LeishMANIAdb
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Putative signal recognition particle receptor like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative signal recognition particle receptor like protein
Gene product:
signal recognition particle receptor like protein - putative
Species:
Leishmania infantum
UniProt:
A4ID41_LEIIN
TriTrypDb:
LINF_360044300
Length:
605

Annotations

Annotations by Jardim et al.

Translation, signal recognition particle receptor like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005785 signal recognition particle receptor complex 3 10
GO:0032991 protein-containing complex 1 10
GO:0098796 membrane protein complex 2 10
GO:0140534 endoplasmic reticulum protein-containing complex 2 10
GO:0005635 nuclear envelope 4 1
GO:0005783 endoplasmic reticulum 5 1
GO:0005789 endoplasmic reticulum membrane 4 3
GO:0016020 membrane 2 3
GO:0031090 organelle membrane 3 3
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4ID41
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID41

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 12
GO:0006612 protein targeting to membrane 5 12
GO:0006613 cotranslational protein targeting to membrane 6 12
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 7 12
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
GO:0045047 protein targeting to ER 6 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0051668 localization within membrane 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0070972 protein localization to endoplasmic reticulum 6 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0072594 establishment of protein localization to organelle 4 12
GO:0072599 establishment of protein localization to endoplasmic reticulum 5 12
GO:0072657 protein localization to membrane 4 12
GO:0090150 establishment of protein localization to membrane 4 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 10
GO:0003924 GTPase activity 7 10
GO:0005047 signal recognition particle binding 4 10
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0016462 pyrophosphatase activity 5 10
GO:0016787 hydrolase activity 2 10
GO:0016817 hydrolase activity, acting on acid anhydrides 3 10
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 10
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 10
GO:0019001 guanyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043021 ribonucleoprotein complex binding 3 10
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0044877 protein-containing complex binding 2 10
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 164 168 PF00656 0.303
CLV_NRD_NRD_1 203 205 PF00675 0.278
CLV_NRD_NRD_1 25 27 PF00675 0.360
CLV_NRD_NRD_1 374 376 PF00675 0.403
CLV_NRD_NRD_1 530 532 PF00675 0.232
CLV_PCSK_KEX2_1 203 205 PF00082 0.364
CLV_PCSK_KEX2_1 231 233 PF00082 0.361
CLV_PCSK_KEX2_1 25 27 PF00082 0.373
CLV_PCSK_KEX2_1 277 279 PF00082 0.486
CLV_PCSK_KEX2_1 353 355 PF00082 0.375
CLV_PCSK_KEX2_1 374 376 PF00082 0.389
CLV_PCSK_PC1ET2_1 231 233 PF00082 0.361
CLV_PCSK_PC1ET2_1 277 279 PF00082 0.517
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.375
CLV_PCSK_SKI1_1 203 207 PF00082 0.319
CLV_PCSK_SKI1_1 257 261 PF00082 0.534
CLV_PCSK_SKI1_1 299 303 PF00082 0.261
CLV_PCSK_SKI1_1 374 378 PF00082 0.344
CLV_PCSK_SKI1_1 55 59 PF00082 0.290
CLV_PCSK_SKI1_1 72 76 PF00082 0.218
DEG_Nend_Nbox_1 1 3 PF02207 0.308
DOC_ANK_TNKS_1 141 148 PF00023 0.240
DOC_CYCLIN_yCln2_LP_2 575 581 PF00134 0.229
DOC_MAPK_gen_1 546 555 PF00069 0.240
DOC_MAPK_gen_1 72 81 PF00069 0.392
DOC_MAPK_MEF2A_6 478 485 PF00069 0.279
DOC_MAPK_MEF2A_6 592 600 PF00069 0.244
DOC_MAPK_MEF2A_6 75 83 PF00069 0.352
DOC_PP2B_LxvP_1 452 455 PF13499 0.244
DOC_PP4_FxxP_1 73 76 PF00568 0.381
DOC_SPAK_OSR1_1 63 67 PF12202 0.250
DOC_USP7_MATH_1 153 157 PF00917 0.335
DOC_USP7_MATH_1 165 169 PF00917 0.394
DOC_USP7_MATH_1 222 226 PF00917 0.291
DOC_USP7_MATH_1 266 270 PF00917 0.541
DOC_USP7_MATH_1 474 478 PF00917 0.395
DOC_USP7_MATH_1 542 546 PF00917 0.375
DOC_USP7_UBL2_3 230 234 PF12436 0.277
DOC_USP7_UBL2_3 328 332 PF12436 0.229
DOC_USP7_UBL2_3 393 397 PF12436 0.393
DOC_USP7_UBL2_3 92 96 PF12436 0.332
LIG_14-3-3_CanoR_1 299 304 PF00244 0.258
LIG_Actin_WH2_2 358 376 PF00022 0.263
LIG_Actin_WH2_2 577 594 PF00022 0.323
LIG_APCC_ABBA_1 178 183 PF00400 0.174
LIG_FHA_1 2 8 PF00498 0.278
LIG_FHA_1 308 314 PF00498 0.375
LIG_FHA_1 417 423 PF00498 0.251
LIG_FHA_2 17 23 PF00498 0.429
LIG_FHA_2 235 241 PF00498 0.209
LIG_FHA_2 258 264 PF00498 0.451
LIG_FHA_2 362 368 PF00498 0.419
LIG_FHA_2 554 560 PF00498 0.229
LIG_FHA_2 585 591 PF00498 0.229
LIG_LIR_Apic_2 237 242 PF02991 0.189
LIG_LIR_Gen_1 123 133 PF02991 0.365
LIG_LIR_Gen_1 357 365 PF02991 0.232
LIG_LIR_Gen_1 556 565 PF02991 0.229
LIG_LIR_Gen_1 587 596 PF02991 0.229
LIG_LIR_Nem_3 102 107 PF02991 0.276
LIG_LIR_Nem_3 123 129 PF02991 0.365
LIG_LIR_Nem_3 357 361 PF02991 0.255
LIG_LIR_Nem_3 539 543 PF02991 0.238
LIG_LIR_Nem_3 556 561 PF02991 0.376
LIG_LIR_Nem_3 587 591 PF02991 0.229
LIG_LIR_Nem_3 61 67 PF02991 0.246
LIG_LYPXL_S_1 69 73 PF13949 0.263
LIG_PCNA_yPIPBox_3 25 37 PF02747 0.245
LIG_Pex14_1 303 307 PF04695 0.229
LIG_REV1ctd_RIR_1 71 75 PF16727 0.375
LIG_SH2_CRK 126 130 PF00017 0.375
LIG_SH2_CRK 399 403 PF00017 0.229
LIG_SH2_STAP1 126 130 PF00017 0.261
LIG_SH2_STAP1 399 403 PF00017 0.277
LIG_SH2_STAT3 420 423 PF00017 0.229
LIG_SH2_STAT3 94 97 PF00017 0.294
LIG_SH2_STAT5 275 278 PF00017 0.558
LIG_SH2_STAT5 307 310 PF00017 0.244
LIG_SH3_3 182 188 PF00018 0.250
LIG_SH3_3 242 248 PF00018 0.327
LIG_SH3_3 590 596 PF00018 0.244
LIG_SUMO_SIM_anti_2 3 11 PF11976 0.297
LIG_SUMO_SIM_par_1 3 11 PF11976 0.297
LIG_SUMO_SIM_par_1 482 488 PF11976 0.230
LIG_TRAF2_1 135 138 PF00917 0.325
LIG_TRAF2_1 170 173 PF00917 0.314
LIG_TRAF2_1 259 262 PF00917 0.407
LIG_UBA3_1 321 328 PF00899 0.375
LIG_WRC_WIRS_1 355 360 PF05994 0.265
MOD_CK1_1 156 162 PF00069 0.349
MOD_CK1_1 217 223 PF00069 0.279
MOD_CK1_1 6 12 PF00069 0.314
MOD_CK2_1 16 22 PF00069 0.487
MOD_CK2_1 167 173 PF00069 0.283
MOD_CK2_1 257 263 PF00069 0.454
MOD_Cter_Amidation 201 204 PF01082 0.268
MOD_Cter_Amidation 23 26 PF01082 0.414
MOD_Cter_Amidation 232 235 PF01082 0.294
MOD_Cter_Amidation 351 354 PF01082 0.289
MOD_GlcNHglycan 10 13 PF01048 0.433
MOD_GlcNHglycan 121 125 PF01048 0.260
MOD_GlcNHglycan 155 158 PF01048 0.355
MOD_GlcNHglycan 167 170 PF01048 0.163
MOD_GlcNHglycan 173 177 PF01048 0.266
MOD_GlcNHglycan 216 219 PF01048 0.419
MOD_GlcNHglycan 225 228 PF01048 0.235
MOD_GlcNHglycan 464 468 PF01048 0.204
MOD_GlcNHglycan 600 603 PF01048 0.257
MOD_GSK3_1 103 110 PF00069 0.372
MOD_GSK3_1 16 23 PF00069 0.387
MOD_GSK3_1 163 170 PF00069 0.322
MOD_GSK3_1 299 306 PF00069 0.368
MOD_GSK3_1 342 349 PF00069 0.235
MOD_GSK3_1 357 364 PF00069 0.333
MOD_GSK3_1 553 560 PF00069 0.240
MOD_LATS_1 255 261 PF00433 0.576
MOD_N-GLC_1 133 138 PF02516 0.327
MOD_N-GLC_1 214 219 PF02516 0.263
MOD_N-GLC_2 534 536 PF02516 0.277
MOD_NEK2_1 1 6 PF00069 0.292
MOD_NEK2_1 103 108 PF00069 0.329
MOD_NEK2_1 369 374 PF00069 0.417
MOD_NEK2_1 485 490 PF00069 0.223
MOD_NEK2_2 433 438 PF00069 0.229
MOD_PK_1 397 403 PF00069 0.229
MOD_PKA_1 203 209 PF00069 0.411
MOD_PKA_1 234 240 PF00069 0.245
MOD_PKA_1 257 263 PF00069 0.557
MOD_PKA_2 203 209 PF00069 0.428
MOD_PKA_2 271 277 PF00069 0.407
MOD_PKB_1 297 305 PF00069 0.258
MOD_Plk_1 346 352 PF00069 0.229
MOD_Plk_4 271 277 PF00069 0.454
MOD_Plk_4 299 305 PF00069 0.302
MOD_Plk_4 3 9 PF00069 0.295
MOD_Plk_4 357 363 PF00069 0.402
MOD_Plk_4 397 403 PF00069 0.229
MOD_Plk_4 425 431 PF00069 0.236
MOD_Plk_4 567 573 PF00069 0.229
MOD_SUMO_for_1 379 382 PF00179 0.378
MOD_SUMO_rev_2 251 260 PF00179 0.419
MOD_SUMO_rev_2 312 321 PF00179 0.294
MOD_SUMO_rev_2 559 565 PF00179 0.229
TRG_DiLeu_BaEn_1 125 130 PF01217 0.356
TRG_ENDOCYTIC_2 126 129 PF00928 0.332
TRG_ENDOCYTIC_2 362 365 PF00928 0.404
TRG_ENDOCYTIC_2 399 402 PF00928 0.229
TRG_ENDOCYTIC_2 588 591 PF00928 0.229
TRG_ENDOCYTIC_2 70 73 PF00928 0.240
TRG_ENDOCYTIC_2 78 81 PF00928 0.216
TRG_ER_diArg_1 203 205 PF00400 0.360
TRG_ER_diArg_1 297 300 PF00400 0.501
TRG_ER_diArg_1 373 375 PF00400 0.394
TRG_NES_CRM1_1 559 574 PF08389 0.229
TRG_NLS_MonoExtC_3 229 234 PF00514 0.250
TRG_NLS_MonoExtN_4 230 235 PF00514 0.276
TRG_Pf-PMV_PEXEL_1 252 256 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3Q5 Leptomonas seymouri 77% 99%
A0A0S4JKS8 Bodo saltans 57% 100%
A0A1X0P3D4 Trypanosomatidae 63% 100%
A0A3R7RBB0 Trypanosoma rangeli 61% 100%
A0A3S7XBC9 Leishmania donovani 100% 100%
A4HPM4 Leishmania braziliensis 87% 99%
D0A8J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9ATD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P08240 Homo sapiens 37% 95%
Q4Q161 Leishmania major 95% 100%
Q9DBG7 Mus musculus 38% 95%
Q9U5L1 Drosophila melanogaster 38% 99%
V5DNM6 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS