LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ID25_LEIIN
TriTrypDb:
LINF_360046000
Length:
452

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ID25
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID25

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 8 1
GO:0006378 mRNA polyadenylation 7 1
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 9 1
GO:0006397 mRNA processing 7 1
GO:0006399 tRNA metabolic process 7 1
GO:0008033 tRNA processing 8 1
GO:0008380 RNA splicing 7 1
GO:0016071 mRNA metabolic process 6 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043631 RNA polyadenylation 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0019205 nucleobase-containing compound kinase activity 5 12
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 422 424 PF00675 0.392
CLV_NRD_NRD_1 9 11 PF00675 0.406
CLV_NRD_NRD_1 95 97 PF00675 0.414
CLV_PCSK_KEX2_1 102 104 PF00082 0.421
CLV_PCSK_KEX2_1 422 424 PF00082 0.402
CLV_PCSK_KEX2_1 5 7 PF00082 0.623
CLV_PCSK_KEX2_1 9 11 PF00082 0.518
CLV_PCSK_KEX2_1 95 97 PF00082 0.487
CLV_PCSK_PC1ET2_1 102 104 PF00082 0.521
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.529
CLV_PCSK_SKI1_1 135 139 PF00082 0.442
CLV_PCSK_SKI1_1 316 320 PF00082 0.382
CLV_PCSK_SKI1_1 341 345 PF00082 0.398
CLV_PCSK_SKI1_1 9 13 PF00082 0.396
CLV_PCSK_SKI1_1 96 100 PF00082 0.489
CLV_Separin_Metazoa 263 267 PF03568 0.271
CLV_Separin_Metazoa 317 321 PF03568 0.412
DEG_ODPH_VHL_1 353 365 PF01847 0.395
DEG_ODPH_VHL_1 390 402 PF01847 0.345
DOC_CYCLIN_RxL_1 335 348 PF00134 0.474
DOC_MAPK_gen_1 102 109 PF00069 0.346
DOC_MAPK_gen_1 134 142 PF00069 0.411
DOC_MAPK_gen_1 4 13 PF00069 0.567
DOC_PP1_RVXF_1 339 346 PF00149 0.430
DOC_PP2B_LxvP_1 149 152 PF13499 0.360
DOC_PP4_FxxP_1 302 305 PF00568 0.480
DOC_USP7_MATH_1 188 192 PF00917 0.411
DOC_USP7_MATH_1 339 343 PF00917 0.500
DOC_USP7_MATH_1 368 372 PF00917 0.381
DOC_USP7_MATH_2 309 315 PF00917 0.420
DOC_WW_Pin1_4 160 165 PF00397 0.398
DOC_WW_Pin1_4 169 174 PF00397 0.328
DOC_WW_Pin1_4 223 228 PF00397 0.353
DOC_WW_Pin1_4 323 328 PF00397 0.388
LIG_14-3-3_CanoR_1 113 119 PF00244 0.278
LIG_14-3-3_CanoR_1 282 287 PF00244 0.447
LIG_14-3-3_CanoR_1 312 319 PF00244 0.470
LIG_14-3-3_CanoR_1 437 446 PF00244 0.352
LIG_14-3-3_CanoR_1 47 52 PF00244 0.405
LIG_14-3-3_CanoR_1 57 63 PF00244 0.355
LIG_14-3-3_CanoR_1 9 14 PF00244 0.443
LIG_14-3-3_CanoR_1 96 106 PF00244 0.400
LIG_APCC_ABBA_1 51 56 PF00400 0.478
LIG_BRCT_BRCA1_1 341 345 PF00533 0.489
LIG_Clathr_ClatBox_1 62 66 PF01394 0.462
LIG_deltaCOP1_diTrp_1 280 286 PF00928 0.301
LIG_FHA_1 102 108 PF00498 0.391
LIG_FHA_1 301 307 PF00498 0.397
LIG_FHA_1 48 54 PF00498 0.421
LIG_FHA_2 342 348 PF00498 0.343
LIG_FHA_2 443 449 PF00498 0.536
LIG_LIR_Apic_2 299 305 PF02991 0.395
LIG_LIR_Gen_1 17 27 PF02991 0.385
LIG_LIR_Gen_1 280 291 PF02991 0.300
LIG_LIR_Gen_1 369 379 PF02991 0.453
LIG_LIR_Gen_1 447 452 PF02991 0.430
LIG_LIR_Nem_3 163 169 PF02991 0.400
LIG_LIR_Nem_3 17 22 PF02991 0.378
LIG_LIR_Nem_3 280 286 PF02991 0.348
LIG_LIR_Nem_3 326 331 PF02991 0.496
LIG_LIR_Nem_3 369 375 PF02991 0.486
LIG_LIR_Nem_3 447 452 PF02991 0.430
LIG_MYND_1 173 177 PF01753 0.281
LIG_NRBOX 122 128 PF00104 0.411
LIG_PCNA_yPIPBox_3 282 295 PF02747 0.331
LIG_PDZ_Class_2 447 452 PF00595 0.409
LIG_SH2_CRK 19 23 PF00017 0.376
LIG_SH2_CRK 200 204 PF00017 0.331
LIG_SH2_CRK 258 262 PF00017 0.469
LIG_SH2_NCK_1 19 23 PF00017 0.376
LIG_SH2_PTP2 449 452 PF00017 0.444
LIG_SH2_SRC 230 233 PF00017 0.287
LIG_SH2_STAP1 49 53 PF00017 0.433
LIG_SH2_STAT3 199 202 PF00017 0.411
LIG_SH2_STAT5 181 184 PF00017 0.380
LIG_SH2_STAT5 19 22 PF00017 0.457
LIG_SH2_STAT5 210 213 PF00017 0.388
LIG_SH2_STAT5 322 325 PF00017 0.311
LIG_SH2_STAT5 401 404 PF00017 0.475
LIG_SH2_STAT5 449 452 PF00017 0.543
LIG_SH2_STAT5 49 52 PF00017 0.391
LIG_SH3_3 161 167 PF00018 0.331
LIG_SH3_3 226 232 PF00018 0.459
LIG_SH3_3 240 246 PF00018 0.354
LIG_SH3_3 261 267 PF00018 0.387
LIG_SH3_3 303 309 PF00018 0.491
LIG_SH3_3 333 339 PF00018 0.435
LIG_SH3_3 362 368 PF00018 0.495
LIG_SH3_3 386 392 PF00018 0.352
LIG_SUMO_SIM_anti_2 104 110 PF11976 0.309
LIG_SUMO_SIM_anti_2 268 275 PF11976 0.390
LIG_SUMO_SIM_par_1 176 182 PF11976 0.276
LIG_SUMO_SIM_par_1 268 275 PF11976 0.282
LIG_TRAF2_1 15 18 PF00917 0.360
LIG_TRAF2_1 415 418 PF00917 0.570
LIG_TRAF2_1 445 448 PF00917 0.417
LIG_TYR_ITIM 256 261 PF00017 0.411
MOD_CDK_SPK_2 169 174 PF00069 0.331
MOD_CK1_1 114 120 PF00069 0.340
MOD_CK1_1 179 185 PF00069 0.364
MOD_CK2_1 230 236 PF00069 0.465
MOD_CK2_1 271 277 PF00069 0.391
MOD_CK2_1 311 317 PF00069 0.412
MOD_CK2_1 341 347 PF00069 0.517
MOD_CK2_1 377 383 PF00069 0.330
MOD_CK2_1 442 448 PF00069 0.443
MOD_GlcNHglycan 113 116 PF01048 0.328
MOD_GlcNHglycan 188 191 PF01048 0.281
MOD_GlcNHglycan 213 217 PF01048 0.331
MOD_GlcNHglycan 32 35 PF01048 0.432
MOD_GlcNHglycan 356 359 PF01048 0.578
MOD_GlcNHglycan 439 442 PF01048 0.322
MOD_GlcNHglycan 99 102 PF01048 0.481
MOD_GSK3_1 188 195 PF00069 0.411
MOD_GSK3_1 230 237 PF00069 0.483
MOD_GSK3_1 323 330 PF00069 0.538
MOD_GSK3_1 432 439 PF00069 0.385
MOD_GSK3_1 5 12 PF00069 0.595
MOD_GSK3_1 97 104 PF00069 0.442
MOD_NEK2_1 203 208 PF00069 0.383
MOD_NEK2_1 234 239 PF00069 0.349
MOD_NEK2_1 331 336 PF00069 0.511
MOD_NEK2_1 436 441 PF00069 0.440
MOD_NEK2_2 432 437 PF00069 0.495
MOD_PKA_1 4 10 PF00069 0.484
MOD_PKA_2 186 192 PF00069 0.411
MOD_PKA_2 265 271 PF00069 0.292
MOD_PKA_2 281 287 PF00069 0.298
MOD_PKA_2 311 317 PF00069 0.521
MOD_PKA_2 432 438 PF00069 0.506
MOD_PKA_2 5 11 PF00069 0.491
MOD_PKA_2 94 100 PF00069 0.436
MOD_Plk_1 17 23 PF00069 0.328
MOD_Plk_1 368 374 PF00069 0.520
MOD_Plk_4 133 139 PF00069 0.360
MOD_Plk_4 17 23 PF00069 0.378
MOD_Plk_4 176 182 PF00069 0.355
MOD_Plk_4 192 198 PF00069 0.227
MOD_Plk_4 203 209 PF00069 0.326
MOD_Plk_4 282 288 PF00069 0.307
MOD_Plk_4 341 347 PF00069 0.482
MOD_Plk_4 395 401 PF00069 0.367
MOD_Plk_4 47 53 PF00069 0.404
MOD_ProDKin_1 160 166 PF00069 0.398
MOD_ProDKin_1 169 175 PF00069 0.328
MOD_ProDKin_1 223 229 PF00069 0.353
MOD_ProDKin_1 323 329 PF00069 0.382
TRG_DiLeu_BaEn_1 17 22 PF01217 0.378
TRG_DiLeu_BaEn_1 408 413 PF01217 0.344
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.472
TRG_ENDOCYTIC_2 19 22 PF00928 0.441
TRG_ENDOCYTIC_2 200 203 PF00928 0.411
TRG_ENDOCYTIC_2 258 261 PF00928 0.411
TRG_ENDOCYTIC_2 449 452 PF00928 0.515
TRG_ER_diArg_1 421 423 PF00400 0.432
TRG_ER_diArg_1 9 11 PF00400 0.533
TRG_NLS_MonoExtN_4 2 8 PF00514 0.634
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.285
TRG_Pf-PMV_PEXEL_1 293 297 PF00026 0.375
TRG_Pf-PMV_PEXEL_1 316 321 PF00026 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJZ5 Leptomonas seymouri 77% 100%
A0A0S4JES6 Bodo saltans 30% 100%
A0A1X0P3J8 Trypanosomatidae 45% 100%
A0A3Q8IL58 Leishmania donovani 100% 100%
A0A422N1N1 Trypanosoma rangeli 45% 100%
A4HPN9 Leishmania braziliensis 94% 100%
D0A8H5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ATF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q144 Leishmania major 97% 100%
V5AU86 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS