LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
Domain of unknown function (DUF3846)/TPR repeat - putative
Species:
Leishmania infantum
UniProt:
A4ID44_LEIIN
TriTrypDb:
LINF_360044000
Length:
371

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ID44
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID44

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 253 257 PF00656 0.494
CLV_NRD_NRD_1 258 260 PF00675 0.397
CLV_PCSK_KEX2_1 258 260 PF00082 0.397
CLV_PCSK_SKI1_1 259 263 PF00082 0.399
CLV_PCSK_SKI1_1 305 309 PF00082 0.423
CLV_PCSK_SKI1_1 362 366 PF00082 0.473
DOC_CYCLIN_RxL_1 276 284 PF00134 0.359
DOC_MAPK_MEF2A_6 9 16 PF00069 0.414
DOC_PIKK_1 19 27 PF02985 0.462
DOC_PP1_RVXF_1 277 284 PF00149 0.361
DOC_PP2B_LxvP_1 14 17 PF13499 0.419
DOC_USP7_MATH_1 119 123 PF00917 0.528
DOC_USP7_MATH_1 66 70 PF00917 0.525
DOC_USP7_MATH_1 83 87 PF00917 0.654
DOC_USP7_UBL2_3 358 362 PF12436 0.487
DOC_USP7_UBL2_3 72 76 PF12436 0.556
LIG_14-3-3_CanoR_1 38 42 PF00244 0.460
LIG_14-3-3_CanoR_1 46 50 PF00244 0.540
LIG_BIR_II_1 1 5 PF00653 0.589
LIG_BIR_III_2 20 24 PF00653 0.410
LIG_BRCT_BRCA1_1 134 138 PF00533 0.357
LIG_BRCT_BRCA1_1 365 369 PF00533 0.407
LIG_FHA_1 121 127 PF00498 0.505
LIG_FHA_1 212 218 PF00498 0.378
LIG_FHA_1 249 255 PF00498 0.466
LIG_FHA_1 312 318 PF00498 0.387
LIG_Integrin_RGD_1 156 158 PF01839 0.349
LIG_LIR_Apic_2 184 190 PF02991 0.406
LIG_LIR_Gen_1 110 119 PF02991 0.407
LIG_LIR_Gen_1 331 339 PF02991 0.444
LIG_LIR_Nem_3 110 114 PF02991 0.406
LIG_LIR_Nem_3 135 141 PF02991 0.364
LIG_LIR_Nem_3 171 176 PF02991 0.376
LIG_LIR_Nem_3 331 336 PF02991 0.453
LIG_NRBOX 272 278 PF00104 0.328
LIG_PCNA_yPIPBox_3 270 279 PF02747 0.361
LIG_Pex14_2 365 369 PF04695 0.475
LIG_SH2_CRK 187 191 PF00017 0.505
LIG_SH2_CRK 333 337 PF00017 0.420
LIG_SH2_GRB2like 187 190 PF00017 0.504
LIG_SH2_NCK_1 111 115 PF00017 0.506
LIG_SH2_NCK_1 187 191 PF00017 0.537
LIG_SH2_NCK_1 222 226 PF00017 0.509
LIG_SH2_NCK_1 323 327 PF00017 0.358
LIG_SH2_SRC 111 114 PF00017 0.485
LIG_SH2_SRC 187 190 PF00017 0.483
LIG_SH2_SRC 195 198 PF00017 0.538
LIG_SH2_SRC 301 304 PF00017 0.420
LIG_SH2_STAP1 183 187 PF00017 0.387
LIG_SH2_STAP1 248 252 PF00017 0.327
LIG_SH2_STAP1 323 327 PF00017 0.392
LIG_SH2_STAT3 105 108 PF00017 0.447
LIG_SH2_STAT5 105 108 PF00017 0.428
LIG_SH2_STAT5 125 128 PF00017 0.352
LIG_SH2_STAT5 13 16 PF00017 0.327
LIG_SH2_STAT5 131 134 PF00017 0.297
LIG_SH2_STAT5 301 304 PF00017 0.526
LIG_SH3_3 113 119 PF00018 0.460
LIG_SH3_3 173 179 PF00018 0.526
LIG_SUMO_SIM_par_1 249 256 PF11976 0.487
LIG_TRAF2_1 23 26 PF00917 0.508
LIG_TRAF2_1 263 266 PF00917 0.481
MOD_CK1_1 48 54 PF00069 0.521
MOD_CK2_1 83 89 PF00069 0.754
MOD_Cter_Amidation 256 259 PF01082 0.396
MOD_GlcNHglycan 133 137 PF01048 0.386
MOD_GlcNHglycan 273 276 PF01048 0.329
MOD_GlcNHglycan 68 71 PF01048 0.540
MOD_GlcNHglycan 85 88 PF01048 0.745
MOD_GSK3_1 211 218 PF00069 0.415
MOD_GSK3_1 248 255 PF00069 0.434
MOD_GSK3_1 341 348 PF00069 0.495
MOD_N-GLC_2 278 280 PF02516 0.435
MOD_NEK2_1 120 125 PF00069 0.433
MOD_NEK2_1 160 165 PF00069 0.426
MOD_NEK2_1 271 276 PF00069 0.305
MOD_NEK2_1 281 286 PF00069 0.376
MOD_NEK2_1 37 42 PF00069 0.367
MOD_NEK2_1 45 50 PF00069 0.571
MOD_PIKK_1 120 126 PF00454 0.437
MOD_PIKK_1 201 207 PF00454 0.537
MOD_PIKK_1 266 272 PF00454 0.485
MOD_PKA_1 215 221 PF00069 0.417
MOD_PKA_2 120 126 PF00069 0.512
MOD_PKA_2 145 151 PF00069 0.361
MOD_PKA_2 209 215 PF00069 0.399
MOD_PKA_2 271 277 PF00069 0.353
MOD_PKA_2 311 317 PF00069 0.428
MOD_PKA_2 37 43 PF00069 0.367
MOD_PKA_2 45 51 PF00069 0.569
MOD_Plk_1 341 347 PF00069 0.480
MOD_Plk_2-3 107 113 PF00069 0.391
MOD_Plk_4 126 132 PF00069 0.338
MOD_Plk_4 45 51 PF00069 0.473
MOD_SUMO_rev_2 18 24 PF00179 0.445
MOD_SUMO_rev_2 211 217 PF00179 0.385
MOD_SUMO_rev_2 354 360 PF00179 0.431
TRG_ENDOCYTIC_2 111 114 PF00928 0.500
TRG_ENDOCYTIC_2 13 16 PF00928 0.327
TRG_ENDOCYTIC_2 183 186 PF00928 0.352
TRG_ENDOCYTIC_2 310 313 PF00928 0.401
TRG_ENDOCYTIC_2 333 336 PF00928 0.402
TRG_NES_CRM1_1 5 20 PF08389 0.421
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.498

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2F3 Leptomonas seymouri 78% 100%
A0A0S4JL72 Bodo saltans 41% 94%
A0A1X0P430 Trypanosomatidae 55% 100%
A0A3S7XBC5 Leishmania donovani 100% 100%
A0A422N1C1 Trypanosoma rangeli 56% 100%
A4HPM1 Leishmania braziliensis 89% 99%
D0A8J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
Q4Q164 Leishmania major 97% 100%
V5BWW6 Trypanosoma cruzi 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS