCore_2 692 697 PF00514 0.525
TRG_NLS_MonoExtC_3 691 696 PF00514 0.611
TRG_NLS_MonoExtN_4 574 580 PF00514 0.447
TRG_NLS_MonoExtN_4 690 697 PF00514 0.612
TRG_Pf-PMV_PEXEL_1 238 242 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 567 572 PF00026 0.388

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P689 Leptomonas seymouri 50% 97%
A0A1X0P424 Trypanosomatidae 35% 100%
A0A3S7XBD6 Leishmania donovani 99% 100%
A4HPL0 Leishmania braziliensis 67% 97%
E9ATC2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q175 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS