DUF2130 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ID35_LEIIN

TriTrypDb:

LINF_360045000

Length:

121

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ID35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	112	116	PF00082	0.616
CLV_PCSK_SKI1_1	50	54	PF00082	0.555
DOC_MAPK_gen_1	78	87	PF00069	0.528
DOC_USP7_MATH_1	44	48	PF00917	0.330
DOC_WW_Pin1_4	26	31	PF00397	0.532
LIG_14-3-3_CanoR_1	112	117	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	19	23	PF00533	0.460
LIG_FHA_1	104	110	PF00498	0.469
LIG_LIR_Gen_1	20	30	PF02991	0.429
LIG_LIR_Nem_3	20	26	PF02991	0.436
LIG_LIR_Nem_3	47	52	PF02991	0.548
LIG_PDZ_Class_3	116	121	PF00595	0.673
LIG_Pex14_2	49	53	PF04695	0.543
LIG_SH2_STAP1	42	46	PF00017	0.419
LIG_SUMO_SIM_par_1	24	29	PF11976	0.513
LIG_UBA3_1	48	56	PF00899	0.580
MOD_CK1_1	31	37	PF00069	0.562
MOD_GSK3_1	3	10	PF00069	0.591
MOD_N-GLC_1	31	36	PF02516	0.565
MOD_NEK2_1	17	22	PF00069	0.500
MOD_NEK2_2	44	49	PF00069	0.324
MOD_Plk_4	44	50	PF00069	0.547
MOD_ProDKin_1	26	32	PF00069	0.539
MOD_SUMO_rev_2	40	47	PF00179	0.497
TRG_ENDOCYTIC_2	96	99	PF00928	0.572
TRG_ER_diArg_1	104	107	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVF5	Leptomonas seymouri	68%	98%
A0A0S4J3L8	Bodo saltans	41%	86%
A0A1X0P3B7	Trypanosomatidae	52%	100%
A0A3S7XBD5	Leishmania donovani	99%	100%
A0A422MYF0	Trypanosoma rangeli	45%	100%
A4HPN1	Leishmania braziliensis	89%	100%
D0A8I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ATE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q154	Leishmania major	96%	100%