RING-type domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ID13_LEIIN

TriTrypDb:

LINF_360047200

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 96

Expansion

Sequence features

A4ID13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.698
CLV_PCSK_KEX2_1	23	25	PF00082	0.698
CLV_PCSK_KEX2_1	293	295	PF00082	0.446
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.434
CLV_PCSK_SKI1_1	76	80	PF00082	0.566
DEG_APCC_DBOX_1	148	156	PF00400	0.474
DEG_SCF_FBW7_1	239	245	PF00400	0.550
DOC_CKS1_1	239	244	PF01111	0.687
DOC_MAPK_gen_1	293	301	PF00069	0.380
DOC_MAPK_MEF2A_6	270	279	PF00069	0.329
DOC_PP2B_LxvP_1	171	174	PF13499	0.492
DOC_USP7_MATH_1	216	220	PF00917	0.708
DOC_USP7_MATH_1	257	261	PF00917	0.649
DOC_USP7_MATH_1	93	97	PF00917	0.692
DOC_USP7_UBL2_3	42	46	PF12436	0.640
DOC_WW_Pin1_4	153	158	PF00397	0.577
DOC_WW_Pin1_4	16	21	PF00397	0.650
DOC_WW_Pin1_4	230	235	PF00397	0.743
DOC_WW_Pin1_4	238	243	PF00397	0.704
LIG_14-3-3_CanoR_1	117	122	PF00244	0.436
LIG_14-3-3_CanoR_1	15	20	PF00244	0.719
LIG_14-3-3_CanoR_1	23	29	PF00244	0.615
LIG_14-3-3_CanoR_1	259	266	PF00244	0.618
LIG_14-3-3_CanoR_1	294	298	PF00244	0.353
LIG_BRCT_BRCA1_1	119	123	PF00533	0.434
LIG_BRCT_BRCA1_1	95	99	PF00533	0.732
LIG_Clathr_ClatBox_1	112	116	PF01394	0.434
LIG_DLG_GKlike_1	117	124	PF00625	0.402
LIG_FHA_1	134	140	PF00498	0.429
LIG_FHA_1	206	212	PF00498	0.642
LIG_FHA_1	256	262	PF00498	0.635
LIG_FHA_1	294	300	PF00498	0.355
LIG_FHA_1	45	51	PF00498	0.563
LIG_FHA_1	70	76	PF00498	0.516
LIG_FHA_2	173	179	PF00498	0.495
LIG_FHA_2	189	195	PF00498	0.475
LIG_FHA_2	239	245	PF00498	0.761
LIG_FHA_2	59	65	PF00498	0.574
LIG_LIR_Gen_1	120	129	PF02991	0.448
LIG_LIR_Nem_3	120	124	PF02991	0.448
LIG_LIR_Nem_3	271	275	PF02991	0.441
LIG_SH2_CRK	121	125	PF00017	0.355
LIG_SH2_CRK	272	276	PF00017	0.447
LIG_SH2_STAT5	288	291	PF00017	0.480
LIG_SH2_STAT5	49	52	PF00017	0.560
LIG_SH3_3	206	212	PF00018	0.615
LIG_SH3_3	236	242	PF00018	0.738
LIG_SH3_3	274	280	PF00018	0.411
MOD_CDK_SPxxK_3	16	23	PF00069	0.712
MOD_CK1_1	225	231	PF00069	0.744
MOD_CK1_1	245	251	PF00069	0.625
MOD_CK2_1	188	194	PF00069	0.556
MOD_CK2_1	23	29	PF00069	0.749
MOD_GlcNHglycan	104	107	PF01048	0.588
MOD_GlcNHglycan	217	221	PF01048	0.734
MOD_GlcNHglycan	95	98	PF01048	0.708
MOD_GSK3_1	153	160	PF00069	0.558
MOD_GSK3_1	218	225	PF00069	0.674
MOD_GSK3_1	238	245	PF00069	0.662
MOD_GSK3_1	255	262	PF00069	0.655
MOD_GSK3_1	288	295	PF00069	0.391
MOD_N-GLC_1	157	162	PF02516	0.559
MOD_N-GLC_1	223	228	PF02516	0.689
MOD_NEK2_1	246	251	PF00069	0.708
MOD_NEK2_1	286	291	PF00069	0.447
MOD_NMyristoyl	1	7	PF02799	0.590
MOD_OFUCOSY	126	131	PF10250	0.391
MOD_OFUCOSY	290	297	PF10250	0.335
MOD_PIKK_1	188	194	PF00454	0.535
MOD_PIKK_1	288	294	PF00454	0.371
MOD_PK_1	24	30	PF00069	0.746
MOD_PKA_1	23	29	PF00069	0.750
MOD_PKA_1	293	299	PF00069	0.446
MOD_PKA_2	188	194	PF00069	0.535
MOD_PKA_2	23	29	PF00069	0.631
MOD_PKA_2	293	299	PF00069	0.354
MOD_Plk_2-3	29	35	PF00069	0.738
MOD_Plk_4	172	178	PF00069	0.516
MOD_Plk_4	242	248	PF00069	0.547
MOD_Plk_4	58	64	PF00069	0.496
MOD_ProDKin_1	153	159	PF00069	0.576
MOD_ProDKin_1	16	22	PF00069	0.651
MOD_ProDKin_1	230	236	PF00069	0.748
MOD_ProDKin_1	238	244	PF00069	0.706
TRG_ENDOCYTIC_2	121	124	PF00928	0.355
TRG_ENDOCYTIC_2	272	275	PF00928	0.447
TRG_ER_diArg_1	186	189	PF00400	0.584
TRG_ER_diArg_1	23	25	PF00400	0.698
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK3	Leptomonas seymouri	56%	98%
A0A0S4JLL7	Bodo saltans	33%	100%
A0A1X0P3L1	Trypanosomatidae	40%	100%
A0A3Q8IJF1	Leishmania donovani	100%	100%
A4HPQ0	Leishmania braziliensis	78%	100%
D0A8G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q132	Leishmania major	95%	100%
V5BIP2	Trypanosoma cruzi	32%	100%