Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ID09_LEIIN

TriTrypDb:

LINF_360047600

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4ID09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ID09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.678
CLV_C14_Caspase3-7	525	529	PF00656	0.703
CLV_C14_Caspase3-7	78	82	PF00656	0.633
CLV_NRD_NRD_1	140	142	PF00675	0.493
CLV_NRD_NRD_1	600	602	PF00675	0.609
CLV_NRD_NRD_1	677	679	PF00675	0.566
CLV_NRD_NRD_1	728	730	PF00675	0.470
CLV_NRD_NRD_1	79	81	PF00675	0.653
CLV_PCSK_KEX2_1	140	142	PF00082	0.493
CLV_PCSK_KEX2_1	600	602	PF00082	0.609
CLV_PCSK_KEX2_1	79	81	PF00082	0.661
CLV_PCSK_SKI1_1	306	310	PF00082	0.530
CLV_PCSK_SKI1_1	356	360	PF00082	0.463
CLV_PCSK_SKI1_1	678	682	PF00082	0.561
DEG_APCC_DBOX_1	677	685	PF00400	0.556
DEG_APCC_DBOX_1	717	725	PF00400	0.469
DEG_SCF_FBW7_1	126	133	PF00400	0.521
DOC_CKS1_1	219	224	PF01111	0.483
DOC_CKS1_1	602	607	PF01111	0.711
DOC_MAPK_DCC_7	541	550	PF00069	0.671
DOC_MAPK_gen_1	678	684	PF00069	0.558
DOC_MAPK_MEF2A_6	30	38	PF00069	0.486
DOC_MAPK_MEF2A_6	541	550	PF00069	0.671
DOC_PP1_RVXF_1	102	108	PF00149	0.383
DOC_USP7_MATH_1	166	170	PF00917	0.440
DOC_USP7_MATH_1	227	231	PF00917	0.660
DOC_USP7_MATH_1	267	271	PF00917	0.563
DOC_USP7_MATH_1	419	423	PF00917	0.761
DOC_USP7_MATH_1	474	478	PF00917	0.669
DOC_USP7_MATH_1	523	527	PF00917	0.819
DOC_USP7_MATH_1	531	535	PF00917	0.612
DOC_USP7_MATH_1	591	595	PF00917	0.728
DOC_USP7_MATH_1	615	619	PF00917	0.711
DOC_USP7_MATH_1	624	628	PF00917	0.682
DOC_USP7_MATH_1	661	665	PF00917	0.548
DOC_USP7_MATH_1	67	71	PF00917	0.648
DOC_USP7_MATH_1	690	694	PF00917	0.567
DOC_USP7_MATH_1	797	801	PF00917	0.548
DOC_USP7_MATH_1	92	96	PF00917	0.609
DOC_WW_Pin1_4	121	126	PF00397	0.689
DOC_WW_Pin1_4	17	22	PF00397	0.526
DOC_WW_Pin1_4	218	223	PF00397	0.534
DOC_WW_Pin1_4	415	420	PF00397	0.734
DOC_WW_Pin1_4	433	438	PF00397	0.518
DOC_WW_Pin1_4	445	450	PF00397	0.615
DOC_WW_Pin1_4	499	504	PF00397	0.602
DOC_WW_Pin1_4	54	59	PF00397	0.545
DOC_WW_Pin1_4	580	585	PF00397	0.677
DOC_WW_Pin1_4	592	597	PF00397	0.550
DOC_WW_Pin1_4	601	606	PF00397	0.639
DOC_WW_Pin1_4	62	67	PF00397	0.583
DOC_WW_Pin1_4	620	625	PF00397	0.741
DOC_WW_Pin1_4	800	805	PF00397	0.614
DOC_WW_Pin1_4	84	89	PF00397	0.666
LIG_14-3-3_CanoR_1	600	605	PF00244	0.671
LIG_14-3-3_CanoR_1	69	77	PF00244	0.638
LIG_14-3-3_CanoR_1	705	713	PF00244	0.464
LIG_14-3-3_CanoR_1	738	746	PF00244	0.445
LIG_Actin_WH2_2	399	415	PF00022	0.434
LIG_BRCT_BRCA1_1	374	378	PF00533	0.524
LIG_BRCT_BRCA1_1	593	597	PF00533	0.581
LIG_CSL_BTD_1	506	509	PF09270	0.522
LIG_FHA_1	190	196	PF00498	0.379
LIG_FHA_1	295	301	PF00498	0.605
LIG_FHA_1	303	309	PF00498	0.489
LIG_FHA_1	426	432	PF00498	0.711
LIG_FHA_1	585	591	PF00498	0.573
LIG_FHA_1	638	644	PF00498	0.730
LIG_FHA_1	694	700	PF00498	0.542
LIG_FHA_1	705	711	PF00498	0.459
LIG_FHA_1	738	744	PF00498	0.446
LIG_FHA_1	762	768	PF00498	0.454
LIG_FHA_2	131	137	PF00498	0.551
LIG_FHA_2	266	272	PF00498	0.461
LIG_FHA_2	360	366	PF00498	0.524
LIG_FHA_2	672	678	PF00498	0.595
LIG_FHA_2	709	715	PF00498	0.461
LIG_FHA_2	817	823	PF00498	0.545
LIG_LIR_Gen_1	100	109	PF02991	0.487
LIG_LIR_Gen_1	35	46	PF02991	0.435
LIG_LIR_Nem_3	100	105	PF02991	0.499
LIG_LIR_Nem_3	236	240	PF02991	0.400
LIG_LIR_Nem_3	35	41	PF02991	0.440
LIG_MYND_1	551	555	PF01753	0.551
LIG_OCRL_FandH_1	101	113	PF00620	0.425
LIG_PCNA_yPIPBox_3	175	188	PF02747	0.519
LIG_Pex14_1	507	511	PF04695	0.558
LIG_SH2_CRK	560	564	PF00017	0.653
LIG_SH2_GRB2like	282	285	PF00017	0.575
LIG_SH2_GRB2like	337	340	PF00017	0.468
LIG_SH2_PTP2	543	546	PF00017	0.681
LIG_SH2_SRC	543	546	PF00017	0.681
LIG_SH2_STAT3	10	13	PF00017	0.432
LIG_SH2_STAT5	10	13	PF00017	0.432
LIG_SH2_STAT5	337	340	PF00017	0.468
LIG_SH2_STAT5	543	546	PF00017	0.784
LIG_SH2_STAT5	560	563	PF00017	0.486
LIG_SH3_1	464	470	PF00018	0.613
LIG_SH3_3	221	227	PF00018	0.563
LIG_SH3_3	232	238	PF00018	0.488
LIG_SH3_3	438	444	PF00018	0.679
LIG_SH3_3	446	452	PF00018	0.749
LIG_SH3_3	462	468	PF00018	0.683
LIG_SH3_3	470	476	PF00018	0.629
LIG_SH3_3	500	506	PF00018	0.663
LIG_SH3_3	543	549	PF00018	0.616
LIG_SH3_3	599	605	PF00018	0.719
LIG_SH3_3	616	622	PF00018	0.635
LIG_SUMO_SIM_par_1	408	416	PF11976	0.449
LIG_SUMO_SIM_par_1	52	57	PF11976	0.430
LIG_SUMO_SIM_par_1	680	686	PF11976	0.496
LIG_SUMO_SIM_par_1	752	757	PF11976	0.495
LIG_TRAF2_1	239	242	PF00917	0.397
LIG_WRC_WIRS_1	157	162	PF05994	0.374
LIG_WW_2	473	476	PF00397	0.571
MOD_CDK_SPxxK_3	218	225	PF00069	0.488
MOD_CDK_SPxxK_3	54	61	PF00069	0.566
MOD_CDK_SPxxK_3	62	69	PF00069	0.586
MOD_CDK_SPxxK_3	800	807	PF00069	0.687
MOD_CDK_SPxxK_3	84	91	PF00069	0.667
MOD_CK1_1	153	159	PF00069	0.481
MOD_CK1_1	270	276	PF00069	0.590
MOD_CK1_1	341	347	PF00069	0.477
MOD_CK1_1	415	421	PF00069	0.699
MOD_CK1_1	436	442	PF00069	0.566
MOD_CK1_1	477	483	PF00069	0.673
MOD_CK1_1	623	629	PF00069	0.745
MOD_CK1_1	651	657	PF00069	0.623
MOD_CK1_1	693	699	PF00069	0.572
MOD_CK1_1	70	76	PF00069	0.672
MOD_CK1_1	800	806	PF00069	0.554
MOD_CK1_1	84	90	PF00069	0.585
MOD_CK1_1	95	101	PF00069	0.497
MOD_CK2_1	130	136	PF00069	0.557
MOD_CK2_1	2	8	PF00069	0.440
MOD_CK2_1	359	365	PF00069	0.451
MOD_CK2_1	436	442	PF00069	0.641
MOD_CK2_1	455	461	PF00069	0.634
MOD_CK2_1	580	586	PF00069	0.569
MOD_CK2_1	623	629	PF00069	0.706
MOD_CK2_1	683	689	PF00069	0.460
MOD_CK2_1	708	714	PF00069	0.461
MOD_DYRK1A_RPxSP_1	601	605	PF00069	0.671
MOD_GlcNHglycan	152	155	PF01048	0.466
MOD_GlcNHglycan	228	232	PF01048	0.579
MOD_GlcNHglycan	302	305	PF01048	0.609
MOD_GlcNHglycan	332	335	PF01048	0.388
MOD_GlcNHglycan	392	396	PF01048	0.588
MOD_GlcNHglycan	438	441	PF01048	0.669
MOD_GlcNHglycan	484	487	PF01048	0.711
MOD_GlcNHglycan	492	495	PF01048	0.818
MOD_GlcNHglycan	525	528	PF01048	0.741
MOD_GlcNHglycan	534	537	PF01048	0.597
MOD_GlcNHglycan	626	629	PF01048	0.700
MOD_GlcNHglycan	661	664	PF01048	0.602
MOD_GlcNHglycan	73	76	PF01048	0.653
MOD_GlcNHglycan	756	759	PF01048	0.548
MOD_GlcNHglycan	793	796	PF01048	0.658
MOD_GlcNHglycan	94	97	PF01048	0.554
MOD_GSK3_1	105	112	PF00069	0.574
MOD_GSK3_1	121	128	PF00069	0.663
MOD_GSK3_1	152	159	PF00069	0.554
MOD_GSK3_1	223	230	PF00069	0.551
MOD_GSK3_1	265	272	PF00069	0.591
MOD_GSK3_1	339	346	PF00069	0.434
MOD_GSK3_1	348	355	PF00069	0.533
MOD_GSK3_1	372	379	PF00069	0.561
MOD_GSK3_1	415	422	PF00069	0.732
MOD_GSK3_1	482	489	PF00069	0.682
MOD_GSK3_1	517	524	PF00069	0.620
MOD_GSK3_1	580	587	PF00069	0.607
MOD_GSK3_1	620	627	PF00069	0.603
MOD_GSK3_1	637	644	PF00069	0.616
MOD_GSK3_1	67	74	PF00069	0.667
MOD_GSK3_1	704	711	PF00069	0.466
MOD_GSK3_1	83	90	PF00069	0.567
MOD_GSK3_1	91	98	PF00069	0.568
MOD_N-GLC_1	109	114	PF02516	0.461
MOD_N-GLC_1	338	343	PF02516	0.462
MOD_N-GLC_1	71	76	PF02516	0.653
MOD_NEK2_1	105	110	PF00069	0.381
MOD_NEK2_1	217	222	PF00069	0.415
MOD_NEK2_1	300	305	PF00069	0.612
MOD_NEK2_1	311	316	PF00069	0.537
MOD_NEK2_1	338	343	PF00069	0.380
MOD_NEK2_1	348	353	PF00069	0.386
MOD_NEK2_1	359	364	PF00069	0.596
MOD_NEK2_1	367	372	PF00069	0.305
MOD_NEK2_1	390	395	PF00069	0.429
MOD_NEK2_1	424	429	PF00069	0.653
MOD_NEK2_1	510	515	PF00069	0.563
MOD_NEK2_1	761	766	PF00069	0.505
MOD_NEK2_1	825	830	PF00069	0.569
MOD_NEK2_1	97	102	PF00069	0.577
MOD_NEK2_2	200	205	PF00069	0.315
MOD_NEK2_2	274	279	PF00069	0.630
MOD_PIKK_1	130	136	PF00454	0.557
MOD_PIKK_1	311	317	PF00454	0.420
MOD_PIKK_1	651	657	PF00454	0.671
MOD_PIKK_1	827	833	PF00454	0.539
MOD_PIKK_1	97	103	PF00454	0.478
MOD_PKA_1	600	606	PF00069	0.642
MOD_PKA_2	2	8	PF00069	0.530
MOD_PKA_2	412	418	PF00069	0.538
MOD_PKA_2	517	523	PF00069	0.535
MOD_PKA_2	600	606	PF00069	0.669
MOD_PKA_2	669	675	PF00069	0.645
MOD_PKA_2	70	76	PF00069	0.644
MOD_PKA_2	704	710	PF00069	0.468
MOD_PKA_2	737	743	PF00069	0.475
MOD_PKA_2	92	98	PF00069	0.555
MOD_PKB_1	69	77	PF00069	0.561
MOD_Plk_1	109	115	PF00069	0.445
MOD_Plk_1	241	247	PF00069	0.382
MOD_Plk_1	270	276	PF00069	0.578
MOD_Plk_1	615	621	PF00069	0.566
MOD_Plk_4	2	8	PF00069	0.440
MOD_Plk_4	241	247	PF00069	0.433
MOD_Plk_4	348	354	PF00069	0.433
MOD_Plk_4	419	425	PF00069	0.764
MOD_Plk_4	455	461	PF00069	0.634
MOD_Plk_4	510	516	PF00069	0.528
MOD_Plk_4	761	767	PF00069	0.526
MOD_ProDKin_1	121	127	PF00069	0.689
MOD_ProDKin_1	17	23	PF00069	0.531
MOD_ProDKin_1	218	224	PF00069	0.551
MOD_ProDKin_1	415	421	PF00069	0.739
MOD_ProDKin_1	433	439	PF00069	0.519
MOD_ProDKin_1	445	451	PF00069	0.612
MOD_ProDKin_1	499	505	PF00069	0.595
MOD_ProDKin_1	54	60	PF00069	0.556
MOD_ProDKin_1	580	586	PF00069	0.679
MOD_ProDKin_1	592	598	PF00069	0.545
MOD_ProDKin_1	601	607	PF00069	0.637
MOD_ProDKin_1	62	68	PF00069	0.583
MOD_ProDKin_1	620	626	PF00069	0.742
MOD_ProDKin_1	800	806	PF00069	0.615
MOD_ProDKin_1	84	90	PF00069	0.665
MOD_SUMO_rev_2	672	681	PF00179	0.576
TRG_DiLeu_BaEn_1	386	391	PF01217	0.385
TRG_DiLeu_BaEn_2	240	246	PF01217	0.377
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.556
TRG_DiLeu_BaLyEn_6	801	806	PF01217	0.633
TRG_ENDOCYTIC_2	282	285	PF00928	0.589
TRG_ENDOCYTIC_2	337	340	PF00928	0.468
TRG_ENDOCYTIC_2	543	546	PF00928	0.681
TRG_ER_diArg_1	139	141	PF00400	0.505
TRG_ER_diArg_1	600	602	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL79	Leptomonas seymouri	41%	94%
A0A3S7XBE3	Leishmania donovani	99%	100%
A4HPQ4	Leishmania braziliensis	66%	99%
E9ATG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q128	Leishmania major	90%	100%