LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ID27_LEIIN
TriTrypDb:
LINF_360045800
Length:
1075

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:0044611 nuclear pore inner ring 3 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4ID27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID27

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 109 113 PF00656 0.377
CLV_C14_Caspase3-7 357 361 PF00656 0.364
CLV_C14_Caspase3-7 384 388 PF00656 0.425
CLV_C14_Caspase3-7 425 429 PF00656 0.482
CLV_C14_Caspase3-7 559 563 PF00656 0.532
CLV_C14_Caspase3-7 994 998 PF00656 0.439
CLV_NRD_NRD_1 1064 1066 PF00675 0.447
CLV_NRD_NRD_1 143 145 PF00675 0.482
CLV_NRD_NRD_1 33 35 PF00675 0.460
CLV_NRD_NRD_1 667 669 PF00675 0.413
CLV_NRD_NRD_1 74 76 PF00675 0.536
CLV_NRD_NRD_1 89 91 PF00675 0.348
CLV_PCSK_KEX2_1 219 221 PF00082 0.440
CLV_PCSK_KEX2_1 302 304 PF00082 0.598
CLV_PCSK_KEX2_1 33 35 PF00082 0.460
CLV_PCSK_KEX2_1 667 669 PF00082 0.413
CLV_PCSK_KEX2_1 74 76 PF00082 0.536
CLV_PCSK_KEX2_1 89 91 PF00082 0.397
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.479
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.578
CLV_PCSK_SKI1_1 1037 1041 PF00082 0.450
CLV_PCSK_SKI1_1 45 49 PF00082 0.502
CLV_PCSK_SKI1_1 576 580 PF00082 0.501
CLV_PCSK_SKI1_1 627 631 PF00082 0.364
CLV_PCSK_SKI1_1 668 672 PF00082 0.398
CLV_PCSK_SKI1_1 761 765 PF00082 0.440
CLV_PCSK_SKI1_1 90 94 PF00082 0.434
DEG_APCC_DBOX_1 229 237 PF00400 0.428
DEG_APCC_DBOX_1 667 675 PF00400 0.399
DEG_APCC_DBOX_1 999 1007 PF00400 0.446
DEG_SPOP_SBC_1 359 363 PF00917 0.466
DEG_SPOP_SBC_1 720 724 PF00917 0.407
DOC_CDC14_PxL_1 447 455 PF14671 0.232
DOC_CYCLIN_RxL_1 83 96 PF00134 0.363
DOC_CYCLIN_yClb5_NLxxxL_5 808 817 PF00134 0.358
DOC_CYCLIN_yCln2_LP_2 462 468 PF00134 0.386
DOC_MAPK_gen_1 117 126 PF00069 0.472
DOC_MAPK_gen_1 228 236 PF00069 0.343
DOC_MAPK_gen_1 667 673 PF00069 0.394
DOC_MAPK_MEF2A_6 607 615 PF00069 0.506
DOC_MAPK_MEF2A_6 767 776 PF00069 0.373
DOC_MAPK_MEF2A_6 810 817 PF00069 0.375
DOC_PP1_RVXF_1 538 544 PF00149 0.431
DOC_PP1_RVXF_1 759 766 PF00149 0.380
DOC_PP1_RVXF_1 835 842 PF00149 0.349
DOC_PP1_RVXF_1 859 866 PF00149 0.498
DOC_PP1_RVXF_1 97 104 PF00149 0.495
DOC_PP2B_LxvP_1 813 816 PF13499 0.426
DOC_PP2B_LxvP_1 934 937 PF13499 0.383
DOC_PP4_FxxP_1 951 954 PF00568 0.471
DOC_USP7_MATH_1 128 132 PF00917 0.447
DOC_USP7_MATH_1 155 159 PF00917 0.505
DOC_USP7_MATH_1 3 7 PF00917 0.586
DOC_USP7_MATH_1 331 335 PF00917 0.482
DOC_USP7_MATH_1 359 363 PF00917 0.655
DOC_USP7_MATH_1 720 724 PF00917 0.509
DOC_USP7_MATH_1 739 743 PF00917 0.569
DOC_USP7_MATH_1 830 834 PF00917 0.412
DOC_USP7_UBL2_3 632 636 PF12436 0.401
DOC_WW_Pin1_4 10 15 PF00397 0.691
DOC_WW_Pin1_4 1018 1023 PF00397 0.429
DOC_WW_Pin1_4 214 219 PF00397 0.468
DOC_WW_Pin1_4 910 915 PF00397 0.367
DOC_WW_Pin1_4 967 972 PF00397 0.475
LIG_14-3-3_CanoR_1 117 126 PF00244 0.553
LIG_14-3-3_CanoR_1 220 226 PF00244 0.422
LIG_14-3-3_CanoR_1 239 244 PF00244 0.446
LIG_14-3-3_CanoR_1 303 308 PF00244 0.576
LIG_14-3-3_CanoR_1 33 41 PF00244 0.642
LIG_14-3-3_CanoR_1 474 482 PF00244 0.489
LIG_14-3-3_CanoR_1 488 496 PF00244 0.327
LIG_14-3-3_CanoR_1 645 651 PF00244 0.431
LIG_14-3-3_CanoR_1 761 766 PF00244 0.403
LIG_14-3-3_CanoR_1 785 791 PF00244 0.378
LIG_14-3-3_CanoR_1 810 816 PF00244 0.443
LIG_Actin_WH2_2 915 932 PF00022 0.399
LIG_APCC_ABBA_1 103 108 PF00400 0.485
LIG_APCC_ABBA_1 243 248 PF00400 0.472
LIG_APCC_ABBA_1 907 912 PF00400 0.353
LIG_APCC_ABBA_1 957 962 PF00400 0.446
LIG_Clathr_ClatBox_1 821 825 PF01394 0.379
LIG_FHA_1 119 125 PF00498 0.414
LIG_FHA_1 320 326 PF00498 0.509
LIG_FHA_1 341 347 PF00498 0.396
LIG_FHA_1 361 367 PF00498 0.268
LIG_FHA_1 391 397 PF00498 0.355
LIG_FHA_1 422 428 PF00498 0.372
LIG_FHA_1 504 510 PF00498 0.551
LIG_FHA_1 628 634 PF00498 0.447
LIG_FHA_1 680 686 PF00498 0.544
LIG_FHA_1 722 728 PF00498 0.412
LIG_FHA_1 921 927 PF00498 0.341
LIG_FHA_2 1048 1054 PF00498 0.416
LIG_FHA_2 107 113 PF00498 0.394
LIG_FHA_2 348 354 PF00498 0.476
LIG_FHA_2 754 760 PF00498 0.490
LIG_FHA_2 985 991 PF00498 0.490
LIG_GBD_Chelix_1 338 346 PF00786 0.343
LIG_GBD_Chelix_1 439 447 PF00786 0.322
LIG_GBD_Chelix_1 849 857 PF00786 0.451
LIG_GBD_Chelix_1 918 926 PF00786 0.444
LIG_LIR_Apic_2 214 218 PF02991 0.426
LIG_LIR_Apic_2 593 598 PF02991 0.509
LIG_LIR_Apic_2 950 954 PF02991 0.381
LIG_LIR_Gen_1 390 397 PF02991 0.445
LIG_LIR_Gen_1 726 735 PF02991 0.524
LIG_LIR_Gen_1 764 772 PF02991 0.391
LIG_LIR_Gen_1 81 86 PF02991 0.372
LIG_LIR_Gen_1 962 971 PF02991 0.536
LIG_LIR_Gen_1 987 996 PF02991 0.384
LIG_LIR_Nem_3 22 27 PF02991 0.572
LIG_LIR_Nem_3 390 394 PF02991 0.349
LIG_LIR_Nem_3 499 505 PF02991 0.428
LIG_LIR_Nem_3 656 662 PF02991 0.406
LIG_LIR_Nem_3 726 731 PF02991 0.489
LIG_LIR_Nem_3 764 768 PF02991 0.382
LIG_LIR_Nem_3 81 85 PF02991 0.376
LIG_LIR_Nem_3 962 966 PF02991 0.455
LIG_LIR_Nem_3 987 992 PF02991 0.381
LIG_MYND_1 461 465 PF01753 0.477
LIG_NRBOX 567 573 PF00104 0.337
LIG_NRBOX 600 606 PF00104 0.396
LIG_PCNA_PIPBox_1 941 950 PF02747 0.409
LIG_PCNA_yPIPBox_3 564 576 PF02747 0.459
LIG_PDZ_Class_1 1070 1075 PF00595 0.556
LIG_PTB_Apo_2 47 54 PF02174 0.504
LIG_PTB_Apo_2 998 1005 PF02174 0.538
LIG_Rb_pABgroove_1 220 228 PF01858 0.399
LIG_Rb_pABgroove_1 579 587 PF01858 0.405
LIG_SH2_CRK 585 589 PF00017 0.354
LIG_SH2_CRK 595 599 PF00017 0.380
LIG_SH2_CRK 676 680 PF00017 0.398
LIG_SH2_CRK 702 706 PF00017 0.407
LIG_SH2_CRK 728 732 PF00017 0.386
LIG_SH2_CRK 82 86 PF00017 0.359
LIG_SH2_CRK 894 898 PF00017 0.446
LIG_SH2_GRB2like 52 55 PF00017 0.408
LIG_SH2_GRB2like 78 81 PF00017 0.378
LIG_SH2_GRB2like 881 884 PF00017 0.300
LIG_SH2_NCK_1 246 250 PF00017 0.373
LIG_SH2_SRC 221 224 PF00017 0.403
LIG_SH2_STAP1 585 589 PF00017 0.321
LIG_SH2_STAP1 681 685 PF00017 0.451
LIG_SH2_STAT3 454 457 PF00017 0.398
LIG_SH2_STAT5 100 103 PF00017 0.364
LIG_SH2_STAT5 114 117 PF00017 0.322
LIG_SH2_STAT5 215 218 PF00017 0.558
LIG_SH2_STAT5 221 224 PF00017 0.457
LIG_SH2_STAT5 232 235 PF00017 0.299
LIG_SH2_STAT5 397 400 PF00017 0.456
LIG_SH2_STAT5 454 457 PF00017 0.398
LIG_SH2_STAT5 52 55 PF00017 0.476
LIG_SH2_STAT5 665 668 PF00017 0.420
LIG_SH2_STAT5 681 684 PF00017 0.239
LIG_SH2_STAT5 78 81 PF00017 0.468
LIG_SH2_STAT5 881 884 PF00017 0.381
LIG_SH2_STAT5 947 950 PF00017 0.487
LIG_SH3_3 149 155 PF00018 0.332
LIG_SH3_3 953 959 PF00018 0.379
LIG_SH3_3 978 984 PF00018 0.482
LIG_SH3_3 99 105 PF00018 0.376
LIG_SUMO_SIM_anti_2 343 350 PF11976 0.423
LIG_SUMO_SIM_anti_2 649 656 PF11976 0.446
LIG_SUMO_SIM_anti_2 730 737 PF11976 0.384
LIG_SUMO_SIM_par_1 232 238 PF11976 0.439
LIG_SUMO_SIM_par_1 343 350 PF11976 0.372
LIG_SUMO_SIM_par_1 438 444 PF11976 0.326
LIG_SUMO_SIM_par_1 820 825 PF11976 0.376
LIG_SUMO_SIM_par_1 90 96 PF11976 0.364
LIG_TRAF2_1 19 22 PF00917 0.452
LIG_TRAF2_1 40 43 PF00917 0.438
LIG_TYR_ITIM 674 679 PF00017 0.399
LIG_UBA3_1 887 895 PF00899 0.366
LIG_WRC_WIRS_1 391 396 PF05994 0.439
LIG_WRC_WIRS_1 762 767 PF05994 0.391
LIG_WRC_WIRS_1 925 930 PF05994 0.383
LIG_WRC_WIRS_1 948 953 PF05994 0.540
LIG_WRC_WIRS_1 989 994 PF05994 0.407
MOD_CDC14_SPxK_1 217 220 PF00782 0.449
MOD_CDK_SPK_2 214 219 PF00069 0.468
MOD_CDK_SPxK_1 214 220 PF00069 0.467
MOD_CK1_1 1068 1074 PF00069 0.460
MOD_CK1_1 15 21 PF00069 0.511
MOD_CK1_1 247 253 PF00069 0.477
MOD_CK1_1 287 293 PF00069 0.334
MOD_CK1_1 319 325 PF00069 0.521
MOD_CK1_1 361 367 PF00069 0.522
MOD_CK1_1 390 396 PF00069 0.455
MOD_CK1_1 422 428 PF00069 0.526
MOD_CK1_1 491 497 PF00069 0.409
MOD_CK1_1 6 12 PF00069 0.706
MOD_CK1_1 64 70 PF00069 0.424
MOD_CK1_1 680 686 PF00069 0.387
MOD_CK1_1 689 695 PF00069 0.335
MOD_CK1_1 709 715 PF00069 0.226
MOD_CK1_1 742 748 PF00069 0.356
MOD_CK1_1 811 817 PF00069 0.408
MOD_CK2_1 16 22 PF00069 0.546
MOD_CK2_1 307 313 PF00069 0.543
MOD_CK2_1 347 353 PF00069 0.461
MOD_CK2_1 428 434 PF00069 0.577
MOD_CK2_1 511 517 PF00069 0.468
MOD_CK2_1 65 71 PF00069 0.433
MOD_CK2_1 713 719 PF00069 0.459
MOD_CK2_1 883 889 PF00069 0.472
MOD_Cter_Amidation 300 303 PF01082 0.527
MOD_GlcNHglycan 130 133 PF01048 0.383
MOD_GlcNHglycan 157 160 PF01048 0.382
MOD_GlcNHglycan 255 259 PF01048 0.546
MOD_GlcNHglycan 287 290 PF01048 0.538
MOD_GlcNHglycan 318 321 PF01048 0.434
MOD_GlcNHglycan 34 37 PF01048 0.659
MOD_GlcNHglycan 424 427 PF01048 0.502
MOD_GlcNHglycan 447 450 PF01048 0.438
MOD_GlcNHglycan 5 8 PF01048 0.565
MOD_GlcNHglycan 557 561 PF01048 0.457
MOD_GlcNHglycan 934 937 PF01048 0.403
MOD_GSK3_1 116 123 PF00069 0.418
MOD_GSK3_1 235 242 PF00069 0.472
MOD_GSK3_1 283 290 PF00069 0.289
MOD_GSK3_1 303 310 PF00069 0.486
MOD_GSK3_1 361 368 PF00069 0.603
MOD_GSK3_1 6 13 PF00069 0.682
MOD_GSK3_1 61 68 PF00069 0.516
MOD_GSK3_1 685 692 PF00069 0.421
MOD_GSK3_1 709 716 PF00069 0.485
MOD_GSK3_1 739 746 PF00069 0.433
MOD_GSK3_1 826 833 PF00069 0.457
MOD_GSK3_1 920 927 PF00069 0.490
MOD_GSK3_1 984 991 PF00069 0.435
MOD_LATS_1 625 631 PF00433 0.370
MOD_N-GLC_1 176 181 PF02516 0.455
MOD_N-GLC_1 239 244 PF02516 0.378
MOD_N-GLC_1 811 816 PF02516 0.371
MOD_NEK2_1 1033 1038 PF00069 0.460
MOD_NEK2_1 106 111 PF00069 0.516
MOD_NEK2_1 16 21 PF00069 0.493
MOD_NEK2_1 234 239 PF00069 0.389
MOD_NEK2_1 254 259 PF00069 0.226
MOD_NEK2_1 284 289 PF00069 0.420
MOD_NEK2_1 296 301 PF00069 0.539
MOD_NEK2_1 342 347 PF00069 0.380
MOD_NEK2_1 419 424 PF00069 0.500
MOD_NEK2_1 453 458 PF00069 0.324
MOD_NEK2_1 496 501 PF00069 0.386
MOD_NEK2_1 509 514 PF00069 0.408
MOD_NEK2_1 516 521 PF00069 0.241
MOD_NEK2_1 570 575 PF00069 0.324
MOD_NEK2_1 646 651 PF00069 0.470
MOD_NEK2_1 65 70 PF00069 0.408
MOD_NEK2_1 663 668 PF00069 0.350
MOD_NEK2_1 685 690 PF00069 0.424
MOD_NEK2_1 727 732 PF00069 0.433
MOD_NEK2_1 786 791 PF00069 0.374
MOD_NEK2_1 808 813 PF00069 0.402
MOD_NEK2_1 85 90 PF00069 0.204
MOD_NEK2_1 93 98 PF00069 0.402
MOD_NEK2_2 221 226 PF00069 0.454
MOD_PIKK_1 1065 1071 PF00454 0.493
MOD_PIKK_1 365 371 PF00454 0.563
MOD_PIKK_1 453 459 PF00454 0.397
MOD_PIKK_1 6 12 PF00454 0.624
MOD_PIKK_1 690 696 PF00454 0.489
MOD_PKA_1 1065 1071 PF00069 0.541
MOD_PKA_2 116 122 PF00069 0.494
MOD_PKA_2 138 144 PF00069 0.444
MOD_PKA_2 32 38 PF00069 0.617
MOD_PKA_2 473 479 PF00069 0.500
MOD_PKA_2 503 509 PF00069 0.539
MOD_PKA_2 866 872 PF00069 0.436
MOD_Plk_1 176 182 PF00069 0.414
MOD_Plk_1 239 245 PF00069 0.350
MOD_Plk_1 247 253 PF00069 0.392
MOD_Plk_1 381 387 PF00069 0.532
MOD_Plk_1 399 405 PF00069 0.289
MOD_Plk_1 491 497 PF00069 0.378
MOD_Plk_1 556 562 PF00069 0.526
MOD_Plk_1 686 692 PF00069 0.496
MOD_Plk_1 706 712 PF00069 0.231
MOD_Plk_1 742 748 PF00069 0.468
MOD_Plk_1 811 817 PF00069 0.408
MOD_Plk_1 883 889 PF00069 0.363
MOD_Plk_2-3 176 182 PF00069 0.404
MOD_Plk_2-3 713 719 PF00069 0.507
MOD_Plk_2-3 753 759 PF00069 0.410
MOD_Plk_4 1006 1012 PF00069 0.303
MOD_Plk_4 120 126 PF00069 0.367
MOD_Plk_4 148 154 PF00069 0.334
MOD_Plk_4 221 227 PF00069 0.382
MOD_Plk_4 239 245 PF00069 0.220
MOD_Plk_4 321 327 PF00069 0.481
MOD_Plk_4 332 338 PF00069 0.266
MOD_Plk_4 342 348 PF00069 0.301
MOD_Plk_4 387 393 PF00069 0.393
MOD_Plk_4 399 405 PF00069 0.324
MOD_Plk_4 518 524 PF00069 0.466
MOD_Plk_4 61 67 PF00069 0.514
MOD_Plk_4 646 652 PF00069 0.379
MOD_Plk_4 713 719 PF00069 0.484
MOD_Plk_4 727 733 PF00069 0.297
MOD_Plk_4 743 749 PF00069 0.412
MOD_Plk_4 848 854 PF00069 0.335
MOD_Plk_4 883 889 PF00069 0.447
MOD_Plk_4 924 930 PF00069 0.398
MOD_Plk_4 984 990 PF00069 0.437
MOD_Plk_4 991 997 PF00069 0.388
MOD_ProDKin_1 10 16 PF00069 0.686
MOD_ProDKin_1 1018 1024 PF00069 0.428
MOD_ProDKin_1 214 220 PF00069 0.467
MOD_ProDKin_1 910 916 PF00069 0.368
MOD_ProDKin_1 967 973 PF00069 0.478
MOD_SUMO_rev_2 546 556 PF00179 0.418
TRG_DiLeu_BaEn_1 566 571 PF01217 0.441
TRG_DiLeu_BaEn_1 81 86 PF01217 0.372
TRG_DiLeu_BaEn_3 1051 1057 PF01217 0.316
TRG_DiLeu_BaEn_3 42 48 PF01217 0.540
TRG_DiLeu_BaLyEn_6 458 463 PF01217 0.389
TRG_DiLeu_BaLyEn_6 695 700 PF01217 0.332
TRG_DiLeu_BaLyEn_6 817 822 PF01217 0.446
TRG_DiLeu_BaLyEn_6 834 839 PF01217 0.477
TRG_ENDOCYTIC_2 100 103 PF00928 0.237
TRG_ENDOCYTIC_2 232 235 PF00928 0.355
TRG_ENDOCYTIC_2 246 249 PF00928 0.517
TRG_ENDOCYTIC_2 502 505 PF00928 0.466
TRG_ENDOCYTIC_2 52 55 PF00928 0.476
TRG_ENDOCYTIC_2 585 588 PF00928 0.334
TRG_ENDOCYTIC_2 676 679 PF00928 0.391
TRG_ENDOCYTIC_2 728 731 PF00928 0.506
TRG_ENDOCYTIC_2 82 85 PF00928 0.360
TRG_ENDOCYTIC_2 894 897 PF00928 0.473
TRG_ER_diArg_1 513 516 PF00400 0.395
TRG_ER_diArg_1 538 541 PF00400 0.451
TRG_ER_diArg_1 643 646 PF00400 0.363
TRG_ER_diArg_1 695 698 PF00400 0.470
TRG_ER_diArg_1 89 91 PF00400 0.465
TRG_NES_CRM1_1 847 862 PF08389 0.368
TRG_Pf-PMV_PEXEL_1 1065 1069 PF00026 0.522
TRG_Pf-PMV_PEXEL_1 488 492 PF00026 0.458
TRG_Pf-PMV_PEXEL_1 668 672 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 820 825 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 875 879 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 942 946 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3Q1 Leptomonas seymouri 59% 100%
A0A1X0P467 Trypanosomatidae 29% 99%
A0A3R7KQG4 Trypanosoma rangeli 28% 100%
A0A3S7XBA5 Leishmania donovani 100% 100%
A4HPN7 Leishmania braziliensis 85% 100%
D0A8H7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ATF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q146 Leishmania major 95% 100%
V5BEA1 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS