Nudix hydrolase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase 3 - putative

Species:

Leishmania infantum

UniProt:

A4ID31_LEIIN

TriTrypDb:

LINF_360045400

Length:

222

Annotations

Annotations by Jardim et al.

Metal Binding, Nudix hydrolase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4ID31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID31

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0047631	ADP-ribose diphosphatase activity	6	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.303
CLV_PCSK_KEX2_1	196	198	PF00082	0.379
CLV_PCSK_KEX2_1	73	75	PF00082	0.292
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.379
CLV_PCSK_SKI1_1	185	189	PF00082	0.340
DEG_APCC_DBOX_1	6	14	PF00400	0.366
DEG_Nend_UBRbox_1	1	4	PF02207	0.411
DOC_ANK_TNKS_1	150	157	PF00023	0.325
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.291
DOC_PP2B_LxvP_1	177	180	PF13499	0.406

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P576	Leptomonas seymouri	65%	97%
A0A0S4JQK4	Bodo saltans	39%	91%
A0A1X0P4G7	Trypanosomatidae	44%	92%
A0A3S7XBB4	Leishmania donovani	99%	100%
A0A422N1K2	Trypanosoma rangeli	45%	92%
A4HPN3	Leishmania braziliensis	85%	100%
D0A8I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	90%
E9ATE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q01976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	96%
Q4Q150	Leishmania major	95%	100%

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