LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF1619) - putative
Species:
Leishmania infantum
UniProt:
A4ID32_LEIIN
TriTrypDb:
LINF_360045300
Length:
585

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 3
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ID32
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID32

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0030030 cell projection organization 4 11
GO:0071840 cellular component organization or biogenesis 2 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 192 196 PF00656 0.435
CLV_C14_Caspase3-7 281 285 PF00656 0.417
CLV_C14_Caspase3-7 33 37 PF00656 0.549
CLV_NRD_NRD_1 182 184 PF00675 0.417
CLV_NRD_NRD_1 395 397 PF00675 0.464
CLV_NRD_NRD_1 560 562 PF00675 0.485
CLV_PCSK_KEX2_1 101 103 PF00082 0.387
CLV_PCSK_KEX2_1 182 184 PF00082 0.387
CLV_PCSK_KEX2_1 395 397 PF00082 0.492
CLV_PCSK_KEX2_1 560 562 PF00082 0.507
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.411
CLV_PCSK_SKI1_1 106 110 PF00082 0.387
CLV_PCSK_SKI1_1 72 76 PF00082 0.417
DEG_Nend_Nbox_1 1 3 PF02207 0.640
DEG_SPOP_SBC_1 470 474 PF00917 0.387
DOC_CKS1_1 273 278 PF01111 0.289
DOC_MAPK_FxFP_2 16 19 PF00069 0.617
DOC_MAPK_MEF2A_6 483 492 PF00069 0.343
DOC_PP1_RVXF_1 201 208 PF00149 0.297
DOC_PP1_RVXF_1 542 548 PF00149 0.435
DOC_PP4_FxxP_1 136 139 PF00568 0.295
DOC_PP4_FxxP_1 16 19 PF00568 0.617
DOC_PP4_FxxP_1 187 190 PF00568 0.307
DOC_PP4_FxxP_1 380 383 PF00568 0.351
DOC_PP4_FxxP_1 515 518 PF00568 0.342
DOC_USP7_MATH_1 274 278 PF00917 0.435
DOC_USP7_MATH_1 470 474 PF00917 0.484
DOC_WW_Pin1_4 175 180 PF00397 0.400
DOC_WW_Pin1_4 272 277 PF00397 0.386
DOC_WW_Pin1_4 31 36 PF00397 0.489
DOC_WW_Pin1_4 347 352 PF00397 0.325
DOC_WW_Pin1_4 39 44 PF00397 0.399
DOC_WW_Pin1_4 514 519 PF00397 0.462
DOC_WW_Pin1_4 579 584 PF00397 0.563
DOC_WW_Pin1_4 82 87 PF00397 0.367
LIG_14-3-3_CanoR_1 395 400 PF00244 0.464
LIG_14-3-3_CanoR_1 96 101 PF00244 0.417
LIG_BRCT_BRCA1_1 343 347 PF00533 0.413
LIG_DLG_GKlike_1 395 403 PF00625 0.448
LIG_FHA_1 147 153 PF00498 0.422
LIG_FHA_1 252 258 PF00498 0.386
LIG_FHA_1 423 429 PF00498 0.380
LIG_FHA_1 457 463 PF00498 0.466
LIG_FHA_1 487 493 PF00498 0.443
LIG_FHA_1 51 57 PF00498 0.353
LIG_FHA_1 520 526 PF00498 0.497
LIG_FHA_1 540 546 PF00498 0.172
LIG_FHA_2 107 113 PF00498 0.394
LIG_FHA_2 190 196 PF00498 0.417
LIG_FHA_2 279 285 PF00498 0.421
LIG_FHA_2 440 446 PF00498 0.514
LIG_FHA_2 527 533 PF00498 0.524
LIG_KLC1_Yacidic_2 107 112 PF13176 0.402
LIG_LIR_Apic_2 13 19 PF02991 0.609
LIG_LIR_Apic_2 377 383 PF02991 0.408
LIG_LIR_Apic_2 81 86 PF02991 0.431
LIG_LIR_Apic_2 89 93 PF02991 0.443
LIG_LIR_Gen_1 169 179 PF02991 0.455
LIG_LIR_Gen_1 26 35 PF02991 0.501
LIG_LIR_Gen_1 277 284 PF02991 0.363
LIG_LIR_Gen_1 458 467 PF02991 0.327
LIG_LIR_Gen_1 537 545 PF02991 0.471
LIG_LIR_Nem_3 130 136 PF02991 0.276
LIG_LIR_Nem_3 169 175 PF02991 0.442
LIG_LIR_Nem_3 178 184 PF02991 0.370
LIG_LIR_Nem_3 249 253 PF02991 0.354
LIG_LIR_Nem_3 26 30 PF02991 0.454
LIG_LIR_Nem_3 277 282 PF02991 0.338
LIG_LIR_Nem_3 458 464 PF02991 0.355
LIG_LIR_Nem_3 475 481 PF02991 0.409
LIG_LIR_Nem_3 537 541 PF02991 0.412
LIG_LIR_Nem_3 546 550 PF02991 0.344
LIG_LIR_Nem_3 573 579 PF02991 0.473
LIG_LIR_Nem_3 84 90 PF02991 0.384
LIG_LYPXL_yS_3 18 21 PF13949 0.568
LIG_MAD2 561 569 PF02301 0.544
LIG_MYND_1 566 570 PF01753 0.614
LIG_NRBOX 1 7 PF00104 0.650
LIG_Pex14_2 331 335 PF04695 0.315
LIG_Pex14_2 543 547 PF04695 0.345
LIG_PTAP_UEV_1 147 152 PF05743 0.413
LIG_SH2_CRK 118 122 PF00017 0.381
LIG_SH2_CRK 181 185 PF00017 0.435
LIG_SH2_CRK 232 236 PF00017 0.381
LIG_SH2_CRK 279 283 PF00017 0.341
LIG_SH2_CRK 494 498 PF00017 0.347
LIG_SH2_CRK 83 87 PF00017 0.432
LIG_SH2_CRK 90 94 PF00017 0.396
LIG_SH2_GRB2like 232 235 PF00017 0.353
LIG_SH2_NCK_1 279 283 PF00017 0.435
LIG_SH2_NCK_1 83 87 PF00017 0.435
LIG_SH2_PTP2 172 175 PF00017 0.435
LIG_SH2_PTP2 326 329 PF00017 0.435
LIG_SH2_STAT3 481 484 PF00017 0.542
LIG_SH2_STAT3 505 508 PF00017 0.498
LIG_SH2_STAT5 110 113 PF00017 0.359
LIG_SH2_STAT5 135 138 PF00017 0.381
LIG_SH2_STAT5 172 175 PF00017 0.400
LIG_SH2_STAT5 326 329 PF00017 0.335
LIG_SH2_STAT5 353 356 PF00017 0.338
LIG_SH2_STAT5 44 47 PF00017 0.405
LIG_SH2_STAT5 481 484 PF00017 0.462
LIG_SH2_STAT5 77 80 PF00017 0.379
LIG_SH2_STAT5 87 90 PF00017 0.294
LIG_SH3_3 139 145 PF00018 0.311
LIG_SH3_3 148 154 PF00018 0.311
LIG_SH3_3 18 24 PF00018 0.470
LIG_SH3_3 270 276 PF00018 0.289
LIG_SH3_3 560 566 PF00018 0.494
LIG_SH3_5 86 90 PF00018 0.417
LIG_SUMO_SIM_par_1 153 158 PF11976 0.426
LIG_SUMO_SIM_par_1 7 14 PF11976 0.609
LIG_TYR_ITIM 492 497 PF00017 0.322
LIG_WRC_WIRS_1 520 525 PF05994 0.418
MOD_CDK_SPxxK_3 175 182 PF00069 0.435
MOD_CDK_SPxxK_3 31 38 PF00069 0.560
MOD_CK1_1 194 200 PF00069 0.430
MOD_CK1_1 300 306 PF00069 0.394
MOD_CK1_1 402 408 PF00069 0.410
MOD_CK1_1 422 428 PF00069 0.175
MOD_CK1_1 474 480 PF00069 0.475
MOD_CK1_1 486 492 PF00069 0.466
MOD_CK1_1 554 560 PF00069 0.556
MOD_CK2_1 106 112 PF00069 0.419
MOD_CK2_1 243 249 PF00069 0.428
MOD_CK2_1 299 305 PF00069 0.402
MOD_GlcNHglycan 13 16 PF01048 0.603
MOD_GlcNHglycan 175 178 PF01048 0.439
MOD_GlcNHglycan 198 201 PF01048 0.372
MOD_GlcNHglycan 245 248 PF01048 0.409
MOD_GlcNHglycan 259 263 PF01048 0.253
MOD_GlcNHglycan 305 308 PF01048 0.417
MOD_GlcNHglycan 354 357 PF01048 0.369
MOD_GlcNHglycan 360 363 PF01048 0.441
MOD_GlcNHglycan 370 373 PF01048 0.272
MOD_GlcNHglycan 377 380 PF01048 0.230
MOD_GlcNHglycan 405 408 PF01048 0.397
MOD_GlcNHglycan 474 477 PF01048 0.497
MOD_GlcNHglycan 68 72 PF01048 0.387
MOD_GSK3_1 123 130 PF00069 0.372
MOD_GSK3_1 173 180 PF00069 0.430
MOD_GSK3_1 207 214 PF00069 0.375
MOD_GSK3_1 264 271 PF00069 0.377
MOD_GSK3_1 274 281 PF00069 0.405
MOD_GSK3_1 299 306 PF00069 0.362
MOD_GSK3_1 395 402 PF00069 0.434
MOD_GSK3_1 465 472 PF00069 0.426
MOD_GSK3_1 479 486 PF00069 0.383
MOD_GSK3_1 539 546 PF00069 0.422
MOD_N-GLC_1 243 248 PF02516 0.384
MOD_N-GLC_1 303 308 PF02516 0.316
MOD_N-GLC_1 31 36 PF02516 0.520
MOD_N-GLC_1 314 319 PF02516 0.262
MOD_N-GLC_1 338 343 PF02516 0.402
MOD_N-GLC_1 412 417 PF02516 0.479
MOD_N-GLC_1 433 438 PF02516 0.503
MOD_N-GLC_1 455 460 PF02516 0.377
MOD_N-GLC_1 486 491 PF02516 0.474
MOD_N-GLC_1 526 531 PF02516 0.492
MOD_NEK2_1 207 212 PF00069 0.393
MOD_NEK2_1 237 242 PF00069 0.371
MOD_NEK2_1 257 262 PF00069 0.321
MOD_NEK2_1 264 269 PF00069 0.341
MOD_NEK2_1 299 304 PF00069 0.375
MOD_NEK2_1 314 319 PF00069 0.311
MOD_NEK2_1 388 393 PF00069 0.524
MOD_NEK2_1 399 404 PF00069 0.382
MOD_NEK2_1 471 476 PF00069 0.397
MOD_NEK2_1 543 548 PF00069 0.378
MOD_NEK2_1 571 576 PF00069 0.496
MOD_NEK2_1 9 14 PF00069 0.627
MOD_PIKK_1 155 161 PF00454 0.435
MOD_PIKK_1 551 557 PF00454 0.526
MOD_PKA_1 395 401 PF00069 0.504
MOD_PKA_2 375 381 PF00069 0.429
MOD_PKA_2 395 401 PF00069 0.184
MOD_PKA_2 95 101 PF00069 0.423
MOD_Plk_1 106 112 PF00069 0.370
MOD_Plk_1 314 320 PF00069 0.435
MOD_Plk_1 338 344 PF00069 0.371
MOD_Plk_1 433 439 PF00069 0.538
MOD_Plk_1 456 462 PF00069 0.372
MOD_Plk_1 486 492 PF00069 0.474
MOD_Plk_1 571 577 PF00069 0.461
MOD_Plk_4 106 112 PF00069 0.389
MOD_Plk_4 268 274 PF00069 0.391
MOD_Plk_4 360 366 PF00069 0.436
MOD_Plk_4 395 401 PF00069 0.457
MOD_Plk_4 439 445 PF00069 0.542
MOD_Plk_4 457 463 PF00069 0.214
MOD_Plk_4 554 560 PF00069 0.526
MOD_Plk_4 571 577 PF00069 0.336
MOD_ProDKin_1 175 181 PF00069 0.400
MOD_ProDKin_1 272 278 PF00069 0.386
MOD_ProDKin_1 31 37 PF00069 0.489
MOD_ProDKin_1 347 353 PF00069 0.325
MOD_ProDKin_1 39 45 PF00069 0.394
MOD_ProDKin_1 514 520 PF00069 0.470
MOD_ProDKin_1 579 585 PF00069 0.567
MOD_ProDKin_1 82 88 PF00069 0.367
MOD_SUMO_rev_2 107 115 PF00179 0.449
MOD_SUMO_rev_2 283 287 PF00179 0.435
TRG_DiLeu_BaEn_1 305 310 PF01217 0.402
TRG_DiLeu_BaLyEn_6 142 147 PF01217 0.435
TRG_ENDOCYTIC_2 118 121 PF00928 0.377
TRG_ENDOCYTIC_2 133 136 PF00928 0.301
TRG_ENDOCYTIC_2 172 175 PF00928 0.454
TRG_ENDOCYTIC_2 18 21 PF00928 0.555
TRG_ENDOCYTIC_2 181 184 PF00928 0.410
TRG_ENDOCYTIC_2 232 235 PF00928 0.353
TRG_ENDOCYTIC_2 279 282 PF00928 0.341
TRG_ENDOCYTIC_2 326 329 PF00928 0.417
TRG_ENDOCYTIC_2 494 497 PF00928 0.405
TRG_ENDOCYTIC_2 538 541 PF00928 0.508
TRG_ER_diArg_1 181 183 PF00400 0.417
TRG_ER_diArg_1 394 396 PF00400 0.496
TRG_ER_diArg_1 559 561 PF00400 0.502
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.435

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2E7 Leptomonas seymouri 59% 100%
A0A0S4J6N9 Bodo saltans 33% 82%
A0A1X0P3E6 Trypanosomatidae 41% 99%
A0A3Q8IJL4 Leishmania donovani 99% 100%
A0A3R7KNL3 Trypanosoma rangeli 38% 91%
D0A8I5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9ATE6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q151 Leishmania major 92% 100%
Q8R2Q6 Mus musculus 25% 98%
V5DNN8 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS