LeishMANIAdb
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Gene product:
Protein of unknown function (DUF498/DUF598) - putative
Species:
Leishmania infantum
UniProt:
A4ID24_LEIIN
TriTrypDb:
LINF_360046100
Length:
627

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0005743 mitochondrial inner membrane 5 11
GO:0016020 membrane 2 11
GO:0019866 organelle inner membrane 4 11
GO:0031090 organelle membrane 3 11
GO:0031966 mitochondrial membrane 4 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4ID24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID24

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 11
GO:0010257 NADH dehydrogenase complex assembly 6 11
GO:0016043 cellular component organization 3 11
GO:0022607 cellular component assembly 4 11
GO:0032981 mitochondrial respiratory chain complex I assembly 7 11
GO:0033108 mitochondrial respiratory chain complex assembly 6 11
GO:0043933 protein-containing complex organization 4 11
GO:0065003 protein-containing complex assembly 5 11
GO:0071840 cellular component organization or biogenesis 2 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 589 593 PF00656 0.538
CLV_NRD_NRD_1 144 146 PF00675 0.489
CLV_NRD_NRD_1 155 157 PF00675 0.544
CLV_NRD_NRD_1 175 177 PF00675 0.426
CLV_NRD_NRD_1 361 363 PF00675 0.271
CLV_NRD_NRD_1 501 503 PF00675 0.536
CLV_NRD_NRD_1 570 572 PF00675 0.467
CLV_NRD_NRD_1 614 616 PF00675 0.588
CLV_NRD_NRD_1 78 80 PF00675 0.526
CLV_PCSK_FUR_1 18 22 PF00082 0.428
CLV_PCSK_FUR_1 562 566 PF00082 0.488
CLV_PCSK_KEX2_1 144 146 PF00082 0.468
CLV_PCSK_KEX2_1 163 165 PF00082 0.566
CLV_PCSK_KEX2_1 174 176 PF00082 0.564
CLV_PCSK_KEX2_1 20 22 PF00082 0.426
CLV_PCSK_KEX2_1 207 209 PF00082 0.473
CLV_PCSK_KEX2_1 336 338 PF00082 0.271
CLV_PCSK_KEX2_1 361 363 PF00082 0.319
CLV_PCSK_KEX2_1 499 501 PF00082 0.544
CLV_PCSK_KEX2_1 564 566 PF00082 0.429
CLV_PCSK_KEX2_1 570 572 PF00082 0.431
CLV_PCSK_KEX2_1 614 616 PF00082 0.588
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.450
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.550
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.559
CLV_PCSK_PC1ET2_1 207 209 PF00082 0.473
CLV_PCSK_PC1ET2_1 336 338 PF00082 0.271
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.621
CLV_PCSK_PC1ET2_1 564 566 PF00082 0.491
CLV_PCSK_PC7_1 16 22 PF00082 0.570
CLV_PCSK_PC7_1 610 616 PF00082 0.580
CLV_PCSK_SKI1_1 235 239 PF00082 0.477
CLV_PCSK_SKI1_1 331 335 PF00082 0.271
CLV_PCSK_SKI1_1 362 366 PF00082 0.309
CLV_PCSK_SKI1_1 486 490 PF00082 0.616
CLV_PCSK_SKI1_1 586 590 PF00082 0.497
CLV_PCSK_SKI1_1 604 608 PF00082 0.547
CLV_PCSK_SKI1_1 86 90 PF00082 0.551
DEG_APCC_DBOX_1 361 369 PF00400 0.329
DEG_Nend_UBRbox_1 1 4 PF02207 0.523
DOC_CKS1_1 126 131 PF01111 0.516
DOC_CKS1_1 249 254 PF01111 0.582
DOC_CKS1_1 344 349 PF01111 0.250
DOC_CYCLIN_RxL_1 318 329 PF00134 0.289
DOC_CYCLIN_yClb1_LxF_4 102 108 PF00134 0.376
DOC_MAPK_gen_1 361 367 PF00069 0.338
DOC_MAPK_MEF2A_6 300 308 PF00069 0.289
DOC_PP1_RVXF_1 10 16 PF00149 0.589
DOC_PP1_RVXF_1 319 326 PF00149 0.279
DOC_PP1_RVXF_1 329 335 PF00149 0.257
DOC_PP1_RVXF_1 84 90 PF00149 0.479
DOC_USP7_MATH_1 162 166 PF00917 0.577
DOC_USP7_MATH_1 178 182 PF00917 0.409
DOC_USP7_MATH_1 196 200 PF00917 0.479
DOC_USP7_MATH_1 43 47 PF00917 0.606
DOC_USP7_MATH_1 442 446 PF00917 0.480
DOC_USP7_MATH_1 522 526 PF00917 0.565
DOC_USP7_MATH_1 66 70 PF00917 0.461
DOC_USP7_UBL2_3 414 418 PF12436 0.522
DOC_USP7_UBL2_3 499 503 PF12436 0.558
DOC_WW_Pin1_4 125 130 PF00397 0.486
DOC_WW_Pin1_4 188 193 PF00397 0.533
DOC_WW_Pin1_4 248 253 PF00397 0.612
DOC_WW_Pin1_4 261 266 PF00397 0.204
DOC_WW_Pin1_4 343 348 PF00397 0.250
DOC_WW_Pin1_4 397 402 PF00397 0.655
DOC_WW_Pin1_4 403 408 PF00397 0.654
LIG_14-3-3_CanoR_1 2 6 PF00244 0.526
LIG_14-3-3_CanoR_1 253 259 PF00244 0.488
LIG_14-3-3_CanoR_1 361 368 PF00244 0.429
LIG_14-3-3_CanoR_1 420 427 PF00244 0.667
LIG_14-3-3_CanoR_1 441 451 PF00244 0.540
LIG_14-3-3_CanoR_1 614 624 PF00244 0.594
LIG_AP2alpha_2 186 188 PF02296 0.477
LIG_EH_1 242 246 PF12763 0.507
LIG_FHA_1 255 261 PF00498 0.491
LIG_FHA_1 299 305 PF00498 0.271
LIG_FHA_1 445 451 PF00498 0.503
LIG_FHA_1 525 531 PF00498 0.653
LIG_FHA_1 547 553 PF00498 0.501
LIG_FHA_1 620 626 PF00498 0.599
LIG_FHA_1 8 14 PF00498 0.566
LIG_FHA_2 482 488 PF00498 0.521
LIG_FHA_2 587 593 PF00498 0.524
LIG_LIR_Gen_1 114 122 PF02991 0.472
LIG_LIR_Gen_1 293 302 PF02991 0.275
LIG_LIR_Gen_1 458 468 PF02991 0.427
LIG_LIR_Nem_3 114 119 PF02991 0.493
LIG_LIR_Nem_3 152 158 PF02991 0.483
LIG_LIR_Nem_3 182 188 PF02991 0.487
LIG_LIR_Nem_3 293 297 PF02991 0.275
LIG_LIR_Nem_3 379 384 PF02991 0.505
LIG_LIR_Nem_3 458 464 PF02991 0.429
LIG_LIR_Nem_3 466 471 PF02991 0.453
LIG_LIR_Nem_3 483 488 PF02991 0.522
LIG_LYPXL_L_2 308 317 PF13949 0.271
LIG_MYND_1 451 455 PF01753 0.501
LIG_MYND_1 518 522 PF01753 0.612
LIG_MYND_3 450 454 PF01753 0.491
LIG_NRBOX 301 307 PF00104 0.314
LIG_Pex14_2 607 611 PF04695 0.566
LIG_PTB_Apo_2 384 391 PF02174 0.500
LIG_RPA_C_Fungi 356 368 PF08784 0.349
LIG_SH2_CRK 431 435 PF00017 0.540
LIG_SH2_CRK 603 607 PF00017 0.538
LIG_SH2_STAT3 194 197 PF00017 0.490
LIG_SH2_STAT5 30 33 PF00017 0.517
LIG_SH2_STAT5 479 482 PF00017 0.493
LIG_SH2_STAT5 587 590 PF00017 0.630
LIG_SH3_3 123 129 PF00018 0.445
LIG_SH3_3 177 183 PF00018 0.507
LIG_SH3_3 28 34 PF00018 0.515
LIG_SH3_3 541 547 PF00018 0.476
LIG_SUMO_SIM_anti_2 301 306 PF11976 0.289
LIG_SUMO_SIM_anti_2 363 369 PF11976 0.404
LIG_SUMO_SIM_anti_2 539 546 PF11976 0.498
LIG_SUMO_SIM_par_1 539 546 PF11976 0.498
LIG_TRAF2_1 168 171 PF00917 0.511
LIG_TRAF2_1 293 296 PF00917 0.271
LIG_TRAF2_1 472 475 PF00917 0.584
LIG_TRFH_1 188 192 PF08558 0.579
LIG_WRC_WIRS_1 291 296 PF05994 0.271
MOD_CDC14_SPxK_1 400 403 PF00782 0.658
MOD_CDK_SPK_2 248 253 PF00069 0.587
MOD_CDK_SPxK_1 397 403 PF00069 0.657
MOD_CDK_SPxxK_3 125 132 PF00069 0.505
MOD_CDK_SPxxK_3 188 195 PF00069 0.527
MOD_CK1_1 212 218 PF00069 0.511
MOD_CK1_1 220 226 PF00069 0.488
MOD_CK1_1 264 270 PF00069 0.289
MOD_CK1_1 360 366 PF00069 0.409
MOD_CK1_1 506 512 PF00069 0.516
MOD_CK2_1 290 296 PF00069 0.275
MOD_CK2_1 481 487 PF00069 0.517
MOD_GlcNHglycan 120 123 PF01048 0.620
MOD_GlcNHglycan 211 214 PF01048 0.503
MOD_GlcNHglycan 216 219 PF01048 0.545
MOD_GlcNHglycan 362 365 PF01048 0.424
MOD_GlcNHglycan 505 508 PF01048 0.490
MOD_GlcNHglycan 524 527 PF01048 0.560
MOD_GSK3_1 254 261 PF00069 0.570
MOD_GSK3_1 275 282 PF00069 0.271
MOD_GSK3_1 388 395 PF00069 0.521
MOD_GSK3_1 43 50 PF00069 0.612
MOD_GSK3_1 524 531 PF00069 0.553
MOD_GSK3_1 615 622 PF00069 0.595
MOD_N-GLC_1 481 486 PF02516 0.517
MOD_NEK2_1 1 6 PF00069 0.565
MOD_NEK2_1 258 263 PF00069 0.289
MOD_NEK2_1 316 321 PF00069 0.271
MOD_NEK2_1 357 362 PF00069 0.257
MOD_NEK2_1 392 397 PF00069 0.559
MOD_NEK2_1 596 601 PF00069 0.475
MOD_NEK2_2 169 174 PF00069 0.497
MOD_NEK2_2 254 259 PF00069 0.574
MOD_PIKK_1 235 241 PF00454 0.485
MOD_PIKK_1 392 398 PF00454 0.523
MOD_PIKK_1 419 425 PF00454 0.651
MOD_PKA_1 336 342 PF00069 0.271
MOD_PKA_2 1 7 PF00069 0.539
MOD_PKA_2 209 215 PF00069 0.491
MOD_PKA_2 258 264 PF00069 0.256
MOD_PKA_2 336 342 PF00069 0.271
MOD_PKA_2 360 366 PF00069 0.404
MOD_PKA_2 419 425 PF00069 0.651
MOD_PKA_2 490 496 PF00069 0.669
MOD_PKA_2 556 562 PF00069 0.430
MOD_Plk_1 197 203 PF00069 0.535
MOD_Plk_1 298 304 PF00069 0.333
MOD_Plk_1 480 486 PF00069 0.508
MOD_Plk_2-3 388 394 PF00069 0.508
MOD_Plk_2-3 481 487 PF00069 0.517
MOD_Plk_2-3 556 562 PF00069 0.430
MOD_Plk_4 264 270 PF00069 0.271
MOD_Plk_4 336 342 PF00069 0.271
MOD_Plk_4 405 411 PF00069 0.562
MOD_Plk_4 463 469 PF00069 0.441
MOD_ProDKin_1 125 131 PF00069 0.483
MOD_ProDKin_1 188 194 PF00069 0.528
MOD_ProDKin_1 248 254 PF00069 0.610
MOD_ProDKin_1 261 267 PF00069 0.204
MOD_ProDKin_1 343 349 PF00069 0.250
MOD_ProDKin_1 397 403 PF00069 0.657
MOD_SUMO_for_1 472 475 PF00179 0.603
MOD_SUMO_rev_2 228 237 PF00179 0.487
MOD_SUMO_rev_2 540 549 PF00179 0.487
MOD_SUMO_rev_2 72 82 PF00179 0.398
TRG_DiLeu_BaEn_1 138 143 PF01217 0.492
TRG_DiLeu_BaEn_2 153 159 PF01217 0.496
TRG_DiLeu_BaEn_4 138 144 PF01217 0.567
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.481
TRG_ENDOCYTIC_2 116 119 PF00928 0.469
TRG_ENDOCYTIC_2 155 158 PF00928 0.486
TRG_ENDOCYTIC_2 185 188 PF00928 0.472
TRG_ENDOCYTIC_2 431 434 PF00928 0.540
TRG_ENDOCYTIC_2 603 606 PF00928 0.534
TRG_ER_diArg_1 143 145 PF00400 0.475
TRG_ER_diArg_1 15 18 PF00400 0.413
TRG_ER_diArg_1 175 177 PF00400 0.567
TRG_ER_diArg_1 5 8 PF00400 0.582
TRG_ER_diArg_1 613 615 PF00400 0.572
TRG_NES_CRM1_1 138 152 PF08389 0.413
TRG_NLS_Bipartite_1 156 178 PF00514 0.479
TRG_NLS_MonoExtC_3 173 178 PF00514 0.553
TRG_Pf-PMV_PEXEL_1 145 150 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 604 608 PF00026 0.547
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDJ3 Leptomonas seymouri 85% 100%
A0A0S4JNA4 Bodo saltans 71% 100%
A0A1X0P3D3 Trypanosomatidae 75% 100%
A0A3S7XBD0 Leishmania donovani 100% 100%
A4HPP0 Leishmania braziliensis 95% 100%
D0A8H4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
E9ATF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q143 Leishmania major 98% 100%
V5B9N8 Trypanosoma cruzi 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS