F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ID38_LEIIN

TriTrypDb:

LINF_360044700

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ID38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.564
CLV_C14_Caspase3-7	473	477	PF00656	0.564
CLV_NRD_NRD_1	198	200	PF00675	0.524
CLV_NRD_NRD_1	29	31	PF00675	0.605
CLV_PCSK_KEX2_1	200	202	PF00082	0.736
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.736
CLV_PCSK_SKI1_1	131	135	PF00082	0.579
CLV_PCSK_SKI1_1	177	181	PF00082	0.635
CLV_PCSK_SKI1_1	394	398	PF00082	0.600
DEG_Nend_UBRbox_2	1	3	PF02207	0.483
DEG_ODPH_VHL_1	58	69	PF01847	0.456
DEG_SPOP_SBC_1	507	511	PF00917	0.424
DOC_CKS1_1	321	326	PF01111	0.457
DOC_CYCLIN_RxL_1	483	493	PF00134	0.554
DOC_MAPK_FxFP_2	118	121	PF00069	0.407
DOC_MAPK_gen_1	136	144	PF00069	0.461
DOC_MAPK_gen_1	16	22	PF00069	0.449
DOC_MAPK_gen_1	72	80	PF00069	0.481
DOC_MAPK_MEF2A_6	72	80	PF00069	0.481
DOC_PP1_RVXF_1	175	182	PF00149	0.439
DOC_PP1_RVXF_1	42	49	PF00149	0.460
DOC_PP2B_LxvP_1	488	491	PF13499	0.582
DOC_PP2B_LxvP_1	58	61	PF13499	0.447
DOC_PP4_FxxP_1	118	121	PF00568	0.407
DOC_USP7_MATH_1	119	123	PF00917	0.468
DOC_USP7_MATH_1	232	236	PF00917	0.509
DOC_USP7_MATH_1	460	464	PF00917	0.521
DOC_WW_Pin1_4	162	167	PF00397	0.405
DOC_WW_Pin1_4	192	197	PF00397	0.498
DOC_WW_Pin1_4	320	325	PF00397	0.455
LIG_14-3-3_CanoR_1	30	40	PF00244	0.387
LIG_14-3-3_CanoR_1	301	306	PF00244	0.465
LIG_14-3-3_CanoR_1	340	345	PF00244	0.445
LIG_14-3-3_CanoR_1	350	359	PF00244	0.368
LIG_14-3-3_CanoR_1	380	384	PF00244	0.437
LIG_14-3-3_CanoR_1	420	426	PF00244	0.502
LIG_AP2alpha_2	231	233	PF02296	0.533
LIG_AP2alpha_2	469	471	PF02296	0.543
LIG_BRCT_BRCA1_1	229	233	PF00533	0.364
LIG_BRCT_BRCA1_1	33	37	PF00533	0.439
LIG_eIF4E_1	95	101	PF01652	0.471
LIG_EVH1_2	255	259	PF00568	0.415
LIG_FHA_1	181	187	PF00498	0.385
LIG_FHA_1	351	357	PF00498	0.443
LIG_FHA_1	380	386	PF00498	0.428
LIG_FHA_1	4	10	PF00498	0.457
LIG_FHA_1	403	409	PF00498	0.459
LIG_FHA_1	425	431	PF00498	0.500
LIG_FHA_1	452	458	PF00498	0.388
LIG_FHA_1	84	90	PF00498	0.449
LIG_FHA_1	96	102	PF00498	0.351
LIG_FHA_2	13	19	PF00498	0.423
LIG_FHA_2	149	155	PF00498	0.423
LIG_FHA_2	193	199	PF00498	0.500
LIG_FHA_2	321	327	PF00498	0.434
LIG_FHA_2	471	477	PF00498	0.515
LIG_FHA_2	493	499	PF00498	0.546
LIG_LIR_Apic_2	160	166	PF02991	0.406
LIG_LIR_Apic_2	319	324	PF02991	0.462
LIG_LIR_Gen_1	328	339	PF02991	0.396
LIG_LIR_Gen_1	405	413	PF02991	0.455
LIG_LIR_Gen_1	501	508	PF02991	0.397
LIG_LIR_Gen_1	53	61	PF02991	0.476
LIG_LIR_Nem_3	265	271	PF02991	0.382
LIG_LIR_Nem_3	34	40	PF02991	0.450
LIG_LIR_Nem_3	382	386	PF02991	0.400
LIG_LIR_Nem_3	405	410	PF02991	0.460
LIG_LIR_Nem_3	436	441	PF02991	0.558
LIG_LIR_Nem_3	493	497	PF02991	0.453
LIG_LIR_Nem_3	501	505	PF02991	0.411
LIG_LIR_Nem_3	53	58	PF02991	0.427
LIG_LYPXL_yS_3	294	297	PF13949	0.415
LIG_SH2_CRK	321	325	PF00017	0.456
LIG_SH2_CRK	438	442	PF00017	0.402
LIG_SH2_CRK	97	101	PF00017	0.478
LIG_SH2_NCK_1	163	167	PF00017	0.460
LIG_SH2_NCK_1	206	210	PF00017	0.575
LIG_SH2_PTP2	55	58	PF00017	0.496
LIG_SH2_STAP1	97	101	PF00017	0.389
LIG_SH2_STAT5	106	109	PF00017	0.413
LIG_SH2_STAT5	13	16	PF00017	0.458
LIG_SH2_STAT5	132	135	PF00017	0.399
LIG_SH2_STAT5	260	263	PF00017	0.423
LIG_SH2_STAT5	383	386	PF00017	0.408
LIG_SH2_STAT5	416	419	PF00017	0.524
LIG_SH2_STAT5	45	48	PF00017	0.445
LIG_SH2_STAT5	453	456	PF00017	0.472
LIG_SH2_STAT5	55	58	PF00017	0.544
LIG_SH2_STAT5	95	98	PF00017	0.372
LIG_SH3_3	250	256	PF00018	0.489
LIG_SH3_3	454	460	PF00018	0.402
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.430
LIG_SUMO_SIM_anti_2	393	401	PF11976	0.404
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.454
LIG_SUMO_SIM_par_1	393	401	PF11976	0.427
LIG_SUMO_SIM_par_1	5	12	PF11976	0.446
LIG_SUMO_SIM_par_1	76	82	PF11976	0.423
LIG_TRAF2_1	39	42	PF00917	0.429
LIG_UBA3_1	64	72	PF00899	0.438
LIG_WRC_WIRS_1	452	457	PF05994	0.483
MOD_CDK_SPxxK_3	192	199	PF00069	0.290
MOD_CK1_1	12	18	PF00069	0.461
MOD_CK1_1	23	29	PF00069	0.429
MOD_CK1_1	304	310	PF00069	0.422
MOD_CK1_1	36	42	PF00069	0.371
MOD_CK1_1	367	373	PF00069	0.471
MOD_CK1_1	379	385	PF00069	0.402
MOD_CK1_1	400	406	PF00069	0.451
MOD_CK1_1	424	430	PF00069	0.544
MOD_CK2_1	12	18	PF00069	0.519
MOD_CK2_1	148	154	PF00069	0.371
MOD_CK2_1	320	326	PF00069	0.428
MOD_CK2_1	349	355	PF00069	0.444
MOD_CK2_1	36	42	PF00069	0.412
MOD_CK2_1	492	498	PF00069	0.502
MOD_GlcNHglycan	127	130	PF01048	0.628
MOD_GlcNHglycan	214	217	PF01048	0.701
MOD_GlcNHglycan	22	25	PF01048	0.602
MOD_GlcNHglycan	240	243	PF01048	0.761
MOD_GlcNHglycan	264	267	PF01048	0.660
MOD_GlcNHglycan	276	279	PF01048	0.535
MOD_GlcNHglycan	516	519	PF01048	0.387
MOD_GlcNHglycan	81	84	PF01048	0.692
MOD_GSK3_1	227	234	PF00069	0.496
MOD_GSK3_1	236	243	PF00069	0.568
MOD_GSK3_1	300	307	PF00069	0.428
MOD_GSK3_1	360	367	PF00069	0.412
MOD_GSK3_1	396	403	PF00069	0.391
MOD_GSK3_1	424	431	PF00069	0.430
MOD_GSK3_1	508	515	PF00069	0.376
MOD_GSK3_1	79	86	PF00069	0.385
MOD_N-GLC_1	237	242	PF02516	0.718
MOD_NEK2_1	148	153	PF00069	0.396
MOD_NEK2_1	180	185	PF00069	0.366
MOD_NEK2_1	20	25	PF00069	0.388
MOD_NEK2_1	217	222	PF00069	0.412
MOD_NEK2_1	261	266	PF00069	0.383
MOD_NEK2_1	273	278	PF00069	0.337
MOD_NEK2_1	305	310	PF00069	0.451
MOD_NEK2_1	349	354	PF00069	0.432
MOD_NEK2_1	402	407	PF00069	0.453
MOD_NEK2_1	512	517	PF00069	0.376
MOD_NEK2_1	79	84	PF00069	0.435
MOD_NEK2_1	9	14	PF00069	0.520
MOD_NEK2_2	182	187	PF00069	0.387
MOD_PIKK_1	59	65	PF00454	0.468
MOD_PIKK_1	95	101	PF00454	0.471
MOD_PK_1	406	412	PF00069	0.471
MOD_PKA_2	300	306	PF00069	0.484
MOD_PKA_2	349	355	PF00069	0.492
MOD_PKA_2	379	385	PF00069	0.426
MOD_PKA_2	411	417	PF00069	0.470
MOD_Plk_1	400	406	PF00069	0.413
MOD_Plk_4	120	126	PF00069	0.475
MOD_Plk_4	148	154	PF00069	0.348
MOD_Plk_4	284	290	PF00069	0.425
MOD_Plk_4	3	9	PF00069	0.457
MOD_Plk_4	33	39	PF00069	0.422
MOD_Plk_4	342	348	PF00069	0.449
MOD_Plk_4	360	366	PF00069	0.427
MOD_Plk_4	379	385	PF00069	0.417
MOD_Plk_4	421	427	PF00069	0.532
MOD_Plk_4	498	504	PF00069	0.317
MOD_Plk_4	508	514	PF00069	0.376
MOD_ProDKin_1	162	168	PF00069	0.403
MOD_ProDKin_1	192	198	PF00069	0.502
MOD_ProDKin_1	320	326	PF00069	0.461
MOD_SUMO_rev_2	36	46	PF00179	0.422
TRG_DiLeu_BaEn_1	42	47	PF01217	0.417
TRG_DiLeu_BaEn_1	73	78	PF01217	0.426
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.432
TRG_ENDOCYTIC_2	294	297	PF00928	0.468
TRG_ENDOCYTIC_2	331	334	PF00928	0.384
TRG_ENDOCYTIC_2	346	349	PF00928	0.424
TRG_ENDOCYTIC_2	438	441	PF00928	0.402
TRG_ENDOCYTIC_2	55	58	PF00928	0.496
TRG_ENDOCYTIC_2	97	100	PF00928	0.410
TRG_NES_CRM1_1	146	160	PF08389	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ9	Leptomonas seymouri	60%	97%
A0A1X0P3D8	Trypanosomatidae	29%	100%
A0A3S7XB84	Leishmania donovani	100%	100%
A4HPM8	Leishmania braziliensis	81%	100%
E9ATE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q157	Leishmania major	92%	100%