MORN repeat family protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat - putative

Species:

Leishmania infantum

UniProt:

A4ID18_LEIIN

TriTrypDb:

LINF_360046700

Length:

314

Annotations

Annotations by Jardim et al.

Flagella, MORON repeat Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005930	axoneme	2	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0036064	ciliary basal body	3	1
GO:0044732	mitotic spindle pole body	4	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ID18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID18

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.522
CLV_C14_Caspase3-7	39	43	PF00656	0.239
CLV_C14_Caspase3-7	92	96	PF00656	0.271
CLV_NRD_NRD_1	293	295	PF00675	0.301
DEG_Nend_UBRbox_2	1	3	PF02207	0.525
DOC_MAPK_FxFP_2	162	165	PF00069	0.405
DOC_MAPK_gen_1	222	231	PF00069	0.273
DOC_MAPK_gen_1	41	50	PF00069	0.389
DOC_MAPK_MEF2A_6	225	233	PF00069	0.295
DOC_MAPK_MEF2A_6	44	52	PF00069	0.353
DOC_PP4_FxxP_1	162	165	PF00568	0.386
DOC_PP4_FxxP_1	233	236	PF00568	0.320
DOC_PP4_MxPP_1	153	156	PF00568	0.330
LIG_14-3-3_CanoR_1	25	31	PF00244	0.211
LIG_APCC_ABBA_1	243	248	PF00400	0.379
LIG_APCC_ABBA_1	50	55	PF00400	0.329
LIG_Integrin_isoDGR_2	252	254	PF01839	0.333
LIG_LIR_Apic_2	161	165	PF02991	0.389
LIG_LIR_Nem_3	203	208	PF02991	0.285
LIG_LIR_Nem_3	239	245	PF02991	0.357
LIG_REV1ctd_RIR_1	74	83	PF16727	0.233
LIG_SH2_NCK_1	307	311	PF00017	0.474
LIG_SH2_PTP2	242	245	PF00017	0.379
LIG_SH2_SRC	208	211	PF00017	0.341
LIG_SH2_SRC	307	310	PF00017	0.417
LIG_SH2_STAP1	289	293	PF00017	0.231
LIG_SH2_STAT3	170	173	PF00017	0.251
LIG_SH2_STAT3	193	196	PF00017	0.318
LIG_SH2_STAT5	170	173	PF00017	0.223
LIG_SH2_STAT5	174	177	PF00017	0.246
LIG_SH2_STAT5	208	211	PF00017	0.326
LIG_SH2_STAT5	217	220	PF00017	0.279
LIG_SH2_STAT5	232	235	PF00017	0.218
LIG_SH2_STAT5	242	245	PF00017	0.266
LIG_SH2_STAT5	51	54	PF00017	0.292
LIG_SH2_STAT5	60	63	PF00017	0.309
LIG_SH2_STAT5	75	78	PF00017	0.262
LIG_SH2_STAT5	85	88	PF00017	0.229
LIG_SH2_STAT5	89	92	PF00017	0.265
LIG_SH3_3	296	302	PF00018	0.364
LIG_TRFH_1	184	188	PF08558	0.379
LIG_WRC_WIRS_1	159	164	PF05994	0.405
MOD_CK1_1	166	172	PF00069	0.365
MOD_CK1_1	262	268	PF00069	0.392
MOD_Cter_Amidation	213	216	PF01082	0.305
MOD_Cter_Amidation	56	59	PF01082	0.396
MOD_GlcNHglycan	165	168	PF01048	0.374
MOD_GlcNHglycan	202	205	PF01048	0.343
MOD_GlcNHglycan	212	215	PF01048	0.336
MOD_GlcNHglycan	22	25	PF01048	0.318
MOD_GlcNHglycan	261	264	PF01048	0.420
MOD_GlcNHglycan	8	11	PF01048	0.340
MOD_GSK3_1	101	108	PF00069	0.405
MOD_GSK3_1	154	161	PF00069	0.473
MOD_N-GLC_1	87	92	PF02516	0.379
MOD_NEK2_1	101	106	PF00069	0.194
MOD_NEK2_1	259	264	PF00069	0.370
MOD_NEK2_1	53	58	PF00069	0.346
MOD_PIKK_1	106	112	PF00454	0.332
MOD_PIKK_1	120	126	PF00454	0.367
MOD_Plk_1	79	85	PF00069	0.418
MOD_Plk_2-3	189	195	PF00069	0.378
MOD_Plk_4	262	268	PF00069	0.455
TRG_ENDOCYTIC_2	242	245	PF00928	0.379
TRG_ENDOCYTIC_2	307	310	PF00928	0.327
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK8	Leptomonas seymouri	24%	88%
A0A0N1PBP4	Leptomonas seymouri	83%	100%
A0A0S4JF26	Bodo saltans	61%	98%
A0A0S4KIY0	Bodo saltans	27%	88%
A0A1X0NTG8	Trypanosomatidae	27%	72%
A0A1X0P1A5	Trypanosomatidae	27%	88%
A0A1X0P3N0	Trypanosomatidae	65%	94%
A0A3R7M394	Trypanosoma rangeli	64%	95%
A0A3R7NAK8	Trypanosoma rangeli	26%	77%
A0A3S7X3U7	Leishmania donovani	27%	88%
A0A3S7XBA2	Leishmania donovani	99%	99%
A0A422P0W0	Trypanosoma rangeli	28%	88%
A4HCH7	Leishmania braziliensis	24%	75%
A4HIR9	Leishmania braziliensis	27%	100%
A4HPP6	Leishmania braziliensis	89%	100%
A4I615	Leishmania infantum	27%	100%
C9ZRE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	88%
C9ZSQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	72%
D0A8G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	97%
E9ACP2	Leishmania major	24%	89%
E9AJY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ATG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q137	Leishmania major	97%	100%
Q4Q6V8	Leishmania major	26%	100%
Q4QBK7	Leishmania major	24%	75%
V5BX28	Trypanosoma cruzi	26%	100%