WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4ID34_LEIIN

TriTrypDb:

LINF_360045100

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A4ID34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID34

Function

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Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.499
CLV_NRD_NRD_1	38	40	PF00675	0.603
CLV_PCSK_KEX2_1	316	318	PF00082	0.506
CLV_PCSK_SKI1_1	174	178	PF00082	0.242
CLV_PCSK_SKI1_1	29	33	PF00082	0.504
DEG_APCC_DBOX_1	28	36	PF00400	0.493
DEG_Nend_UBRbox_3	1	3	PF02207	0.464
DEG_SCF_FBW7_1	94	101	PF00400	0.481
DOC_CYCLIN_RxL_1	363	376	PF00134	0.515
DOC_MAPK_gen_1	180	188	PF00069	0.552

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ1	Leptomonas seymouri	80%	100%
A0A0S4JA64	Bodo saltans	23%	66%
A0A1X0P3H5	Trypanosomatidae	49%	100%
A0A3S7XBC0	Leishmania donovani	100%	100%
A0A422MYE0	Trypanosoma rangeli	47%	100%
A4HPN2	Leishmania braziliensis	93%	100%
D0A8I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q153	Leishmania major	97%	100%
V5B728	Trypanosoma cruzi	49%	100%

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