Similar to leishmania major. l411.4-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similar to leishmania major. l411.4-like protein

Species:

Leishmania infantum

UniProt:

A4ID10_LEIIN

TriTrypDb:

LINF_360047500

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	11
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4ID10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID10

Function

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Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	11
GO:0009566	fertilization	2	11
GO:0022414	reproductive process	1	11

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	522	524	PF00675	0.453
CLV_PCSK_KEX2_1	522	524	PF00082	0.509
CLV_PCSK_SKI1_1	254	258	PF00082	0.406
CLV_PCSK_SKI1_1	452	456	PF00082	0.505
CLV_PCSK_SKI1_1	523	527	PF00082	0.526
CLV_PCSK_SKI1_1	530	534	PF00082	0.489
DEG_APCC_DBOX_1	94	102	PF00400	0.309
DEG_SPOP_SBC_1	193	197	PF00917	0.320
DEG_SPOP_SBC_1	459	463	PF00917	0.253
DOC_CKS1_1	19	24	PF01111	0.497

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A060A682	Tetrahymena thermophila	21%	78%
A0A0N1I7I3	Leptomonas seymouri	49%	93%
A0A0S4KHY6	Bodo saltans	24%	86%
A0A1X0P0J5	Trypanosomatidae	25%	94%
A0A3Q8IW91	Leishmania donovani	99%	100%
A0A3R7NLN3	Trypanosoma rangeli	25%	99%
A4HPQ3	Leishmania braziliensis	75%	99%
D0A4L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	93%
Q4Q129	Leishmania major	93%	100%
V5BFV7	Trypanosoma cruzi	26%	98%

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