LeishMANIAdb
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Mitogen activated kinase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen activated kinase-like protein
Gene product:
mitogen activated kinase-like protein
Species:
Leishmania infantum
UniProt:
A4ID28_LEIIN
TriTrypDb:
LINF_360045700
Length:
977

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Annotations by Jardim et al.

Protein kinase, Mitogen activated kinase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4ID28
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID28

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 14
GO:0006796 phosphate-containing compound metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009987 cellular process 1 14
GO:0016310 phosphorylation 5 14
GO:0019538 protein metabolic process 3 14
GO:0036211 protein modification process 4 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043412 macromolecule modification 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
GO:0006355 regulation of DNA-templated transcription 6 2
GO:0009889 regulation of biosynthetic process 4 2
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051252 regulation of RNA metabolic process 5 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0080090 regulation of primary metabolic process 4 2
GO:1903506 regulation of nucleic acid-templated transcription 7 2
GO:2001141 regulation of RNA biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003824 catalytic activity 1 14
GO:0004672 protein kinase activity 3 14
GO:0005488 binding 1 14
GO:0005524 ATP binding 5 14
GO:0016301 kinase activity 4 14
GO:0016740 transferase activity 2 14
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 14
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.621
CLV_C14_Caspase3-7 392 396 PF00656 0.491
CLV_C14_Caspase3-7 637 641 PF00656 0.660
CLV_C14_Caspase3-7 856 860 PF00656 0.484
CLV_C14_Caspase3-7 965 969 PF00656 0.738
CLV_NRD_NRD_1 138 140 PF00675 0.601
CLV_NRD_NRD_1 169 171 PF00675 0.431
CLV_NRD_NRD_1 229 231 PF00675 0.451
CLV_NRD_NRD_1 25 27 PF00675 0.328
CLV_NRD_NRD_1 59 61 PF00675 0.441
CLV_NRD_NRD_1 593 595 PF00675 0.326
CLV_NRD_NRD_1 659 661 PF00675 0.324
CLV_NRD_NRD_1 683 685 PF00675 0.418
CLV_PCSK_FUR_1 227 231 PF00082 0.455
CLV_PCSK_KEX2_1 168 170 PF00082 0.469
CLV_PCSK_KEX2_1 229 231 PF00082 0.458
CLV_PCSK_KEX2_1 483 485 PF00082 0.565
CLV_PCSK_KEX2_1 59 61 PF00082 0.401
CLV_PCSK_KEX2_1 644 646 PF00082 0.386
CLV_PCSK_KEX2_1 674 676 PF00082 0.413
CLV_PCSK_KEX2_1 682 684 PF00082 0.430
CLV_PCSK_KEX2_1 784 786 PF00082 0.271
CLV_PCSK_KEX2_1 883 885 PF00082 0.267
CLV_PCSK_PC1ET2_1 483 485 PF00082 0.627
CLV_PCSK_PC1ET2_1 644 646 PF00082 0.386
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.421
CLV_PCSK_PC1ET2_1 682 684 PF00082 0.430
CLV_PCSK_PC1ET2_1 784 786 PF00082 0.271
CLV_PCSK_PC1ET2_1 883 885 PF00082 0.284
CLV_PCSK_PC7_1 479 485 PF00082 0.518
CLV_PCSK_PC7_1 55 61 PF00082 0.301
CLV_PCSK_SKI1_1 330 334 PF00082 0.318
CLV_PCSK_SKI1_1 352 356 PF00082 0.643
CLV_PCSK_SKI1_1 426 430 PF00082 0.577
CLV_PCSK_SKI1_1 530 534 PF00082 0.338
CLV_PCSK_SKI1_1 594 598 PF00082 0.320
CLV_PCSK_SKI1_1 684 688 PF00082 0.350
CLV_PCSK_SKI1_1 799 803 PF00082 0.230
CLV_PCSK_SKI1_1 816 820 PF00082 0.224
DEG_APCC_DBOX_1 425 433 PF00400 0.395
DEG_APCC_DBOX_1 504 512 PF00400 0.360
DEG_APCC_DBOX_1 593 601 PF00400 0.589
DOC_CKS1_1 100 105 PF01111 0.533
DOC_CYCLIN_RxL_1 320 329 PF00134 0.661
DOC_CYCLIN_RxL_1 421 431 PF00134 0.451
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.559
DOC_CYCLIN_yCln2_LP_2 531 537 PF00134 0.343
DOC_MAPK_gen_1 227 236 PF00069 0.659
DOC_MAPK_gen_1 352 362 PF00069 0.335
DOC_MAPK_gen_1 434 442 PF00069 0.381
DOC_MAPK_gen_1 59 70 PF00069 0.557
DOC_MAPK_gen_1 816 825 PF00069 0.424
DOC_MAPK_MEF2A_6 436 444 PF00069 0.399
DOC_MAPK_MEF2A_6 762 771 PF00069 0.424
DOC_PP1_RVXF_1 275 282 PF00149 0.613
DOC_PP2B_LxvP_1 109 112 PF13499 0.667
DOC_PP2B_LxvP_1 531 534 PF13499 0.343
DOC_PP4_FxxP_1 196 199 PF00568 0.629
DOC_USP7_MATH_1 79 83 PF00917 0.529
DOC_USP7_MATH_1 95 99 PF00917 0.605
DOC_USP7_MATH_1 962 966 PF00917 0.718
DOC_USP7_MATH_2 895 901 PF00917 0.540
DOC_USP7_UBL2_3 661 665 PF12436 0.538
DOC_USP7_UBL2_3 720 724 PF12436 0.424
DOC_USP7_UBL2_3 861 865 PF12436 0.540
DOC_WW_Pin1_4 522 527 PF00397 0.269
DOC_WW_Pin1_4 690 695 PF00397 0.544
DOC_WW_Pin1_4 956 961 PF00397 0.783
DOC_WW_Pin1_4 99 104 PF00397 0.644
LIG_14-3-3_CanoR_1 438 443 PF00244 0.402
LIG_14-3-3_CanoR_1 484 493 PF00244 0.369
LIG_14-3-3_CanoR_1 505 509 PF00244 0.424
LIG_14-3-3_CanoR_1 573 581 PF00244 0.522
LIG_14-3-3_CanoR_1 921 929 PF00244 0.484
LIG_14-3-3_CanoR_1 96 103 PF00244 0.550
LIG_14-3-3_CanoR_1 963 972 PF00244 0.734
LIG_APCC_ABBA_1 469 474 PF00400 0.356
LIG_APCC_ABBA_1 932 937 PF00400 0.609
LIG_BIR_II_1 1 5 PF00653 0.642
LIG_BRCT_BRCA1_1 115 119 PF00533 0.290
LIG_BRCT_BRCA1_1 728 732 PF00533 0.508
LIG_BRCT_BRCA1_1 972 976 PF00533 0.653
LIG_FHA_1 123 129 PF00498 0.346
LIG_FHA_1 205 211 PF00498 0.660
LIG_FHA_1 265 271 PF00498 0.586
LIG_FHA_1 30 36 PF00498 0.564
LIG_FHA_1 339 345 PF00498 0.333
LIG_FHA_1 374 380 PF00498 0.399
LIG_FHA_1 456 462 PF00498 0.356
LIG_FHA_1 484 490 PF00498 0.354
LIG_FHA_1 526 532 PF00498 0.325
LIG_FHA_1 711 717 PF00498 0.466
LIG_FHA_1 764 770 PF00498 0.467
LIG_FHA_1 796 802 PF00498 0.482
LIG_FHA_1 837 843 PF00498 0.475
LIG_FHA_1 922 928 PF00498 0.512
LIG_FHA_1 95 101 PF00498 0.610
LIG_FHA_2 238 244 PF00498 0.647
LIG_FHA_2 270 276 PF00498 0.552
LIG_FHA_2 314 320 PF00498 0.608
LIG_FHA_2 505 511 PF00498 0.313
LIG_FHA_2 71 77 PF00498 0.482
LIG_FHA_2 776 782 PF00498 0.540
LIG_Integrin_RGD_1 645 647 PF01839 0.410
LIG_LIR_Apic_2 195 199 PF02991 0.705
LIG_LIR_Apic_2 849 855 PF02991 0.434
LIG_LIR_Gen_1 116 126 PF02991 0.305
LIG_LIR_Gen_1 312 321 PF02991 0.586
LIG_LIR_Gen_1 487 496 PF02991 0.346
LIG_LIR_Gen_1 66 75 PF02991 0.604
LIG_LIR_Nem_3 116 122 PF02991 0.305
LIG_LIR_Nem_3 17 22 PF02991 0.553
LIG_LIR_Nem_3 195 200 PF02991 0.703
LIG_LIR_Nem_3 395 401 PF02991 0.448
LIG_LIR_Nem_3 41 47 PF02991 0.642
LIG_LIR_Nem_3 487 493 PF02991 0.359
LIG_LIR_Nem_3 62 67 PF02991 0.586
LIG_LIR_Nem_3 685 690 PF02991 0.618
LIG_PAM2_1 411 423 PF00658 0.483
LIG_PCNA_PIPBox_1 377 386 PF02747 0.374
LIG_PCNA_yPIPBox_3 776 788 PF02747 0.508
LIG_PTB_Apo_2 463 470 PF02174 0.335
LIG_SH2_CRK 197 201 PF00017 0.693
LIG_SH2_CRK 44 48 PF00017 0.486
LIG_SH2_CRK 490 494 PF00017 0.378
LIG_SH2_PTP2 439 442 PF00017 0.336
LIG_SH2_SRC 13 16 PF00017 0.617
LIG_SH2_STAP1 31 35 PF00017 0.500
LIG_SH2_STAP1 74 78 PF00017 0.517
LIG_SH2_STAT3 164 167 PF00017 0.469
LIG_SH2_STAT3 172 175 PF00017 0.552
LIG_SH2_STAT5 31 34 PF00017 0.635
LIG_SH2_STAT5 439 442 PF00017 0.367
LIG_SH2_STAT5 631 634 PF00017 0.521
LIG_SH2_STAT5 757 760 PF00017 0.459
LIG_SH2_STAT5 807 810 PF00017 0.430
LIG_SH3_1 784 790 PF00018 0.439
LIG_SH3_3 3 9 PF00018 0.590
LIG_SH3_3 520 526 PF00018 0.280
LIG_SH3_3 784 790 PF00018 0.468
LIG_SH3_4 861 868 PF00018 0.439
LIG_SUMO_SIM_anti_2 127 132 PF11976 0.394
LIG_SUMO_SIM_anti_2 149 155 PF11976 0.380
LIG_SUMO_SIM_anti_2 21 26 PF11976 0.514
LIG_SUMO_SIM_anti_2 267 273 PF11976 0.603
LIG_SUMO_SIM_anti_2 559 565 PF11976 0.539
LIG_SUMO_SIM_par_1 266 273 PF11976 0.554
LIG_SUMO_SIM_par_1 340 345 PF11976 0.336
LIG_SUMO_SIM_par_1 346 351 PF11976 0.431
LIG_SUMO_SIM_par_1 507 512 PF11976 0.299
LIG_SUMO_SIM_par_1 561 567 PF11976 0.455
LIG_SUMO_SIM_par_1 609 614 PF11976 0.574
LIG_SUMO_SIM_par_1 923 931 PF11976 0.543
LIG_TRAF2_1 676 679 PF00917 0.549
LIG_TRAF2_1 894 897 PF00917 0.471
LIG_TRAF2_1 952 955 PF00917 0.754
LIG_TYR_ITSM 40 47 PF00017 0.345
LIG_UBA3_1 532 538 PF00899 0.472
LIG_UBA3_1 561 568 PF00899 0.388
LIG_Vh1_VBS_1 111 129 PF01044 0.160
LIG_WRC_WIRS_1 380 385 PF05994 0.486
MOD_CDK_SPK_2 956 961 PF00069 0.563
MOD_CDK_SPxxK_3 956 963 PF00069 0.552
MOD_CK1_1 149 155 PF00069 0.382
MOD_CK1_1 192 198 PF00069 0.617
MOD_CK1_1 2 8 PF00069 0.675
MOD_CK1_1 367 373 PF00069 0.608
MOD_CK1_1 389 395 PF00069 0.612
MOD_CK1_1 39 45 PF00069 0.524
MOD_CK1_1 525 531 PF00069 0.400
MOD_CK1_1 579 585 PF00069 0.498
MOD_CK1_1 693 699 PF00069 0.283
MOD_CK1_1 714 720 PF00069 0.259
MOD_CK1_1 82 88 PF00069 0.535
MOD_CK1_1 900 906 PF00069 0.355
MOD_CK1_1 964 970 PF00069 0.580
MOD_CK2_1 237 243 PF00069 0.688
MOD_CK2_1 313 319 PF00069 0.516
MOD_CK2_1 70 76 PF00069 0.514
MOD_CK2_1 860 866 PF00069 0.421
MOD_GlcNHglycan 1 4 PF01048 0.528
MOD_GlcNHglycan 291 294 PF01048 0.462
MOD_GlcNHglycan 344 347 PF01048 0.423
MOD_GlcNHglycan 412 416 PF01048 0.600
MOD_GlcNHglycan 421 424 PF01048 0.545
MOD_GlcNHglycan 461 464 PF01048 0.451
MOD_GlcNHglycan 486 489 PF01048 0.582
MOD_GlcNHglycan 499 503 PF01048 0.493
MOD_GlcNHglycan 513 516 PF01048 0.375
MOD_GlcNHglycan 576 579 PF01048 0.479
MOD_GlcNHglycan 728 731 PF01048 0.331
MOD_GlcNHglycan 84 87 PF01048 0.282
MOD_GlcNHglycan 862 865 PF01048 0.324
MOD_GlcNHglycan 884 887 PF01048 0.438
MOD_GlcNHglycan 901 905 PF01048 0.376
MOD_GSK3_1 338 345 PF00069 0.308
MOD_GSK3_1 360 367 PF00069 0.493
MOD_GSK3_1 389 396 PF00069 0.592
MOD_GSK3_1 455 462 PF00069 0.524
MOD_GSK3_1 579 586 PF00069 0.446
MOD_GSK3_1 710 717 PF00069 0.276
MOD_GSK3_1 830 837 PF00069 0.276
MOD_GSK3_1 860 867 PF00069 0.439
MOD_GSK3_1 916 923 PF00069 0.328
MOD_GSK3_1 95 102 PF00069 0.511
MOD_GSK3_1 962 969 PF00069 0.581
MOD_N-GLC_1 574 579 PF02516 0.373
MOD_NEK2_1 146 151 PF00069 0.302
MOD_NEK2_1 20 25 PF00069 0.397
MOD_NEK2_1 289 294 PF00069 0.493
MOD_NEK2_1 313 318 PF00069 0.515
MOD_NEK2_1 364 369 PF00069 0.477
MOD_NEK2_1 373 378 PF00069 0.574
MOD_NEK2_1 455 460 PF00069 0.615
MOD_NEK2_1 70 75 PF00069 0.400
MOD_NEK2_1 823 828 PF00069 0.340
MOD_NEK2_1 966 971 PF00069 0.555
MOD_NEK2_2 284 289 PF00069 0.495
MOD_NEK2_2 583 588 PF00069 0.517
MOD_PIKK_1 163 169 PF00454 0.329
MOD_PIKK_1 189 195 PF00454 0.421
MOD_PIKK_1 371 377 PF00454 0.514
MOD_PIKK_1 386 392 PF00454 0.413
MOD_PIKK_1 393 399 PF00454 0.598
MOD_PIKK_1 693 699 PF00454 0.325
MOD_PIKK_1 823 829 PF00454 0.421
MOD_PIKK_1 938 944 PF00454 0.486
MOD_PIKK_1 95 101 PF00454 0.420
MOD_PK_1 438 444 PF00069 0.552
MOD_PKA_1 483 489 PF00069 0.472
MOD_PKA_1 59 65 PF00069 0.393
MOD_PKA_2 264 270 PF00069 0.436
MOD_PKA_2 483 489 PF00069 0.499
MOD_PKA_2 504 510 PF00069 0.568
MOD_PKA_2 59 65 PF00069 0.393
MOD_PKA_2 726 732 PF00069 0.376
MOD_PKA_2 920 926 PF00069 0.259
MOD_PKA_2 95 101 PF00069 0.479
MOD_PKA_2 962 968 PF00069 0.593
MOD_PKB_1 436 444 PF00069 0.463
MOD_Plk_1 307 313 PF00069 0.413
MOD_Plk_1 386 392 PF00069 0.494
MOD_Plk_1 411 417 PF00069 0.600
MOD_Plk_1 763 769 PF00069 0.318
MOD_Plk_1 938 944 PF00069 0.456
MOD_Plk_1 967 973 PF00069 0.614
MOD_Plk_2-3 775 781 PF00069 0.347
MOD_Plk_4 113 119 PF00069 0.423
MOD_Plk_4 124 130 PF00069 0.272
MOD_Plk_4 149 155 PF00069 0.308
MOD_Plk_4 192 198 PF00069 0.650
MOD_Plk_4 20 26 PF00069 0.443
MOD_Plk_4 242 248 PF00069 0.477
MOD_Plk_4 264 270 PF00069 0.497
MOD_Plk_4 344 350 PF00069 0.376
MOD_Plk_4 379 385 PF00069 0.508
MOD_Plk_4 39 45 PF00069 0.372
MOD_Plk_4 504 510 PF00069 0.460
MOD_Plk_4 576 582 PF00069 0.491
MOD_Plk_4 923 929 PF00069 0.290
MOD_Plk_4 967 973 PF00069 0.566
MOD_ProDKin_1 522 528 PF00069 0.269
MOD_ProDKin_1 690 696 PF00069 0.422
MOD_ProDKin_1 956 962 PF00069 0.761
MOD_ProDKin_1 99 105 PF00069 0.572
MOD_SUMO_for_1 537 540 PF00179 0.604
MOD_SUMO_rev_2 273 279 PF00179 0.517
MOD_SUMO_rev_2 351 356 PF00179 0.420
MOD_SUMO_rev_2 441 449 PF00179 0.594
MOD_SUMO_rev_2 612 618 PF00179 0.492
MOD_SUMO_rev_2 671 676 PF00179 0.514
MOD_SUMO_rev_2 856 863 PF00179 0.421
TRG_AP2beta_CARGO_1 17 26 PF09066 0.372
TRG_DiLeu_BaEn_1 66 71 PF01217 0.482
TRG_DiLeu_BaLyEn_6 158 163 PF01217 0.405
TRG_DiLeu_BaLyEn_6 557 562 PF01217 0.551
TRG_DiLeu_BaLyEn_6 696 701 PF01217 0.324
TRG_ENDOCYTIC_2 197 200 PF00928 0.645
TRG_ENDOCYTIC_2 314 317 PF00928 0.412
TRG_ENDOCYTIC_2 439 442 PF00928 0.459
TRG_ENDOCYTIC_2 44 47 PF00928 0.542
TRG_ENDOCYTIC_2 490 493 PF00928 0.479
TRG_ENDOCYTIC_2 64 67 PF00928 0.269
TRG_ER_diArg_1 168 170 PF00400 0.405
TRG_ER_diArg_1 227 230 PF00400 0.487
TRG_ER_diArg_1 248 251 PF00400 0.513
TRG_ER_diArg_1 436 439 PF00400 0.618
TRG_ER_diArg_1 476 479 PF00400 0.461
TRG_ER_diArg_1 58 60 PF00400 0.444
TRG_NES_CRM1_1 605 619 PF08389 0.342
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.328
TRG_Pf-PMV_PEXEL_1 399 403 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 426 431 PF00026 0.554

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HX31 Leptomonas seymouri 65% 100%
A0A0S4JAS0 Bodo saltans 43% 97%
A0A0S4JMC0 Bodo saltans 47% 100%
A0A1X0P3F4 Trypanosomatidae 50% 98%
A0A1X0P7I2 Trypanosomatidae 28% 97%
A0A3Q8IGC6 Leishmania donovani 99% 100%
A0A3R7K5X0 Trypanosoma rangeli 28% 97%
A4HPN6 Leishmania braziliensis 82% 100%
C9ZXD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 96%
E9ATF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q147 Leishmania major 94% 100%
V5BJQ6 Trypanosoma cruzi 27% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS