LeishMANIAdb
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Glycine--tRNA ligase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycine--tRNA ligase
Gene product:
glycyl tRNA synthetase - putative
Species:
Leishmania infantum
UniProt:
A4ID12_LEIIN
TriTrypDb:
LINF_360047300
Length:
628

Annotations

Annotations by Jardim et al.

tRNA synthetase, glycyl tRNA synthetase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ID12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID12

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006418 tRNA aminoacylation for protein translation 6 12
GO:0006426 glycyl-tRNA aminoacylation 7 12
GO:0006520 amino acid metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043038 amino acid activation 4 12
GO:0043039 tRNA aminoacylation 5 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0000959 mitochondrial RNA metabolic process 6 1
GO:0070127 tRNA aminoacylation for mitochondrial protein translation 7 1
GO:0070150 mitochondrial glycyl-tRNA aminoacylation 8 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004812 aminoacyl-tRNA ligase activity 4 12
GO:0004820 glycine-tRNA ligase activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140101 catalytic activity, acting on a tRNA 4 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 25 27 PF00675 0.450
CLV_NRD_NRD_1 490 492 PF00675 0.294
CLV_PCSK_KEX2_1 203 205 PF00082 0.266
CLV_PCSK_KEX2_1 24 26 PF00082 0.455
CLV_PCSK_KEX2_1 490 492 PF00082 0.294
CLV_PCSK_KEX2_1 499 501 PF00082 0.277
CLV_PCSK_PC1ET2_1 203 205 PF00082 0.266
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.277
CLV_PCSK_SKI1_1 150 154 PF00082 0.492
CLV_PCSK_SKI1_1 232 236 PF00082 0.267
CLV_PCSK_SKI1_1 239 243 PF00082 0.223
CLV_PCSK_SKI1_1 25 29 PF00082 0.437
CLV_PCSK_SKI1_1 307 311 PF00082 0.240
CLV_PCSK_SKI1_1 386 390 PF00082 0.366
CLV_PCSK_SKI1_1 455 459 PF00082 0.271
CLV_PCSK_SKI1_1 500 504 PF00082 0.258
CLV_PCSK_SKI1_1 513 517 PF00082 0.213
DEG_APCC_DBOX_1 231 239 PF00400 0.451
DEG_APCC_DBOX_1 385 393 PF00400 0.576
DEG_ODPH_VHL_1 509 521 PF01847 0.413
DOC_CYCLIN_RxL_1 383 393 PF00134 0.578
DOC_CYCLIN_yCln2_LP_2 562 568 PF00134 0.402
DOC_CYCLIN_yCln2_LP_2 603 609 PF00134 0.538
DOC_MAPK_DCC_7 513 521 PF00069 0.402
DOC_MAPK_gen_1 24 33 PF00069 0.243
DOC_MAPK_gen_1 259 268 PF00069 0.483
DOC_MAPK_gen_1 554 564 PF00069 0.402
DOC_MAPK_MEF2A_6 513 521 PF00069 0.426
DOC_MAPK_MEF2A_6 558 566 PF00069 0.402
DOC_PP2B_LxvP_1 508 511 PF13499 0.440
DOC_PP2B_LxvP_1 562 565 PF13499 0.402
DOC_PP4_FxxP_1 166 169 PF00568 0.320
DOC_PP4_FxxP_1 249 252 PF00568 0.451
DOC_USP7_MATH_1 2 6 PF00917 0.401
DOC_USP7_MATH_1 355 359 PF00917 0.440
DOC_USP7_MATH_1 436 440 PF00917 0.625
DOC_USP7_MATH_1 51 55 PF00917 0.340
DOC_USP7_UBL2_3 155 159 PF12436 0.308
DOC_USP7_UBL2_3 255 259 PF12436 0.473
DOC_USP7_UBL2_3 399 403 PF12436 0.501
DOC_WW_Pin1_4 157 162 PF00397 0.276
DOC_WW_Pin1_4 462 467 PF00397 0.566
DOC_WW_Pin1_4 503 508 PF00397 0.505
DOC_WW_Pin1_4 76 81 PF00397 0.260
LIG_14-3-3_CanoR_1 323 333 PF00244 0.589
LIG_14-3-3_CanoR_1 500 506 PF00244 0.486
LIG_14-3-3_CanoR_1 539 544 PF00244 0.506
LIG_14-3-3_CanoR_1 590 600 PF00244 0.433
LIG_AP2alpha_1 166 170 PF02296 0.320
LIG_AP2alpha_2 168 170 PF02296 0.389
LIG_BIR_III_4 140 144 PF00653 0.391
LIG_BRCT_BRCA1_1 166 170 PF00533 0.237
LIG_deltaCOP1_diTrp_1 267 271 PF00928 0.451
LIG_EH_1 163 167 PF12763 0.293
LIG_EH1_1 472 480 PF00400 0.427
LIG_FHA_1 37 43 PF00498 0.319
LIG_FHA_1 391 397 PF00498 0.565
LIG_FHA_1 432 438 PF00498 0.538
LIG_FHA_1 463 469 PF00498 0.542
LIG_FHA_1 73 79 PF00498 0.262
LIG_FHA_2 15 21 PF00498 0.267
LIG_FHA_2 240 246 PF00498 0.429
LIG_FHA_2 284 290 PF00498 0.463
LIG_FHA_2 526 532 PF00498 0.461
LIG_FHA_2 577 583 PF00498 0.402
LIG_FHA_2 77 83 PF00498 0.258
LIG_LIR_Apic_2 247 252 PF02991 0.446
LIG_LIR_Apic_2 267 272 PF02991 0.352
LIG_LIR_Apic_2 377 382 PF02991 0.500
LIG_LIR_Gen_1 132 142 PF02991 0.390
LIG_LIR_Gen_1 258 268 PF02991 0.487
LIG_LIR_Gen_1 611 620 PF02991 0.486
LIG_LIR_Gen_1 91 98 PF02991 0.315
LIG_LIR_Nem_3 132 137 PF02991 0.348
LIG_LIR_Nem_3 258 263 PF02991 0.479
LIG_LIR_Nem_3 344 349 PF02991 0.465
LIG_LIR_Nem_3 504 508 PF02991 0.564
LIG_LIR_Nem_3 611 615 PF02991 0.463
LIG_LIR_Nem_3 91 96 PF02991 0.327
LIG_MYND_1 507 511 PF01753 0.523
LIG_NRBOX 478 484 PF00104 0.419
LIG_Pex14_1 60 64 PF04695 0.230
LIG_Pex14_2 112 116 PF04695 0.358
LIG_Pex14_2 166 170 PF04695 0.252
LIG_Pex14_2 172 176 PF04695 0.450
LIG_SH2_GRB2like 411 414 PF00017 0.488
LIG_SH2_NCK_1 556 560 PF00017 0.402
LIG_SH2_SRC 411 414 PF00017 0.479
LIG_SH2_STAT3 619 622 PF00017 0.581
LIG_SH2_STAT5 303 306 PF00017 0.407
LIG_SH2_STAT5 411 414 PF00017 0.475
LIG_SH2_STAT5 464 467 PF00017 0.458
LIG_SH2_STAT5 480 483 PF00017 0.387
LIG_SH3_3 432 438 PF00018 0.586
LIG_SH3_3 465 471 PF00018 0.425
LIG_SH3_3 586 592 PF00018 0.402
LIG_SH3_3 603 609 PF00018 0.471
LIG_SUMO_SIM_par_1 433 439 PF11976 0.530
LIG_TRAF2_1 375 378 PF00917 0.514
LIG_TRAF2_1 439 442 PF00917 0.605
LIG_TRAF2_1 451 454 PF00917 0.577
LIG_TRAF2_1 79 82 PF00917 0.283
LIG_TRFH_1 43 47 PF08558 0.297
LIG_TYR_ITIM 478 483 PF00017 0.409
LIG_TYR_ITSM 342 349 PF00017 0.429
LIG_UBA3_1 388 394 PF00899 0.571
LIG_UBA3_1 516 522 PF00899 0.469
LIG_WRC_WIRS_1 449 454 PF05994 0.588
LIG_WRC_WIRS_1 502 507 PF05994 0.542
MOD_CDK_SPK_2 157 162 PF00069 0.237
MOD_CK1_1 366 372 PF00069 0.495
MOD_CK1_1 548 554 PF00069 0.434
MOD_CK2_1 14 20 PF00069 0.292
MOD_CK2_1 239 245 PF00069 0.431
MOD_CK2_1 283 289 PF00069 0.553
MOD_CK2_1 436 442 PF00069 0.573
MOD_CK2_1 448 454 PF00069 0.580
MOD_CK2_1 464 470 PF00069 0.366
MOD_CK2_1 525 531 PF00069 0.493
MOD_CK2_1 576 582 PF00069 0.402
MOD_CK2_1 66 72 PF00069 0.273
MOD_CK2_1 76 82 PF00069 0.243
MOD_Cter_Amidation 401 404 PF01082 0.376
MOD_Cter_Amidation 552 555 PF01082 0.202
MOD_GlcNHglycan 207 210 PF01048 0.307
MOD_GlcNHglycan 232 235 PF01048 0.314
MOD_GlcNHglycan 356 360 PF01048 0.245
MOD_GlcNHglycan 413 416 PF01048 0.334
MOD_GlcNHglycan 438 441 PF01048 0.380
MOD_GlcNHglycan 86 89 PF01048 0.449
MOD_GSK3_1 460 467 PF00069 0.521
MOD_GSK3_1 591 598 PF00069 0.563
MOD_GSK3_1 72 79 PF00069 0.263
MOD_GSK3_1 84 91 PF00069 0.262
MOD_N-GLC_1 297 302 PF02516 0.227
MOD_N-GLC_1 366 371 PF02516 0.356
MOD_NEK2_1 175 180 PF00069 0.467
MOD_NEK2_1 19 24 PF00069 0.245
MOD_NEK2_1 205 210 PF00069 0.477
MOD_NEK2_1 310 315 PF00069 0.497
MOD_NEK2_1 342 347 PF00069 0.431
MOD_NEK2_1 483 488 PF00069 0.422
MOD_NEK2_1 525 530 PF00069 0.479
MOD_NEK2_1 84 89 PF00069 0.274
MOD_NEK2_2 576 581 PF00069 0.402
MOD_OFUCOSY 71 77 PF10250 0.472
MOD_PIKK_1 144 150 PF00454 0.248
MOD_PIKK_1 360 366 PF00454 0.465
MOD_PIKK_1 584 590 PF00454 0.506
MOD_PK_1 539 545 PF00069 0.506
MOD_PKA_2 283 289 PF00069 0.513
MOD_PKA_2 582 588 PF00069 0.402
MOD_PKA_2 98 104 PF00069 0.263
MOD_PKB_1 237 245 PF00069 0.434
MOD_Plk_1 239 245 PF00069 0.431
MOD_Plk_1 297 303 PF00069 0.424
MOD_Plk_1 355 361 PF00069 0.451
MOD_Plk_1 441 447 PF00069 0.593
MOD_Plk_1 483 489 PF00069 0.433
MOD_Plk_1 545 551 PF00069 0.519
MOD_Plk_1 66 72 PF00069 0.271
MOD_Plk_1 73 79 PF00069 0.246
MOD_Plk_4 464 470 PF00069 0.460
MOD_Plk_4 483 489 PF00069 0.509
MOD_Plk_4 595 601 PF00069 0.538
MOD_ProDKin_1 157 163 PF00069 0.276
MOD_ProDKin_1 462 468 PF00069 0.562
MOD_ProDKin_1 503 509 PF00069 0.501
MOD_ProDKin_1 76 82 PF00069 0.264
MOD_SUMO_for_1 521 524 PF00179 0.402
MOD_SUMO_for_1 592 595 PF00179 0.417
MOD_SUMO_for_1 9 12 PF00179 0.319
MOD_SUMO_rev_2 451 460 PF00179 0.505
TRG_DiLeu_BaEn_1 133 138 PF01217 0.342
TRG_DiLeu_BaEn_2 244 250 PF01217 0.430
TRG_DiLeu_BaLyEn_6 504 509 PF01217 0.461
TRG_ENDOCYTIC_2 346 349 PF00928 0.472
TRG_ENDOCYTIC_2 480 483 PF00928 0.440
TRG_ENDOCYTIC_2 556 559 PF00928 0.402
TRG_ER_diArg_1 236 239 PF00400 0.442
TRG_ER_diArg_1 24 26 PF00400 0.255
TRG_ER_diArg_1 489 491 PF00400 0.507
TRG_Pf-PMV_PEXEL_1 111 115 PF00026 0.471
TRG_Pf-PMV_PEXEL_1 386 391 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZB0 Leptomonas seymouri 84% 95%
A0A0S4JJA5 Bodo saltans 66% 100%
A0A1X0P3R2 Trypanosomatidae 72% 100%
A0A3Q8IPA6 Leishmania donovani 100% 100%
A0A422MT81 Trypanosoma rangeli 70% 100%
A0B5U4 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 37% 100%
A4FZX1 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 37% 100%
A4HPQ1 Leishmania braziliensis 94% 100%
A5IT93 Staphylococcus aureus (strain JH9) 27% 100%
A6QHA8 Staphylococcus aureus (strain Newman) 27% 100%
A6U237 Staphylococcus aureus (strain JH1) 27% 100%
A6URK3 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 37% 100%
A6VIK1 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 38% 100%
A7X2W2 Staphylococcus aureus (strain Mu3 / ATCC 700698) 27% 100%
A8Z4A4 Staphylococcus aureus (strain USA300 / TCH1516) 27% 100%
A9A885 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 38% 100%
C5A1H0 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 37% 100%
C6A317 Thermococcus sibiricus (strain DSM 12597 / MM 739) 36% 100%
D0A8G2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9ATG6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O23627 Arabidopsis thaliana 48% 86%
O27874 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 38% 100%
O29346 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 40% 100%
O59235 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 36% 100%
P38088 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 45% 91%
P41250 Homo sapiens 45% 85%
P56206 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 30% 100%
P67034 Staphylococcus aureus (strain Mu50 / ATCC 700699) 27% 100%
P67035 Staphylococcus aureus (strain MW2) 27% 100%
P99129 Staphylococcus aureus (strain N315) 27% 100%
Q04451 Bombyx mori 44% 86%
Q06817 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 100%
Q10039 Caenorhabditis elegans 44% 85%
Q10179 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 96%
Q2FGF8 Staphylococcus aureus (strain USA300) 27% 100%
Q2FY08 Staphylococcus aureus (strain NCTC 8325 / PS 47) 27% 100%
Q2YT14 Staphylococcus aureus (strain bovine RF122 / ET3-1) 27% 100%
Q4Q131 Leishmania major 98% 100%
Q57681 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 39% 100%
Q5HFJ5 Staphylococcus aureus (strain COL) 27% 100%
Q5I0G4 Rattus norvegicus 45% 86%
Q5JID8 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 36% 100%
Q5RBL1 Pongo abelii 45% 85%
Q6G902 Staphylococcus aureus (strain MSSA476) 27% 100%
Q6GGD5 Staphylococcus aureus (strain MRSA252) 27% 100%
Q6M0Q7 Methanococcus maripaludis (strain S2 / LL) 37% 100%
Q72L85 Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) 29% 100%
Q8SQZ6 Encephalitozoon cuniculi (strain GB-M1) 41% 100%
Q8TYY9 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 37% 100%
Q8U0G2 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 37% 100%
Q9CZD3 Mus musculus 45% 86%
Q9V176 Pyrococcus abyssi (strain GE5 / Orsay) 36% 100%
Q9VUK8 Drosophila melanogaster 44% 82%
Q9YBF8 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 34% 100%
V5AU76 Trypanosoma cruzi 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS