Squalene/phytoene synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytoene synthase - putative

Species:

Leishmania infantum

UniProt:

A4ID42_LEIIN

TriTrypDb:

LINF_360044200

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ID42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID42

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.345
CLV_NRD_NRD_1	25	27	PF00675	0.450
CLV_NRD_NRD_1	266	268	PF00675	0.252
CLV_NRD_NRD_1	314	316	PF00675	0.322
CLV_NRD_NRD_1	388	390	PF00675	0.647
CLV_NRD_NRD_1	77	79	PF00675	0.390
CLV_PCSK_KEX2_1	128	130	PF00082	0.229
CLV_PCSK_KEX2_1	25	27	PF00082	0.413
CLV_PCSK_KEX2_1	314	316	PF00082	0.251
CLV_PCSK_KEX2_1	340	342	PF00082	0.301
CLV_PCSK_KEX2_1	390	392	PF00082	0.525
CLV_PCSK_KEX2_1	77	79	PF00082	0.390
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.251
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.301
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.525
CLV_PCSK_SKI1_1	104	108	PF00082	0.397
CLV_PCSK_SKI1_1	114	118	PF00082	0.226
CLV_PCSK_SKI1_1	162	166	PF00082	0.247
CLV_PCSK_SKI1_1	267	271	PF00082	0.246
CLV_PCSK_SKI1_1	286	290	PF00082	0.251
CLV_PCSK_SKI1_1	4	8	PF00082	0.500
DEG_APCC_DBOX_1	266	274	PF00400	0.251
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DOC_CYCLIN_RxL_1	262	272	PF00134	0.251
DOC_MAPK_gen_1	229	236	PF00069	0.229
DOC_MAPK_gen_1	262	271	PF00069	0.271
DOC_MAPK_gen_1	92	100	PF00069	0.325
DOC_PP1_RVXF_1	112	119	PF00149	0.229
DOC_PP1_RVXF_1	231	237	PF00149	0.285
DOC_PP1_RVXF_1	265	272	PF00149	0.271
DOC_USP7_MATH_1	258	262	PF00917	0.271
DOC_USP7_MATH_1	41	45	PF00917	0.464
LIG_14-3-3_CanoR_1	104	113	PF00244	0.229
LIG_14-3-3_CanoR_1	162	171	PF00244	0.229
LIG_14-3-3_CanoR_1	233	239	PF00244	0.285
LIG_14-3-3_CanoR_1	94	98	PF00244	0.293
LIG_14-3-3_CterR_2	389	392	PF00244	0.582
LIG_BRCT_BRCA1_1	319	323	PF00533	0.344
LIG_EH1_1	270	278	PF00400	0.285
LIG_eIF4E_1	191	197	PF01652	0.229
LIG_FHA_1	205	211	PF00498	0.228
LIG_FHA_1	293	299	PF00498	0.285
LIG_FXI_DFP_1	56	60	PF00024	0.297
LIG_LIR_Gen_1	183	193	PF02991	0.271
LIG_LIR_Gen_1	345	354	PF02991	0.534
LIG_LIR_Gen_1	46	56	PF02991	0.286
LIG_LIR_Gen_1	58	66	PF02991	0.295
LIG_LIR_Nem_3	183	188	PF02991	0.229
LIG_LIR_Nem_3	21	27	PF02991	0.413
LIG_LIR_Nem_3	295	299	PF02991	0.243
LIG_LIR_Nem_3	301	307	PF02991	0.265
LIG_LIR_Nem_3	334	338	PF02991	0.404
LIG_LIR_Nem_3	343	347	PF02991	0.466
LIG_LIR_Nem_3	46	52	PF02991	0.337
LIG_LIR_Nem_3	58	62	PF02991	0.243
LIG_LIR_Nem_3	7	13	PF02991	0.428
LIG_LIR_Nem_3	79	83	PF02991	0.256
LIG_MYND_1	141	145	PF01753	0.229
LIG_Pex14_2	160	164	PF04695	0.229
LIG_Pex14_2	188	192	PF04695	0.271
LIG_PTB_Apo_2	327	334	PF02174	0.357
LIG_PTB_Apo_2	361	368	PF02174	0.463
LIG_Rb_pABgroove_1	176	184	PF01858	0.229
LIG_SH2_CRK	10	14	PF00017	0.447
LIG_SH2_CRK	231	235	PF00017	0.229
LIG_SH2_GRB2like	304	307	PF00017	0.251
LIG_SH2_GRB2like	362	365	PF00017	0.473
LIG_SH2_PTP2	49	52	PF00017	0.330
LIG_SH2_STAP1	304	308	PF00017	0.251
LIG_SH2_STAT3	71	74	PF00017	0.353
LIG_SH2_STAT5	191	194	PF00017	0.229
LIG_SH2_STAT5	308	311	PF00017	0.251
LIG_SH2_STAT5	362	365	PF00017	0.473
LIG_SH2_STAT5	49	52	PF00017	0.333
LIG_SH3_3	139	145	PF00018	0.229
LIG_SUMO_SIM_par_1	195	200	PF11976	0.251
LIG_SUMO_SIM_par_1	96	102	PF11976	0.330
LIG_TYR_ITIM	47	52	PF00017	0.332
LIG_UBA3_1	270	278	PF00899	0.271
MOD_CK2_1	192	198	PF00069	0.251
MOD_CK2_1	93	99	PF00069	0.341
MOD_GlcNHglycan	29	33	PF01048	0.435
MOD_GlcNHglycan	319	322	PF01048	0.343
MOD_GlcNHglycan	377	380	PF01048	0.524
MOD_GlcNHglycan	381	384	PF01048	0.599
MOD_GlcNHglycan	43	46	PF01048	0.366
MOD_GSK3_1	130	137	PF00069	0.228
MOD_GSK3_1	37	44	PF00069	0.630
MOD_GSK3_1	375	382	PF00069	0.483
MOD_LATS_1	373	379	PF00433	0.411
MOD_N-GLC_1	317	322	PF02516	0.224
MOD_N-GLC_1	363	368	PF02516	0.435
MOD_N-GLC_2	222	224	PF02516	0.271
MOD_NEK2_1	106	111	PF00069	0.271
MOD_NEK2_1	136	141	PF00069	0.229
MOD_NEK2_1	192	197	PF00069	0.233
MOD_NEK2_1	234	239	PF00069	0.271
MOD_NEK2_1	317	322	PF00069	0.322
MOD_NEK2_1	86	91	PF00069	0.310
MOD_PIKK_1	99	105	PF00454	0.371
MOD_PK_1	346	352	PF00069	0.332
MOD_PKA_2	215	221	PF00069	0.271
MOD_PKA_2	369	375	PF00069	0.388
MOD_PKA_2	93	99	PF00069	0.298
MOD_Plk_1	197	203	PF00069	0.285
MOD_Plk_1	317	323	PF00069	0.322
MOD_Plk_1	363	369	PF00069	0.426
MOD_Plk_4	192	198	PF00069	0.251
MOD_SUMO_for_1	202	205	PF00179	0.251
MOD_SUMO_for_1	277	280	PF00179	0.251
MOD_SUMO_for_1	50	53	PF00179	0.284
TRG_ENDOCYTIC_2	10	13	PF00928	0.440
TRG_ENDOCYTIC_2	189	192	PF00928	0.229
TRG_ENDOCYTIC_2	231	234	PF00928	0.229
TRG_ENDOCYTIC_2	308	311	PF00928	0.251
TRG_ENDOCYTIC_2	347	350	PF00928	0.343
TRG_ENDOCYTIC_2	49	52	PF00928	0.288
TRG_ENDOCYTIC_2	80	83	PF00928	0.267
TRG_ER_diArg_1	168	171	PF00400	0.251
TRG_ER_diArg_1	24	26	PF00400	0.516
TRG_ER_diArg_1	76	78	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3G5	Trypanosomatidae	75%	68%
A0A422N197	Trypanosoma rangeli	64%	100%
A2AIL4	Mus musculus	24%	100%
A4HPM3	Leishmania braziliensis	94%	100%
A7YVD7	Bos taurus	26%	100%
D0A8J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	71%
D3ZN43	Rattus norvegicus	24%	100%
E9ATD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q330K2	Homo sapiens	24%	100%
Q4Q162	Leishmania major	99%	100%
V5B709	Trypanosoma cruzi	74%	84%